Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Metabolism and Cancer Progression (X4)

Organizer(s): Eileen P. White, Craig B. Thompson and Chi Van Dang
March 12 - 17, 2010
Fairmont Hotel Vancouver · Vancouver, British Columbia
Abstract Deadline: November 12, 2009
Late Abstract Deadline: December 10, 2009
Scholarship Deadline: November 12, 2009
Early Registration Deadline: January 12, 2010

Sponsored by Celgene Corporation

Joint meeting: Cell Death Pathways: Apoptosis, Autophagy and Necrosis (X3)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Otto Warburg initially drew attention to the distinct metabolic state of tumors compared to normal tissues over 75 years ago, where tumor cells commonly favor glycolysis over oxidative phosphorylation even in the presence of oxygen (Warburg effect or aerobic glycolysis). Insight into the role and mechanism of this metabolic switch in tumorigenesis, and the utility of and means to therapeutically exploit altered metabolism in cancer was not clear, other than for utilization for FDG-PET imaging. Recently the metabolic requirements of tumor cells and the links to common pathway alterations in human cancers have been gradually emerging. It is now apparent that metabolic demand in tumor cells is high due to deregulation of cell growth, and that this constitutive activation of growth signaling pathways can disconnect cellular metabolism from nutrient and growth factor availability. Subversion of cellular metabolism for biosynthetic purposes is required to sustain deregulated tumor cell growth but can also restrict energy production that can limit tumor cell adaptation to metabolic stress. Hypoxic and acidic conditions in the tumor microenvironment are byproducts of these events and are common features of the tumor microenvironment that can activate stress responses, influence tumor growth, and impair treatment. Many of the oncogenic pathways altered in tumor cells modulate cell metabolism while enabling growth in these adverse conditions. Adaptation of tumor cells to stress through activation of the catabolic pathway of autophagy and its role in damage mitigation and promoting tumor cell survival to metabolic stress is also now emerging. The vision for this meeting is to bring together leaders in the fields of cancer, signaling and metabolism to discuss emerging discoveries and their application to improving cancer therapy.

Friday, March 12
3:00 - 7:30 PM	Registration	BC Foyer
6:30 - 7:30 PM	Refreshments	BC Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	British/Columbia Ballroom
	* Eileen P. White, Rutgers University
	Joan S. Brugge, Harvard Medical School Diversity of Cell Death Pathways in Organogenesis and Oncogenesis
	Lewis C. Cantley, Harvard Medical School PI 3-Kinase and Cancer Cell Metabolism
Saturday, March 13
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Metabolism Regulation in Model Organisms	Columbia Ballroom
	* Joan S. Brugge, Harvard Medical School
	Steven L. McKnight, University of Texas Southwestern Medical Center Lessons from Metabolic Regulation in Yeast

	Nika N. Danial, Dana Farber Cancer Institute Energy Metabolism in Genetically Defined Subtypes of Diffuse Large B Cell Lymphoma
	Yue Xiong, University of North Carolina at Chapel Hill Acetylation Regulation of Metabolism

