Keystone Symposia

Natural Variation and Quantitative Genetics in Model Organisms (J2)

Organizer(s): Detlef Weigel and Bruce Walsh
January 8 - 13, 2004
Beaver Run Resort · Breckenridge, Colorado
Abstract Deadline: October 15, 2003
Early Registration Deadline: November 10, 2003

Supported by Keystone Symposia

Joint meeting: Human Genome Sequence Variation and the Inherited Basis of Common Disease (J1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2004 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Despite tremendous advances in the genetic analysis of many biological processes, the molecular basis of the variation seen within and between species remains largely unknown. ·Standard genetic analyses in model organisms have focused on laboratory-induced mutations with large phenotypic effects, which contrasts with the variation seen in natural populations, which is mostly continuous. The phenotypic variation seen within or between closely related species also contrasts with the phenotypic variation seen between more distantly related species. It seems likely, however, that intra- and interspecific variation are two sides of the same coin, although a unifying molecular framework has not yet been developed. Now is an exciting time to revisit these questions because of several major technological advances. These include new analytical tools, such as high-throughput genotyping, new statistical and computational methods, comprehensive transcriptome and proteome profiling, as well as opportunities to compare entire genomes between closely and distantly related organisms. Understanding the molecular basis of natural variation has important implications both for understanding the evolution of new traits, as well as for understanding how selection has shaped genomes, including the human genome. The meeting will have as a major focus both animal and plant model organisms, in which the use of quantitative genetics is experiencing a renaissance. The molecular study of Quantitative Trait Loci, several of which have been traced back to individual genes, is allowing important conclusions as to the type of genes and type of changes that underlie quantitative phenotypic variation. A second focus of the meeting will be recent discoveries of how changes in key regulatory factors cause major phenotypic differences in more distantly related taxa. The overall goal of this meeting is to bring together a diverse group of investigators that includes scientists interested in the evolution of developmental diversity, quantitative geneticists and population geneticists. ·Finally, the proposed meeting, which will focus on genetic model organisms such as Drosophila and Arabidopsis, will be an excellent complement to the meeting that is to be held concurrently, on Human Genetic Diversity.

Thursday, January 8
3:00 - 7:00 PM	Registration	Foyer
6:15 - 7:15 PM	Refreshments	Foyer
7:15 - 7:30 PM	Orientation	Peaks 4-5
7:30 - 9:30 PM	Keynote Session: Genetic Dissection of Complex Traits (Joint)	Peaks 4-5
	* David M. Altshuler, Massachusetts General Hospital
	* Detlef Weigel, Max Planck Institute for Developmental Biology
	Charles H. Langley, University of California, Davis Polymorphism and Divergence Across the Drosophila Genome
	Aravinda Chakravarti, Johns Hopkins School of Medicine The Nature of Variation in Complex Disease
Friday, January 9
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	QTL in Animals I	Peaks 1-3
	* Trudy F.C. Mackay, North Carolina State University
	Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center Genetic Analysis of Reproductive Isolation in Sticklebacks
	Peter D. Keightley, University of Edinburgh Analysing Quantitative Genetic Variation for Growth in Mice
	Kari J. Buck, Oregon Health & Science University Genetic Control of Physical Dependence and Associated Withdrawal Episodes in Mice
	Thomas E. Johnson, University of Colorado QTLs in Mice and Worms; Use of Recombinant Inbred Strains
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 14-16
1:00 - 10:00 PM	Poster Viewing	Peaks 14-16
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Exploiting Inbred Strains to Understand Complex Traits (Joint)	Peaks 4-5
	* Peter D. Keightley, University of Edinburgh

