Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Axonal Connections: Molecular Cues for Development and Regeneration (J6)

Organizer(s): John G. Flanagan, Marie T. Filbin and Liqun Luo
February 17 - 22, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 17, 2008
Late Abstract Deadline: November 18, 2008
Scholarship Deadline: October 17, 2008
Early Registration Deadline: December 17, 2008

Sponsored by Eli Lilly and Company

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Joint meeting: Neurodegenerative Diseases: New Molecular Mechanisms (J5)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2009 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Synapses: Formation, Function and Misfunction (Z3)
April 11 - 15, 2010

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The functioning of the nervous system depends on formation of a complex pattern of connections during development. If these connections are subsequently lost through injury or degeneration, axons in the adult CNS fail to regenerate, creating a major clinical challenge. The last several years have seen tremendous progress in identifying molecular mechanisms for axon development and regeneration, although much remains to be learned about these complex processes. Rapid progress is being made in identifying new classes of extracellular regulators, understanding the mechanisms by which this extracellular information is transduced by the neuron into appropriate responses, and learning the underlying molecular logic for the formation of neural connectivity. This meeting will bring together researchers in the fields of axon development, degeneration and regeneration. The meeting will promote exchange of ideas, information and collaboration among these fields, and will train young scientists in the questions, approaches, and opportunities in these exciting and topical research areas. It will also promote scientific and translational goals of understanding the basic mechanisms for the formation of neural circuits, and developing new strategies for therapeutic repair.

Tuesday, February 17
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Address (Joint)	Grays Peak / Longs Peak


	Michael E. Greenberg, Harvard Medical School Signaling Networks that Control Synapse Development and Cognitive Function
	Huda Y. Zoghbi, Howard Hughes Medical Institute, Baylor College of Medicine Pathogenic Mechanisms in Neurodegenerative Disorders
Wednesday, February 18
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:00 AM	Molecular Cues for Axon Guidance	Grays Peak
	* Rüdiger Klein, Max Planck Institute of Neurobiology

	Yimin Zou, University of California, San Diego Wnt Signaling and Axon Guidance Along the CNS Anteroposterior Axis
	Dietmar Schmucker, Dana-Farber Cancer Institute, Harvard Medical School Functional and Molecular Studies of the Hypervariable Receptor Dscam
	Hitoshi Sakano, University of Tokyo Axon Wiring in the Mouse Olfactory System
	Fred Charron, Montreal Clinical Research Institute (IRCM) Short Talk: Sonic Hedgehog Guides Axons through a Novel, Non-Canonical Signaling Pathway

	Eric O. Williams, Cornell University Short Talk: Identifying Axon Guidance Molecules during the Development and Regeneration of the Mouse Olfactory System
	Jason W. Triplett, University of California, Santa Cruz Short Talk: Activity-Driven Alignment of Visual Topographic Maps in the Superior colliculus
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Axon Degeneration (Joint)	Grays Peak / Longs Peak
	* Marie T. Filbin, Hunter College

	Freda D. Miller, Hospital for Sick Children, University of Toronto p75 and Axon Degeneration: From Pruning to Injury
	Marc R. Freeman, University of Massachusetts Medical School Wallerian Degeneration and Wlds Function in Drosophila
	Wenbiao Gan, Skirball Institute Program of Molecular Neurobiology Imaging Neuronal Injury and Repair
	Marc Tessier-Lavigne, Genentech, Inc. Axonal Self-Destruction and Neurodegenerative Disease
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 1	Quandary 1-3
Thursday, February 19
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Signaling Pathways in Neural Connectivity	Grays Peak
	* Stephen M. Strittmatter, Yale University
	David G. Ginty, Johns Hopkins School of Medicine Growth Factor Signals Controlling Development of the Peripheral Nervous System

	Alex L. Kolodkin, Johns Hopkins University School of Medicine Molecular Mechanisms Underlying the Establishment of Neuronal Connectivity
	Liqun Luo, Stanford University Cell Autonomous Function of NMDA Receptor in Dendrite Patterning
	Yi Rao, Peking University Slit and Netrin
	Thomas Fothergill, University of Queensland Short Talk: DCC Modulates Slit-Robo Signaling during Corpus callosum Development
	Uwe Drescher, King's College London Short Talk: Neurotrophin Receptors in EphrinA Reverse Signaling
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	RNA and Regulated Protein Expression in Axon Guidance	Grays Peak
	* Michael E. Greenberg, Harvard Medical School

