Keystone Symposia

The Transient Receptor Potential Ion Channel Superfamily (Q1)

Organizer(s): James W. Putney, Bernd Nilius and Craig Montell
September 18 - 23, 2007
Beaver Run Resort · Breckenridge, Colorado
Abstract Deadline: May 18, 2007
Late Abstract Deadline: June 19, 2007
Scholarship Deadline: May 18, 2007
Early Registration Deadline: July 18, 2007

Supported by the Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2007 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Transmembrane Signaling by GPCRs and Channels (B1)
January 23 - 28, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
In recent years, knowledge of TRP channel biology has increased at a tremendous pace. These channels are now known to be regulated in two general ways: by physical perturbations (i.e., temperature, mechanical) or by classical signal transduction cascades (most commonly phospholipases). In addition, mutations in TRP channels are known to be the basis for a number of inherited diseases, including mucolipidosis and polycystic kidney disease. However, there is a great deal of controversy regarding the mechanisms of activation and regulation of many TRPs, especially those thought to be involved in the long elusive mechanism of store-operated channels. This symposium will highlight current knowledge of structure, function, regulation and pharmacology of the TRPs, especially with regard to current controversies. Additionally, the roles of TRPs in diseases will be addressed, including the potential for treating diseases through knowledge of their regulation, and through design of therapeutic agents to modify their behavior.

Tuesday, September 18
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 8:30 PM	Keynote Session	Peaks 4 - 5
	Craig Montell, Johns Hopkins University TRP Channels: Mediators of Sensory Signaling
Wednesday, September 19
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	TRPs: Temperature and Pain	Peaks 4 - 5
	* Owen P. Hamill, University of Texas Medical Branch
	Makoto Tominaga, National Institutes of Natural Sciences Physiological Significance of the Thermosensitive TRP Channels

	Ardem Patapoutian, The Scripps Research Institute Molecular Mechanisms of Temperature Sensation
	Michael J. Caterina, Johns Hopkins School of Medicine A Novel Mechanism of Use - Dependent Changes in TRPV Channel Signaling

	Paul Garrity, Brandeis University Feeling the Heat: Thermosensory Behavior in Drosophila
	Vera Y. Moiseenkova-Bell, Baylor College of Medicine Short Talk: Cryo-Electron Microscopy of TRP Family Channels
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 1-3
1:00 - 10:00 PM	Poster Viewing	Peaks 1-3
4:00 - 4:30 PM	Coffee Available	Foyer
4:30 - 6:30 PM	TRPs: Taste and Mechanosensation	Peaks 4 - 5
	* Bernd Nilius, Katholieke Universiteit Leuven
	Emily Liman, University of Southern California TRPM5 and Taste Transduction

	Diana Bautista, University of California, Berkeley Mammalian Mechanotransduction
	Owen P. Hamill, University of Texas Medical Branch The Role of the Mechanosensitive Ca2+ Permeant Channel in Prostate Tumor Cell Migration
	Julia F. Doerner, Ruhr University Short Talk: Direct Activation of TRPA1 by Ca2+
6:30 - 7:30 PM	Social Hour w/ Lite Bites	Peaks 1 - 3
7:00 - 9:30 PM	Poster Session 1	Peaks 1 - 3
Thursday, September 20
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Activation Mechanisms	Peaks 4 - 5
	* Shmuel Muallem, University of Texas Southwestern Medical Center
	Johannes Oberwinkler, Universitaet des Saarlandes TRPM3, A Novel Ionotropic Steroid Receptor in the Endocrine System
	Andrea Fleig, Queen's Medical Center Gating Mechanisms of TRPM2
	Donald L. Gill, Temple University School of Medicine TRPC Channels – Transducers of Multiple Signals
	Lutz Birnbaumer, NIEHS, National Institutes of Health Molecular Basis of Capacitative Calcium Entry (CCE): TRPCs, 1P3rs, STIMs, and Orai
	Moshe Parnas, Hebrew University Short Talk: Membrane Lipids Remove Divalent Open Channel Block in TRP and NMDA Channels
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 AM - 1:00 PM	Poster Setup	Peaks 1-3
1:00 - 10:00 PM	Poster Viewing	Peaks 1-3
2:30 - 4:00 PM	Workshop 1: Controversies Concerning Activation Mechanisms I: Direct Activation by Thermal and Mechanical Stimuli	Peaks 4 - 5
	* Andrea Fleig, Queen's Medical Center
	Adriana Sumoza-Toledo, Columbus Children's Hospital Reactive Oxygen Species Induce Calcium Influx and Phagocyte Cell Death by a Mechanism Dependent on ADPR and PARP-1; Possible Functional Role for TRPM2 Cation Channel

	Frank John Patrick Kühn, Institute of Physiology Activation of TRPM8 Channel by Icilin and Menthol is Mediated on Different Sides of the Cell Membrane
	Gerard Ahern, Georgetown University Voltage is a Partial Activator of Thermo-Sensitive TRP Channels

