Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Role of Inflammation in Oncogenesis (J5)

Organizer(s): Nina Bhardwaj and Giorgio Trinchieri
February 7 - 12, 2010
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 7, 2009
Late Abstract Deadline: November 6, 2009
Scholarship Deadline: October 7, 2009
Early Registration Deadline: December 7, 2009

Sponsored by Celgene Corporation, Hoffmann-La Roche, Inc. and Pfizer Global Research & Development

Joint meeting: Molecular and Cellular Biology of Immune Escape in Cancer (J6)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Cancer is characterized by accelerated and uncontrolled growth, dysregulation of apoptosis, invasion and metastasis. While genetic and epigenetic mechanisms may underlie transformation, the tumor microenvironment promotes the neoplastic process. Chronic inflammation and infection, in particular, are linked to the development of cancer. Examples include the association between inflammatory bowel disease and colon cancer, Helicobacter pylori infection with gastric cancer and HPV with cervical cancer. Recent studies have linked the innate immune system, through production of inflammatory cytokines, with cancer progression. Factors such as TNF alpha, IL-6, and TGF beta, produced by macrophages and dendritic cells amongst other cells, enhance tumor growth, invasion, metastasis, and angiogenesis, while simultaneously impairing anti-tumor immune mechanisms. There have been several advances in our understanding of the influences of inflammation on tumorigenesis. However, critical elements of the involved inflammatory pathways that modulate tumor progression still remain to be identified. The complex interrelationship between inflammatory vs. immune suppressive cytokines and their effects on the neoplastic process remain to be defined. The association between DNA damage and inflammation and the link between pathogen associated molecular patterns (PAMPs) and novel pattern recognition molecules (TLRs and NOD like receptors) in driving tumor development require further characterization. How cancer associated inflammation might actively dysregulate the innate immune system, in particular of dendritic cell, NK and NKT cell anti-tumor function, is also an area of interest and intense speculation. This meeting will focus specifically on mechanisms of inflammation-induced carcinogenesis, and will bring together investigators with diverse interests and expertise - immunology, signal transduction, cancer biology and therapeutics. It is anticipated that the pairing with the concurrent Keystone Symposia meeting on Immune Escape in Cancer will attract a large body of scientists who share a common interest in cancer pathogenesis, inflammation and mechanisms underlying immune evasion. The goal of the meeting is to enhance discussion, foster collaborations, report on new paradigms, and ultimately to develop approaches that will modulate inflammation-associated tumor progression.

Sunday, February 7
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	Grays/Longs Peak
	* Nina Bhardwaj, New York University School of Medicine
	* Dmitry I. Gabrilovich, University of South Florida
	* George C. Prendergast, Lankenau Institute for Medical Research
	* Giorgio Trinchieri, National Cancer Institute at Frederick
	Robert D. Schreiber, Washington University School of Medicine Co-Evolution of Immunoediting on Oncogenesis during Tumor Formation
	Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School Inflammatory Cytokines and Autocrine Tumor-Promoting Networks
Monday, February 8
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:15 AM	Tumor Microenvironment and Immune Escape (Joint)	Grays/Longs Peak
	* Robert D. Schreiber, Washington University School of Medicine
	Lisa M. Coussens, University of California, San Francisco Role of Inflammation in Tumor Progression
	Claire E. Lewis, University of Sheffield Medical School Role of Macrophages in Tumor Progression and Response to Therapy
	Arya Biragyn, National Institute of Aging, National Institutes of Health Short Talk: Primary Breast Cancer Actively Generates Regulatory T and B Cells (Tregs and Bregs) to Facilitate Lung Metastasis
	Gerard I. Evan, University of California, San Francisco Immune Function and Angiogenesis in Myc-Mediated Tumor Formation
	Hans Schreiber, University of Chicago The Role of Tumor Stroma in Immune Escape of Cancer
	Esteban Celis, Moffitt Cancer Center Short Talk: Interferon-gamma Induced T Cell Epitope Purging: Another Mode of Tumor Immune Escape?
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Rockies Ballroom
1:00 - 10:00 PM	Poster Viewing	Rockies Ballroom
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Inflammation in the Tumor Microenvironment	Grays Peak
	* Frances R. Balkwill, Queen Mary University of London, Barts and The London Medical School


