Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Common Mechanisms in Arrhythmias and Heart Failure (D3)

Organizer(s): Alfred L. George, Jeffrey A. Towbin and Elizabeth M. McNally
April 2 - 7, 2009
Keystone Resort · Keystone, Colorado
Abstract Deadline: December 3, 2008
Late Abstract Deadline: January 5, 2009
Scholarship Deadline: December 3, 2008
Early Registration Deadline: February 2, 2009

Supported by the Directors' Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Electrical and mechanical disturbances in heart function underlie most cardiovascular morbidity and mortality. Investigations into the causes of cardiac arrhythmias and heart failure have led to considerable improvements in diagnosis and treatment of these conditions. Recent advances uncovering the molecular genetic basis for familial cardiomyopathy and inherited arrhythmia susceptibility have fueled greater interest in defining common pathophysiological mechanisms. This Keystone Symposia meeting will bring together experts in both fields to exchange ideas and explore common areas of interest. Major areas of emphasis for the symposium will include genetic mechanisms, electrical and transcriptional remodeling, regulation and disorders of cardiac ion homeostasis, and the complex interplay between molecules governing electrical and contractile events in the heart. The goal of this meeting is to stimulate new areas of investigation at the interface between the biology of heart rhythm and contraction, ideally leading to new therapeutic strategies and targets.

Thursday, April 2
3:00 - 7:30 PM	Registration	Shavano Peak Foyer
6:30 - 7:30 PM	Refreshments	Shavano Peak Foyer
7:30 - 8:30 PM	Keynote Address	Shavano Peak
	* Alfred L. George, Jr., Vanderbilt University
	Christine E. Seidman, Harvard Medical School Molecular Genetics of Familial Cardiomyopathies
Friday, April 3
7:00 - 8:00 AM	Breakfast	Torreys Peak 1-4
8:00 - 11:00 AM	Genetic Modifiers	Shavano Peak
	* Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center
	Connie R. Bezzina, Academic Medical Center Modifier Genes in Cardiac Sodium Channelopathy

	Dan Arking, Johns Hopkins School of Medicine QT Interval Genes as Modifiers of Sudden Cardiac Death
	Michael R. Bristow, University of Colorado Health Sciences Center Modifier Genes in the Cardiomyopathies
	Howard A. Rockman, Duke University Medical Center Mapping Modifiers in Drosophila
	Sharlene M. Day, University of Michigan Short Talk: Genetic and Phenotypic Complexity in a Unique Family with Arrhythmogenic Right Ventricular Cardiomyopathy
9:20 - 9:40 AM	Coffee Break	Torreys Peak 1-4
11:00 AM -	On Own for Lunch
11:00 AM - 1:00 PM	Poster Setup	Torreys Peak 1-4
1:00 - 10:00 PM	Poster Viewing	Torreys Peak 1-4
4:30 - 5:00 PM	Coffee Available	Torreys Peak 1-4
5:00 - 7:00 PM	Transcriptional Remodeling	Shavano Peak
	* Howard A. Rockman, Duke University Medical Center
	Katherine T. Murray, Vanderbilt University Medical Center Transcriptional Profiles in Healthy and Arrhythmic Heart


	Nikhil V. Munshi, University of Texas Southwestern Medical Center A GATA4-Dependent Transcriptional Pathway Regulates Normal Atrioventricular Delay

	Fikru B. Bedada, University of Minnesota Short Talk: MiR208 Prevents Phenylephrine Induced Hypertrophy in Adult Rat Cardiac Myocytes
	Farah Sheikh, University of California, San Diego Short Talk: Early Defects in Connexin Signaling Underlie Arrhythmogenic Right Ventricular Cardiomyopathy in a Novel Mouse Model
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Torreys Peak 1-4
7:30 - 10:00 PM	Poster Session 1	Torreys Peak 1-4
Saturday, April 4
7:00 - 8:00 AM	Breakfast	Torreys Peak 1-4
8:00 - 11:15 AM	Physiological Remodeling	Shavano Peak
	* Alfred L. George, Jr., Vanderbilt University
	Penelope A. Boyden, Columbia University Ionic Mechanisms Influencing Regional Action Potentials and Conduction
	Marc A. Vos, UMC Utrecht Proarrhythmic Myocardial Remodeling
	Jeffrey E. Saffitz, Beth Israel Deaconess Medical Center Modulation of Gap Junctions in Heart Disease
	George E. Billman, Ohio State University Autonomic Neural Remodeling after Myocardial Infarction
	Michael P. O'Quinn, Medical University of South Carolina Short Talk: A Peptide Containing the Carboxy-Terminal Domain of Connexin43 Inhibits Cardiac Dilation and Reduces Arrhythmias after Myocardial Injury
	Rolf Bodmer, Burnham Institute for Medical Research Short Talk: Studying the Genetics of Cardiac Dysfunction in Drosophila
9:20 - 9:40 AM	Coffee Break	Torreys Peak 1-4
11:15 AM -	On Own for Lunch
11:15 AM - 1:00 PM	Poster Setup	Torreys Peak 1-4
1:00 - 10:00 PM	Poster Viewing	Torreys Peak 1-4
4:30 - 5:00 PM	Coffee Available	Torreys Peak 1-4
5:00 - 7:00 PM	Novel Genetic Pathways	Shavano Peak
	* Connie R. Bezzina, Academic Medical Center
	Jeffrey A. Towbin, Cincinnati Children's Hospital Medical Center Final Common Pathways in Cardiomyopathy and Arrhythmias
	William J. McKenna, Heart Hospital Genetics of Arrhythmogenic Right Ventricular Cardiomyopathy
	Michael J. Ackerman, Mayo Clinic Novel Pathogenic Mechanisms for Heritable Arrhythmia Syndromes
	Marie-Louise Bang, Institute of Biomedical Technologies (ITB), Italian Research Council (CNR) Short Talk: Ablation of Myopalladin Results in Pressure Overload-Induced Dilated Cardiomyopathy
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Torreys Peak 1-4
7:30 - 10:00 PM	Poster Session 2	Torreys Peak 1-4
Sunday, April 5
7:00 - 8:00 AM	Breakfast	Torreys Peak 1-4
8:00 - 11:15 AM	Regulation and Disorders of Ion Homeostasis I	Shavano Peak
	* Penelope A. Boyden, Columbia University
	Donald M. Bers, University of California, Davis Regulation of Intracellular Sodium and Calcium in Cardiac Myocytes

