| Sunday, June 21 |
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3:00 - 7:30 PM
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Registration
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INEC Conference Centre Foyer
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6:30 - 7:30 PM
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Refreshments
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INEC Conference Centre Foyer
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7:30 - 9:45 PM
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Keynote Session
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INEC Main Auditorium
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Frank Gannon,
Science Foundation Ireland
Welcoming Remarks
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René Bernards,
Netherlands Cancer Institute
Finding Mechanisms and Biomarkers of Drug Resistance in Cancer
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Robert G. Roeder,
Rockefeller University
Function of Transcriptional Coactivators in Animal Cells
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| Monday, June 22 |
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8:00 - 9:00 AM
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Breakfast
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INEC Conference Centre Foyer
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9:00 AM - 12:00 PM
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Transcriptional Regulation through Epigenetic Control in Cancer
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INEC Main Auditorium
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Kristian Helin,
University of Copenhagen
Histone Methyltransferases and Demethylases in Cell Proliferation and Cancer
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Maarten Van Lohuizen,
Netherlands Cancer Institute
Regulation of Stem Cell Commitment and Tumor Development by Polycomb Repressors
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Sung Hee Baek,
Seoul National University
Short Talk: Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
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Reuven Agami,
Netherlands Cancer Institute
BRD7 is Required for P53-tumor Suppressor Activity
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Manel Esteller,
IDIBELL
Epigenetic Dysregulation in Human Cancer
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10:20 - 10:40 AM
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Coffee Break
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INEC Conference Centre Foyer
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12:00 PM -
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On Own for Lunch
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12:00 - 1:00 PM
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Poster Setup
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INEC Conference Centre Foyer
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1:00 - 10:00 PM
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Poster Viewing
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INEC Conference Centre Foyer
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3:00 - 4:30 PM
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Workshop 1: Presentations Selected from Submitted Abstracts
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INEC Main Auditorium
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Deborah L. Johnson,
University of Southern California
The c-Jun-N-Terminal Kinases Differentially Regulate RNA Polymerase III Transcription by Coordinately Modulating the Expression of all TFIIIB Subunits
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Rajnish A. Gupta,
Stanford University School of Medicine
Reprogramming of the Breast Cancer Epigenome and Promotion of Metastasis by a HOX Long Noncoding RNA
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Ralf Kittler,
University of Chicago
A Nuclear Receptor Cis-regulatory Map for Breast Cancer
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Erich S. Huang,
Duke University Medical Center
An Experimentally-Annotated Strategy for Developing Factor Models of Oncogenic Activities & Sensitivity to Pathway-Specific Therapeutics
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Anchit Khanna,
IMT, University of Tampere
C-Myc-Dependent Regulation and Prognostic Role of c-Myc Stabilizing Protein CIP2A, in Human Gastric Cancer
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4:30 - 5:00 PM
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Coffee Available
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INEC Conference Centre Foyer
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5:00 - 7:15 PM
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Mechanisms of Transcriptional Misregulation
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INEC Main Auditorium
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Joan W. Conaway,
Stowers Institute for Medical Research
Alc1, a Putative Oncogene and Chromatin Remodeling Enzyme Regulated by Poly(ADP-ribosyl)ation
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Beverly M. Emerson,
The Salk Institute
Aberrant Transcriptional Silencing in Human Cancers
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Peter N. Cockerill,
Leeds Institute of Molecular Medicine
Epigeneitc and Transcriptional Mechanisms Regulating Haematopoeitic Cells in Normal and Malignant Cancer Cells
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Howard Y. Chang,
Stanford University
A Histone Demethylase in Cell Cycle Control
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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INEC Conference Centre Foyer
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7:30 - 10:00 PM
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Poster Session 1
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INEC Conference Centre Foyer
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| Tuesday, June 23 |
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8:00 - 9:00 AM
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Breakfast
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INEC Conference Centre Foyer
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8:00 - 9:00 AM
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Poster Setup
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INEC Conference Centre Foyer
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9:00 AM - 12:00 PM
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Tumor Promotion through Aberrant Transcription
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INEC Main Auditorium
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Karen H. Vousden,
Beatson Institute for Cancer Research
Functions of Mutant p53 in Promoting Invasion
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Joaquín M. Espinosa,
University of Colorado, Boulder
Novel Mechanisms of Transcriptional Control in the p53 and Serum Response Gene Networks
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Constanze Bonifer,
St. James University
Short Talk: Aberrant Transcriptional Activation of CSF-1R in Hodgkins Lymphoma
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Hugues de Thé,
Hopital St. Louis
Recent Insights into PML/RARA Function in APL Pathogenesis
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Michael Karin,
University of California, San Diego
Inflammation induced Transcriptional Reprogramming in Metastatic Progression
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9:00 AM - 5:30 PM
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Poster Viewing
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INEC Conference Centre Foyer
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10:20 - 10:40 AM
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Coffee Break
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INEC Conference Centre Foyer
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12:00 - 1:00 PM
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Lunch
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INEC Conference Centre Foyer
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12:30 - 3:00 PM
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Poster Session 2
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INEC Conference Centre Foyer
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3:00 - 3:30 PM
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Coffee Available
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INEC Conference Centre Foyer
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3:30 - 5:30 PM
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Activation of Developmental Transcription Pathways in Cancer
