| Wednesday, January 21 |
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3:00 - 7:30 PM
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Registration
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Promenade
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6:30 - 7:30 PM
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Refreshments
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Promenade
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7:30 - 8:30 PM
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Keynote Address
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Mesa Ballroom
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Howard L. Weiner,
Brigham and Women's Hospital
Role of the Innate Immune System in Multiple Sclerosis
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8:30 - 9:00 PM
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Orientation for New Attendees and New Investigators
Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.
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Mesa Ballroom
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| Thursday, January 22 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa
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8:00 - 11:15 AM
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Pathogenetic Mechanisms of Demyelination and MS
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Mesa Ballroom
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*
John Fleming,
University of Wisconsin-Madison
Overview of MS and Major Challenges; and The Hygiene Hypothesis and Multiple Sclerosis
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Alberto Ascherio,
Harvard School of Public Health
Epidemiology of MS: Could MS be Prevented?
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Claudia Lucchinetti,
Mayo Clinic
Evolution of Pathogenic Concepts in Multiple Sclerosis
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Nicole Schaeren-Wiemers,
University Hospital Basel
Short Talk: Characterization of Molecular Alterations in Normal Appearing Grey Matter of Multiple Sclerosis Brain Tissues
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Stephen D. Miller,
Northwestern University Medical School
Pathogenic Mechanisms and Regulation of Susceptibility/Resistance to Theiler’s Virus-Induced Demyelination by CD4+CD25+ Regulatory T Cells
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Alison L. Christy,
Northwestern University
Short Talk: Mast Cells Regulate BBB Permeability in EAE
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:15 AM -
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On Own for Lunch
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11:15 AM - 1:00 PM
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Poster Setup
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Chamisa/Ortiz
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1:00 - 10:00 PM
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Poster Viewing
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Chamisa/Ortiz
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Biology and Pathobiology of the Myelinated Axon
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Mesa Ballroom
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*
James L. Salzer,
New York University School of Medicine
Assembly and Molecular Architecture of Myelinated Axons
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Klaus-Armin Nave,
Max Planck Institut of Experimental Medicine
An Emerging Role of Oligodendrocytes in Maintaining Axonal Integrity
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Bruce D. Trapp,
Cleveland Clinic Foundation, Lerner Research Institute
Mechanisms of Axonal Degeneration in Chronic MS Lesions
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Volker Siffrin,
Charité University Medicine Berlin
Short Talk: Intravital Imaging of Immune-Neuronal Interaction in Experimental Autoimmune Encephalomyelitis
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Chamisa/Ortiz
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7:30 - 10:00 PM
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Poster Session 1
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Chamisa/Ortiz
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| Friday, January 23 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa
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7:00 - 8:00 AM
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Poster Setup
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Chamisa/Ortiz
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8:00 - 11:15 AM
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Immunopathogenetic Mechanisms in MS
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Mesa Ballroom
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Vijay K. Kuchroo,
Brigham and Women's Hospital, Harvard Medical School
T-regs and Th17 Cells: Role in Induction and Regulation of Tissue Inflammation
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Zsuzsanna Fabry,
University of Wisconsin
Short Talk: Intracerebral Dendritic Cells Modulate Encephalitogenic Versus Regulatory Immune Responses in the CNS
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Dan R. Littman,
New York University School of Medicine
Transcriptional Regulation of Th17 Cell Differentiation
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Izumi Kawachi,
Brain Research Institute, Niigata University
Short Talk: The Distinct Lineage: Double Negative T Cells Expressing IL-17 in MS
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Colleen E. Hayes,
University of Wisconsin-Madison
Regulatory Role of Vitamin D in Autoimmune Demyelination
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*
Joan Goverman,
University of Washington
Triggering CD8+ T Cells to Mediate CNS Autoimmunity
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:15 AM - 12:00 PM
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Lunch
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Ortiz/Chamisa
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12:00 - 2:30 PM
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Poster Session 2
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Chamisa/Ortiz
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2:30 - 4:30 PM
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Workshop 1: Mechanisms of Myelination and Remyelination Cells
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Mesa Ballroom
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*
Klaus-Armin Nave,
Max Planck Institut of Experimental Medicine
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Maria Traka,
University Of Chicago
Development of a Mouse Model for Adult Onset Ablation of Oligodendrocytes
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Jayshree Samanta,
New York University
Role of Sonic Hedgehog in Remyelination
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Kevin S. Carbajal,
University of California, Irvine
CXCL12 Enhances Migration of Implanted Glial-Committed Progenitor Cells in a Viral Model of Multiple Sclerosis
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Angeliki Mela,
Columbia University
KAI1/CD82 is Required for CNS Myelination by Oligodendrocyte Progenitors
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Patrick Kuery,
University of Duesseldorf
CXCL12-Dependent Oligodendroglial Differentiation
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Manzoor Bhat,
University of North Carolina, Chapel Hill
Formation and Maintenance of the Paranodal Axo-glial Junctions in Myelinated Axons
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Mechanisms of T Cell Trafficking into the CNS
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Mesa Ballroom
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*
Richard M. Ransohoff,
Cleveland Clinic
