Keystone Symposia Conference | Metabolism and Cancer Progression

Meeting Program

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Friday, March 12
3:00 - 7:30 PM	Registration	BC Foyer
6:30 - 7:30 PM	Refreshments	BC Foyer
7:30 - 9:30 PM	Keynote Session (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British/Columbia Ballroom
	* Eileen P. White, Rutgers University, USA
	Joan S. Brugge, Harvard Medical School, USA Diversity of Cell Death Pathways in Organogenesis and Oncogenesis
	Lewis C. Cantley, Harvard Medical School, USA PI 3-Kinase and Cancer Cell Metabolism
Saturday, March 13
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Metabolism Regulation in Model Organisms Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Columbia Ballroom
	* Joan S. Brugge, Harvard Medical School, USA
	Steven L. McKnight, University of Texas Southwestern Medical Center, USA Lessons from Metabolic Regulation in Yeast
	Chi Van Dang, Johns Hopkins University School of Medicine, USA Regulation of Cancer Metabolism by Myc
	Nika N. Danial, Dana Farber Cancer Institute, USA Talk Title to be Determined
	Yue Xiong, University of North Carolina at Chapel Hill, USA Acetylation Regulation of Metabolism
	William C. Comb, University of North Carolina, Chapel Hill, USA Short Talk: IKK-Dependent Phosphorylation and Feedback Inhibition of PI3K Promotes Nutrient Deprivation-Induced Autophagy
	Jing Chen†, Winship Cancer Institute, Emory University, USA Short Talk: Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
Following Session is for Cell Death Pathways (X3)
8:00 - 11:15 AM	Apoptosis Pathways Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Anthony G. Letai, Dana-Farber Cancer Institute, USA
	Suzanne Cory, Walter and Eliza Hall Institute of Medical Research, Australia The Bcl-2 Family in Cancer Development and Cancer Treatment
	Loren Walensky, Dana-Farber Cancer Institute, USA Dissecting the Activation Pathway of Pro-Apoptotic BAX: Mechanistic Insights and Pharmacologic Opportunities
	Xin Niu, McMaster University, Canada Short Talk: Identification and Mechanistic Characterization of Novel Bax Inihibitors
	Vishva M. Dixit, Genentech, Inc., USA Identification of a Stabilizing Deubiquitinase for Mcl-1 that is Over-Expressed in Tumors
	David W. Andrews, McMaster University, Canada Mechanisms of Mitochondrial Membrane Permeabilization by Pro-Apoptotic Bcl-2 Family Proteins
	Ingrid E. Wertz, Genentech, Inc., USA Short Talk: Resistance to Anti-tubulin Chemotherapeutics is Regulated by Mcl–1 and FBW7
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
2:30 - 4:30 PM	Workshop 1: PI3 Kinase Regulation and Cancer	Columbia Ballroom
	* Lewis C. Cantley, Harvard Medical School, USA
	Brian Grabiner, Whitehead Institute, USA Identification and Clinical Assessment of Genes that Regulate the Response of Cancers to Rapamycin through Pooled RNAi Screens
	Ralph J. DeBerardinis, University of Texas-Southwestern Medical Center, USA Alternative Metabolic Strategies for Growth in Glioblastoma: Glucose vs. Glutamine for Support of Cell Proliferation and Tumorigenesis
	Barry Bochner, Biolog, Inc., USA Metabolic Analysis of Isogenic Cells with Altered Cancer-Related Genes
	Jonathan L. Coloff, Duke University, USA A Metabolic Checkpoint Controls Puma Transcription and Protein Stability For Survival of Activated and Leukemic T Cells
	Kurt Fisher, Transplant Center at the Nebraska Medical Center, USA The Molecular Scaffold, Kinase Suppressor of Ras 1 (KSR1), Potentiates H-RasV12 Induced Transformation and Expands Cellular Capacity for Glycolysis and Oxidative Phosphorylation
	Ching-yi Chang, Duke University Medical Center, USA The Metabolic Regulator ERRalpha, a Downstream Target of HER2/IGF1, as a Therapeutic Target in Breast Cancer
	Christina H. Eng, Pfizer, USA Ammonia Derived from Glutaminolysis is a Diffusible Regulator of Autophagy
	James M. Phang†, NCI at Frederick, CCR, NIH, USA MiR-23b Regulates Proline Oxidase, a Mitochondrial Metabolic Tumor Suppressor, in Renal Cancer*
Following Workshop is for Cell Death Pathways (X3)
2:30 - 4:30 PM	Workshop 1: Methods for the Detection of Non-Apoptotic Cell Death Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Douglas R. Green, St. Jude Children's Research Hospital, USA
	Vassiliki Karantza†, Cancer Institute of New Jersey, USA Autophagy Regulates keratin 8 Homeostasis in Mammary Epithelial Cells and in Breast Tumors
	Brandon White, San Jose State University, USA Flavonoids Kill Breast Cancer Cells While Inhibiting Caspase Activity: Is this Apoptosis?
	Katharina Simon, Institute of Molecular Medicine, UK Detection of Autophagic Flux in Clinical Samples
