Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Neurodegenerative Diseases: New Molecular Mechanisms (J5)

Organizer(s): Valina L. Dawson and David M. Holtzman
February 17 - 22, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 17, 2008
Late Abstract Deadline: November 18, 2008
Scholarship Deadline: October 17, 2008
Early Registration Deadline: December 17, 2008

Sponsored by Eli Lilly and Company and Schering-Plough Research Institute

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The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Axonal Connections: Molecular Cues for Development and Regeneration (J6)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
There have been significant advances in our understanding of the causes and pathologic progression of neurodegenerative diseases. Identification of disease-causing mutations has provided unprecedented opportunities to develop new and predictive models and move closer to new therapeutic treatments. Technological advances in biochemistry, genomics, proteomics and imaging have facilitated the ability to pose and answer complex questions in complex disease, as well as an appreciation that neurodegenerative diseases have distinct cell death signaling cascades that can share some common molecular events. In this meeting an emphasis will be placed on understanding mechanisms that may be common and those that are distinct in neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), triple repeat diseases, amyotrophic lateral sclerosis (ALS) and others.

Tuesday, February 17
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	Longs Peak / Grays Peak


	Michael E. Greenberg, Harvard Medical School Signaling Networks that Control Synapse Development and Cognitive Function
	Huda Y. Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine Pathogenic Mechanisms in Neurodegenerative Disorders
Wednesday, February 18
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Autophagy - Common Themes in Neurodegenerative Disease?	Longs Peak
	* Richard I. Morimoto, Northwestern University
	David C. Rubinsztein, Cambridge Institute for Medical Research Autophagy Induction: A Possible Therapeutic Strategy for Neurodegenerative Diseases Caused by Aggregate-Prone Intracytoplasmic Proteins

	Masaaki Komatsu, Tokyo Metropolitan Institute of Medical Science Inclusion Body Formed by Autophagy-Deficient Mice

	Ron R. Kopito, Stanford University Prion-Like Properties of Polyglutamines
	Matthew J. Elrick, University of Michigan Short Talk: Tau Deletion Exacerbates the Phenotype of Niemann-Pick Type C Mice and Implicates Autophagy in Pathogenesis
	Ishrat Ahmed, Johns Hopkins School of Medicine Short Talk: Dopamine Neurons are Sensitive to Impaired Autophagy in Vivo
	Mona Bains, University of Colorado Denver Short Talk: Regulation of Neuronal Autophagy
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Axon Degeneration (Joint)	Longs Peak / Grays Peak
	* Marie T. Filbin, Hunter College

	Freda D. Miller, Hospital for Sick Children, University of Toronto p75 and Axon Degeneration: From Pruning to Injury
	Marc R. Freeman, University of Massachusetts Medical School Wallerian Degeneration and Wlds Function in Drosophila
	Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology Imaging Neuronal Injury and Repair
	Marc Tessier-Lavigne, Genentech, Inc. Axonal Self-Destruction and Neurodegenerative Disease
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1	Quandary 1-3
Thursday, February 19
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Proteostasis in Neurodegenerative Disease: Chaperones and Protein Misfolding	Longs Peak
	* Ron R. Kopito, Stanford University
	Richard I. Morimoto, Northwestern University Proteostasis Networks and the Regulation of Proteotoxicity in Neurodegenerative Disease
	Heather Leigh True-Krob, Washington University Yeast Prions as Intragenic and Extragenic modifiers of protein aggregation
	Marc I. Diamond, University of California, San Francisco Prion-Like Properties of the Microtubule Associated Protein Tau: Diversity and Propagation of Protein Misfolding