	Chi Van Dang, Johns Hopkins University School of Medicine Regulation of Cancer Metabolism by Myc
	Jing Chen, Winship Cancer Institute, Emory University Short Talk: Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
	William C. Comb, University of North Carolina, Chapel Hill Short Talk: IKK-Dependent Phosphorylation and Feedback Inhibition of PI3K Promotes Nutrient Deprivation-Induced Autophagy
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
2:30 - 4:30 PM	Workshop 1: PI3 Kinase Regulation and Cancer	Columbia Ballroom
	* Lewis C. Cantley, Harvard Medical School
	Brian Grabiner, Whitehead Institute Identification and Clinical Assessment of Genes that Regulate the Response of Cancers to Rapamycin through Pooled RNAi Screens
	Ralph J. DeBerardinis, University of Texas-Southwestern Medical Center Alternative Metabolic Strategies for Growth in Glioblastoma: Glucose vs. Glutamine for Support of Cell Proliferation and Tumorigenesis
	Barry Bochner, Biolog, Inc. Metabolic Analysis of Isogenic Cells with Altered Cancer-Related Genes
	Jonathan L. Coloff, Duke University A Metabolic Checkpoint Controls Puma Transcription and Protein Stability For Survival of Activated and Leukemic T Cells
	Kurt Fisher, Transplant Center at the Nebraska Medical Center The Molecular Scaffold, Kinase Suppressor of Ras 1 (KSR1), Potentiates H-RasV12 Induced Transformation and Expands Cellular Capacity for Glycolysis and Oxidative Phosphorylation
	Ching-yi Chang, Duke University Medical Center The Metabolic Regulator ERRalpha, a Downstream Target of HER2/IGF1, as a Therapeutic Target in Breast Cancer
	Christina H. Eng, Pfizer Ammonia Derived from Glutaminolysis is a Diffusible Regulator of Autophagy
	James M. Phang, NCI at Frederick, CCR, NIH MiR-23b Regulates Proline Oxidase, a Mitochondrial Metabolic Tumor Suppressor, in Renal Cancer*
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Metabolic Differences between Normal and Cancer Cells	Columbia Ballroom
	* David M. Sabatini, Whitehead Institute for Biomedical Research
	Eyal Gottlieb, Beatson Institute for Cancer Research The Roles of Prolyl Hydroxylases in Metabolism and Cancer
	Valeria Fantin, Agios Pharmaceuticals Inc Metabolic Signaling in Cancer
	Sybille Mazurek, Universität Gießen, ScheBo Biotech AG Pyruvate Kinase M2 and Cancer
	Claudio Santos, London Research Institute Short Talk: Identification of Metabolic Enzymes Essential for Survival of Prostate Cancer Cells by Functional Studies
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 1	Pacific Ballroom
Sunday, March 14
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:00 AM	Metabolic Adaptation in Cancer (Joint)	British/Columbia Ballroom
	* Marja Jäättelä, Danish Cancer Society
	Eileen P. White, Rutgers University Role of Autophagy in Cancer and Therapy
	Guido Kroemer, INSERM, U848, Institut Gustave Roussy Autophagy in Stress Adaptation, Avoidance of Cell Death and Longevity
	Karen H. Vousden, Beatson Institute for Cancer Research Control of Metabolism by p53
	Rob Cairns, University Health Network Short Talk: Cancer-Associated Metabolite 2-Hydroxyglutarate Accumulates in AML with IDH1/2 Mutations
	Joshua L. Andersen, Duke University Short Talk: Metabolic Regulation of Caspase-2
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Therapeutic Modulation of Metabolism	Columbia Ballroom
	* Robert T. Abraham, Pfizer Biopharmaceuticals
	Peter F. Carmeliet, University of Leuven Oxygen, Metabolism and Angiogenesis
	John L. Cleveland, The Scripps Research Institute Therapeutic Modulation of Autophagy in Cancer
	Uwe Haberkorn, University Hospital Heidelberg Imaging Metabolism in Cancer
	Paul C. McDonald, British Columbia Cancer Research Center Short Talk: Therapeutic Targeting of Carbonic Anhydrase IX Results in Inhibition of Growth and Metastasis of Breast Tumors
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 2	Pacific Ballroom
Monday, March 15
7:00 - 11:00 AM	Poster Setup	Pacific Ballroom
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Survival and Death in Development and Disease (Joint)	British/Columbia Ballroom
	* Karen H. Vousden, Beatson Institute for Cancer Research
	Noboru Mizushima, Tokyo Medical and Dental University Lessons from Autophagy Deficient Mouse Models
	Marja Jäättelä, Danish Cancer Society Lysosomal Sphingolipid Metabolism as a Target for Cancer Therapy
	Douglas R. Green, St. Jude Children's Research Hospital The Mitochondrion: The Weapon Employed in Apoptopic Suicide
	Gerard I. Evan, University of California, San Francisco Inhibiting Oncogenes for Cancer Therapy
	Joan Boren, Cambridge Research Institute, CRUK Short Talk: Changes in Cell Lipid Content during Induction of Apoptosis
	Rebecca Lock, University of California, San Francisco Short Talk: Autophagy Inhibition Alters Glucose Metabolism and Promotes Epithelial Differentiation During Ras-Mediated Oncogenic Transformation
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:30 AM - 12:30 PM	Lunch	Pacific Ballroom
12:30 - 2:30 PM	Poster Session 3	Pacific Ballroom
2:30 - 4:30 PM	Workshop 2: Metabolic Assessment and Regulation	Columbia Ballroom
	* Craig B. Thompson, Abramson Family Cancer Center and Research Institute, University of Pennsylvania
	Michelle F. Clasquin, Princeton University High-Resolution Full-Scan Mass Spectrometry for Discovery and Characterization of Unknown Metabolites
	Andrew N. Lane, University of Louisville Translational Metabolomics in Human Lung Cancer
	Kenjiro Kami, Keio University, Japan CE-MS-based Metabolomics Identified a Novel Anaerobic Energy Metabolism of Cancer Cells
	Fionnuala M. Morrish, Fred Hutchinson Cancer Research Center The Metabolism of Tumor Progression and Regression in the pInsMycERTam/Bcl-xL Mouse Model of Pancreatic Beta Cell Neoplasia
	Min Wu, Seahorse Bioscience Metabolic Dependency on Fatty Acid Oxidation of Glioblastoma SF188
	Ameeta Kelekar, University of Minnesota Post-Translational Regulation of Human Noxa; its Role in Glucose Deprivation Induced Death
	Kathryn E. Wellen, University of Pennsylvania The Hexosamine Biosynthetic Pathway Links Glutamine Metabolism and Signaling to Regulate Cell Growth
	Linda Z. Penn, Ontario Cancer Institute Connecting the Dots between Tumor Cell Metabolism and the Mevalonate Pathway
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Cancer and Predisposition Genes	Columbia Ballroom
	* William G. Kaelin Jr., Dana Farber Cancer Institute
	Cheryl L. Walker, University of Texas MD Anderson Cancer Center Participation of TSC2 in a Cytoplasmic ATM Signaling Pathway that Regulates mTORC1 in Response to ROS
	Kwok-Kin Wong, Dana-Farber Cancer Institute Integrative Genomic and Proteomic Analyses Identify Novel Targets for Lkb1 Deficient Metastatic Lung Tumors
	Jason A. Chesney, University of Louisville Coupling Glycolysis With Cell Cycle Progression

