Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Cardiovascular Development and Repair (X2)

Organizer(s): Doris A. Taylor and Brian H. Annex
February 28 - March 5, 2010
Keystone Resort · Keystone, Colorado
Abstract Deadline: October 28, 2009
Late Abstract Deadline: November 30, 2009
Scholarship Deadline: October 28, 2009
Early Registration Deadline: December 28, 2009

Sponsored by Gilead Sciences, Inc.

Joint meeting: Angiogenesis in Health and Disease (X1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
During fetal development, cardiocytes and vascular progenitors proliferate, coalesce and organize to form a nascent organ. Yet during adult mammalian life, these same cells are incapable of responding to repair injured heart. This Keystone Symposia meeting is designed: 1) to expose scientists in the field of cardiac and vascular repair to models of successful cardiac repair in lower vertebrates, 2) to discuss repair in the context of cardiac development and 3) to begin to ask what cues and targets from each may be applicable in the adult mammal. As a companion to and overlapping with an Angiogenesis meeting, it will provide meeting-goers access to both preclinical and clinical components of cardiac and vascular repair using cells, genes and small molecules.

Sunday, February 28
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	Grays/Longs Peaks
	* Michael Simons, Yale University
	* Doris A. Taylor, University of Minnesota
	Eric N. Olson, University of Texas Southwestern Medical Center at Dallas MicroRNA Control of Cardiovascular Development and Disease
Monday, March 1
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:15 AM	Cardiac Development as a Model for Repair	Longs Peak
	* Doris A. Taylor, University of Minnesota
	Richard P. Harvey, University of New South Wales, Victor Chang Cardiac Research Institute The Pericyte Continuum in Heart Development and Repair
	Paul R. Riley, University College London Epicardium-Induced Coronary Development and Repair
	Nadia A. Rosenthal, European Molecular Biology Laboratory Epicardium: The Outer Limits of Stem Cells
	Gordon M. Keller, University Health Network, MaRS Centre Cardiovascular Development from Human Pluripotent Stem Cells


	Santanu Chakraborty, Cincinnati Children's Research Foundation Short Talk: Twist1 Overexpression Promotes Heart Valve Cell Proliferation and Alters Extracellular Matrix Remodeling whereas Tbx20 Overexpression Causes Abnormal Heart Valve Primordia Formation in vivo in Mice
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Models of Successful Cardiac Repair	Longs Peak
	* Nadia A. Rosenthal, European Molecular Biology Laboratory

	Eduardo Marbán, Cedars-Sinai Medical Center Cardiac Cell Therapy: From Concept to Clinical Reality
	Kenneth Poss, Duke University Medical Center Heart Regeneration in Zebrafish
	Walter J. Koch, Jefferson Medical College Using Gene Therapy to Repair the Failing Heart

	Maria Paola Santini, Heart Science Centre, NHLI, Imperial College London Short Talk: Cells and Factors for Cardiac Regeneration: mIGF-1-Mediated Cross-Talk between the Heart and the Bone Marrow
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 1	Quandary Peak
Tuesday, March 2
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Aging Cardiocytes and Matrix - Molecular Targets for Repair	Longs Peak
	* Eduardo Marbán, Cedars-Sinai Medical Center
	Jeffery D. Molkentin, Cincinnati Children's Hospital Medical Center TRPC Channels Underlie Muscle Degeneration and Hypertrophy in Response to Alterations in the ECM - Sarcolemma
	Jeffrey N. Keller, Pennington Biomedical Research Center Aging and Diet Effects on Proteasome and Oxidative Stress in the Heart
	R. John Solaro, University of Illinois at Chicago Quantitative Comparison of Sarcomeric Phosphoproteomes of Neonatal and Adult Rat Hearts
	Kyoko Imanaka-Yoshida, Mie University, Graduate School of Medicine Tenascin-C as a Target for Regulation of Cardiac Remodeling
	Arti Anushka Ramkisoensing, Leiden University Medical Center Short Talk: Embryonic and Fetal Mesenchymal Stem Cells do Undergo Cardiac Differentiation in Contrast to their Adult Counterparts: The Younger the Better

9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch and Recreation
11:00 AM - 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
2:30 - 4:30 PM	Workshop: Conversations on Deriving and Differentiating Stem Cells for Cardiac Repair	Longs Peak
	* Doris A. Taylor, University of Minnesota
2:30 - 3:30 PM	Deriving Stem Cells	Longs Peak
	Stefan Braam, Leiden University Medical Center Isolation and Characterization of Multipotent Human NKX2-5 Cardiovascular Progenitors
	Xuejun Huang Parsons, University of California, Riverside Deriving Cardiac Elements from Pluripotent Human Embryonic Stem Cells for Heart Reconstitution
	Alexander Ruvantha Pinto, EMBL Tissue Resident CX3CR1-Positive Macrophages and Dendritic Cells in the Injured and Uninjured Heart
	Linda W. van Laake, University Medical Center Utrecht Reporter-Based Isolation of Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Limited Gene Expression Variance
3:30 - 4:30 PM	Differentiating Stem/Progenitor Cells	Longs Peak
	Miriam Brodt-Ivenshitz, Weizmann Institute of Science BMP-Mediated Inhibition of FGF Signaling Lies at the Heart of Differentiation
	Maria Grazia Perino, National Institutes of Health Ascorbic Acid Promotes Cardiomyogenesis in Mouse Embryonic Stem Cells via Modulation of SMADs

