Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

NF-kappaB in Inflammation and Disease (A1)

Organizer(s): Michelle A. Kelliher, Manolis Pasparakis and Jürg Tschopp
January 5 - 10, 2010
Eldorado Hotel & Spa · Santa Fe, New Mexico
Abstract Deadline: September 14, 2009
Late Abstract Deadline: October 5, 2009
Scholarship Deadline: September 14, 2009
Early Registration Deadline: November 2, 2009

Sponsored by Amgen Inc.

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
In the past 10 years, impressive progress has been made on how the NF- kappaB transcription factor is regulated and how diverse signals frequently use ubiquitin-dependent mechanisms to activate NF- kappaB. Many of the signal transducers and regulatory enzymes have been identified and their essential roles in NF- kappaB regulation revealed through genetic analyses in mice. More recent work highlights the importance of NF- kappaB in innate immune signaling by cell surface Toll-like receptors and cytosolic Nod-like receptors. Although current research clearly implicates NF- kappaB in diabetes, inflammatory diseases and cancer, a challenge for the future will be to reveal the precise molecular and cellular mechanisms of NF- kappaB dysfunction in disease. The realization that NF- kappaB activity is regulated by kinases and ubiquitin modifying enzymes presents multiple opportunities for therapeutic intervention. In addition to highlights from basic research, results from clinical trials using IKK and other NF- kappaB inhibitors are expected to be presented at this meeting.

Tuesday, January 5
3:00 - 7:30 PM	Registration	Zia Concourse
6:30 - 7:30 PM	Refreshments	Zia Concourse
7:30 - 8:30 PM	Keynote Address	Anasazi Ballroom
	* Michelle A. Kelliher, University of Massachusetts Medical School
	Vishva M. Dixit, Genentech, Inc. The Importance of Restraint – Ubiquitin Hydrolases – Brakes in Signaling
Wednesday, January 6
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Regulation of the NF-kappaB Pathway	Anasazi Ballroom
	* Michael Karin, University of California, San Diego
	Zhijian James Chen, University of Texas Southwestern Medical Center Mechanism of Protein Kinase Activation by Ubiquitin in the NFkappaB Pathways
	Ivan Dikic, Goethe University Medical School Ubiquitin Chains in NFkappaB Signaling
	Kazuhiro Iwai, Osaka University Short Talk: Linear Polyubiquitination: A Newly Identified Regulator of NF-kappaB Signaling
	David Komander, MRC Laboratory of Molecular Biology Short Talk: Specificity of TAB2 Ubiquitin Interaction
	Hao Wu, Weill Medical College of Cornell University Crystal Structures of TRAF2, cIAP2 and TRAF1:TRAF2:cIAP Complexes

9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM - 1:00 PM	Poster Setup	Sunset Room/Eldorado Court
11:00 AM -	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sunset Room/Eldorado Court
2:30 - 4:30 PM	Workshop 1: NF-kappaB Regulation	Anasazi Ballroom
	* Zhijian James Chen, University of Texas Southwestern Medical Center
	Trevor William Siggers, Brigham & Women's Hospital, Harvard Medical School Examining the DNA Binding Specificity Landscape of NF-kB Dimers using Protein-Binding Microarrays
	Noula D. Shembade, University of Miami Sylvester Comprehensive Cancer Centre A20 Downregulates NF-kappaB Signaling by Disrupting E2:E3 Ubiquitin Enzyme Complexes
	Alain Chariot, University of Liege, CHU Insights into the BCL-3 Oncogene Through Interactomic Studies
	Mireille Y. Delhase, Nagoya City University Medical School Insights into the Anti-Apoptotic Function of the Protein Kinase TBK1
	Dirk Brenner, Princess Margaret Hospital Phosphorylation of CARMA1 by HPK1 is Critical for NF-kappaB Activation in T Cells
	Markus Brechmann, German Cancer Research Center Genetic Screening for Phosphatases that Regulate NF-kappB Activity in T Lymphocytes
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	Transcriptional Regulation by NF-kappaB	Anasazi Ballroom
	* David Baltimore, California Institute of Technology
	Gioacchino Natoli, IEO, European Institute of Oncology The Epigenome and the Control of the NF-kB Transcriptional Responses in Innate Immunity and Inflammation

