| Sunday, February 15 |
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3:00 - 7:30 PM
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Registration
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Promenade
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6:30 - 7:30 PM
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Refreshments
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Promenade
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7:30 - 9:30 PM
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Keynote Session: Roles of NMR and X-ray in the Future of Biology
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Mesa Ballroom
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*
Michael F. Summers,
University of Maryland Baltimore County and HHMI
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Peter E. Wright,
The Scripps Research Institute
Beyond 3D Structure: Insights from NMR into Protein Disorder, Dynamics, and Interactions
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Wayne A. Hendrickson,
Columbia University
Prospects and Challenges for X-ray Diffraction in Biology
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| Monday, February 16 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa/Ortiz
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8:00 - 11:00 AM
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New Methods
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Mesa Ballroom
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*
Mitsuhiko Ikura,
Ontario Cancer Institute
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Ad Bax,
NIDDK, National Institutes of Health
Proteins, Membranes, and their Interaction Viewed by NMR
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Stephan Grzesiek,
University of Basel
Probing Protein Structure and Dynamics of Unfolded and Folded Proteins by NMR
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Christian Griesinger,
Max Planck Institute for Biophysical Chemistry
Recognition Dynamics from NMR Residual Dipolar Couplings
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Robert G. Griffin,
Massachusetts Institute of Technology
Protein Structure Determination with Solid State NMR
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Erik R. P. Zuiderweg,
University of Michigan
Short Talk: Structural Basis of the Allosteric Trigger of the Hsp70 Chaperone Proteins
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:00 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Chamisa/Mesa C
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1:00 - 10:00 PM
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Poster Viewing
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Chamisa/Mesa C
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2:30 - 4:30 PM
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Workshop 1: Tackling Membrane Proteins
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Mesa Ballroom
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*
Angela M. Gronenborn,
University of Pittsburgh
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Mark Girvin,
Albert Einstein College Of Medicine
Talk Title to be Determined
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Francesca M. Marassi,
Burnham Institute
NMR of Membrane Proteins in Lipid Bilayers, Bicelles, and Micelles
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Ichio Shimada,
University of Tokyo
Interaction Analyses between Membrane Proteins and Ligands
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Chad M. Rienstra,
University of Illinois
Magic-Angle Spinning NMR for Membrane Protein Structure Determination
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Volker Dötsch,
University of Frankfurt
Combination of Cell-Free Expression and Liquid State NMR Spectroscopy for the Structural Investigation of Membrane Proteins
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Protein Folding and Dynamics
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Mesa Ballroom
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*
Ann E. McDermott,
Columbia University
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Charles R. Sanders,
Vanderbilt University School of Medicine
NMR Studies of the Transmembrane C-Terminal Domain of the Amyloid Precursor Protein: Does APP Function as a Cholesterol Sensor?
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Brian F. Volkman,
Medical College of Wisconsin
Native State Interconversion between Unrelated Protein Folds
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Robert Tycko,
National Institutes of Health
Solid State NMR of Amyloid Fibrils and Freeze-Trapped Protein Folding Intermediates
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Anthony Mittermaier,
McGill University
Short Talk: Mapping the Energy Landscape of Protein Folding and Binding Using NMR and Calorimetry
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Chamisa/Ortiz
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7:30 - 10:00 PM
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Poster Session 1
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Chamisa/Mesa C
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| Tuesday, February 17 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa/Ortiz
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7:00 - 8:00 AM
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Poster Setup
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Chamisa/Mesa C
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8:00 - 11:00 AM
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Membrane Proteins
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Mesa Ballroom
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*
Hideo Akutsu,
Osaka University
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Ann E. McDermott,
Columbia University
Conformational Changes in Enzymes and Membrane Proteins
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Lukas K. Tamm,
University of Virginia
Structure and Dynamics of OmpG in Detergent Micelles
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Mei Hong,
Iowa State University
Dynamic Conformation and Orientation of Membrane Proteins
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Stanley J. Opella,
University of California, San Diego
Membrane Proteins Studied by Solid State NMR
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Daniel Nietlispach,
University of Cambridge
Short Talk: Solution-NMR Structural Studies of the 7-Helix Transmembrane Receptor Sensory Rhodopsin pSRII
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:00 AM - 12:00 PM
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Lunch
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Chamisa
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12:00 - 2:30 PM
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Poster Session 2
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Chamisa/Mesa C
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2:30 - 4:30 PM
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Workshop 2: Paramagnetic Relaxation Enhancement and Residual Dipolar Coupling
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Mesa Ballroom
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*
Kevin H. Gardner,
University of Texas Southwestern Medical Center
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Angela M. Gronenborn,
University of Pittsburgh
Title to be Determined
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Alexander Grishaev,
NIDDK, National Institutes of Health
Combining RDC and Scattering Data for Structure Determination
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Lucia Banci,
University of Florence
Approaches for Characterizing Metal- or Redox-Mediated Protein Complexes
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Rieko Ishima,
University of Pittsburgh School of Medicine
Application of F-19 NMR to Study Protein Structure and Dynamics
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Rafael Bruschweiler,
Florida State University
Structural Protein Dynamics Elucidated by Spin Relaxation, Dipolar Couplings, and Computation
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Protein Dynamics and Transient States
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Mesa Ballroom
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*
A. Joshua Wand,
University of Pennsylvania
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G. Marius Clore,
