| Wednesday, April 7 |
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3:00 - 7:30 PM
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Registration
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Foyer
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6:30 - 7:30 PM
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Refreshments
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Foyer
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7:30 - 8:30 PM
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Keynote Address
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Peaks 4-5
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Brian K. Kobilka,
Stanford University
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Shaun R. Coughlin,
University of California, San Francisco
The Long Road from GPCR Cloning to a Drug: Lessons from Protease-Activated Receptor-1
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| Thursday, April 8 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Ligand Efficacy and Compartmentalized Signaling
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Peaks 4-5
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Peaks 1-3
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1:00 - 10:00 PM
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Poster Viewing
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Peaks 1-3
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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GPCR Structure and Activation I
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Peaks 4-5
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*
Heidi E. Hamm,
Vanderbilt University School of Medicine
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Martin J. Lohse,
Universität Würzburg
Real-Time Monitoring of GPCR Signaling in Living Cells
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Jonathan A. Javitch,
Columbia University
Pick Your Partner Carefully: Communication between Protomers of GPCR Dimers Modulates Activation
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Michael F. Brown,
University of Arizona
The Role of Lipids in GPCR Structure and Function
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Martin Cottet,
Institut de Génomique Fonctionnelle
Short Talk: Fluorescent Ligands and TR-FRET for the Labeling and Detection of GPCR Dimers in Native Tissues
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Foyer/Peaks 1-3
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7:30 - 10:00 PM
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Poster Session 1
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Peaks 1-3
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| Friday, April 9 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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GPCR Structure and Activation II
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Peaks 4-5
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*
Leonardo Pardo,
Universitad Autonoma Barcelona
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Oliver P. Ernst,
CharitéCenter, Universitätsmedizin Berlin
Inactive and Active Conformations of Rhodopsin: Insights from Spectroscopic and Structural Studies
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H. Eric Xu,
Van Andel Research Institute
Ligand Recognition by Family B GPCRs
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Gebhard F. X. Schertler,
Paul Scherrer Institut
Structure of a Constitutively Active Rhodopsin: Implications for Ligand Binding and Activation of GPCRs.
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Brian K. Kobilka,
Stanford University
Structural Insights into Ligand Efficacy
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Jesús Giraldo,
Universitat Autònoma de Barcelona
Short Talk: Mathematical Modeling of Symmetrically/ Asymmetrically Activated GPCR Dimers Provides New Clues on Receptor Signaling
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Irina Kufareva,
University of California, San Diego
Short Talk: Rational Design of Point Mutations Improving GPCR Stability and Conformational Homogeneity
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Peaks 1-3
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1:00 - 10:00 PM
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Poster Viewing
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Peaks 1-3
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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Structure-Based Drug Discovery as Applied to Soluble Proteins
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Peaks 4-5
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*
Brian K. Shoichet,
University of California, San Francisco
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Tom L. Blundell,
University of Cambridge
Structural Biology, Drug Discovery and Fragment-based Screening
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Philip J. Hajduk,
Abbott Laboratories
Fragment-Based Approaches to Soluble and Membrane Proteins
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Jonathan M. Moore,
Vertex Pharmaceuticals Incorporated
Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism
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Liquan Yang,
University of Rochester
Short Talk: GPR56 Inhibits VEGF Secretion and Suppresses Melanoma Angiogenesis
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Foyer/Peaks 1-3
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7:30 - 10:00 PM
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Poster Session 2
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Peaks 1-3
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| Saturday, April 10 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:30 AM
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G Proteins, Arrestins and Other Signaling Molecules Activated by GPCRs
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Peaks 4-5
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Jonathan A. Javitch,
Columbia University
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Heidi E. Hamm,
Vanderbilt University School of Medicine
New Insights into R*-G High Affinity Complex from Structural, Biophysical and Modeling Studies
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Vsevolod V. Gurevich,
Vanderbilt University
Structural Basis of Arrestin Function: Redesigning a Marvel of Evolutionary Engineering