	Alberto Mantovani, Istituto Clinico Humanitas Tumor Microenvironment: Sculpting the Inflammatory Response during Tumor Formation
	Susan E. Erdman, Massachusetts Institute of Technology Unifying Roles for Regulatory T Cells and Inflammation in Cancer
	Michele W. Teng, Peter MacCallum Cancer Centre IL-23 Suppresses Innate Immune Response during Carcinogenesis and Metastasis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
7:30 - 10:00 PM	Poster Session 1	Rockies Ballroom
Tuesday, February 9
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:15 AM	Inflammation and Carcinogenesis	Grays Peak
	* Alberto Mantovani, Istituto Clinico Humanitas

	Eva M. Hernando, New York University Cancer Center miRNAs that Contribute to Melanoma Metastasis by Modulating Immune Evasion
	Yinling Hu, National Cancer Institute at Frederick Role of IKKalpha in Skin Cancer
	Pauline M. Andreu, University of California San Francisco Short Talk: FcRgamma Activation Regulates Inflammation-Associated Squamous Carcinogenesis
	Giorgio Trinchieri, National Cancer Institute at Frederick Innate Resistance and Cancerogenesis

	Carlos Bais, Genentech, Inc. Stromal Cells and VEGF-Independent Angiogenesis
	Brendan J. Jenkins, Monash Institute of Medical Research Short Talk: Deregulated Cytokine Signaling as a Crucial Bridge Linking Pathogen-Driven Gastric Inflammation and Tumorigenesis
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Rockies Ballroom
1:00 - 10:00 PM	Poster Viewing	Rockies Ballroom
2:30 - 4:30 PM	Workshop: Inflammation and Carcinogenesis This session will focus on the role of inflammatory cytokines, immunosuppressive factors and innate immune cells in modulating growth of cancer. The session will cover relevant signaling pathways, contribution of tumor invasive macrophages and dendritic cells and effects on the tumor micro-environment.	Grays Peak


	* Jacqueline Bromberg, Memorial Sloan Kettering Cancer Center
	* Carlos Bais, Genentech, Inc.
	David G. DeNardo, University of Califonia, San Francisco CD4+ T Lymphocytes Regulate Pulmonary Metastasis of Mammary Carcinomas by Enhancing the Pro-Tumor Properties of Macrophages
	Mercedes B. Fuertes, University of Chicago Host Type I IFN Signals Mediate Awareness of Tumor and Promote Spontaneous Adaptive Immune Responses Against Tumor-Associated Antigens
	Esther N. Arwert, Cambridge Research Institute (CR-UK) Tumor Formation Initiated by Nondividing Epidermal Cells via an Inflammatory Infiltrate
	Jack D. Bui, University of California, San Diego Evidence for Macrophage-Mediated Cancer Immunoediting
	Sharon A. Glynn, National Cancer Institute, National Institutes of Health Joint Expression of NOS2 and COX2 in ER-Negative Breast Cancer – Acquisition of a Poor Prognosis Phenotype

