| Saturday, April 25 |
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3:00 - 7:30 PM
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Registration
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Palm Court
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6:30 - 7:30 PM
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Refreshments
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Palm Court
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7:30 - 9:30 PM
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Keynote Session
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Crystal Ballroom
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Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research
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Erik Sontheimer,
Northwestern University
Welcoming Remarks
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Andrew Fire,
Stanford University
Adventures in the Small RNA-ome
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David P. Bartel,
Massachusetts Institute of Technology
MicroRNAs and Other Small Regulatory RNAs
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| Sunday, April 26 |
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7:00 - 8:00 AM
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Breakfast
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Crystal Ballroom
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8:00 - 11:30 AM
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Mechanism of Small RNAs I
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Salon B-C
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David C. Baulcombe,
University of Cambridge
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V. Narry Kim,
Seoul National University
Biogenesis of miRNAs
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Gunter Meister,
Max Planck Institute of Biochemistry
Regulation of Argonaute Function
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Qinghua Liu,
University of Texas Southwestern Medical Center
Short Talk: C3PO Promotes Drosophila RNAi by Enhancing RISC Activity
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Bruce M. Paterson,
National Cancer Institute, National Institutes of Health
Short Talk: Identification of an RNA-Dependent RNA Polymerase in Drosophila Involved in RNAi and Transposon Suppression
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Erik Sontheimer,
Northwestern University
CRISPR Interference in Bacteria
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Dinshaw J. Patel,
Memorial Sloan-Kettering Cancer Center
Structural Biology of Argonaute-Mediated RNA Silencing
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Jin-Biao Ma,
University of Alabama at Birmingham
Short Talk: Structural Insights into the Molecular Mechanism of the Small RNA Methyltransferase HEN1
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9:20 - 9:40 AM
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Coffee Break
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Prefunction, Level 2
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11:30 AM -
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On Own for Lunch
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11:30 AM - 1:00 PM
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Poster Setup
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Salon A
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1:00 - 10:00 PM
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Poster Viewing
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Salon A
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4:30 - 5:00 PM
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Coffee Available
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Prefunction, Level 2
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5:00 - 7:15 PM
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Chromatin Silencing and Modification
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Salon B-C
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Irene Bozzoni,
University La Sapienza, Rome
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Shiv I. S. Grewal,
National Institutes of Health
Epigenetic Genome Control by RNAi and Transposon-Derived Proteins
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Nicholas J. Proudfoot,
University of Oxford
Autoregulation of Convergent RNAi Genes by Transient Heterochromatin Formation in S. pombe
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Thomas A. Volpe,
Northwestern University, Feinberg School of Medicine
Short Talk: RNA-Dependent RNA Polymerase Links Assembly of Heterochromatin Domains to Secondary siRNA Synthesis
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Steven E. Jacobsen,
HHMI/University of California, Los Angeles
DNA Methylation on Arabidopsis
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Andrzej T. Wierzbicki,
Washington University
Short Talk: RNA Polymerase V Transcription Recruits AGO4 to Chromatin
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Salon A
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7:30 - 10:00 PM
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Poster Session 1
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Salon A
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| Monday, April 27 |
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7:00 - 8:00 AM
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Breakfast
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Crystal Ballroom
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7:00 - 8:00 AM
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Poster Setup
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Salon A
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8:00 - 11:30 AM
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Mechanism of Small RNAs II
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Salon B-C
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Javier A. Martinez,
Institute of Molecular Biotechnology of the Austrian Academy of Sciences
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Scott G. Kennedy,
University of Wisconsin
siRNAs Initiate a NRDE-2-Dependent Co-Transcriptional Gene Silencing Program that Regulates RNAP II Elongation
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Craig C. Mello,
University of Massachusetts Medical School
Complexity of RNA Silencing in C. elegans
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Thomas F. Duchaine,
McGill University
Short Talk: Architecture of the ERI endoRNAi Initiation Machinery in C. elegans
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David C. Baulcombe,
University of Cambridge
Imprinted Expression of siRNA loci in Arabidopsis
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Peter Sarnow,
Stanford University School of Medicine
Modulation of Hepatitis C Virus RNA Abundance by Liver-Specific microRNA miR-122
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Yukihide Tomari,
University of Tokyo
Short Talk: Dissection of Ago1-RISC Assembly Pathway in Drosophila
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Eric C. Lai,