	Antoine J.P. Bondue, Université Libre de Bruxelles Deciphering the Cellular and Transcriptional Hierarchy Acting during the Earliest Step of Multipotent Cardiovascular Progenitor Specification

4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Cardiac Stem Cell Sources and Niches	Longs Peak
	* Calum A. MacRae, Brigham & Women's Hospital
	Edward E. Morrisey, University of Pennsylvania Regulation of Cardiac Progenitor Expansion and Differentiation by Wnt Signaling


	Claudia Zierold, University of Minnesota LV-Derived Stem Cells: Is it a Feasible Goal from Humans?


	Adriana Gittenberger-de Groot, Leiden University Medical Center Short Talk: From Cardiogenesis to Cardiac Regeneration. Focus on Epicardium Derived Cells
	Elaine L. Shelton, Vanderbilt University Short Talk: The Omentum: A Source of Vascular Smooth Muscle Cells for Development and Repair
7:15 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 2	Quandary Peak
Wednesday, March 3
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Cardiovascular Genetics (Joint)	Grays/Longs Peaks
	* William C. Sessa, Yale University School of Medicine
	* Brian H. Annex, University of Virginia
	Elizabeth M. McNally, University of Chicago Dissecting Modifier Genes for Heart and Muscle Disease
	Arya Mani, Yale University The Genetic Link between Coronary Artery Disease and Metabolic Risk Factors
	Calum A. MacRae, Brigham & Women's Hospital Genetic Basis of Atrial Fibrillation

	Jonathan G. Seidman, Harvard Medical School Genetic Mechanisms of Hypertrophic Cardiomyopathy


	Christian Kupatt, University of Munich Short Talk: Pathophysiological Consequences of Chronic Endothelial Angiopoietin-2 Overexpression
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch and Recreation
11:00 AM - 1:00 PM	Poster Setup	Quandary Peak
1:00 - 10:00 PM	Poster Viewing	Quandary Peak
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Lessons from Cardiac Hypertrophy and Autophagy	Longs Peak
	* Jonathan G. Seidman, Harvard Medical School

	Leslie A. Leinwand, University of Colorado Sex Differences in Cardiac Hypertrophy: Are they Relevant for Repair?
	Joseph A. Hill, University of Texas Southwestern Medical Center Autophagy in Cardiac Plasticity and Disease
	Francis G. Spinale, Medical University of South Carolina Regulation and Control of the Matrix in Hypertrophy/Failure: Relevance to Cell and Regenerative Repair

	Yulia Anatolevna Chudinovskikh†, Russian Cardiovascular Scientific Center Short Talk: New Aspects of the Morphological Features and Pathogenesis of Hypertrophic Cardiomyopathy
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
7:30 - 10:00 PM	Poster Session 3	Quandary Peak
Thursday, March 4
7:00 - 8:00 AM	Breakfast	Quandary Peak
8:00 - 11:00 AM	Mechanisms in Cardiac Repair	Longs Peak
	* Brian H. Annex, University of Virginia
	Michael J. Galko, University of Texas M.D. Anderson Cancer Center The Drosophila Open Circulatory System as a Source of Cells and Signals for Tissue Repair
	Nikolaos G. Frangogiannis, Baylor College of Medicine The Role of the Inflammatory Response in Cardiac Repair
	* Howard A. Rockman, Duke University Medical Center Genetics versus Genes

	Roger J. Hajjar, Mount Sinai School of Medicine Short Talk: Myocardial Delivery of AAV1.SERCA2a in Patients with Advanced Heart Failure: A Phase I/II Clinical Trial
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	The Future of Cardiac Repair	Longs Peak
	* Roger J. Hajjar, Mount Sinai School of Medicine
	Brian H. Annex, University of Virginia Systems Biology Consideration in Angiogenesis and Cell Therapy: Bench to Bedside


	Doris A. Taylor, University of Minnesota Re-Endothelialization of Decellularized Heart Reduces Vascular Thrombogenicity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Quandary Peak
8:00 - 11:00 PM	Entertainment	Quandary Peak
Friday, March 5
	Departure

*Session Chair †Speaker invited, not yet responded.