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Molecular Targets for Control of Vector-Borne Diseases: Bridging Lab and Field Research (F2)

Organizer(s): Kenneth D. Vernick, Elena A. Levashina, Gerry Killeen and Anthony A. James
April 11 - 16, 2010
Copper Mountain Resort  ·  Copper Mountain, Colorado
Abstract Deadline: December 11, 2009
Late Abstract Deadline: January 6, 2010
Scholarship Deadline: December 11, 2009
Early Registration Deadline: February 11, 2010


Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Joint meeting: Malaria: New Approaches to Understanding Host-Parasite Interactions (F1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Vigorous research since the completion of the Anopheles gambiae genome sequence has established the malaria mosquito as a model organism for host-pathogen biology. However, the translation of this growing post-genomic knowledge base into new vector-targeted malaria control strategies is a distinct challenge that now leads laboratory-based molecular researchers to confront the complexity and heterogeneity of the natural malaria transmission system. Simultaneously, a body of field-based vector researchers has been developing new ways to utilize existing vector control tools such as bednets and insecticides that, if consistently implemented, can yield impressive outcomes. Lab and field based practitioners attend different meetings and rarely engage in direct dialog. This conference will examine the tension between the development of new practical malaria control tools, including genomic ones, and the advantages of more fully exploiting existing tools. It is hoped that the scientific discussion will help influence individual and programmatic research priorities.

