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Stem Cell Differentiation and Dedifferentiation (B4)

Organizer(s): Shinya Yamanaka and Fiona M. Watt
February 15 - 20, 2010
Keystone Resort  ·  Keystone, Colorado
Abstract Deadline: October 15, 2009
Late Abstract Deadline: November 16, 2009
Scholarship Deadline: October 15, 2009
Early Registration Deadline: December 15, 2009


Sponsored by Genzyme Corporation, Pfizer Global Research & Development and Sangamo BioSciences, Inc.



This meeting took place in the 2010 season.

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Summary of Meeting
Recent progress in induced pluripotent stem (iPS) cells has shown that stem cells can be generated from differentiated progenies by introducing just a few defined factors. In addition, various stem cells have been isolated from human tissues. Stem cells from patients will provide various tools in understanding disease mechanisms, searching for effective drugs, and evaluating toxicity of drug candidates. Furthermore, human iPS cells and other stem cells may provide various types of cells for regenerative medicine. In this meeting, we will discuss how stem cells, including iPS cells, are isolated, generated and maintained. We will also provide an update on induction of differentiated cells from stem cells. We then will discuss progress in application of pluripotent stem cells and other stem cells in basic research, drug discovery, toxicology, and regenerative medicine.

Monday, February 15
3:00 - 7:30 PM Registration Longs Peak Foyer
6:30 - 7:30 PM Refreshments Longs Peak Foyer
7:30 - 8:30 PM Keynote Address Grays/Longs Peak
* Fiona M. Watt, CRUK Cambridge Research Institute
* Shinya Yamanaka, Kyoto University/Gladstone Institute
James A. Thomson, Morgridge Institute for Research, University of Wisconsin
Human ES Cells and iPS Cells
Tuesday, February 16
7:00 - 8:00 AM Breakfast Shavano/Torreys
8:00 - 11:15 AM iPS Cells Grays/Longs Peak
* Fiona M. Watt, CRUK Cambridge Research Institute
Shinya Yamanaka, Kyoto University/Gladstone Institute
Induction of Pluripotency by Defined Factors
Rudolf Jaenisch, Whitehead Institute for Biomedical Research
Molecular Mechanisms of Pluripotency and Reprogramming
Juan Carlos Izpisúa-Belmonte, The Salk Institute
Linking the p53 Tumor Suppressor Pathway to Somatic Cell Reprogramming
Helen M. Blau, Stanford University
Reprogramming Towards Pluripotency Requires AID-Dependent DNA Demethylation
Jing Liao, Shanghai Institute of Biochemistry and Cell Biology
Short Talk: Generation of Induced Pluripotent Stem Cell Lines from Rat Adult Cells
Christoph Bock, Harvard University
Short Talk: The Epigenome of Pluripotent Cells: Variations of a Common Theme
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:15 AM - On Own for Lunch and Recreation
11:15 AM - 1:00 PM Poster Setup Shavano/Torreys
1:00 - 10:00 PM Poster Viewing Shavano/Torreys
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:15 PM Pluripotency Grays/Longs Peak
* Shinya Yamanaka, Kyoto University/Gladstone Institute
Austin G. Smith, University of Cambridge
Intrinsic and Extrinsic Regulation of the Pluripotent Ground State
Ihor R. Lemischka, Mount Sinai School of Medicine
Genome-Wide Analyses of Molecular Mechanisms Underlying Pluripotency
Amanda G. Fisher, Imperial College London
Stem Cells and Epigenetic Reprogramming
Lay Teng Ang, University of Cambridge/Genome Institute of Singapore
Short Talk: MicroRNA Function in Regulating Pluripotency and Differentiation of Human Embryonic Stem Cells
Li-Fang Chu, Baylor College of Medicine
Short Talk: Primordial Germ Cells as the Immediate Precursors of Embryonic Stem Cells
7:15 - 8:15 PM Social Hour w/ Lite Bites Shavano/Torreys
7:30 - 10:00 PM Poster Session 1 Shavano/Torreys
Wednesday, February 17
7:00 - 8:00 AM Breakfast Shavano/Torreys
8:00 - 11:30 AM Reprogramming Grays/Longs Peak
* Austin G. Smith, University of Cambridge
M. Azim Surani, University of Cambridge
Resetting the Epigenome during Germ Cell Specification and by LIF-STAT3 Signaling
Hans R. Schöler, Max Planck Institute for Molecular Biomedicine
Induction of Pluripotency in Adult Somatic and Germline Stem Cells
Kevin C. Eggan, Harvard University
Identification and Characterization of Small Reprogramming Molecules
Chad A. Cowan, Harvard University
Programming and Reprogramming: New Approaches for Understanding Disease
Azadeh Golipour, Samuel Lunenfeld Research Institute
Short Talk: A Systematic Approach to Identify Novel Regulators of Somatic Cell Reprogramming
