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TH17 Cells in Health and Disease (F1)

Organizer(s): Chen Dong, Vijay Kuchroo and Brigitta Stockinger
February 5 - 10, 2009
Fairmont Hotel Vancouver  ·  Vancouver, British Columbia
Abstract Deadline: October 6, 2008
Late Abstract Deadline: November 6, 2008
Scholarship Deadline: October 6, 2008
Early Registration Deadline: December 5, 2008


Supported by the Directors' Fund



This meeting took place in the 2009 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
T lymphocytes are important mediators of autoimmune diseases and their tolerance to self-antigens is tightly regulated. Regulatory T (Treg) cells maintain immune tolerance. Recently, a novel subset of CD4+ T cells that produce IL-17 (named Th17) has been identified and shown to be highly pathogenic in many autoimmune diseases. Surprisingly, there appears to be a reciprocal relationship between Th17 and Treg cells in their generation, and function. Therefore, T cell biology needs to be further re-examined in the context of molecular pathways that are required for their generation, mechanisms that are involved in their antagonism and function. The goal of this symposium is to bring the leaders in the field together to assess the increased complexity in the generation of pathogenic and regulatory T cells at the cellular, molecular and organismal levels and discuss the potential impact of these new findings on the development of treatments of human autoimmune diseases.

Thursday, February 5
3:00 - 7:30 PM Registration BC Foyer
6:30 - 7:30 PM Refreshments BC Foyer
7:30 - 8:30 PM Keynote Address British Ballroom
* Chen Dong, MD Anderson Cancer Center
Richard A. Flavell, Yale University School of Medicine
Helper T Cell Differentiation and Autoimmunity
Friday, February 6
7:00 - 8:00 AM Breakfast Columbia Ballroom
8:00 - 11:00 AM Cytokines and TH17 Differentiation British Ballroom
* Brigitta Stockinger, National Institute for Medical Research
Daniel J. Cua, Schering-Plough Biopharma
IL-23 and TH17 Regulation
Marc Veldhoen, National Institute for Medical Research
Modulation of Th17 Differentiation and Function
Christopher A. Hunter, University of Pennsylvania
IL-27 and Th17 Regulation
Ed C. Lavelle, Trinity College Dublin
Promotion of IL-1 and TH17 Cells using Vaccine Adjuvants
9:20 - 9:40 AM Coffee Break BC Foyer
11:00 AM - On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Columbia Ballroom
1:00 - 10:00 PM Poster Viewing Columbia Ballroom
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM IL-17 Signaling British Ballroom
* Jay K. Kolls, LSU Health Sciences Center
Sarah L. Gaffen, University of Pittsburgh
Mechanisms of IL-17 Receptor Signaling
Steven D. Levin, ZymoGenetics, Inc.
Identification of the IL-17 Receptor Related Molecule, IL-17RC as the Receptor for IL-17F
Reen Wu, University of California, Davis
IL-17 and Airway Mucosal Immunity
7:00 - 8:00 PM Social Hour w/ Lite Bites Columbia Ballroom
7:30 - 10:00 PM Poster Session 1 Columbia Ballroom
Saturday, February 7
7:00 - 8:00 AM Breakfast Columbia Ballroom
7:00 - 8:00 AM Poster Setup Columbia Ballroom
8:00 - 11:00 AM Treg, TH17 and Autoimmunity British Ballroom
* Casey T. Weaver, University of Alabama at Birmingham
Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School
Reciprocal Relationship between CD4+, Fox-P3+ T-reg and Proinflammatory Th17 Cells
Hilde Cheroutre, La Jolla Institute for Allergy and Immunology
Controlling Tolerance and Protective Immunity from the Outside In
Joan Goverman, University of Washington
Th17/Th1 Ratios Shape Neuroinflammatory Responses
Marie Wahren-Herlenius, Karolinska Institute
Short Talk: Ro52 and TH17-Mediated Skin Inflammation
Julie Magarian Blander, Mount Sinai School of Medicine
Short Talk: Innate Immune Recognition of Infected Apoptotic Cells Directs TH17 Cell Differentiation
9:20 - 9:40 AM Coffee Break BC Foyer
11:00 AM - 12:00 PM Lunch Columbia Ballroom
12:00 - 2:30 PM Poster Session 2 Columbia Ballroom
2:30 - 4:30 PM Workshop 1: Regulation of TH17 Cells British Ballroom
* Rachel R. Caspi, National Institutes of Health
Koji Atarashi, Osaka University
Lamina Propria TH17 Cell Differentiation is Controlled by ATP Derived from Commensal Bacteria
Song Guo Zheng, University of Southern California
Neither Smad2 or Smad3 is Essential for TGF-â to Induce Foxp3+ Tregs and Th17
Alessandra B. Pernis, Columbia University
IBP (IRF-4 Binding Protein) Inhibits IL-17 and IL-21 Production by Controlling IRF-4 Function
Elisabetta Volpe, Curie Institut
A Multiparametric Analysis of Cytokine-Driven Human Th17 Differentiation
Kojiro Sato, Saitama Medical University