	Suzanne Hibbs, Sigma-Aldrich Research Biotech, USA An Application of Zinc Finger Nuclease Technology to Create Knockout Cancer Lines
	Jayanta Debnath, University of California, San Francisco, USA ATG12 Conjugation to ATG3 Restricts The Expansion of Mitochondrial Mass and Promotes Cell Death
	Haymanti Bhanot, University of Toledo, College of Medicine, USA Mechanisms Underlying Methuosis in Human Glioblastoma Cells
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Metabolic Differences between Normal and Cancer Cells Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Columbia Ballroom
	* David M. Sabatini, Whitehead Institute for Biomedical Research, USA
	Eyal Gottlieb, Beatson Institute for Cancer Research, UK The Roles of Prolyl Hydroxylases in Metabolism and Cancer
	Valeria Fantin, Agios Pharmaceuticals, USA Metabolic Signaling in Cancer
	Sybille Mazurek, Universität Gießen, ScheBo Biotech AG, Germany Pyruvate Kinase M2 and Cancer
	Claudio Santos, London Research Institute, UK Short Talk: Identification of Metabolic Enzymes Essential for Survival of Prostate Cancer Cells by Functional Studies
Following Session is for Cell Death Pathways (X3)
5:00 - 7:00 PM	Non-Apoptotic Pathways in Model Organisms Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Daniel J. Klionsky, University of Michigan, USA
	Frank Madeo, University of Graz, Austria Programmed Cell Death in Yeast: Subroutines, Mechanisms and Purposes
	Vladimir I. Titorenko, Concordia University, Canada Short Talk: Novel Anti-Aging Compounds Greatly Extend Yeast Life Span by Targeting a Programmed Necrotic Cell Death Pathway Triggered by the Age-Related Buildup of Free Fatty Acids
	Thomas P. Neufeld, University of Minnesota, USA Autophagic Pathways in Drosophila: Good or Evil?
	John M. Abrams, University of Texas Southwestern Medical Center, USA Cell Death Regulatory Networks in Drosophila
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 1 Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Pacific Ballroom
Sunday, March 14
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:00 AM	Metabolic Adaptation in Cancer (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British/Columbia Ballroom
	* Marja Jäättelä, Danish Cancer Society, Denmark
	Eileen P. White, Rutgers University, USA Autophagy Tumor Suppression by Protein Quality Control
	Guido Kroemer, INSERM, U848, Institut Gustave Roussy, France Autophagy in Stress Adaptation, Avoidance of Cell Death and Longevity
	Karen H. Vousden, Beatson Institute for Cancer Research, UK Control of Metabolism by p53
	Rob Cairns, University Health Network, Canada Short Talk: Cancer-Associated Metabolite 2-Hydroxyglutarate Accumulates in AML with IDH1/2 Mutations
	Joshua L. Andersen, Duke University, USA Short Talk: Metabolic Regulation of Caspase-2
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM-	On Own for Lunch and Recreation
11:15 AM- 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Therapeutic Modulation of Metabolism Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Columbia Ballroom
	* Robert T. Abraham, Pfizer Biopharmaceuticals, USA
	John L. Cleveland, The Scripps Research Institute, USA Therapeutic Modulation of Autophagy in Cancer
	Peter F. Carmeliet, University of Leuven, Belgium Oxygen, Metabolism and Angiogenesis
	Uwe Haberkorn, University Hospital Heidelberg, Germany Imaging Metabolism in Cancer
	Paul C. McDonald, British Columbia Cancer Research Center, Canada Short Talk: Therapeutic Targeting of Carbonic Anhydrase IX Results in Inhibition of Growth and Metastasis of Breast Tumors
Following Session is for Cell Death Pathways (X3)
5:00 - 7:00 PM	Autophagic Pathways Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Noboru Mizushima, Tokyo Medical and Dental University, Japan
	Daniel J. Klionsky, University of Michigan, USA The Regulation of Macroautophagy
	Francesco Cecconi, Dulbecco Telethon Institute, University of Rome, Italy Short Talk: Ambra1 Regulates Autophagosome Formation and Plays a Role in Controlling Cell Proliferation
	Ana Maria Cuervo, Albert Einstein College of Medicine, USA Chaperone-Mediated Autophagy in Organismal Aging
	Vojo Deretic, University of New Mexico, USA Autophagy in Immunity: Microbes, Mitochondria and Cell Survival vs Cell Death
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 2 Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Pacific Ballroom
Monday, March 15
7:00 - 11:00 AM	Poster Setup	Pacific Ballroom
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Survival and Death in Development and Disease (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British/Columbia Ballroom