Collin A. Melton, University of California, San Francisco
Short Talk: Opposing microRNA Families Regulate Self-Renewal in Mouse Embryonic Stem Cells
Larry Stanton, Genome Institute of Singapore
Short Talk: Converting Sox17 into a Pluripotency Reprogramming Factor
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:30 AM - On Own for Lunch and Recreation
11:30 AM - 1:00 PM Poster Setup Shavano/Torreys
1:00 - 10:00 PM Poster Viewing Shavano/Torreys
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Other Pluripotent Stem Cells Grays/Longs Peak
* Hans R. Schöler, Max Planck Institute for Molecular Biomedicine
Takashi Shinohara, Kyoto University
Positive and Negative Regulators of Mouse Germline Stem (GS) Cell Proliferation
Anthony Atala, Wake Forest University
Amniotic Fluid and Placental-Derived Stem Cells
Thomas P. Zwaka, Baylor College of Medicine
Short Talk:
Shin-Ichi Nishikawa, RIKEN Center for Developmental Biology
The Pathway of Hematopoietic Stem Cell Development Explained
7:00 - 8:00 PM Social Hour w/ Lite Bites Shavano/Torreys
7:30 - 10:00 PM Poster Session 2 Shavano/Torreys
Thursday, February 18
7:00 - 8:00 AM Breakfast Shavano/Torreys
8:00 - 11:15 AM Somatic Stem Cells Grays/Longs Peak
* Hideyuki Okano, Keio University School of Medicine
Fiona M. Watt, CRUK Cambridge Research Institute
Defining the Epidermal Stem Cell Niche
Toshio Suda, Keio University
Hematopoietic Stem Cells and their Niches
Amy J. Wagers, Harvard University
Regenerative Potential of Skeletal Muscle Stem Cells
Fred H. Gage, The Salk Institute for Biological Studies
Neural Stem Cells and their Fates
Valerie Horsley, Yale University
Short Talk: Extrinsic Regulation of Skin Stem Cells
Tae-Hee Kim, Dana-Farber Cancer Institute, Harvard Medical School
Short Talk: A Role for Notch Signaling in Stomach Epithelial Stem Cell Homeostasis
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:15 AM - On Own for Lunch and Recreation
11:15 AM - 1:00 PM Poster Setup Shavano/Torreys
1:00 - 10:00 PM Poster Viewing Shavano/Torreys
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:30 PM Differentiation of Stem Cells I Grays/Longs Peak
* Toshio Suda, Keio University
Deepak Srivastava, Gladstone Institute of Cardiovascular Disease
microRNA Regulation of Cardiac Stem Cell Fate
Hideyuki Okano, Keio University School of Medicine
Regeneration of the Damaged CNS with iPS Cells
Hans Keirstead, University of California, Irvine
Clinically-Compliant Differentiation of hESCs for the Treatment of Spinal Cord Injury and Disease
Catherin Niemann, University of Cologne
Short Talk: Important Role of Hair Follicle Stem Cells for Generation and Differentiation of Sebaceous Gland Cells during Skin Homeostasis
7:30 - 8:30 PM Social Hour w/ Lite Bites Shavano/Torreys
7:30 - 10:00 PM Poster Session 3 Shavano/Torreys
Friday, February 19
7:00 - 8:00 AM Breakfast Shavano/Torreys
8:00 - 11:00 AM Differentiation of Stem Cells II Grays/Longs Peak
* Deepak Srivastava, Gladstone Institute of Cardiovascular Disease
E. Edward Baetge, Novocell, Inc.
Functional Pancreatic Islet Cells from Embryonic Stem Cells
Ronald D. McKay, National Institutes of Health
Neural Differentiation of Stem Cells
Rita R. Perlingeiro, University of Minnesota
From ES Cells to Skeletal Muscle Precursors
Nobuko Uchida, StemCells Inc.
Therapeutic Potential of Human Central Nervous System-Stem Cell: Neuroprotection Strategies
Micha Drukker, Stanford University School of Medicine
Short Talk: Prospective Isolation of Four of the Earliest Precursors to Emerge from Human Embryonic Stem Cells
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM - On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available Longs Peak Foyer
5:00 - 7:00 PM Application of Stem Cells Grays/Longs Peak
* Ronald D. McKay, National Institutes of Health
Amy Sinor, Harvard Stem Cell Institute
ES Cell-Derived Cells for Disease Mechanism and Drug Discovery
Zhong Zhong, GlaxoSmithKline R&D China
Drug Discovery Targeting Neural Stem Cells
Gabriela Gebrin Cezar, University of Wisconsin
Metabolomics of Human Embryonic Stem Cells: Unraveling Biochemical Pathways of Neurodevelopmental Disorders
Karl-Dimiter Bissig, The Salk Institute
Short Talk: Cell Based Therapy for Liver Disease
7:00 - 8:00 PM Social Hour w/ Lite Bites Shavano/Torreys
8:00 - 11:00 PM Entertainment Shavano/Torreys
Saturday, February 20
Departure
*Session Chair   †Speaker invited, not yet responded.



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