	Sankar Ghosh, Columbia University Regulation of Gene Expression by NFkappaB and Regulation of Inflammation by NFkappaB

	Alexander Hoffmann, University of California, San Diego Short Talk: Two Roles of IkBs: Inhibitors and Generators of NFkappaB
	Michael R.H. White, University of Liverpool Short Talk: Control of Gene Expression by NF-kappaB Oscillations: A Source and Function for Cellular Heterogeneity?
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 1	Sunset Room/Eldorado Court
Thursday, January 7
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Innate Immune Receptor Signaling to NF-kappaB	Anasazi Ballroom
	* Vishva M. Dixit, Genentech, Inc.
	Jürg Tschopp, University of Lausanne The NALP3 Inflammasome: A Sensor for Metabolic Danger
	Michelle A. Kelliher, University of Massachusetts Medical School RIP Proteins Mediate Diverse Stress Responses
	Laurence Arbibe, Institut Pasteur Innate Immune Subversion by Chromatin Manipulation: A New Face of Host-Bacterial Pathogen Interaction


	Jun-Ichiro Inoue, Institute of Medical Science, University of Tokyo Short Talk: Two Mechanistically and Temporally Distinct NF-kappaB Activation Pathways in IL-1 Signaling
	Mikyoung Chang, MD Anderson Cancer Center Short Talk: Peli1 Facilitates TRIF-Dependent Toll-like Receptor Signaling and Proinflammatory Cytokine Production
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM - 1:00 PM	Poster Setup	Sunset Room/Eldorado Court
11:00 AM -	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sunset Room/Eldorado Court
2:30 - 4:30 PM	Workshop 2: NF-kappaB and Innate Immunity	Anasazi Ballroom
	* Gioacchino Natoli, IEO, European Institute of Oncology
	Ido Amit, Massachusetts Institute of Technology Reconstructing the Regulatory Circuit of Pathogen Sensing in Mammals
	Mathieu J.M. Bertrand, VIB / Ghent University Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2
	Ee Tsin Wong, Institute of Molecular and Cell Biology Identification of a Factor Essential for Toll-like Receptor Signaling
	Christine S. Cheng, University of California, San Diego The NF-kappaB p50 Homodimer is a Regulator of Interferon Regulatory Elements (IRE) and Anti-Viral Innate Immune Responses
	Marc Riemann, Leibniz Institute for Age Research - Fritz Lipmann Institute Role of RelA and RelB in Medullary Thymic Epithelial Cells for the Establishment of Immunological Self-Tolerance
	Lawrence P. Kane, University of Pittsburgh Recruitment of the IKK Complex to TCR Microclusters during T Cell Activation
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	NF-kappaB in the Immune Response	Anasazi Ballroom
	* Sankar Ghosh, Columbia University
	David Baltimore, California Institute of Technology MicroRNAs and Regulation of NF-kB
	Margot Thome, University of Lausanne MALT1: Role of its Protease Activity in T cell Activation and Lymphoma Development

	Bruce H. Horwitz, Brigham and Women's Hospital Short talk: Regulation of Inflammation by p50/p105
	Ashish K. Jain, National Institutes of Health Short Talk: CYLD Regulates TGFâ Signaling in T cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 2	Sunset Room/Eldorado Court
Friday, January 8
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	NF-kappaB in Disease	Anasazi Ballroom
	* Jürg Tschopp, University of Lausanne
	Manolis Pasparakis, University of Cologne IKK/NFkappaB Signaling in Mouse Models of Inflammatory Disease and Cancer