	* Karen H. Vousden, Beatson Institute for Cancer Research, UK
	Noboru Mizushima, Tokyo Medical and Dental University, Japan Lessons from Autophagy Deficient Mouse Models
	Marja Jäättelä, Danish Cancer Society, Denmark Lysosomal Sphingolipid Metabolism as a Target for Cancer Therapy
	Douglas R. Green, St. Jude Children's Research Hospital, USA The Mitochondrion: The Weapon Employed in Apoptopic Suicide
	Gerard I. Evan, University of California, San Francisco, USA Inhibiting Oncogenes for Cancer Therapy
	Joan Boren, Cambridge Research Institute, CRUK, UK Short Talk: Changes in Cell Lipid Content during Induction of Apoptosis
	Rebecca Lock, University of California, San Francisco, USA Short Talk: Autophagy Inhibition Alters Glucose Metabolism and Promotes Epithelial Differentiation During Ras-Mediated Oncogenic Transformation
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:30 AM- 12:30 PM	Lunch	Pacific Ballroom
12:30 - 2:30 PM	Poster Session 3 Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Pacific Ballroom
2:30 - 4:30 PM	Workshop 2: Metabolic Assessment and Regulation	Columbia Ballroom
	* Craig B. Thompson, Abramson Family Cancer Center and Research Institute, University of Pennsylvania, USA
	Michelle F. Clasquin, Princeton University, USA High-Resolution Full-Scan Mass Spectrometry for Discovery and Characterization of Unknown Metabolites
	Andrew N. Lane, University of Louisville, USA Translational Metabolomics in Human Lung Cancer
	Kenjiro Kami, Keio University, Japan, Japan CE-MS-based Metabolomics Identified a Novel Anaerobic Energy Metabolism of Cancer Cells
	Fionnuala M. Morrish, Fred Hutchinson Cancer Research Center, USA The Metabolism of Tumor Progression and Regression in the pInsMycERTam/Bcl-xL Mouse Model of Pancreatic Beta Cell Neoplasia
	Min Wu, Seahorse Bioscience, USA Metabolic Dependency on Fatty Acid Oxidation of Glioblastoma SF188
	Ameeta Kelekar, University of Minnesota, USA Post-Translational Regulation of Human Noxa; its Role in Glucose Deprivation Induced Death
	Kathryn E. Wellen, University of Pennsylvania, USA The Hexosamine Biosynthetic Pathway Links Glutamine Metabolism and Signaling to Regulate Cell Growth
	Linda Z. Penn, Ontario Cancer Institute, Canada Connecting the Dots between Tumor Cell Metabolism and the Mevalonate Pathway
Following Workshop is for Cell Death Pathways (X3)
2:30 - 4:30 PM	Workshop 2: Pathological Implications of Non-Apoptotic Cell Death Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Junying Yuan, Harvard Medical School, USA
	Nelson Cesar Di Paolo, University of Washington, USA Necrosis and Autophagy, but not Apoptosis, are Induced in Macrophages in vivo upon Interaction with Adenovirus
	Sam McNeal, Rhode Island Hospital, USA Divergent Roles of RIP1 in Septic Liver Injury
	Cristina Muñoz-Pinedo, Institut d'Investigació Biomèdica de Bellvitge, Spain Glucose Deprivation Induces an Atypical Form of Apoptosis Mediated by Caspase-8 in Bax, Bak Deficient Cells
	Andrey A. Parkhitko, Brigham and Women's Hospital Harvard Medical School, USA Role of Autophagy in the Pathogenesis of Tuberous Sclerosis Complex
	Poonam Sansanwal, Stanford University, USA Mitochondrial Autophagy: A Novel Mechanism for Cellular Injury in Nephropathic Cystinosis
	Andrew M. Leidal, Dalhousie University, Canada Autophagy Contributes to KSHV v-cyclin-induced Senescence
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Cancer and Predisposition Genes Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Columbia Ballroom
	* William G. Kaelin Jr., Dana Farber Cancer Institute, USA
	Cheryl L. Walker, University of Texas MD Anderson Cancer Center, USA Participation of TSC2 in a Cytoplasmic ATM Signaling Pathway that Regulates mTORC1 in Response to ROS
	Kwok-Kin Wong, Dana-Farber Cancer Institute, USA Integrative Genomic and Proteomic Analyses Identify Novel Targets for Lkb1 Deficient Metastatic Lung Tumors
	Jason A. Chesney, University of Louisville, USA Coupling Glycolysis With Cell Cycle Progression
	Sang-Min Jeon, University of Illinois at Chicago, USA Short Talk: The LKB1-AMPK Pathway is Essential for Cell Survival during Glucose Starvation through Redox Regulation
Following Session is for Cell Death Pathways (X3)
5:00 - 7:00 PM	Cell Death Induction for Cancer Therapy Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Suzanne Cory, Walter and Eliza Hall Institute of Medical Research, Australia
	Anthony G. Letai, Dana-Farber Cancer Institute, USA Why Chemotherapy Works – Chemosensitive Cancer Cells are more Primed for Apoptosis