	Andrew G. Dillin, The Salk Institute for Biological Studies Connecting Mechanisms of Aging and Neurodegeneration
	Jeppe Pedersen Falsig, H. Lundbeck A/S Short Talk: Neurodegeneration in Organotypic Brain Slice Cultures
	Kenneth Matthew Scaglione, University of Michigan Short Talk: Deciphering the Ubiquitination Cycle: The de Ubiquitinating Enzyme Ataxin-3 Regulates the Chaperone-Dependent Ligase CHIP
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Models of Neurodegenerative Diseases	Longs Peak
	* Bart De Strooper, Center for Human Genetics
	Susan L. Ackerman, The Jackson Laboratory Novel Pathways Underlying Neurodegeneration Revealed by Forward Genetics
	Ted M. Dawson, Johns Hopkins School of Medicine Molecular Mechanisms Underlying Mitochondrial Dysfunction and Neurodegeneration in Parkinson’s Disease


	Karen Duff, Columbia University Insight into Pathogenic Mechanisms and Potential Therapeutic Approaches from Transgenic Models of AD
	Sara K. Custer, University of Pennsylvania Short Talk: Mutant VCP Leads to Cytotoxicity and Redistribution of TDP-43 in vivo
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2	Quandary 1-3
Friday, February 20
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Axon Regeneration (Joint)	Longs Peak / Grays Peak
	* Liqun Luo, Stanford University
	Marie T. Filbin, Hunter College Signaling Axonal Regeneration in the CNS
	Jerry Silver, Case Western Reserve University Functional Regeneration Into and Beyond the Glial Scar

	Zhigang He, Children's Hospital, Boston Intrinsic Control of Axon Regeneration
	Stephen M. Strittmatter, Yale University Failure of Adult CNS Axonal Growth after Injury
	Andrew Chisholm, University of California, San Diego Short Talk: Mechanisms of Axonal Regeneration in C. elegans
	Alvaro Sagasti, UCLA Short Talk: Plasticity of Sensory Axon Arbors in the Zebrafish Skin is Controlled by a Nogo Receptor/RhoA Pathway
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	RNA Actions in Neurodegeneration	Longs Peak
	* Ted M. Dawson, Johns Hopkins School of Medicine

	Bart De Strooper, Center for Human Genetics The Role of miRNA in Alzheimer¡¦s Disease and recent insights in ƒ×-secretase biology
	Shai Shaham, Rockefeller University A New C. elegans Cell Death Program
	Valina L. Dawson, Johns Hopkins School of Medicine Survival and Death Choices Regulated by MiR's
	Wim Mandemakers, Katholieke Universiteit, Leuven Short Talk: Regulation of Alpha-Synuclein Expression by miRNAs
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3	Quandary 1-3
Saturday, February 21
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Stem Cells (Joint)	Longs Peak / Grays Peak
	* David M. Holtzman, Washington University
	Fred H. Gage, The Salk Institute for Biological Studies Stem Cells in the Adult Brain
	Fiona Doetsch, Columbia University Stem Cells and their Niche in the Adult Mammalian Brain
	Hongjun Song, Johns Hopkins University School of Medicine Activity-Dependent Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis
	Lorenz Studer, Memorial Sloan Kettering Cancer Center Pluripotent Stem Cell Based Strategies for Disease Modeling and Cell Repair in Neurodegenerative Disease
	Orly Lazarov, University of Illinois at Chicago Short Talk: Presenilin-1 Regulates Neurogenesis in the Adult Brain
	Maria Lehtinen, Harvard Medical School Short Talk: The Cerebrospinal Fluid (CSF) Proteome Provides a Niche for Neural Progenitor Cells
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	New Therapeutic Approaches	Longs Peak
	* Valina L. Dawson, Johns Hopkins School of Medicine

	David M. Holtzman, Washington University Fluid Biomarkers of Antecedent Alzheimer's Disease and New Therapies and Methods to Assess Treatments in Neurodegenerative Disease

	Beverly L. Davidson, University of Iowa Noncoding RNAs and Huntington’s Disease
	Timothy M. Miller, Washington University School of Medicine Gene Downregulation as a Therapy for ALS
	Leila M. Luheshi, University of Cambridge Short Talk: Inhibiting the Aggregation and Toxicity of Amyloid Beta in Vivo using an Engineered Amyloid Beta Binding Protein
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Sunday, February 22
	Departure

*Session Chair †Speaker invited, not yet responded.