Sunday, April 11
3:00 - 7:30 PM Registration Kokopelli's
6:30 - 7:30 PM Refreshments Kokopelli's
7:30 - 9:30 PM Keynote Address (Joint) Big Horn Ballroom
Michael F. Good, Queensland Institute of Medical Research
Malaria Vaccines: Lessons from Immune Escape Instruct New Strategies
Anthony A. James, University of California, Irvine
Transgenic Strategies for Pathogen Transmission Control
Monday, April 12
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:00 AM Vector Populations Big Horn C
* Gerry F. Killeen, Ifakara Health Research and Development Centre
Didier Fontenille, Institut de Recherche pour le Developpement (IRD)
Complexity of the Malaria Vectorial System in Africa
Nora J. Besansky, University of Notre Dame
Chromosome Structural Polymorphism and the Malaria Transmission System
Gregory Lanzaro, University of California, Davis
The Genetic Structure of Anopheles Gambiae Populations
William C. Black IV, Colorado State University
Population Genetics of Aedes aegypti and Dengue Transmission
9:20 - 9:40 AM Coffee Break Kokopelli's
11:00 AM - 1:00 PM Poster Setup Big Horn Ballroom
11:00 AM - On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Big Horn Ballroom
2:30 - 4:30 PM Workshop 1 Big Horn C
* Kenneth D. Vernick, Institut Pasteur
2:30 - 3:30 PM Special Topics
Debaditya Bhattacharya, Tufts Medical Center
Development of a Reservoir-Targeted Vaccine against Yersinia pestis
Ramavati Pal, Victoria University of Wellington
Insect Glutathione S-transferase Proteome and Insecticide Resistance
Linda De Vooght, Institute of Tropical Medicine, Antwerp
Expression of Trypanosome-Development Inhibitory Proteins into the Periplasm of Sodalis glossinidius, a Bacterial Symbiont of the Tsetse Fly
3:30 - 4:30 PM Vector Biology Funding Priorities and Perspectives
* Adriana Costero-Saint Denis, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Vector Biology Funding Opportunities at the National Institute of Allergy and Infectious Diseases
Inmaculada Peñas Jiménez, European Commission, CORDIS
European Union Funded Research on Vector Biology
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Olfaction, Host Seeking and Behavior Big Horn C
* Anthony A. James, University of California, Irvine
Laurence J. Zwiebel, Vanderbilt University
Olfactory and Thermosensory Genomics as a Basis for Disrupting Disease Transmission by Vector Mosquitoes
Flaminia Catteruccia, Imperial College London
Molecular Bases of Anopheles gambiae Reproductive Biology: A Laboratory and Field Study
Willem Takken, Wageningen University
Olfaction and Behavioral Ecology of Disease Vectors
7:00 - 8:00 PM Social Hour w/ Lite Bites Kokopelli's
7:30 - 10:00 PM Poster Session 1 Big Horn Ballroom
Tuesday, April 13
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:00 AM Insecticides and Resistance Big Horn C
* Elena A. Levashina, Institut de Biologie Moleculaire et Cellulaire
Hilary Ranson, Liverpool School of Tropical Medicine
The Molecular Genetics of Insecticide Resistance in Mosquitoes
Maureen Coetzee, University of Witwatersrand
Insecticides and Malaria Epidemiology
Janet Hemingway, Liverpool School of Tropical Medicine
Biochemistry of Insecticide Resistance
Brian D. Foy, Colorado State University
The Effects of Anthelmintics on Anthropophilic Mosquitoes in the Lab and Field
9:20 - 9:40 AM Coffee Break Kokopelli's
11:00 AM - 1:00 PM Poster Setup Big Horn Ballroom
11:00 AM - On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Big Horn Ballroom
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Pathogen Receptors and Cellular Interactions Big Horn C
* Kenneth D. Vernick, Institut Pasteur
Robert E. Sinden, Imperial College London
The Cell Biology of Plasmodium in the Mosquito
Kenneth E. Olson, Colorado State University
Interactions between Arboviruses and the Mosquito’s RNAi Pathway
Serap Aksoy, Yale University School of Medicine
Microbiome Influences on Host Vector Competence
7:00 - 8:00 PM Social Hour w/ Lite Bites Kokopelli's
7:30 - 10:00 PM Poster Session 2 Big Horn Ballroom
Wednesday, April 14
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:00 AM Host-Parasite Evolution Big Horn C
* Gerry F. Killeen, Ifakara Health Research and Development Centre
Louis Lambrechts, Institut Pasteur
Genetic Specificity of Interactions between Dengue Viruses and Mosquito Vectors
Andrew Read, Pennsylvania State University
Evolution-Proofing Existing Malaria Control Tools
Brian P. Lazzaro, Cornell University
Evolution of Anopheles Immune Defense Genes
Marc A.T. Muskavitch, Boston College
Short Talk: Implementation of a High-Density SNP Genotyping Array for the Vector Mosquito Anopheles gambiae for Analysis of Population Structure and Genetic Mapping
9:20 - 9:40 AM Coffee Break Kokopelli's
11:00 AM - 1:00 PM Poster Setup Big Horn Ballroom
11:00 AM - On Own for Lunch and Recreation
1:00 - 10:00 PM Poster Viewing Big Horn Ballroom
2:30 - 4:30 PM Workshop 2: Special Topics Big Horn C
* Elena A. Levashina, Institut de Biologie Moleculaire et Cellulaire
Luciano Andrade Moreira, University of Queensland
A Wolbachia Symbiont in Aedes aegypti Limits Infection with Dengue, Chikungunya and Plasmodium
Kostas Iatrou, National Centre for Scientific Research
Volatile Constituents of Plant Origin Bind Selectively Various Odorant Binding Proteins of the Malaria Vector Anopheles gambiae and Act as Strong Repellents Capable of Interfering with the Vector’s Host Seeking and Blood Feeding Activities
Igor V. Sharakhov, Virginia Polytechnic Institute
Genome Landscape and Evolutionary Plasticity of Chromosomes in Malaria Mosquitoes
Judith Lum Ndamukong, University of Buea
Biting Densities and Transmission Potential of Malaria Vectors in the Mount Cameroon Region at Contrasting Altitudinal Zones
Hirotaka Kanuka, Obihiro University of Agriculture and Veterinary Medicine
Midgut Bacteria Regulates Plasmodium Development in Malaria Vector Anopheles Mosquitoes
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Insect Immunity Big Horn C
* Anthony A. James, University of California, Irvine
Elena A. Levashina, Institut de Biologie Moleculaire et Cellulaire
Complement-Like System in Immune Responses of Anopheles gambiae
Alexander S. Raikhel, University of California, Riverside
Mosquito Immune Signaling Pathways
Kenneth D. Vernick, Institut Pasteur
Mapping and Functional Dissection of Mosquito Resistance to Plasmodium
7:00 - 8:00 PM Social Hour w/ Lite Bites Kokopelli's
7:30 - 10:00 PM Poster Session 3 Big Horn Ballroom
Thursday, April 15
7:00 - 8:00 AM Breakfast Kokopelli's/Ptarmigan B-C
8:00 - 11:00 AM Control Strategies - Current and Future I Big Horn C
* Kenneth D. Vernick, Institut Pasteur
Andrea Crisanti, Imperial College London
Homing Endonuclease Transgenes in the Main Human Malaria Vector Anopheles Gambiae: From Dominant Sterility to Genetic Drive
Gerry F. Killeen, Ifakara Health Research and Development Centre
Ecology: A Prerequisite for Malaria Elimination and Eradication
Catherine Bourgouin, Institut Pasteur
Vector Targeted Immunological Control of Malaria Transmission
Christian Lengeler, Swiss Tropical and Public Health Institute
From Technology Development and Field Validation to Large-Scale Vector Control Interventions
9:20 - 9:40 AM Coffee Break Kokopelli's
11:00 AM - On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available Kokopelli's
5:00 - 7:00 PM Control Strategies - Current and Future II Big Horn C
* Kenneth D. Vernick, Institut Pasteur
Gregor J. Devine, Ifakara Health Institute
Adult Mosquitoes as Insecticide Delivery Agents
Luke S. Alphey, Oxitec Ltd
Sterile Insects for Vector Control
7:00 - 8:00 PM Social Hour w/ Lite Bites Jack's
8:00 - 11:00 PM Entertainment Jack's
Friday, April 16
Departure
*Session Chair   †Speaker invited, not yet responded.



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