	Jerry M. Adams, Walter and Eliza Hall Institute of Medical Research, Australia Short Talk: Puma-Mediated Leukocyte Apoptosis is Critical for gamma-Irradiation-Induced Thymic Lymphoma Development
	Saul H. Rosenberg, Abbott Laboratories, USA Bcl-2 Family Inhibitors for the Treatment of Cancer
	Leigh S. Zawel, Novartis Institutes for BioMedical Research, USA Therapeutic Targeting of Inhibitor of Apoptosis Proteins
7:00 PM-	On Own for Dinner
Tuesday, March 16
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	mTOR and Nutrient Sensing Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Columbia Ballroom
	* Gerard I. Evan, University of California, San Francisco, USA
	David M. Sabatini, Whitehead Institute for Biomedical Research, USA mTOR and the Control of Growth
	Reuben J. Shaw, The Salk Institute, USA The LKB1/ AMPK Pathway Controls Metabolism and Cell Growth
	Michael N. Hall, University of Basel Biozentrum, Switzerland TOR Signaling and the Control of Cell and Animal Growth
	Robert T. Abraham, Pfizer Biopharmaceuticals, USA Interplay between Glutamine Metabolism and mTOR Signaling during Autophagy
	Bin Zheng, Beth Israel Deaconess Medical Center, USA Short Talk: Cross-Talk between the LKB1-AMPK and BRAF-MEK-ERK Signaling Pathways
	Matthew J. Martin, Institute of Cancer Research, UK Short Talk: AMP-Activated Protein Kinase in Melanoma: Biology and Therapeutic Opportunities
Following Session is for Cell Death Pathways (X3)
8:00 - 11:15 AM	Non-Conventional Cell Death Pathways Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Frank Madeo, University of Graz, Austria
	Junying Yuan, Harvard Medical School, USA Mechanisms of Programmed Cell Death: From Apoptosis to Necroptosis
	Michael B. Yaffe, Massachusetts Institute of Technology, USA Mitotic Catastrophe: Mechanisms and Therapeutic Induction for Cancer Treatment
	Paul R. Clarke, University of Dundee, UK Short Talk: Controlling Apoptosis in Mitosis and during Mitotic Arrest
	Peter Vandenabeele, VIB, Ghent University, Belgium TNF-Induced Necrosis, Multiple Regulation of RIP1 Kinase Activity
	Oliver Florey, Memorial Sloan Kettering Cancer Centre, USA Short Talk: A Case for Murder: Entosis is a Cell Killing Mechanism Requiring Autophagy Proteins
	Dale E. Bredesen, Buck Institute for Age Research, USA Role of Cell Death Signaling in Alzheimer's Disease
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM-	On Own for Lunch and Recreation
3:30 - 4:30 PM	Special Lecture (Joint) Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British/Columbia Ballroom
	Craig B. Thompson, Abramson Family Cancer Center and Research Institute, University of Pennsylvania, USA Therapeutic Exploitation of Metabolic Differences between Normal and Cancer Cells
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Hypoxia and Metabolic Stress Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	Columbia Ballroom
	* Peter F. Carmeliet, University of Leuven, Belgium
	Pierre Sonveaux, University of Louvain (UCL) Medical School, Belgium Short Talk: Targeting Lactate-Fueled Respiration Selectively Kills Hypoxic Tumor Cells
	Adrian L. Harris, Molecular Oncology Laboratories, UK Role of Carbonic Anhydrase 9 in Regulation of Tumour pH and Response to Antiangiogenic Therapy
	Sally A. Kornbluth, Duke University Medical Center, USA Metabolic Control of Caspases
	William G. Kaelin Jr., Dana Farber Cancer Institute, USA Dioxygenases as Therapeutic Targets in Cancer
Following Session is for Cell Death Pathways (X3)
5:00 - 7:00 PM	Immunologic Cell Death Registered attendees for this meeting can view Abstracts for this session starting on 02/12/2010	British Ballroom
	* Guido Kroemer, INSERM, U848, Institut Gustave Roussy, France
	Polly Matzinger, National Institutes of Health, USA Conversations between Tissues and T Cells
	Matthew L. Albert, Institut Pasteur, France The Immunogenicity of Distinct Cell Death Modalities