	Keith R. Davis, Icoria, Inc High-Throughput Plant Gene Function Analysis in Arabidopsis
	Wayne Frankel, The Jackson Laboratory Effects of Genetic Background on Induced and Spontaneous, Monogenic and Polygenic Models for Epilepsy in Mice
	Michael Snyder, Stanford University School of Medicine Identification of Functional Regions in the Genomes of Yeast and Humans
6:45 - 7:20 PM	Comparative Genomics
	Eric S. Lander, Broad Institute, Massachusetts Institute of Technology
7:20 - 8:00 PM	Social Hour	Peaks 14-16
7:30 - 10:00 PM	Poster Session 1	Peaks 14-16
Saturday, January 10
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	QTL in Animals II	Peaks 1-3
	* Catherine (Katie) L. Peichel, Fred Hutchinson Cancer Research Center
	Trudy F.C. Mackay, North Carolina State University Molecular Quantitative Genetics of Drosophila Life Span
	Chung-I Wu, Chinese Academy of Sciences Molecular Genetics of Speciation

	John H. Werren, University of Rochester Evolutionary Genetics of Species Differences in Nasonia

	Marta L. Wayne, University of Florida Sex Dimorphism and Non-Additivity in Gene Expression in Drosophila melanogaster
9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	QTL in Plants I	Peaks 1-3
	* Joanne Chory, The Salk Institute
	Masahiro Yano, National Institute of Agrobiological Resources Natural Variation in Flowering Time in Rice


	Leonie C. Moyle, University of California, Davis Salad Speciation: Genetics of Species Differences and Hybrid Incompatibility in Lycopersicon

	Justin O. Borevitz, University of Chicago Towards the Arabidopsis Haplotype Map Using Arrays

7:00 - 8:00 PM	Social Hour	Peaks 14-16
Sunday, January 11
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Inherited Variation in Gene Expression (Joint)	Peaks 4-5
	* Leonid Kruglyak, Princeton University Regulatory Variation in Yeast
	Kevin P. White, Yale University School of Medicine Evolution of Gene Expression in Drosophila

	Stephanie Monks, University of Washington-Seattle/Rosetta Inpharmatics LLC The Genetics of Gene Expression in Mice

	Justin Fay, Washington University Short Talk: Genetic Variation in Gene Expression is Associated with Phenotypic Variation Sequence Divergence

	Matt Rockman, Duke University Short Talk: Cis-Regulated Polymorphism: Evolution, Natural Variation, and Common Disease
9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	QTL in Plants II	Peaks 1-3
	* Masahiro Yano, National Institute of Agrobiological Resources
	Joanne Chory, The Salk Institute and Howard Hughes Medical Institute and
	Olivier Loudet, Institut National de La Recherche Agronomique Natural Variation in Light Signaling in Arabidopsis

	Carlos Alonso-Blanco, Centro Nacional de Biotecnologia, CSIC Natural Variation for Life History Traits in Arabidopsis

	Dani Zamir, Cornell University Real Time QTL of Tomato Yield

7:00 - 8:00 PM	Social Hour	Peaks 14-16
Monday, January 12
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Evolution of Adaptive Traits	Peaks 1-3
	* Neelima Sinha, University of California, Davis
	June B. Nasrallah, Cornell University Diversification of Self-Incompatibility Genes in the Brassicaceae
	Thomas Mitchell-Olds, Max Planck Institute of Chemical Ecology, Jena Nucleotide Polymorphism and Quantitative Trait Variation in Arabidopsis and Related Species
	Sean B. Carroll, University of Wisconsin-Madison Genetic and Developmental Mechanisms Underlying Divergent and Convergent Patterns of Evolution

	Ying Tan, University of Massachusetts-Boston Molecular Evolution of Color Vision Genes in Primates
9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Variation between Distant Taxa	Peaks 1-3

	* Ying Tan, University of Massachusetts-Boston

	Nipam H. Patel, University of California, Berkeley The Evolution of Arthropod Pattern Formation
	Neelima Sinha, University of California, Davis The Development and Evolution of Leaves
	Marie-Anne Felix, Institut Jacques Monod Evolution of Nematode Vulva Development: A Microevolutionary Approach
7:00 - 8:00 PM	Social Hour	Peaks 14-16
8:00 - 11:00 PM	Entertainment	Peaks 4-5
Tuesday, January 13
	Departure

*Session Chair †Speaker invited, not yet responded.

Keystone Symposia Meeting

Natural Variation and Quantitative Genetics in Model Organisms (J2)

This meeting took place in the 2004 season.