Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Inflammation and Cancer (B8)

Organizer(s): Raymond N. DuBois and Lisa M. Coussens
February 27 - March 3, 2005
Beaver Run Resort · Breckenridge, Colorado
Abstract Deadline: October 27, 2004
Early Registration Deadline: December 27, 2004

Supported by The Director's Fund

This meeting took place in the 2005 season.

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see our meeting list, or search for a meeting.

Summary of Meeting
Chronic or recurrent inflammation is responsible for the development of many human cancers, including those affecting the liver, esophagus, stomach, large intestine, and urinary bladder [Coussens and Werb, [2002]]. Inflammation might influence the pathogenesis of cancers by (i) inflicting cell and genome damage, (ii) triggering restorative cell proliferation to replace damaged cells, (iii) elaborating a portfolio of cytokines that promote cell replication, angiogenesis and tissue repair [Coussens and Werb, [2002]]. Oxidative damage to DNA and other cellular components accompanying chronic or recurrent inflammation could increase risk by increasing the mutation rate. In response to infections, inflammatory cells produce a variety of toxic compounds designed to eradicate microorganisms. These include superoxide, hydrogen peroxide, singlet oxygen, as well as nitric oxide that can react further to form the highly reactive peroxynitrite. Some of these reactive oxygen and nitrogen species can directly interact with DNA in the host bystander cells, or react with other cellular components such as lipid, initiating a free radical chain reaction. If the damage is severe, these compounds can kill host bystander cells as well as pathogens, and can produce DNA damage and mutations among host cell survivors. As a consequence of an acquired defect in defenses against oxidant and electrophilic carcinogens associated with CpG island hypermethylation, normal epithelial cells may acquire a heightened susceptibility to oxidative genome damage in an inflammatory milieu, leading to neoplastic transformation and cancer progression.

Sunday, February 27
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 8:30 PM	Keynote Address	Peaks 4-5
	Harold F. Dvorak, Beth Israel Deaconess Medical Center Inflammation And Cancer Induce Neovascular Stroma By Common Mechanisms.
Monday, February 28
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:15 AM	Innate Immunity and Malignancy	Peaks 4-5
	Alberto Mantovani, Istituto Clinico Humanitas Innate Immunity and Cancer
	Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School The Role of Inflammatory Cytokines and Chemokines in Cancer Progression
	Alison K. Bauer, Michigan State University Short Talk: A Protective Role for Toll-like Receptor (TLR)-4 in Butylated Hydroxytoluene (BHT)-Induced Mouse Pulmonary Inflammation and Tumorigenesis
	* Lisa M. Coussens, University of California, San Francisco Innate and Adaptive Immune Interactions Promote Cancer Development
	P. Charles Lin, Vanderbilt University Short Talk: Expansion of Myeloid Immune Suppressor Gr+CD11b+ Cells in Tumor-bearing Host Directly Promotes Tumor Angiogenesis
	Jeffrey W. Pollard, Albert Einstein College of Medicine Tumor-educated macrophages promote mammary tumor progression and metastasis
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Peaks 1-3
1:00 - 10:00 PM	Poster Viewing	Peaks 1-3
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Inflammatory Stressors and Cancer Progression	Peaks 4-5
	Curtis C. Harris, NCI, National Institutes of Health Radical Causes of Human Cancer
	* Thea D. Tlsty, University of California, San Francisco Epigenetic And Genetic Changes Control Tumorigenic Phenotypes and Occur In Vivo in Human Mammary Epithelia
	William L. Farrar, National Cancer Institute, National Institutes of Health Short Talk: Interleukin 6 (IL-6) Regulates and maintains Epigenetic Silencing of Tumor Suppressor and DNA Repair Genes in Human Multiple Myeloma Cells
	Kathy Helzlsouer, Johns Hopkins University C-Reactive Protein Levels and Subsequent Cancer Outcomes: Results from a Prospective Cohort Study and Implications for Prevention
7:00 - 8:00 PM	Social Hour	Peaks 1-3
7:30 - 10:00 PM	Poster Session 1	Peaks 1-3
Tuesday, March 1
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Tumor Immunotherapy	Peaks 4-5
	Olivera J. Finn, University of Pittsburgh School of Medicine Premalignant lesions as targets for cancer vaccines
	Brian P. Dolan, NIAID, National Institutes of Health Short Talk: Dendritic Cells Acquire Functional Peptide-MHC Complexes from Necrotic Tumor Cells
	Drew M. Pardoll, Johns Hopkins University School of Medicine Molecular Immunology and Tumor Immunotherapy

	Ainhoa Perez-Diez, NIAID, National Institutes of Health Short Talk: CD4 Cells Can Be More Efficient at Tumor Rejection Than CD8 Cells
	* Glenn Dranoff, Dana-Farber Cancer Institute Sequential Cancer Immunothherapy
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 1-3
1:00 - 10:00 PM	Poster Viewing	Peaks 1-3
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Inflammation Fibrosis and Malignant Pathogenesis	Peaks 4-5
	* William G. Nelson, Johns Hopkins School of Medicine Inflammation and Prostate Carcinogenesis

	Michael A. Hollingsworth, University of Nebraska Medical Center MUC1 and the Pathogenesis of Pancreatic Cancer
	Anna Moore, Massachusetts General Hospital Short Talk: UMUC-1 Tumor Antigen as an Imaging and Therapeutic Target
	Dafna Bar-Sagi, New York University School of Medicine A Mouse Model of Hereditary Pancreatitis: Insights Into The Initiation of Pancreatic Cancer
7:00 - 8:00 PM	Social Hour	Peaks 1-3
7:30 - 10:00 PM	Poster Session 2	Peaks 1-3
Wednesday, March 2
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:15 AM	Host Response to Pathogens and Soluble Mediators	Peaks 4-5
	* Martin J. Blaser, New York University School of Medicine Helicobacter pylori diversity and interaction with gastric epithelial cells.

	Bernhard Homey, Heinrich-Heine University Dussseldorf Chemokine Receptors in Tumor Progression and Metastasis
	Douglas McClain Noonan, Università degli Studi dell'Insubria Short Talk: Inflammation Associated Angiogenesis: A New Potential Target for Tumor Therapy
	M. Celeste Simon, University of Pennsylvania Hypoxia, Angiogenesis, and Tumor Progression
	Joseph S. Palumbo, Cincinnati Children's Hospital Medical Center Short Talk: Mechanisms Linking Innate Hemostatic Factors and Innate Immunity to Metastatic Potential
	Thomas Doetschman, University of Cincinnati TGFbeta, Inflammation and Colon Cancer Progression
9:20 - 9:40 AM	Coffee Break	Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Foyer
5:00 - 7:00 PM	Molecular Mechanisms for Cancer Prevention	Peaks 4-5
	Michael Karin, University of California, San Diego The IKK Complex: Providing a Link Between Inflammation and Cancer


	Ilan Stein, Hebrew University of Jerusalem Short Talk: NF-kappaB Functions as a Tumor Promoter in Inflammation-Associated Cancer
	George C. Prendergast, Lankenau Institute for Medical Research Short Talk: IDO in Immune Suppression, Cancer, and Cancer Therapy
	* Raymond N. DuBois, University of Texas MD Anderson Cancer Center COX-2, Inflammatory Mediators and Cancer Prevention
7:00 - 8:00 PM	Social Hour	Copper top
8:00 - 11:00 PM	Entertainment	Copper top
Thursday, March 3
	Departure

*Session Chair †Speaker invited, not yet responded.