	John G. Flanagan, Harvard Medical School RNA-Based Regulation Mechanisms in Axon Development
	Gary Bassell, Emory University Mechanisms of mRNA Transport and Local Protein Synthesis in Axon Guidance and Regeneration
	Oliver Hobert, Columbia University Medical Center Molecular Mechanisms of Maintaining Nervous System Architecture
	Catia Andreassi, University College London Short Talk: Identification of a Novel Localization Element that Targets mRNA Transcripts in Sympathetic Neuron Axons
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 2	Quandary 1-3
Friday, February 20
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Axon Regeneration (Joint)	Grays Peak / Longs Peak
	* Liqun Luo, Stanford University
	Marie T. Filbin, Hunter College Signaling Axonal Regeneration in the CNS

	Jerry Silver, Case Western Reserve University Functional Regeneration Into and Beyond the Glial Scar
	Zhigang He, Children's Hospital, Boston Intrinsic Control of Axon Regeneration
	Stephen M. Strittmatter, Yale University Failure of Adult CNS Axonal Growth after Injury
	Andrew Chisholm, University of California, San Diego Short Talk: Mechanisms of Axonal Regeneration in C. elegans
	Alvaro Sagasti, UCLA Short Talk: Plasticity of Sensory Axon Arbors in the Zebrafish Skin is Controlled by a Nogo Receptor/RhoA Pathway
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Quandary 1-3
1:00 - 10:00 PM	Poster Viewing	Quandary 1-3
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Synapse Formation	Grays Peak
	* Marc Tessier-Lavigne, Genentech, Inc.

	Kang Shen, Stanford University Regulators of Synapse Formation in C. elegans

	Rüdiger Klein, Max Planck Institute of Neurobiology Cell Autonomous Function of NMDA Receptor in Dendritic Patterning
	Ben A. Barres, Stanford University How do Astrocytes Induce CNS Synapse Formation?
	Wei Shen, University of Wisconsin, Madison Short Talk: Autophagy and Ubiquitin Proteasome System Converge in Regulating Drosophila Synaptic Growth
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
7:30 - 10:00 PM	Poster Session 3	Quandary 1-3
Saturday, February 21
7:00 - 8:00 AM	Breakfast	Quandary 1-3
8:00 - 11:15 AM	Stem Cells (Joint)	Grays Peak / Longs Peak
	* David M. Holtzman, Washington University
	Fred H. Gage, The Salk Institute for Biological Studies Stem Cells in the Adult Brain
	Fiona Doetsch, Columbia University Stem Cells and their Niche in the Adult Mammalian Brain
	Hongjun Song, Johns Hopkins University School of Medicine Activity-Dependent Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis
	Lorenz Studer, Memorial Sloan Kettering Cancer Center Pluripotent Stem Cell Based Strategies for Disease Modeling and Cell Repair in Neurodegenerative Disease
	Orly Lazarov, University of Illinois at Chicago Short Talk: Presenilin-1 Regulates Neurogenesis in the Adult Brain
	Maria Lehtinen, Harvard Medical School Short Talk: The Cerebrospinal Fluid (CSF) Proteome Provides a Niche for Neural Progenitor Cells
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Dendrite Patterning and Complex Circuits	Grays Peak
	* Ben A. Barres, Stanford University


	Andrew D. Huberman, Stanford University Short Talk: Genetic Dissection of Mammalian Neural Circuitry
	Wesley B. Grueber, Columbia University Medical Center Control of Dendritic Deversification


	Ofer Reizes, Cleveland Clinic Foundation Short Talk: Axonal Connections in the Circuits Controlling Feeding Behavior in Syndecan-3 Null Mice are Wired for Leanness
	Catherine C. Dulac, Harvard University Molecular and Genetic Approaches to Brain Circuits and Behavior
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary 1-3
8:00 - 11:00 PM	Entertainment	Quandary 1-3
Sunday, February 22
	Departure

*Session Chair †Speaker invited, not yet responded.