	Jorge Moscat, University of Cincinnati College of Medicine The p62/atypical PKC Complex in Cancer and Metabolism
	Etienne Meylan, Koch Institute for Integrative Cancer Research at MIT Requirement for NFkappaB Signaling in a Mouse Model of Lung Adenocarcinoma
	Daniela S. Basseres, University of North Carolina at Chapel Hill Role of NFkappaB in Ras Induced Lung Tumorigenesis
	Yousef Abu-Amer, Washington University School of Medicine The Role of IKKâ in Skeletal Pathophysiology
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM - 1:00 PM	Poster Setup	Sunset Room/Eldorado Court
11:00 AM -	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Sunset Room/Eldorado Court
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	NF-kappaB and Inhibitors in Preclinical Models	Anasazi Ballroom
	* Inder M. Verma, The Salk Institute NF-kB: Regulation and Function

	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center Roles of NFkappaB in Pathogenesis and Treatment of Type 2 Diabetes


	Friedrich Thaiss, University Hospital Short Talk: Resolution of Renal Inflammation: A New Role for IKK2/ NF-kappaB Pathway in Nephrotoxic Nephritis
	Lih-Ling Lin, Pfizer Pharmaceuticals Targeting TPL2 and IKK2 for Treating Rheumatoid Arthritis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 3	Sunset Room/Eldorado Court
Saturday, January 9
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	NF-kappaB and Cancer	Anasazi Ballroom

	Michael Karin, University of California, San Diego IKK Signaling in Cancer
	Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School Intricate Control of the p53 Tumor Suppressor Function in the Gut
	William C. Hahn, Harvard Medical School Non Canonical IKKs and Cancer
	Laura Pasqualucci, Columbia University Mutations of Multiple Signaling Proteins Deregulate NF-kappaB in Diffuse Large B-Cell Lymphoma
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM -	On Own for Lunch and Recreation
2:30 - 4:30 PM	Workshop 3: NF-kappaB in Disease Pathogenesis	Anasazi Ballroom
	* Yinon M. Ben-Neriah, Hebrew University, Hadassah Medical School
	Michael Lattke, Ulm University Astrocyte-Specific IKK2 Activation is Sufficient to Induce Neuroinflammation and Results in Impaired Brain Development
	Daniel Starczynowski, BC Cancer Research Centre miR-145 and miR-146a Mediate the Pathogenesis of 5q- Syndrome by Targeting TRAF6 Signaling
	Paul D. Robbins, University of Pittsburgh Role of IKK/NF-kappaB in Aging
	Geert van Loo, VIB-Ghent University Study of A20/tnfaip3 in Mouse Models of Inflammatory Disease
	Dietrich B. Conze, National Cancer Institute, National Institutes of Health Non-Canonical NF-kappB Activation and Abnormal B Cell Accumulation in Mice Expressing Ubiquitin Protein Ligase-Inactive c-IAP2
	Zhaohui Wu, University of Tennessee Health Science Center ATM-Dependent ELKS Ubiquitination Coordinates TAK1-Mediated IKK Activation upon Genotoxic Stress
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:15 PM	NF-kappaB Response to Genotoxic and Oxidative Stress	Anasazi Ballroom
	* Michelle A. Kelliher, University of Massachusetts Medical School
	Martin Krönke, Institute of Medical Microbiology, Immunology and Hygiene TNF Signaling and Regulation of ROS Production
	Richard M. Siegel, National Institutes of Health ROS and Abnormal TNFR1 Signaling in TRAPS
	Renée Johnson, University of Bristol Short Talk: An Interaction between RelA and Mortalin Regulates Mitochondrial Function and Cellular Respiration
	Claus Scheidereit, Max Delbrück Center for Molecular Medicine Short Talk: Mechanism of IKK Activation by Genotoxic Stress
	Shigeki Miyamoto, University of Wisconsin-Madison Short Talk Autoinhibitory Feedback and SUMO Protease Regulation of NFkappaB Signaling by DNA Damage
	Manolis Pasparakis, University of Cologne Concluding Remarks
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
8:00 - 11:00 PM	Entertainment	Eldorado Court/Sunset Room
Sunday, January 10
	Departure

*Session Chair †Speaker invited, not yet responded.