	Sang-Min Jeon, University of Illinois at Chicago Short Talk: The LKB1-AMPK Pathway is Essential for Cell Survival during Glucose Starvation through Redox Regulation
7:00 PM -	On Own for Dinner
Tuesday, March 16
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	mTOR and Nutrient Sensing	Columbia Ballroom
	* Gerard I. Evan, University of California, San Francisco
	David M. Sabatini, Whitehead Institute for Biomedical Research mTOR and the Control of Growth
	Reuben J. Shaw, The Salk Institute The LKB1/ AMPK Pathway Controls Metabolism and Cell Growth
	Michael N. Hall, University of Basel Biozentrum TOR Signaling and the Control of Cell and Animal Growth
	Robert T. Abraham, Pfizer Biopharmaceuticals Interplay between Glutamine Metabolism and mTOR Signaling during Autophagy
	Bin Zheng, Beth Israel Deaconess Medical Center Short Talk: Cross-Talk between the LKB1-AMPK and BRAF-MEK-ERK Signaling Pathways
	Matthew J. Martin, Institute of Cancer Research Short Talk: AMP-Activated Protein Kinase in Melanoma: Biology and Therapeutic Opportunities
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM -	On Own for Lunch and Recreation
3:30 - 4:30 PM	Special Lecture (Joint)	British/Columbia Ballroom
	Craig B. Thompson, Abramson Family Cancer Center and Research Institute, University of Pennsylvania Therapeutic Exploitation of Metabolic Differences between Normal and Cancer Cells
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Hypoxia and Metabolic Stress	Columbia Ballroom
	* Peter F. Carmeliet, University of Leuven
	Pierre Sonveaux, University of Louvain (UCL) Medical School Short Talk: Targeting Lactate-Fueled Respiration Selectively Kills Hypoxic Tumor Cells
	Adrian L. Harris, University of Oxford, Weatherall Institute of Molecular Medicine Role of Carbonic Anhydrase 9 in Regulation of Tumour pH and Response to Antiangiogenic Therapy
	Sally A. Kornbluth, Duke University Medical Center Metabolic Control of Caspases
	William G. Kaelin Jr., Dana Farber Cancer Institute Dioxygenases as Therapeutic Targets in Cancer
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
8:00 - 11:00 PM	Entertainment	Pacific Ballroom
Wednesday, March 17
	Departure

*Session Chair †Speaker invited, not yet responded.