Keystone Symposia

Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6)

Organizer(s): R. Balfour Sartor, Lloyd F. Mayer, Charles O. Elson and Scott Plevy
January 13 - 18, 2009
Sagebrush Inn and Conference Center · Taos, New Mexico
Abstract Deadline: September 18, 2008
Late Abstract Deadline: October 15, 2008
Scholarship Deadline: September 18, 2008
Early Registration Deadline: November 13, 2008

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Microbial Communities as Drivers of Ecosystem Complexity (C8)
March 25 - 30, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Recent studies have demonstrated the key role of mucosal defenses and immunoregulation in maintaining homeostasis in the distal intestine in concert with the commensal microbiota. This meeting discusses the latest information regarding the protective and effector innate and adaptive immune responses to the commensal intestinal microbiota that lead to mucosal homeostasis vs. chronic immune-mediated intestinal inflammation. We highlight the protective role of innate mucosal immune responses induced by ligation of toll- like receptors (TLR) to activate NF-kappaB and other signaling pathways. Mechanisms of bacterial killing by epithelial and phagocytic cells are explored. The interface of antigen presenting cell/ T cell activation leading to effector or regulatory T cell function in the intestine is examined with a particular emphasis on bacterial antigen-specific responses. Finally, biomedical applications of these basic research observations are explored. These basic and translational studies have direct implications for understanding the pathophysiology of chronic intestinal inflammation such as Crohn’s disease, ulcerative colitis and pouchitis and emphasize innate and adaptive immunoregulatory mechanisms that mediate mucosal homeostasis in a hostile environment. Major unresolved issues in mucosal immunology are as follows: (1) understanding how epithelial cells coexist with commensal intestinal bacteria, yet recognize the pathogenic organisms; (2) understanding how effector mechanisms in innate immune cells and T cells are appropriately downregulated; and (3) how understanding of basic immune regulation and inflammation can lead to the development of novel therapeutic agents for chronic inflammatory bowel diseases. This meeting presents state of the art lectures on the most recent research on innate, adaptive and regulatory immune responses to commensal bacteria, promotes interdisciplinary research interactions and explores several novel therapeutic approaches derived from recent pathogenic insights.

Tuesday, January 13
3:00 - 7:30 PM	Registration	Chamisa Lobby
6:30 - 7:30 PM	Refreshments	Chamisa Ballroom 2
7:30 - 8:00 PM	Welcoming Remarks	Chamisa Ballroom 2
	R. Balfour Sartor, University of North Carolina at Chapel Hill Welcoming Remarks: An Overview of the Intestinal Microbiota and Mechanisms of Host/ Microbial Interactions
Wednesday, January 14
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Protective Role of Innate Mucosal Immune Responses to Commensal Microbiota	Chamisa Ballroom 1
	* Lloyd F. Mayer, Mount Sinai Medical Center
	Scott Plevy, University of North Carolina Protective Role of Heme Oxygenase and PI3 Kinase Isoforms
	Maria T. Abreu, University of Miami, Miller School of Medicine Mucosal TLR Regulation of Epithelial Integrity and Malignancy
	Eyal Raz, University of California, San Diego Gut, Germs and Genes: The Tumorigenic Triad
	Andrea Cerutti, Mount Sinai School of Medicine Regulation of IgA Switching by Epithelial Cells in Response to Bacterial Stimuli
	Sergio A. Lira, Mount Sinai School of Medicine Short Talk: TLRs, Chemokines and Intestinal Homeostasis
	Nouara Lhocine, Institut Pasteur Short Talk: PIMS Modulates Immune Tolerance to Commensal Bacteria by Regulating Drosophila Imd Pathway
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Activation and Regulation of Mucosal NF-kappaB	Chamisa Ballroom 1
	* Maria T. Abreu, University of Miami, Miller School of Medicine
	Christian Jobin, University of North Carolina at Chapel Hill Host/Microbes Interaction: Lessons from Gnotobiotic Murine and Zebrafish NF-kB Reporter Gene System
	Averil I. Ma, University of California, San Francisco Ubiquitin and Innate Immunity: ABIN-1 and TNF Responses
	Maria del Carmen Alonso Cotoner, Massachusetts General Hospital and Harvard Medical School Short Talk: GEF-H1 Mediates NOD1 Dependent NF-kB Activation Initiated by Shigella Flexneri Effectors
	Wen Zhou, University of Texas Southwestern Medical Center Short Talk: Deletion of FoxO4 Elevates Susceptibility of Mice to Trinitrobenzene Sulfonic Acid-Induced Colitis
	Jun Sun, University of Rochester Short Talk: Vitamin D Receptor Negatively Regulates in vivo NF-kappaB Activity in the Normal Colon and during Bacterial-Induced Intestinal Inflammation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 1	Chamisa Ballroom 2
Thursday, January 15
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Mechanisms of Bacterial Killing by Epithelial and Phagocytic Cells	Chamisa Ballroom 1
	* R. Balfour Sartor, University of North Carolina at Chapel Hill
	Ramnik Xavier, Massachusetts General Hospital Autophagy – Defender of the Cytoplasm
	Jan Wehkamp, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology Antimicrobial Host Defense: from Epithelial Stem Cells to Chronic Inflammation
	Lora V. Hooper, University of Texas Southwestern Medical Center Innate Defense of Gut Epithelial Surfaces
	Arlette Darfeuille-Michaud, Université d'Auvergne Crohn’s Disease-Associated Adherent-Invasive E. coli: Mechanisms of Intestinal Colonization, Evasion of Intracellular Killing and Development of Gut Inflammation
	Ye Yang, University of Oregon Short Talk: IAP (Intestinal Alkaline Phosphatase) Up-Regulated by LPS Detoxifies LPS to Prevent Inflammation in Response to the Gut Microbiota
	Ajay S. Gulati, University of North Carolina, Chapel Hill Short Talk: Effects of Murine Strain Variation on Intestinal Antimicrobial Peptide Expression
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Dendritic Cell Function at Mucosal Surfaces	Chamisa Ballroom 1
	* Scott Plevy, University of North Carolina
	Hans-Christian Reinecker, Massachusetts General Hospital Dendritic Cell Function at the Mucosal Surfaces