MS Pathogenesis from the Outside-In: A New Perspective
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Britta Engelhardt,
Theodor Kocher Institute/Universitat Bern
Imaging Leukocyte Recruitment across the Blood Brain Barrier
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Robyn S. Klein,
Washington University School of Medicine
Blood-Brain Barrier Dysfunction During MS: Signals that Promote T Cell Entry
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Harald F. Langer,
National Cancer Institute, National Institutes of Health
Short Talk: A Novel Function of Platelets in the Pathogenesis of Experimental Autoimmune Encephalomyelitis (EAE)
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7:00 PM -
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On Own for Dinner
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| Saturday, January 24 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa
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8:00 - 11:00 AM
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Identification of Genetic Risk Factors for MS and Autoimmune Diseases
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Mesa Ballroom
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*
David A. Hafler,
Harvard Medical School
Common Risk Alleles Associated with Multiple Sclerosis
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Jacob McCauley,
University of Miami
Interleukin-7 Receptor (IL7R) Pathway Genes as Risk Factors for MS
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Sergio E. Baranzini,
University of California, San Francisco
Genomic Approaches in MS
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Allan James Bieber,
Mayo Clinic
Short Talk: Genetic Determinants of CNS Repair
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Mario Clerici,
University of Milano
Short Talk: RAC2 Gene Single Nucleotide Polymorphisms Modulate
MBP-Specific Immune Responses and Correlate with Disease Progression in MS
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:00 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Chamisa/Ortiz
|
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1:00 - 10:00 PM
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Poster Viewing
|
Chamisa/Ortiz
|
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4:30 - 5:00 PM
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Coffee Available
|
Promenade
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5:00 - 7:00 PM
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Evaluation of MS Lesions and Axonal Pathology
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Mesa Ballroom
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Gavin Giovannoni,
Queen Mary's School of Medicine and Dentistry
Biomarkers in Multiple Sclerosis
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Yanming Wang,
Case Western Reserve University
Short Talk: Direct Quantification of Myelin Changes in the Vertebrate Nervous System
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Sheng-Kwei Song,
Washington University School of Medicine
Distinguishing Axonal from Myelin Pathology by DTI
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*
Paul M. Matthews,
Hammersmith Hospital
Using fMRI to Study MS: Understanding Plasticity
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Chamisa/Ortiz
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7:30 - 10:00 PM
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Poster Session 3
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Chamisa/Ortiz
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| Sunday, January 25 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa
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8:00 - 11:15 AM
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Emergent Immunotherapeutics: What Do They Teach Us About MS?
|
Mesa Ballroom
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Lawrence Steinman,
Beckman Center for Molecular Medicine, Stanford University
Antigen Specific Tolerance in MS
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Gordon Francis,
Elan Pharmaceuticals
Natalizumab Therapy in MS
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Lisa M. Mendoza,
Bayer Healthcare Pharmaceuticals
Short Talk: A Role for Leukotriene A4 Hydrolase in Disease Progression in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis
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*
Anne H. Cross,
Washington University
B Cell Depletion in MS Patients using Rituximab (antiCD20)
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Mehrdad Matloubian,
University of California, San Francisco
Regulation of Lymphocyte Egress by Innate and Adaptive Immune Responses
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Patrizia De Sarno,
University of Alabama at Birmingham
Short Talk: Targeting GSK3 is Therapeutic in EAE: Effects on Dendritic Cells and Encephalitogenic Activity of T Cells
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:15 AM -
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On Own for Lunch
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2:30 - 4:30 PM
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Workshop 2: New Therapeutic Approaches to MS
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Mesa Ballroom
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*
Lawrence Steinman,
Beckman Center for Molecular Medicine, Stanford University
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*
Henry McFarland,
NINDS, National Institutes of Health
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Jacqueline Kirchner,
Amgen
Prophylactic or Therapeutic Administration of Anti-GM-CSF-M250 Inhibits Disease in Multiple Experimental Autoimmune Models of MS
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Jennifer S. Lam,
SRI International
SR16951, a New Small Molecule for the Treatment of Multiple Sclerosis
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V. Wee Yong,
University of Calgary
EMMPRIN: A New Regulator of Neuroinflammation in Multiple Sclerosis
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Jochen Schmitz,
Rigel, Inc.
The Orally Bioavailable Portein Kinase C Inhibitor RGE-80 can Abrogate EAE Disease Induction and Ameliorates Disease in a Therapeutic Setting
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Chandra Deb,
Mayo Clinic College of Medicine
Neuronal Stress Sensitizes Axons to Immune-Mediated Injury
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Takashi Yamamura,
National Institute of Neuroscience, NCNP
NKT Cell-Dependent Amelioration of EAE by Altering Gut Flora
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Neural Protection and Remyelination
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Mesa Ballroom
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*
Robin Franklin,
University of Cambridge
The Biology of CNS Remyelination – the Key to Therapeutic Advances
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Sha Mi,
Biogen Idec, Inc.
Remyelination and Repair of the CNS by anti-LINGO1 Antibody
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Rhonda R. Voskuhl,
University of California, Los Angeles
Hormone Treatment in MS
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Marnie Preston,
Oregon National Primate Research Center
Short Talk: Hyaluronidase Activity Prevents Remyelination and Inhibits Neural Stem Cell and Oligodendrocyte Progenitor Differentiation
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8:00 - 9:00 PM
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Social Hour w/ Lite Bites
|
Mesa C
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8:00 - 11:00 PM
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Entertainment
|
Mesa C
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| Monday, January 26 |
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Departure
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