	Xander H.T. Wehrens, Baylor College of Medicine Role of Ryanodine Receptor Leak in Heart Failure and Sudden Cardiac Death
	Björn C. Knollmann, Vanderbilt University School of Medicine Calsequestrin in Cardiac Calcium Homeostasis and Arrhythmogenesis
	James N. Weiss, University of California, Los Angeles Early Afterdepolarizations: How They Synchronize in Tissue to Cause Arrhythmias

	Changwon Kho, Mount Sinai School of Medicine Short Talk: SUMO Modification Modulates SERCA2a Function

	Saumya Das, Massachusetts General Hospital Short Talk: The Serum and Glucocorticoid Responsive Kinase-1 (SGK1) Mediates Hypertrophy-Induced Changes in SCN5a by Phosphorylation and Altered Binding to Ubiquitin Ligase Nedd4-2
9:20 - 9:40 AM	Coffee Break	Torreys Peak 1-4
11:15 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Torreys Peak 1-4
5:00 - 7:00 PM	Regulation and Disorders of Ion Homeostasis II	Shavano Peak
	* Donald M. Bers, University of California, Davis
	Mark E. Anderson, University Of Iowa Calmodulin Kinase II in Heart Failure and Arrhythmias
	Kenneth D. Philipson, University of California, Los Angeles Cardiac-Specific Knockout of Na-Ca Exchange
	Alfred L. George, Jr., Vanderbilt University Sodium Channel Dysfunction in Arrhythmias and Heart Failure
	Hiroshi Watanabe, Niigata University School of Medicine Short Talk: D1275N SCN5A Mutation causes Dilated Cardiomyopathy and Arrhythmias: Mechanisms Revealed in Mice but Absent by Heterologous Expression
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Torreys Peak 1-4
Monday, April 6
7:00 - 8:00 AM	Breakfast	Torreys Peak 1-4
8:00 - 11:00 AM	Sarcomeric and Cystoskeletal Proteins I	Shavano Peak
	* Michael J. Ackerman, Mayo Clinic
	R. John Solaro, University of Illinois at Chicago Arrhythmias, Heart Failure, and Signaling in Cardiac Sarcomeres
	Gisèle Bonne, INSERM UR 582 Laminopathies
	Peter J. Mohler, University of Iowa Dysfunction in Ankyrin-Based Pathways and Human Arrhythmia
	Elizabeth M. McNally, University of Chicago Disorders of the Dystrophin-Sarcoglycan Complex
	Carolina Vasquez, New York University School of Medicine Short Talk: Arrhythmogenic Potential of Activated Fibroblasts
9:20 - 9:40 AM	Coffee Break	Torreys Peak 1-4
11:00 AM -	On Own for Lunch
4:30 - 5:00 PM	Coffee Available	Torreys Peak 1-4
5:00 - 7:00 PM	Sarcomeric and Cystoskeletal Proteins II	Shavano Peak
	* Elizabeth M. McNally, University of Chicago
	Matteo Vatta, Baylor College of Medicine Z-Disk Disruption in Cardiac Failure and Arrhythmias
	Jil C. Tardiff, Albert Einstein College Of Medicine Thin Filament Protein Dynamics and Cardiomyopathies
	Jeffrey Robbins, Cincinnati Children's Hospital Research Foundation Myosin Binding Protein C and Regulation of Cardiac Hemodynamics
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Torreys Peak 1-4
8:00 - 11:00 PM	Entertainment	Torreys Peak 1-4
Tuesday, April 7
	Departure

*Session Chair †Speaker invited, not yet responded.