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Static depictions are appearing in ever-increasing numbers of the detailed structures of individual macromolecules. A key challenge for structural biology is how to parlay this reservoir of fundamental information into a comparably detailed understanding of how functional complexes assemble; what ranges of alternative conformations they may assume at successive stages of their functional cycles; how they recognize each other; and how their propensities to bind small molecules, cofactors and other macromolecules are specified; and how they behave in cells. This meeting will explore ongoing developments in structural biology on several fronts including the following: the frontier between in vitro and in situ observations; the frontier between traditional experimental approaches and newly emerging complementary ones; and the frontier represented by computational structural biology as a means to analyze, integrate, and unify information emerging from diverse experimental sources.