	Céline E. Riera, The Salk Institute for Biological Studies Artificial Sweeteners and Metallic Tasting Salts Activate TRPV1 Receptors
4:00 - 4:30 PM	Coffee Available	Foyer
4:30 - 6:30 PM	TRPs and Protein-Protein Interaction	Peaks 4 - 5
	* Emily Liman, University of Southern California
	René J.M. Bindels, Radboud University Nijmegen Medical Centre Regulation of Epithelial TRP Channels
	Shmuel Muallem, University of Texas Southwestern Medical Center The TRPML Channels: Properties and Function
	Rachelle Gaudet, Harvard University Unexpected Journey from Crystal Structure to New Model of TRPV1 Activity
	Rui Xiao, Ohio State University Short Talk: Synergistic Activation of TRPC4 and TRPC5 by Receptor Signaling through Gq/11 and Gi/o Proteins
6:30 - 7:30 PM	Social Hour w/ Lite Bites	Peaks 1 - 3
7:00 - 9:30 PM	Poster Session 2	Peaks 1 - 3
Friday, September 21
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Reverse Genetic Approaches	Peaks 4 - 5
	* Craig Montell, Johns Hopkins University
	Bernd Nilius, Katholieke Universiteit Leuven Functional Roles of TRP Channels: Unexpected Views

	Yasuo Mori, Kyoto University Oxidative Stress-Activated Ca2+ Channel TRPM2 Mediates Inflammation via Chemokine Production
	X.Z. Shawn Xu, University of Michigan TRP Channel Regulation of Proprioception and Drug Dependence in C. elegans
	Thomas Gudermann, Ludwig-Maximilians-Universitaet TRPC Channel Function in the Cardiopulmonary System
	Melissa A. Fowler, University of Texas Southwestern Medical Center Short Talk: Corticolimbic Expression of TRPC1, TRPC4, and TRPC5 Channels in the Rodent Brain
9:20 - 9:40 AM	Coffee Break	Foyer
11:00 - 11:30 AM	Poster Setup	Peaks 1-3
11:30 - 12:30 PM	Lunch	Foyer / Peaks 1 - 3
12:00 - 9:00 PM	Poster Viewing	Peaks 1-3
12:00 - 2:30 PM	Poster Session 3	Peaks 1 - 3
2:30 - 4:00 PM	Workshop 2: Controversies Concerning Activation Mechanisms II: Activation by Signal Transduction Cascades	Peaks 4 - 5
	* Donald L. Gill, Temple University School of Medicine
	Tibor Rohacs, UMDNJ - New Jersey Medical School Dual Regulation of TRPV1 by Phosphoinositides
	Leonidas Tsiokas, Oklahoma University Health Science Center Assembly of TRPP2 and TRPC1 Forms a Novel G Protein Coupled Receptor-Activated Ion Channel

	Sandeep C. Pingle, Georgetown University Medical Center TRP and Store-Operated Calcium Channels in Dendritic Cells
	Sohag Saleh, St. George's University, London Diverse TRPC Heteromultimers Form Store- Operated Channels in Native Vascular Smooth Muscle Preparations
	Nathaniel A. Jeske, University of Texas Health Science Center PKA Sensitization of TRPV1 is Dependent on A-Kinase Anchoring Protein
4:00 - 4:30 PM	Coffee Available	Foyer
4:30 - 6:30 PM	TRPs in the Nervous System	Peaks 4 - 5
	* Indu S. Ambudkar, NIDCR, National Institutes of Health
	Martha C. Nowycky, UMDNJ-New Jersey Medical School TRPC5 Channels: Function and Properties

	Michael Tymianski, Toronto Western Research Institute (TWRI) Role of TRP Channels in Ischemic Brain Damage
	Guo-li Ming, Johns Hopkins University TRPC in Neuronal Navigation: Development and Guidance


	Seog Bae Oh, Seoul National University Short Talk: Membrane-Delimited Activation of Transient Receptor Potential Vanilloid 1 by mGluR5 in Nociceptors
Saturday, September 22
7:00 - 8:00 AM	Breakfast	Peaks 6-12
8:00 - 11:00 AM	Store-Operated Channels	Peaks 4 - 5
	* Thomas Gudermann, Ludwig-Maximilians-Universitaet
	James W. Putney, Jr., NIEHS, National Institutes of Health Store-Activation of CRAC and TRPC Channels
	Indu S. Ambudkar, NIDCR, National Institutes of Health Function and Regulation of TRPC1 in Salivary Gland
	Victoria Bolotina, Boston Medical Center Calcium Influx Factor

	Patrick G. Hogan, Harvard Medical School Stim-Orai Signalling in T-Lymphocytes
	Paul Rosenberg, Duke University Short Talk: STIM1/Orai1 Signaling Controls Store Operated Calcium Entry in Skeletal Muscle
9:20 - 9:40 AM	Coffee Break	Foyer
4:00 - 4:30 PM	Coffee Available	Foyer
4:30 - 6:30 PM	TRPs and Disease	Peaks 4 - 5
	* Michael Tymianski, Toronto Western Research Institute (TWRI)

	Michael Köttgen, Johns Hopkins University Calcium Signaling through TRPP2: from Polycystic Kidney Disease to Fly Sperm

	Chris Benham, University of Hertfordshire TRPM2 Channels and Neurodegeneration: TRPV1 and Inflammatory Pain

	Thierry Capiod, Inserm U800 Short Talk: Capacitative Calcium Entry and TRPC6 Expression Control Human Hepatoma Cells Proliferation
	James W. Putney, Jr., NIEHS, National Institutes of Health Meeting Highlights
6:30 - 7:30 PM	Social Hour w/ Lite Bites	Peaks 1 - 3
7:30 - 10:30 PM	Entertainment	Peaks 1 - 3
Sunday, September 23
	Departure

*Session Chair †Speaker invited, not yet responded.

Keystone Symposia Meeting

The Transient Receptor Potential Ion Channel Superfamily (Q1)

This meeting took place in the 2007 season.