Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Triglycerides and Triglyceride-Rich Particles in Health and Disease (A3)

Organizer(s): Robert H. Eckel, Ira J. Goldberg and Ruth McPherson
January 9 - 14, 2010
Big Sky Resort · Big Sky, Montana
Abstract Deadline: September 15, 2009
Late Abstract Deadline: October 12, 2009
Scholarship Deadline: September 15, 2009
Early Registration Deadline: November 9, 2009

Supported by The Directors' Fund

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Triglycerides are important storage molecules that play important roles in lipid and lipoprotein metabolism, insulin action, energy balance, and atherosclerosis. The purpose of this meeting will be to critically examine the broad spectrum of triglyceride biology from the molecular biology of triglyceride biosynthesis in the liver and intestine to lipoprotein assembly and secretion to lipid fuel partitioning to adipose tissue, muscle and the liver. A discussion of the regulation of free fatty acid flux from adipose tissue to the liver by insulin and pro- and anti-inflammatory cytokines will precede a detailed coverage of chylomicron and VLDL transport, intravascular lipolysis and tissue-specific lipid partitioning. A transition to the science and medicine of triglycerides will then occur with expected updates on the understanding of the genetic basis of disorders of triglyceride-rich lipoprotein metabolism and the pathogenesis of atherosclerosis that relate specifically to circulating triglyceride-rich particles. The clinical relevance of hypertriglyceridemia, new insights into the mechanisms of pharmacological treatment of hypertriglyceridemia, and clinical trial evidence pro and con that triglyceride lowering reduces cardiovascular disease risk will follow. The meeting should attract basic, clinical, and population scientists from academia and industry, and will deal with the many issues that remain unclear or controversial surrounding triglycerides and triglyceride rich particles in health and disease.

Saturday, January 9
3:00 - 7:30 PM	Registration	Lower Atrium
6:30 - 7:30 PM	Refreshments	Lower Atrium
7:30 - 8:30 PM	Keynote Address	Gallatin
	Henry N. Ginsberg, Columbia University College of Physicians and Surgeons Increased Assembly and Secretion of Triglyceride-Rich Lipoproteins in Insulin Resistance: Greasing the Path to Atherosclerosis
Sunday, January 10
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 8:15 AM	Welcome and Scientific Introduction	Gallatin
	Robert H. Eckel, University of Colorado Denver, Anschutz Medical Campus Triglycerides in Health and Disease
8:15 - 11:30 AM	Molecular/Cell Biology and Physiology of Triglyceride Synthesis and TG-Rich Lipoprotein Assembly and Secretion	Gallatin
	* Mats Rudling, Karolinska Institutet

	* Douglas G. Mashek, University of Minnesota
	Rosalind A. Coleman, University of North Carolina at Chapel Hill Metabolic Channeling and Control of Fatty Acid Metabolism

	Bart Staels, Institut Pasteur de Lille, University of Lille 2 Nuclear Receptor Control of Triglyceride Metabolism
	Edward A. Fisher, New York University School of Medicine Omega-3 Fatty Acids and Lipoprotein Metabolism: Mechanistic Basis for their Clinical Effects
	Mark D. Erion, Merck & Co., Inc. Reduction in Plasma and Liver Triglycerides with a Liver-Targeted Thyroid Hormone Receptor-beta Agonist
	John M. Stafford, Vanderbilt University Short Talk: Impaired Inactivation of FoxO1 Contributes to Glucose-Mediated Increases in Serum VLDL
	J. Brandon Dixon, Georgia Institute of Technology Short Talk: Quantifying the Functional Transport of Lipoproteins by Lymphatic Endothelial Cells
11:30 AM -	On Own for Lunch and Recreation
9:20 - 9:40 AM	Coffee Break	Lower Atrium
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Regulation of Lipolysis in Man and Rodents	Gallatin
	* Miklos Péterfy, Cedars-Sinai Medical Center
	* Richard Lehner, University of Alberta
	Rudolf Zechner, University of Graz Intracellular Lipolysis and the Regulation of Lipid and Lipoprotein Metabolism
	Susan K. Fried, Boston Medical Center Adipokines and Lipolysis in Human Obesity
	Samuel Klein, Washington University School of Medicine Therapeutic Implications of Adipose Tissue and Hepatic Lipid Metabolism in Obesity
	Janna A. van Diepen, Leiden University Medical Center Short Talk: Hepatocyte-Specific Inflammation Enhances VLDL Production in Mice
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
Monday, January 11
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:15 AM	Chylomicron and VLDL Transport, Lipolysis and Tissue-Specific Lipid Partitioning	Gallatin
	* Andre Bensadoun, Cornell University

	* Rudolf Zechner, University of Graz
	Ira J. Goldberg, Columbia University LPL Mediated Lipid Uptake
	Nada A. Abumrad, Washington University Free Fatty Acid Uptake and Intracellular Trafficking: Evolving Concepts
	Keith N. Frayn, University of Oxford Triglyceride Uptake into Human Adipose Tissue
	Stephen G. Young, University of California, Los Angeles An Endothelial Cell Protein Required for the Lipolytic Processing of Triglyceride-Rich Lipoproteins
	Jason A. Magida, University of Colorado, Boulder Short Talk: Genetic Heart Disease Results in a Diabetic Phenotype via Reduced Clearance of VLDL-Triglycerides
	Douglas G. Mashek, University of Minnesota Short Talk: Hepatic Adipose Triglyceride Lipase (ATGL) Alters Hepatic Triglyceride Turnover, Fatty Acid Channeling and PPAR-alpha Activity
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:15 AM - 1:00 PM	Poster Setup	Jefferson/Madison
1:00 - 10:00 PM	Poster Viewing	Jefferson/Madison
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Genetics and Pathophysiology of Disorders of TG-Rich Lipoprotein Metabolism	Gallatin
	* John D. Brunzell, University of Washington
	* Leanne Hodson, University of Oxford