National Institute of Diabetes and Digestive and Kidney Diseases
Visualizing Lowly-Populated Regions of the Free Energy Landscape of Macromolecular Complexes by Paramagnetic Relaxation Enhancement
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Dorothee Kern,
Brandeis University
The Climb Over the Mountain – Molecular Pathways of Conformational Transitions
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Gary P. Drobny,
University of Washington
Dynamics of Nucleic Acids
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Giuseppe Melacini,
McMaster University
Short Talk: Understanding cAMP-Dependent Allostery by NMR Spectroscopy
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7:00 PM -
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On Own for Dinner
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| Wednesday, February 18 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa/Ortiz
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8:00 - 11:00 AM
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Human Disease Targets
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Mesa Ballroom
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*
John L. Markley,
University of Wisconsin, Madison
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Torleif Härd,
University of Gothenburg
An Engineered Monomer Binding Protein Eliminates Alzheimer Amyloid-Beta Peptide Neurotoxicity
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Michael F. Summers,
University of Maryland Baltimore County and HHMI
Structural Basis for Trafficking of HIV-1 and HIV-2 Proteins to Virus Assembly Sites
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Michael K. Rosen,
University of Texas Southwestern Medical Center
Dynamic Origins of Interdomain Cooperativity in the Vav1 Proto-Oncoprotein
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Juli Feigon,
University of California, Los Angeles
Structure and Function of Human Telomerase and H/ACA RNA
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Christopher B. Marshall,
University Health Network
Short Talk: Characterization of Intrinsic and TSC2 GAP-Accelerated GTPase Activity of Rheb by Real-Time NMR
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:00 AM -
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On Own for Lunch
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11:00 AM - 1:00 PM
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Poster Setup
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Chamisa/Mesa C
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1:00 - 10:00 PM
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Poster Viewing
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Chamisa/Mesa C
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2:30 - 4:30 PM
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Workshop 3: Automation and Refinement Methods
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Mesa Ballroom
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*
Frank D. Sönnichsen,
Christian Albrechts Universität
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John L. Markley,
University of Wisconsin, Madison
Approaches to the Investigation of More Challenging Proteins and Protein Complexes
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Masatsune Kainosho,
Nagoya University
Applications of the Residue-Selective SAIL Approach for Structures and Dynamics of Proteins
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David A. Case,
Rutgers University
Building Better Models for Rotational Diffusion in Biomolecular NMR
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Alexandre M.J.J. Bonvin,
Universiteit Utrecht
Information-Driven Modeling of Biomolecular Complexes
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Vladislav Orekhov,
Gothenburg University
Hyper-Dimensional NMR Spectroscopy with Multi Dimensional Decomposition
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Macromolecular Interactions
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Mesa Ballroom
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*
Robert Kaptein,
University of Utrecht
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Robert B. Russell,
EMBL-Heidelberg
Discovery of New Peptides Mediating Interaction Networks
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James Jeiwen Chou,
Harvard Medical School
NMR Studies of Viral Proton Channels
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Gerhard Wagner,
Harvard Medical School
Topology and Regulation of the eIF4A/4G/4H Helicase Complex in Translation Initiation
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Masayori Inouye†,
University of Medicine and Dentistry of New Jersey
Short Talk: Production and Isotopic Enrichment of a Single Membrane Protein in E. coli for NMR Studies without Purification
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Chamisa/Ortiz
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7:30 - 10:00 PM
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Poster Session 3
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Chamisa/Mesa C
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| Thursday, February 19 |
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7:00 - 8:00 AM
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Breakfast
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Chamisa/Ortiz
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8:00 - 11:00 AM
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Drug Discovery and Chemical Biology
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Mesa Ballroom
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*
Melissa A. Starovasnik,
Genentech, Inc.
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Maurizio Pellecchia,
Burnham Institute
NMR Based Drug Discovery: Screening and Design of Novel Chemical Probes
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Patricia J. LiWang,
University of California, Merced
Structural and Functional Studies of Chemokines: Blocking HIV-1 and Stopping Inflammation
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Wolfgang Jahnke,
Novartis Institutes for BioMedical Research
NMR in Drug Discovery: The Blessing and Curse of Versatility
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Benjamin F. Cravatt III,
The Scripps Research Institute
Activity-Based Proteomics
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Timothy A. Cross,
Florida State University
Short Talk: Solid State NMR: A Novel Approach for Membrane Protein Drug Screening
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9:20 - 9:40 AM
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Coffee Break
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Promenade
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11:00 AM -
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On Own for Lunch
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4:30 - 5:00 PM
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Coffee Available
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Promenade
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5:00 - 7:00 PM
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Large Systems and New Methods
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Mesa Ballroom
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*
Ad Bax,
NIDDK, National Institutes of Health
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Patrik Lundstrom,
University of Toronto
Short Talk: Accurate Measurement of Protein Excited State Chemical Shifts by Relaxation Dispersion NMR Spectroscopy
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Charalampos Kalodimos,
Rutgers University
NMR of the Transcription Machinery
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James H. Prestegard,
University of Georgia
Sparse Labeling and Resonance Assignments for Structural Studies of Large and Glycosylated Proteins
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Kurt Wüthrich,
ETH Zurich/The Scripps Research Institute
Automation in NMR Structure Determination of Proteins in Solution
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Mesa C
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8:00 - 11:00 PM
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Mesa C
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| Friday, February 20 |
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Departure
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