	Seung Hyun Han, Seoul National University, South Korea Short Talk: Functional and Phenotypic Changes in Dendritic Cells Loaded with Irradiation-Induced Apoptotic Cancer Cells
	Michel F. Gilliet, University of Texas MD Anderson Cancer Center, USA Breaking Innate Immune Tolerance to Self-Nucleic Acids Released by Dying Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
8:00 - 11:00 PM	Entertainment	Pacific Ballroom
Wednesday, March 17
	Departure
*=Session Chair †=Speaker invited, not yet responded.

Keystone Symposia would like to thank the sponsor of this meeting for their generous support:

We gratefully acknowledge additional support for this conference from:


Pfizer Biopharmaceuticals

The Directors' Fund

These generous unrestricted gifts allow our Directors to schedule meetings in a wide variety of important areas, many of which are in the early stages of research.

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We gratefully acknowledge the generous grant for this conference provided by:

National Institutes of Health
National Cancer Institute (NCI)
Grant No. 1R13CA144429-01

The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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Otto Warburg initially drew attention to the distinct metabolic state of tumors compared to normal tissues over 75 years ago, where tumor cells commonly favor glycolysis over oxidative phosphorylation even in the presence of oxygen (Warburg effect or aerobic glycolysis). Insight into the role and mechanism of this metabolic switch in tumorigenesis, and the utility of and means to therapeutically exploit altered metabolism in cancer was not clear, other than for utilization for FDG-PET imaging. Recently the metabolic requirements of tumor cells and the links to common pathway alterations in human cancers have been gradually emerging. It is now apparent that metabolic demand in tumor cells is high due to deregulation of cell growth, and that this constitutive activation of growth signaling pathways can disconnect cellular metabolism from nutrient and growth factor availability. Subversion of cellular metabolism for biosynthetic purposes is required to sustain deregulated tumor cell growth but can also restrict energy production that can limit tumor cell adaptation to metabolic stress. Hypoxic and acidic conditions in the tumor microenvironment are byproducts of these events and are common features of the tumor microenvironment that can activate stress responses, influence tumor growth, and impair treatment. Many of the oncogenic pathways altered in tumor cells modulate cell metabolism while enabling growth in these adverse conditions. Adaptation of tumor cells to stress through activation of the catabolic pathway of autophagy and its role in damage mitigation and promoting tumor cell survival to metabolic stress is also now emerging. The vision for this meeting is to bring together leaders in the fields of cancer, signaling and metabolism to discuss emerging discoveries and their application to improving cancer therapy.

Metabolism and Cancer Progression (X4)