	Ruth McPherson, University of Ottawa Heart Institute Triglycerides and CAD Risk: Insights from Genome-Wide Association Studies
	Alan R. Shuldiner, University of Maryland School of Medicine Genome-Wide Studies of Serum Lipids: Lessons from the Old Order Amish
	Gary F. Lewis, Toronto General Hospital ApoB Production - Human Gut and Liver
	Michael Olivier, Medical College of Wisconsin Short Talk: Genomic and Proteomic Analysis of Human Dyslipidemia Characteristic of the Metabolic Syndrome
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
7:30 - 10:00 PM	Poster Session 1	Jefferson/Madison
Tuesday, January 12
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:15 AM	TG-Rich Lipoproteins and Mechanisms of Atherosclerosis	Gallatin
	* Bo Angelin, Karolinska Institutet
	* Lars B. Nielsen, Rigshospitalet, University of Copenhagen
	Frank M. Sacks, Harvard School of Public Health Apolipoprotein C-III: Diverse Actions Contributing to Dyslipidemia and Atherosclerosis
	Sudha B. Biddinger, Harvard University Deconvoluting the Metabolic Syndrome: The Role of Hepatic Insulin Resistance
	John C. Rutledge, University of California, Davis Triglyceride-Rich Lipoproteins and Mechanisms of Inflammation and Atherosclerosis
	Clay F. Semenkovich, Washington University School of Medicine Lipids and Stress Responses in the Evolution of Atherosclerosis
	Dagmar Kratky, Medical University of Graz Short Talk: Adipose Triglyceride Lipase Deficiency Affects Macrophage Morphology and Function and Significantly Reduces Atherosclerosis in LDLR(-/-) Mice
	Nora Gray, University of California, Berkeley Short Talk: The Role of Angiopoietin-like 4 in Glucocorticoid-Regulated Lipid Metabolism
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:15 AM - 1:00 PM	Poster Setup	Jefferson/Madison
11:15 AM -	On Own for Lunch and Recreation
1:00 - 10:00 PM	Poster Viewing	Jefferson/Madison
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Population Science on the Relationship between TG-Rich Lipoproteins and ASCVD	Gallatin
	* Geesje M. Dallinga-Thie, AMC
	* Ruth McPherson, University of Ottawa Heart Institute

	Michael H. Criqui, University of California, San Diego Population Studies of TG and ASCVD
	Børge Nordestgaard, University of Copenhagen Non-Fasting TGs and CVD Risk
	Elizabeth J. Parks, University of Texas Southwestern Medical Center Dietary Influences on Triglyceride-Rich Lipoprotein Production
	Carlos O. Mendivil, Harvard School of Public Health Short Talk: Tryglicerides in VLDL and LDL with apoC-III are a Strong Coronary Heart Disease Risk Factor when LDL Cholesterol is Low
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
7:30 - 10:00 PM	Poster Session 2	Jefferson/Madison
Wednesday, January 13
7:00 - 8:00 AM	Breakfast	Jefferson/Madison
8:00 - 11:15 AM	Therapeutics of Hypertriglyceridemia	Gallatin

	* Mark W. Sleeman, Regeneron Pharmaceuticals Inc.

	* Walter Singleton, Isis Pharmaceuticals

	Rosanne M. Crooke, Isis Pharmaceuticals Development of Novel Antisense Inhibitors for the Treatment of Hypertriglyceridemia
	Dong Cheng, Bristol-Myers Squibb Company Are DGAT Inhibitors a Target for Triglyceride Lowering?

	Matthew T. Flowers, University of Wisconsin, Madison Tissue-Specific Roles for SCD1 in Regulating Obesity

	David Robert Neff, Merck The Potential Role of CETP Inhibition to Manage Dyslipidemia and CVD Risk
	Mark Graham, Isis Pharmaceuticals Short Talk: Antisense Inhibition of Angiopoietin-Like 3 in Rodent Models
	Jennifer L. Lachey, Acceleron Pharma Short Talk: Treatment with a Soluble Activin Receptor Type IIB Attenuates Diet-Induced Obesity in High-Fat Diet-Fed Mice
9:20 - 9:40 AM	Coffee Break	Lower Atrium
11:15 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Lower Atrium
5:00 - 7:00 PM	Clinical Trials of Triglyceride Lowering and Outcomes	Gallatin
	* Henry N. Ginsberg, Columbia University College of Physicians and Surgeons
	* Robert H. Eckel, University of Colorado Denver, Anschutz Medical Campus

	Marshall B. Elam, Veterans Affairs Medical Center Memphis, University of Tennessee Fibrates and Cardiovascular Risk Reduction
	Alan Chait, University of Washington School of Medicine Modalities of Triglyceride Lowering in the Prevention and Treatment of Cardiovascular Disease – Role of Niacin
	M. Mahmood Hussain, SUNY Downstate Medical Center Regulation and Targeting of Microsomal Triglyceride Transfer Protein (MTP)
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Jefferson/Madison
8:00 - 11:00 PM	Entertainment	Jefferson/Madison
Thursday, January 14
	Departure

*Session Chair †Speaker invited, not yet responded.