Sloan-Kettering Institute
Short Talk: Sorting of miRNA* Strands in Drosophila
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9:20 - 9:40 AM
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Coffee Break
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Prefunction, Level 2
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11:30 AM - 12:30 PM
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Lunch
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Salon A
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12:00 - 2:30 PM
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Poster Session 2
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Salon A
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12:00 - 7:15 PM
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Poster Viewing
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2:30 - 4:30 PM
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Workshop 1: Identification of New miRNA Targets
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Salon B-C
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Mihaela Zavolan,
Biozentrum, University of Basel
Sequence and Structure Determinants of miRNA Targeting Specificity
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Daehyun Baek,
Whitehead Institute for Biomedical Research
The Impact of microRNAs on Protein Output
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Artemis G. Hatzigeorgiou,
BSRC "Al. Fleming"
DIANA-MicroT 4: Machine Learning based microRNA Target Prediction
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Markus Hafner,
Rockefeller University
PURE-CLIP - Transcriptome-Wide Identification of miRNA Targets and RNA Targets and Binding Sites of RNA-Binding Proteins
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Dimitrios G. Zisoulis,
University of California, San Diego
Massive Identification of miRNA Target Sites in Endogenous mRNAs
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Vincenzo Alessandro Gennarino,
Telethon Institute of Genetics and Medicine
MicroRNA Target Prediction by Expression Analysis of Host Genes
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Francesca Moretti,
European Molecular Biology Laboratory
Positional Effects of microRNA-Mediated Translational Regulation and their Mechanistic Basis
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Yevgeniy Grigoryev,
The Scripps Research Institute
The Role of miRNAs in Regulating Human T and B Lymphocyte Activation
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4:30 - 5:00 PM
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Coffee Available
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Prefunction, Level 2
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5:00 - 7:15 PM
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Intersection of RNAi/miRNA Silencing with Other Cellular Pathways
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Salon B-C
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Brenda L. Bass†,
University of Utah
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Olivier Voinnet,
Institut de Biologie Moléculaire des Plantes
RNAi and Pathogen Defense in Plants
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Bryan R. Cullen,
Duke University Medical Center
Viruses, microRNAs and RNA Interference
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Craig P. Hunter,
Harvard University
Intercellular RNA Transporters in Worms and Vertebrates
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Raul Andino,
University of California, San Francisco
Short Talk: Antiviral Immunity in Drosophila Requires Systemic RNAi Spread
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Yi Liu,
University of Texas Southwestern Medical Center
Short Talk: A Novel Type of Small Interference RNA Induced by DNA Damage
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7:15 PM -
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On Own for Dinner
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| Tuesday, April 28 |
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7:00 - 8:00 AM
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Breakfast
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Crystal Ballroom
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8:00 - 11:30 AM
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Regulation of Translation and Stability by miRNAs
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Salon B-C
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Haruhiko Siomi,
Keio University School of Medicine
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Elisa Izaurralde,
MPI for Developmental Biology
GW182 Proteins are Essential for miRNA-mediated Gene Silencing in Animal Cells
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Witold Filipowicz,
Friedrich Miescher Institute for Biomedical Research
Mechanism and Regulation of miRNA Repression in Mammalian Cells
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Xiaozhong Alec Wang,
Northwestern University
Short Talk: Genetic Analysis of Argonaute Function in ES Cells
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Nahum Sonenberg,
McGill University
Dissecting microRNA Mechanisms of Action in vitro
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Joan A. Steitz,
Howard Hughes Medical Institute, Yale University
MicroRNPs: Versatile Regulators of Translation in Vertebrate Cells
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Sara R. Cherry,
University of Pennsylvania School of Medicine
Short Talk: Ars2 Regulates both miRNA- and siRNA-Dependent Silencing and Suppresses RNA Virus Infection in Drosophila
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Helge Großhans,
Friedrich Miescher Institute (FMI)
Short Talk: Active Turnover Modulates Mature microRNA Activity in C. elegans
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9:20 - 9:40 AM
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Coffee Break
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Prefunction, Level 2
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11:30 AM -
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On Own for Lunch
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11:30 AM - 1:00 PM
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Poster Setup
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Salon A
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1:00 - 10:00 PM
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Poster Viewing
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Salon A
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2:30 - 4:30 PM
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Workshop 2: Lessons from Deep Sequencing
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Salon B-C
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Nikolaus Rajewsky,
Max Delbruck Center for Molecular Medicine
Dynamic Small RNA Expression in Precisely Staged Early C. elegans Embryos and the Planarian Small RNAome
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Thomas Hohn,
University of Basel
RNA-Based Silencing Suppression
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Nicholas D. Socci,