Proto-Oncogene MAF Plays an Important Role in Th17-Cell Differentiation
Andrew M. Jackson, University of Nottingham
Interleukin-17 Expression in Human Tumours: Association with Survival and Cancer Invasiveness
Luis Alejandro Zúñiga, Stanford University School of Medicine
IL17A Moderates Adipocyte Lipid Accumulation in vitro and Obesity in vivo, and is Expressed by gammadelta T-Cells in Fat
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Human TH17 Cells British Ballroom
* Dan R. Littman, New York University School of Medicine
Federica Sallusto, Institute for Research in Biomedicine
Human TH17 Differentiation
Rene de Waal Malefyt, Schering-Plough
The Role of IL-23 and Th17 Cells in Chronic Immune Mediated Inflammatory Diseases
David A. Hafler, Harvard Medical School
Natural Human CD4+CD25high Tregs and Th17 Effector Cells
7:00 PM - On Own for Dinner
Sunday, February 8
7:00 - 8:00 AM Breakfast Columbia Ballroom
8:00 - 11:00 AM Molecular Control of TH17 Cells British Ballroom
* Vijay K. Kuchroo, Brigham and Women's Hospital, Harvard Medical School
Dan R. Littman, New York University School of Medicine
RORgammat and TH17 Differentiation
Michael Lohoff, University of Marburg
The Role of the Transcription Factor IRF4 for T Helper Cell Differentiation
John J. O'Shea, NIAMS, National Institutes of Health
STATs and T Cell Differentiation
Gang Pei, TongJi University
A microRNA mediated Regulation of Th17 Cell Differentiation Contributes to Multiple Sclerosis
9:20 - 9:40 AM Coffee Break BC Foyer
11:00 AM - On Own for Lunch
11:00 AM - 1:00 PM Poster Setup Columbia Ballroom
1:00 - 10:00 PM Poster Viewing Columbia Ballroom
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM TH17 in Mucosal Immunity British Ballroom
* Wenjun Ouyang, Genentech
Casey T. Weaver, University of Alabama at Birmingham
TH17 Cell and Intestinal Inflammation
Andrea M. Cooper, Trudeau Institute, Inc.
Protection versus Pathogenesis in Tuberculosis, the Role of IL-17, IL-23 and IL-27
Jay K. Kolls, LSU Health Sciences Center
Th17 Cells and Cytokines: Roles in Mucosal Immunity and Chronic Inflammation
7:00 - 8:00 PM Social Hour w/ Lite Bites Columbia Ballroom
7:30 - 10:00 PM Poster Session 3 Columbia Ballroom
Monday, February 9
7:00 - 8:00 AM Breakfast Columbia Ballroom
8:00 - 11:00 AM TH17 Cytokines British Ballroom
* Daniel J. Cua, Schering-Plough Biopharma
Yoichiro Iwakura, Institute of Medical Science, University of Tokyo
The Roles of IL-17A and IL-17F in the Immune System
Wenjun Ouyang, Genentech
The Roles of Th17 Cytokine IL-22 and IL-17 in Autoimmune and Infectious Diseases
Chen Dong, MD Anderson Cancer Center
Regulation and Function of TH17 Cells
Deborah Ann Young, Wyeth Research
IL-22: A Th17 Cytokine Contributes to Chronic Skin Inflammation
9:20 - 9:40 AM Coffee Break BC Foyer
11:00 AM - On Own for Lunch
2:30 - 4:30 PM Workshop 2: Novel Function of TH17 Cells/IL-17 British Ballroom
* Sarah L. Gaffen, University of Pittsburgh
Christopher Crowe, University of Pittsburgh
Critical Role for IL-17RA Signaling in Immunopathology of Influenza Infection
Gaia Codolo, University of Padua
NapA of Borrelia Burgdorferi Drives Th17 Inflammation in Lyme Arthritis
Meena S. Kumar, Emory University
Interleukin 17 Modulates Expression of Inflammatory Markers in Vascular Cells and Promotes the Late Phase of Angiotensin II Induced Hypertension In Vivo
Christine Delprat, CNRS5239
IL-17A Induces Cell Fusion and a New Anti Mycobacterium Program in GM-CSF-Stimulated Monocyte-Derived Dendritic Cells
Marika C. Kullberg, Centre for Immunology and Infection, University of York
Th17 Cells in Helicobacter Hepaticus-Induced Intestinal Inflammation
Cintia S. De Paiva, Cullen Eye Institute, Baylor College of Medicine
Neutralization of IL-17 Ameliorates Desiccating Stress-Induced Corneal Barrier Dysfunction
Manuela Raffatellu, University of California, Irvine
Lipocalin-2, an IL-17 and IL-22-Induced Antimicrobial Peptide, is a Host Defense Exploited by Salmonella Typhimurium to Colonize the Inflamed Gut
4:30 - 5:00 PM Coffee Available BC Foyer
5:00 - 7:00 PM Targeting TH17 in Clinics British Ballroom
* Chen Dong, MD Anderson Cancer Center
Michael Elliott, Centocor Inc.
Targeting IL-12/23 p40 in Autoimmune Disease
Tadamitsu Kishimoto, Osaka University
Anti-IL6 Receptor, TH17 and Arylhydrocarbon Receptor
Dhavalkumar D. Patel, Novartis Institutes for BioMedical Research
Inhibition of IL-17A in Psoriasis
7:00 - 8:00 PM Social Hour w/ Lite Bites Columbia Ballroom
8:00 - 11:00 PM Entertainment Columbia Ballroom
Tuesday, February 10
Departure
*Session Chair   †Speaker invited, not yet responded.



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