	Peter Velázquez, Skirball Institute Short Talk: Delineating Mucosal Dendritic Cell Networks via Intravital Microscopy
	Jacqueline Perrigoue, University of Pennsylvania Short Talk: Delineating Requirements for Antigen Presentation in the Intestine: Dendritic Cells and Beyond
	Ting Feng, University of Alabama Birmingham Short Talk: Regulation of Toll-like Receptor 5 Gene Expression in Mucosal Dendritic Cells
	R. William DePaolo, University of Chicago Short Talk: Regulation of Intestinal Immunity to Yersinia Enterocolitica by TLR1&TLR6
	InYoung Kim, University of Chicago Short Talk: The Role of Hsp70 in Intestinal Immune Homeostasis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 2	Chamisa Ballroom 2
Friday, January 16
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Effector T Cell Responses in Intestinal Inflammation	Chamisa Ballroom 1
	* Charles O. Elson, University of Alabama
	Casey T. Weaver, University of Alabama at Birmingham Late Plasticity in Th17 Development: a Basis for Revised Models of Intestinal Inflammtion
	Fiona M. Powrie, University of Oxford IL-23 and Intestinal Homeostasis
	Bana Jabri, University of Chicago Innate-Mediated Tolerance by TLR6: a Journey from Yersinia Pestis in the Gut
	Jesús Rivera-Nieves, University of Colorado Health Sciences Center Recruitment of T Cells to Chronically Inflamed Small Intestine
	Anisa Ismail, University of Texas, Southwestern Medical Center Short Talk: Reciprocal Interactions between Commensal Bacteria and gamma delta Intraepithelial Lymphocytes during Mucosal Injury
	Kim Phung Le Nguyen, University of California, San Diego Short Talk: Induction of Th17: Is It too Early for a Paradigm?
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 2
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 2
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Microbial Activation of Immune-Mediated Intestinal Inflammation	Chamisa Ballroom 1
	* Casey T. Weaver, University of Alabama at Birmingham
	Charles O. Elson, University of Alabama Flagellin-Specific T Cell Responses in Experimental Colitis
	Sandra Kim, University of North Carolina at Chapel Hill Functional Characteristics of Escherichia Coli in Immune-Mediated Experimental Colitis
	Jochen Mattner, Cincinnati Children's Hospital Medical Center The Role of Alphaproteobacteria in the Induction of Autoimmunity
	Wendy S. Garrett, Harvard School of Public Health Short Talk: Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
7:30 - 10:00 PM	Poster Session 3	Chamisa Ballroom 2
Saturday, January 17
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Regulation of Mucosal Immune Response to Microbial Components	Chamisa Ballroom 1

	* Bana Jabri, University of Chicago
	Craig L. Maynard, University of Alabama at Birmingham Development of Gut-Protective Regulatory T Cells
	Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School Tregs and Th17 Cells: Role of Induction and Regulation of Tissue Inflammation
	Yasmine Belkaid, NIAID, National Institutes of Health Modulation of Foxp3+ Regulatory T Cells by Microbes
	William A. Faubion, Mayo Clinic PRR Inhibition of Treg Apoptosis and the Pathigenesis of Crohn’s Disease
	Betsy C. Taylor, University of Pennsylvania Short Talk: TSLP Regulates Intestinal Immunity and Inflammation

9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:00 PM	Translation of Basic Research to Biomedical Applications	Chamisa Ballroom 1
	* Scott Plevy, University of North Carolina
	Rene de Waal Malefyt, Schering-Plough The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases

	Kevan C. Herold, Yale University Induction of CD8+ Regulatory T Cells with Anti-CD3 Monoclonal Antibody
	Huabao Xiong, Mount Sinai School of Medicine Blocking the TLR Signaling Pathway using TLR Peptides in the Treatment of Colitis
	Edwin F. de Zoeten, Children's Hospital of Philadelphia Short Talk: Regulation of Foxp3+ Regulatory T Cells (Treg) by Small Molecule Targeting of HDAC6, Enhances Treg Function and Ameliorates Development of IBD in Murine Models
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Chamisa Ballroom 2
8:00 - 11:00 PM	Entertainment	Chamisa Ballroom 2
Sunday, January 18
	Departure

*Session Chair †Speaker invited, not yet responded.

Keystone Symposia Meeting

Innate, Adaptive and Regulatory Immune Responses to Intestinal Microbiota (A6)

This meeting took place in the 2009 season.