Memorial Sloan Kettering Cancer Center
Analysis of SmallRNA Expression Profiles in Liposarcoma via Deep Sequencing
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Priyamvada Rajasethupathy,
Columbia University
Characterization of Small RNAs in Aplysia Reveals Neuronal piRNAs and a Neuron-Specific miRNA that Constrains Long-Term Synaptic Plasticity
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Xiaoming Zhang,
University of California, Riverside
Diverse Classes of Endogenous siRNAs with Distinct Biogenesis Pathways Identified from Bacterial-Challenged Arabidopsis
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Michael Thomas McManus,
University of California, San Francisco
EXPANDed RNAi Libraries for High-Throughput Deep Screening
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Constance Ciaudo,
Institut de Biologie Moleculaire des Plantes
Highly Dynamic and Sex-Specific Expression of Micro RNAs during Early ES Cell Differentiation
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Hervé Seitz,
CNRS
The Spectacular Diversity of Small Silencing RNAs in Animals is Ancient and not a Vertebrate Innovation
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4:30 - 5:00 PM
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Coffee Available
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Prefunction, Level 2
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5:00 - 7:15 PM
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RNA Silencing in the Germline
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Salon B-C
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Richard W. Carthew,
Northwestern University
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Gregory J. Hannon,
Cold Spring Harbor Laboratory
Conserved Roles of Small RNAs in Genome Defense
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Mikiko C. Siomi,
Keio University School of Medicine
PiRNA Biogenesis Systems in Drosophila Germline Cells
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René F. Ketting,
Hubrecht Institute
RNAi and Chromosome Segregation
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Yohei Kirino,
University of Pennsylvania School of Medicine
Short Talk: Methylation of Piwi Proteins is Conserved across Phyla
and in D. melanogaster it is Catalyzed by PRMT5 and Required for Ago3 and Aub Stability
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Michael Reuter,
EMBL
Short Talk: Loss of the Mili-Associated Tudor Domain Containing Protein 1 Specifically Derepresses LINE1 Transposons
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Salon A
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7:30 - 10:00 PM
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Poster Session 3
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Salon A
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| Wednesday, April 29 |
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7:00 - 8:00 AM
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Breakfast
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Crystal Ballroom
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8:00 - 11:30 AM
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MicroRNAs in Development
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Salon B-C
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Olivier Voinnet,
Institut de Biologie Moléculaire des Plantes
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Richard W. Carthew,
Northwestern University
Silencing by Small RNAs is Linked to Endosome Trafficking
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Victor Ambros,
University of Massachusetts
MicroRNA Pathways in Animal Development
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Antonio J. Giraldez,
Yale School of Medicine
The Role of microRNAs during Zebrafish Development
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Gerhard Schratt,
University of Heidelberg
Short Talk: microRNA Regulation of Dendritic and Synaptic Plasticity
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Eran Hornstein,
Weizmann Institute of Science
Short Talk: Loss of miRNA Activity in Pathogenesis of ALS-like Motor Neuron Disease
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Hun-Way Hwang,
Johns Hopkins University
Short Talk: Cell-Cell Contact Globally Activates microRNA Biogenesis
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Yang Yu,
Case Western Reserve University
Short Talk: Enhanced Magnitude of miRNA-Mediated Regulation Upon Muscle Differentiation
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Joel Neilson,
Baylor College of Medicine
Short Talk: 3' UTR Dynamics in Cellular Activation and Transformation
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9:20 - 9:40 AM
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Coffee Break
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Prefunction, Level 2
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11:30 AM -
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On Own for Lunch
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4:30 - 5:00 PM
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Coffee Available
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Prefunction, Level 2
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5:00 - 7:30 PM
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Small RNAs in Medicine
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Salon B-C
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Anastasia Khvorova,
RXi Pharma
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John Van der Oost,
Wageningen University
Interference by Small CRISPR RNA in Prokaryotes
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Gunther Hartmann,
Universitätsklinikum Bonn
RIG-I Immunorecognition of siRNA and Application for Tumor Therapy
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Beverly L. Davidson,
University of Iowa
Noncoding RNAs and Huntington’s disease.
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Tariq M. Rana,
Burnham Institute for Medical Research
Short Talk: Role of P-Bodies and microRNAs in Modulating Host-HIV-1 Interactions
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Kumi Sakurai,
City of Hope Graduate School of Biological Sciences
Short Talk: Characterization and in vivo Application of a Dual Inhibitory Aptamer-siRNA Delivery System for HIV-1 Therapy
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Sakari Kauppinen,
Santaris Pharma
Short Talk: Therapeutic Silencing of microRNA-122 in Primates with Chronic HCV Infection
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7:30 - 8:30 PM
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Social Hour w/ Lite Bites
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Crystal Ballroom
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8:00 - 11:00 PM
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Entertainment
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Crystal Ballroom
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| Thursday, April 30 |
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Departure
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