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INEC Main Auditorium
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Katherine A. Jones,
The Salk Institute
SKIP/SNW1 Regulates Transcription Elongation and Methylation
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Stephen C. Blacklow,
Brigham and Women's Hospital
Transcriptional Dysregulation by Aberrant Notch Signaling in Leukemia
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Jason S. Carroll,
Cancer Research UK
Short Talk: Defining the Role for Pioneer Factors in Estrogen Receptor Transcriptional Activity
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Thea D. Tlsty,
University of California, San Francisco
Clues on the Activation and Regulation of Epigenetic Remodeling in Cancer
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5:30 PM -
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On Own for Dinner
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| Wednesday, June 24 |
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8:00 - 9:00 AM
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Breakfast
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INEC Conference Centre Foyer
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9:00 AM - 12:00 PM
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Mapping the Transcriptome in Cancer States
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INEC Main Auditorium
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Bing Ren,
University of California, San Diego
Global Analysis of Gene Regulation in Human Cells
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Alexander Meissner,
Harvard University, Broad Institute
Epigenomics and Cellular States
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Dearbhaile Collins,
Royal College of Surgeons, Ireland
Short Talk: Steroid and Growth Factor Pathway Crosstalk in Breast Cancer: The Impact of c-Myc and SMRT Interaction
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Yijun Ruan,
Genome Institute of Singapore
Mapping Cancer Transcriptome and Long-Range Chromatin Interactions of Transcription Regulatory Elements through Genomic Sequencing Approaches
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Edison T. Liu,
Genome Institute of Singapore
Cellular Decisions in Transcription: The Topology of Transcription Factor Binding and Decision Nodes for Binding Site Selection
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10:20 - 10:40 AM
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Coffee Break
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INEC Conference Centre Foyer
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12:00 PM -
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On Own for Lunch
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12:00 - 1:00 PM
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Poster Setup
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INEC Conference Centre Foyer
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1:00 - 10:00 PM
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Poster Viewing
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INEC Conference Centre Foyer
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3:00 - 4:30 PM
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Workshop 2: Panel Discussion, Perspectives on Transcription as a Therapeutic Target
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INEC Main Auditorium
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René Bernards,
Netherlands Cancer Institute
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Robert G. Roeder,
Rockefeller University
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Gregory L. Verdine,
Harvard University
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Paul Workman,
Institute of Cancer Research
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John J. Rossi,
Beckman Research Institute of the City of Hope
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4:30 - 5:00 PM
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Coffee Available
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INEC Conference Centre Foyer
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5:00 - 7:00 PM
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Gene Expression Cassettes and Transcriptional Networks in Cancer
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INEC Main Auditorium
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Joseph R. Nevins,
Duke University Medical Center
Genomic Analysis of Oncogenic Cell Signaling Networks
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Erik S. Knudsen,
Kimmel Cancer Center
Short Talk: Disruption of the RB/E2F Regulatory Network in Cancer: Variant Impact on Tumorigenesis & Therapeutic Response
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Fabrizio Bianchi,
IFOM Foundation
Short Talk: Global Mapping of Oncogenic Expression Signatures in Lung Adenocarcinoma
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Arul M. Chinnaiyan,
University of Michigan
The Next Generation of Gene Fusion Discovery in Cancer
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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INEC Conference Centre Foyer
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7:30 - 10:00 PM
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Poster Session 3
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INEC Conference Centre Foyer
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| Thursday, June 25 |
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8:00 - 9:00 AM
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Breakfast
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INEC Conference Centre Foyer
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9:00 AM - 12:00 PM
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Modifying Transcription and Transcription Targeted Therapeutics I
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INEC Main Auditorium
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Gregory L. Verdine,
Harvard University
Drugging “Undruggable” Targets Using Stapled Peptides
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John J. Rossi,
Beckman Research Institute of the City of Hope
RNAi Post-transcriptional and Transcriptional Gene Silencing Mechanism
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Sandra E. Dunn,
University of British Columbia
YB-1 induces CD44 and CD49f thereby promoting the capacity for tumor initiation
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Qiang Yu,
Genome Institute of Singapore
Combinatorial Treatment Targeting EZH2-Mediated Epigenetic Event for Cancer Therapy
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Lyubomir T. Vassilev,
Roche Pharmaceuticals
Small Molecule Inhibitors of p53-MDM2 Complexes for Cancer Therapy
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10:20 - 10:40 AM
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Coffee Break
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INEC Conference Centre Foyer
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12:00 PM -
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On Own for Lunch
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4:30 - 5:00 PM
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Coffee Available
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INEC Conference Centre Foyer
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5:00 - 7:00 PM
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Modifying Transcription and Transcription Targeted Therapeutics II
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INEC Main Auditorium
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Paul Workman,
Institute of Cancer Research
Drugging the Cancer Genome
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Sheng Ding,
The Scripps Research Institute
Stem Cell Biology
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Elisabeth D. Martinez,
University of Texas Southwestern Medical Center
Short Talk: An Epigenetic Cell Based Screen Identifies a Novel Small Molecule with Specific Anti-Cancer Activity
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Yosef Yarden,
Weizmann Institute of Science
Oncogenic Signal Transduction Networks and their Feedback Regulation
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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INEC Conference Centre Foyer
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7:30 - 10:00 PM
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Entertainment
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INEC Conference Centre Foyer
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| Friday, June 26 |
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Departure
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