	Abby L. Geis, Johns Hopkins Medical Institute A Human Commensal Promotes Colorectal Cancer in Min Mice: Role of the Treg / Th17 Balance in the colitis-Induced Carcinogenesis
	Maria Grazia Ruocco, Skirball, New York University School of Medicine Stress-Induced Signals Facilitate T Cell Arrest and Lead to Tumor Eradication
	Li Yang, National Cancer Institute, National Institutes of Health Short Talk: TGFbeta, an Inflammation and Immune Suppressor in Tumor Progression
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Innate Resistance and Tumor Escape	Grays Peak
	* Nina Bhardwaj, New York University School of Medicine
	David H. Raulet, University of California, Berkeley NKG2D, NKG2D Ligands and Spontaneous Malignancy
	Laurence Zitvogel, Institut Gustave Roussy NKp30/NCR3 Isoforms and Prognosis of Human Malignancies: Revisiting the DC/NK Cross Talk
	Mark J. Smyth, Peter MacCallum Cancer Centre Suppression and Innate Immune Surveillance
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
7:30 - 10:00 PM	Poster Session 2	Rockies Ballroom
Wednesday, February 10
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:15 AM	Transcriptional Regulation of Immune Escape (Joint)	Grays/Longs Peak
	* George C. Prendergast, Lankenau Institute for Medical Research
	Hua E. Yu, Beckman Research Institute, City of Hope STAT3 in Cancer Inflammation and Immune Escape
	Erwin F. Wagner, Spanish National Cancer Research Centre Stress-responsive and context dependent transcription factor complex
	Mitsugu Fujita, University of Pittsburgh Cancer Institute A Pivotal Role of Type-1 Interferons in Anti-glioma Immunosurveillance
	Thomas F. Gajewski, University of Chicago Transcriptional regulation of T cell anergy: Implications for cancer immunotherapy
	Michael Karin, University of California, San Diego Tumor elicited inflammation and lymphocyte infiltrates in metastatic progression
	Jahan Khalili, MD Anderson Cancer Center Short Talk: The Role of B-raf V600E Mutation on PD-1 Ligand Expression in Melanocytic nevi
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Rockies Ballroom
1:00 - 10:00 PM	Poster Viewing	Rockies Ballroom
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Innate Receptors, Cancer and Inflammation	Grays Peak
	* Mark J. Smyth, Peter MacCallum Cancer Centre

	Xiaoxia Li, Cleveland Clinic Foundation SIGIRR-Mediated Tumor Suppression
	Felix Yarovinsky, University of Texas Southwestern Medical Center Short Talk: A Novel Transgenic Mouse Model for Chronic Inflammation: Linking Toll-like Receptor (TLR) Responses with Carcinogenesis

	Nina Linde, German Cancer Research Center (DKFZ) Inflammation in Epithelial Skin Tumors

	Irving Coy Allen, University of North Carolina at Chapel Hill Short Talk: NLRP3 is an Essential Regulator of Interleukin-1beta and Interleukin-18 during Inflammation Driven Colon Tumorigenesis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
7:30 - 10:00 PM	Poster Session 3	Rockies Ballroom
Thursday, February 11
7:00 - 8:00 AM	Breakfast	Rockies Ballroom
8:00 - 11:00 AM	Dendritic Cells and Macrophages in Cancer	Grays Peak
	* Laurence Zitvogel, Institut Gustave Roussy
	Nina Bhardwaj, New York University School of Medicine Modulating Inflammatory Dendritic Cell Responses against Cancer
	Shannon J. Turley, Dana-Farber Cancer Institute, Harvard Medical School Novel Aspects of Tolerance in the Tumor Microenvironment


	Miriam Merad, Mount Sinai Medical Center Identification of a DC lineage with unique functions in tissues immunity
	Ana Carrizosa Anderson, Harvard Medical School New Roles for TIM Family Members in Immune Regulation
	Emmanuelle Godefroy, New York University, School of Medicine Short Talk: MMP-2 Conditions Dendritic Cells to Prime Inflammatory TH2 Cells via an IL-12 and OX40L-Dependent Pathway
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Cytokines in the Tumor Microenvironment	Grays Peak
	* Giorgio Trinchieri, National Cancer Institute at Frederick
	Jacqueline Bromberg, Memorial Sloan Kettering Cancer Center The IL-6/Stat3 Signaling Pathway Promotes Mammary Tumorigenesis and Metastases
	Martin Oft, Merck Switching Tumor Promoting Inflammation into Tumor Immune Surveillance
	Charles Drake, Johns Hopkins University Th17 Cells in Tumors
	Jiyoung Park, University of Texas Southwestern Medical Center Short Talk: Peripheral Leptin Promotes Mammary Tumor Progression and Metastasis through Activation of the Jak2/STAT3 Pathway in vivo
	Alexander J. Muller, Lankenau Institute for Medical Research Short Talk: IDO Contributes to Pathologies Associated with Chronic Inflammation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rockies Ballroom
8:00 - 11:00 PM	Entertainment	Rockies Ballroom
Friday, February 12
	Departure

*Session Chair †Speaker invited, not yet responded.