Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)

Organizer(s): David M. Altshuler, Lon Cardon and Leonid Kruglyak
January 8 - 13, 2004
Beaver Run Resort · Breckenridge, Colorado
Abstract Deadline: October 15, 2003
Early Registration Deadline: November 10, 2003

Supported by Keystone Symposia

Joint meeting: Natural Variation and Quantitative Genetics in Model Organisms (J2)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2004 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The goal of this meeting is to understand patterns of sequence variation in the human genome and how they impact biology and disease. Specifically, the meeting will explore how genome sequences and patterns of gene expression vary in populations, and the forces that shaped these patterns (both molecular and demographic). We will review approaches to studying complex traits in both model systems and in human populations, including the genetic architecture of common human diseases. Finally, we will review recent examples of genetic contributions to common human diseases, and the impact of such information on biology, pharmaceutical development and medicine. The goal of the joint meetings is to bring together scientists and perspectives from population genetics, quantitative genetics, human genetics, genomics and epidemiology. The synthesis of these capabilities and frameworks will surely be required to make progress in the genetic analysis of common human disease.

Thursday, January 8
3:00 - 7:00 PM	Registration	Foyer
6:15 - 7:15 PM	Refreshments	Foyer
7:15 - 7:30 PM	Orientation	Peaks 4-5
7:30 - 9:30 PM	Keynote Session: Genetic Dissection of Complex Traits (Joint)	Peaks 4-5
	* David M. Altshuler, Massachusetts General Hospital
	* Detlef Weigel, Max Planck Institute for Developmental Biology
	Charles H. Langley, University of California, Davis Polymorphism and Divergence Across the Drosophila Genome
	Aravinda Chakravarti, Johns Hopkins School of Medicine The Nature of Variation in Complex Disease
Friday, January 9
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Patterns of Human Genome Sequence Variation	Peaks 4-5
	* Peter Donnelly, University of Oxford
	Mark Daly, Massachusetts General Hospital Human Haplotype Structure
	Lon Cardon, University of Oxford Haplotype Structure Across Chromosomes
	Kelly A. Frazer, The Scripps Research Institute Genetic Variation and Human Disease

	Andrew G. Clark, Cornell University Lessons from Candidate Gene Studies about the Genetics of Complex Traits
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 14-16
1:00 - 10:00 PM	Poster Viewing	Peaks 14-16
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Exploiting Inbred Strains to Find Complex Traits (Joint)	Peaks 4-5
	* Peter D. Keightley, University of Edinburgh

	Keith R. Davis, Icoria, Inc High-Throughput Plant Gene Function Analysis in Arabidopsis
	Wayne Frankel, The Jackson Laboratory Effects of Genetic Background on Induced and Spontaneous Mouse Models for Epilepsy
	Michael Snyder, Stanford University School of Medicine Identification of Functional Regions in the Genomes of Yeast and Humans
6:45 - 7:20 PM	Comparative Genomics
	Eric S. Lander, Broad Institute, Massachusetts Institute of Technology
7:20 - 8:00 PM	Social Hour	Peaks 14-16
7:30 - 10:00 PM	Poster Session 1	Peaks 14-16
Saturday, January 10
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Molecular Forces Shaping Genome Sequence Variation	Peaks 4-5
	* Andrew G. Clark, Cornell University
	Peter Donnelly, University of Oxford Understanding Fine-Scale Variation in Recombination Rates
	Richard Hudson, University of Chicago Fine-Scale Mapping with Linkage Disequilibrium

	Chris Toomajian, University of Southern California The Pattern of Polymorphism in the Arabidopsis Genome

	Evan E. Eichler, University of Washington Structural Variation and Large-Scale Polymorphism within Segmental Duplications
	Richard M. Durbin, Wellcome Trust Sanger Institute Short Talk: Significant Correspondence of Recombination Events in Pedigrees with Haplotype Block Boundaries
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 14-16
1:00 - 10:00 PM	Poster Viewing	Peaks 14-16
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Population History and Human Sequence Variation	Peaks 4-5
	* Stephen J. O'Brien, National Cancer Institute, National Institutes of Health
	David B. Goldstein, Duke University Haployptes, Human History, and Pharmacogenetics
	John Raelson, Galileo Genomics Short Talk: General Extent of LD in the Quebec Founder Population


	Mark Patterson, Public Library of Science Short Talk: Public Library of Science
7:00 - 8:00 PM	Social Hour	Peaks 14-16
7:30 - 10:00 PM	Poster Session 2	Peaks 14-16
Sunday, January 11
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Inherited Variation in Gene Expression (Joint)	Peaks 4-5
	* Leonid Kruglyak, Princeton University Regulatory Variation in Yeast
	Kevin P. White, Yale University School of Medicine Evolution of Gene Expression in Drosophila
	Stephanie Monks, University of Washington-Seattle/Rosetta Inpharmatics LLC The Genetics of Gene Expression in Mice


	Justin Fay, Washington University Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence

	Matt Rockman, Duke University Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 14-16
1:00 - 10:00 PM	Poster Viewing	Peaks 14-16
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Genetic Architecture of Human Disease	Peaks 4-5
	* Lon Cardon, University of Oxford
	Stephen J. O'Brien, National Cancer Institute, National Institutes of Health Architecture of Disease: Lessons from HIV Resistance
	Nicholas Katsanis, Johns Hopkins School of Medicine Modeling Oligogenic Disorders


	John A. Phillips, Vanderbilt University School of Medicine Short Talk: PPH is a Complex Disease Caused by Rare and Common Variants
	Hua Tang, University of Chicago Short Talk: Genetic Diseases and Natural Selection in Human
	Örjan Carlborg, Roslin Institute Short Talk: The Use of Epistasis in Genetic Dissection of Complex Traits
7:00 - 8:00 PM	Social Hour	Peaks 14-16
7:30 - 10:00 PM	Poster Session 3	Peaks 14-16
Monday, January 12
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Genetic Determinants of Common Disease	Peaks 4-5
	* Francis S. Collins, NHGRI, National Institutes of Health
	Richard P. Lifton, Yale University School of Medicine Genetic Dissection of Hypertension
	Gilles Thomas, NCI - National Institutes of Health The Genetics of CARD15, a Susceptibility Gene for an Inflammatory Bowel Disease
	David M. Altshuler, Massachusetts General Hospital Genetic Analysis of Diabetes
	David Hunter, Harvard Medical School Gene-Environment Interactions

9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Application to Biology, Medicine and Society	Peaks 4-5
	* Richard P. Lifton, Yale University School of Medicine

	Georgia Dunston, Howard University The GRAD Biobank: A Resource for Exploring Genome Variation and Environment Interaction in Common Complex Diseases
	Klaus Lindpaintner, F. Hoffmann-La Roche AG Pharmacogenetics: A Realistic View
	Francis S. Collins, NHGRI, National Institutes of Health Applying Genetics to Medicine and Society
7:00 - 8:00 PM	Social Hour	Peaks 14-16
8:00 - 11:00 PM	Entertainment	Peaks 4-5
Tuesday, January 13
	Departure

*Session Chair †Speaker invited, not yet responded.