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Gang Pei,
TongJi University
Arrestin Signaling and Diseases
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Jürgen Wess,
National Institutes of Health
Mapping the Receptor-G Protein Interface: Cross-Linking Analysis of a GPCR/G Protein Complex
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Kristoffer Sahlholm,
Karolinska Institutet
Short Talk: Agonist-Specific Voltage-Sensitivity at the Dopamine D2S Receptor; Effects of Binding Site Mutations
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George Essien Umanah,
University of Tennessee
Short Talk: Residue-to-Residue Contacts between G alpha and its GPCR in the Ligand Bound and Unbound State
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Xavier Deupi,
Universitat Autonoma de Barcelona. School of Medicine
Short Talk: Integration of GPCR Structure, Dynamics and Function
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:00 AM - 1:00 PM
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Poster Setup
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Peaks 1-3
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1:00 - 10:00 PM
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Poster Viewing
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Peaks 1-3
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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GPCR Structure and Activation III
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Peaks 4-5
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*
Gebhard F. X. Schertler,
Paul Scherrer Institut
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Steven O. Smith,
Stony Brook University
Structural Insights into the Mechanism of Light-Activation of the Visual Pigment Rhodopsin
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Carsten Hoffmann,
University of Würzburg
Receptor Activation Studied by Site Specific Fluorescence Labeling of GCPRs in Living Cells
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Nigel J.M. Birdsall,
National Institute for Medical Research
Single Molecule Imaging of GPCR Monomers and Dimers in Living Cells
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Michael J. Overduin,
University of Birmingham
Short Talk: Amphipathic Polymer-based Nanoparticles for Purifying and Characterizing Stable and Active GPCRs without Detergents
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Peaks 1-3
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7:30 - 10:00 PM
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Poster Session 3
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Peaks 1-3
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| Sunday, April 11 |
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7:00 - 8:00 AM
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Breakfast
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Summit Gallery
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8:00 - 11:15 AM
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Computational Approaches to GPCR Structure and Signaling
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Peaks 4-5
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*
Brian K. Kobilka,
Stanford University
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Leonardo Pardo,
Universitad Autonoma Barcelona
Deciphering Mechanisms of G Protein-Coupled Receptor Activation
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Thue W. Schwartz,
University of Copenhagen
From Ligands to Efficiancy in 7 TM Receptors
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Brian K. Shoichet,
University of California, San Francisco
Exploiting GPCR Structures for Ligand Discovery
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Robert D. Harvey,
University of Nevada, Reno
Compartmentation of cAMP Signaling in Cardiac Myocytes: A Computational Study
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Marta Filizola,
Mount Sinai School of Medicine
Short Talk: Exploring G Protein-Coupled Receptor Processes at the Molecular Level Using Enhanced Molecular Dynamics Methods
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Vsevolod Katritch,
University of California San Diego
Short Talk: Ligand-Guided Receptor Optimization for GPCR Drug Discovery
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9:20 - 9:40 AM
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Coffee Break
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Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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4:30 - 5:00 PM
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Coffee Available
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Foyer
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5:00 - 7:00 PM
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New Topics in GPCR Drug Development
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Peaks 4-5
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*
Thue W. Schwartz,
University of Copenhagen
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Annette G. Beck-Sickinger,
Leipzig University
Peptides as GPCR Drugs in Therapy and Diagnosis
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Thomas Klabunde,
Sanofi-Aventis Pharma Deutschland GmbH
Chemogenomics-Approaches to GPCR Lead Finding –Sequence-Derived 3D-Pharmacophore Models
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Lakshmi A. Devi,
Mount Sinai School of Medicine
G Protien Coupled Receptor Hetero Dimerization in Drug Discovery
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Wayne M. Stallaert,
Université de Montréal
Short Talk: Monitoring the Multiple Signaling Pathways of beta-Adrenergic Receptors Using a Label-Free Impedance-Based Detection Method
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Kenneth E. Carlson,
Anchor Therapeutics
Short Talk: Identification of a Pepducin Agonist of the CXCR4 Receptor
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Breckenridge Ballroom
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8:00 - 11:00 PM
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Entertainment
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Breckenridge Ballroom
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| Monday, April 12 |
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Departure
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