| Tuesday, January 19 |
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3:00 - 7:30 PM
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Registration
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Longs Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 8:30 PM
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Keynote Address
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Grays/Longs Peaks
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Gregg L. Semenza,
Johns Hopkins University School of Medicine
Molecular Mechanisms Underlying Responses to Hypoxia
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| Wednesday, January 20 |
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7:00 - 8:00 AM
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Breakfast
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Quandary Peak
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8:00 - 11:15 AM
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Biology of Hypoxia Signaling
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Grays/Longs Peaks
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Volker H. Haase,
Vanderbilt University Medical Center
Pathophysiological Consequences of Chronic HIF Activation
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Peter F. Carmeliet,
University of Leuven
Genetic Analyses of Prolyl Hydroxylases in Mice
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Peter J. Ratcliffe,
University of Oxford
Protein Hydroxylation and the Signaling of Hypoxia
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Joel I. Perez-Perri,
Instituto Leloir
Short Talk: Drosophila Genome-Wide RNAi Screen Identifies Multiple Regulators of HIF Dependent Transcription in Hypoxia
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Peter J. Espenshade,
Johns Hopkins School of Medicine
Short Talk: Oxygen-Regulated Degradation of Yeast SREBP by a Candidate Prolyl Hydroxylase
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Quandary Peak
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1:00 - 10:00 PM
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Poster Viewing
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Quandary Peak
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2:30 - 4:30 PM
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Workshop 1: Graduate Students/PostDoc Symposium
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Grays/Longs Peaks
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Volker H. Haase,
Vanderbilt University Medical Center
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David Hoogewijs,
University of Zürich
A Zinc Finger and BTB Domain-Containing Protein as a Novel PHD Interactor
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Sarah Linke,
Karolinska Institutet
The LL-Motif in HIF-alpha Contributes to FIH-1 Binding
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Heidi Menrad,
Goethe-University Frankfurt
Divergent Roles of HIF-1alpha vs. HIF-2alpha in the Survival of Multicellular Tumor Spheroids
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Zhizhong Li,
Duke University
Hypoxic Microenvironment and Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells
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Kevin Rouault,
INSERM
HIF-1a and -2a Knockdown Induced Deficiency in the Long-Term Reconstitution Ability of Human Haematopoietic Cells
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Kate M. Harms,
University of New Mexico School of Medicine
Neural Stem/Progenitor Cells Display a Glycolytic Metabolic Phenotype Under Non-Hypoxic Conditions: Role of Constitutive Stabilization of Hypoxia Inducible Factor-1alpha (HIF-1alpha)
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Carissa L. Perez,
Fred Hutchinson Cancer Research Center
Exposure to Hypoxic Environments Results in Elevated de novo Fatty Acid Synthesis as Revealed by a 13C Isotope Labeling Strategy
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Federico Formenti,
University of Oxford
Chuvash Polycythaemia Demonstrates the Importance of Hypoxia-Inducible Factor in Human Skeletal Muscle Metabolism
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Pulmonary Responses to Hypoxia
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Grays/Longs Peaks
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Paul T. Schumacker,
Northwestern University
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Karen M. Ridge,
Northwestern University
Cytoskeletal Rearrangements in Lung Cells during Hypoxia
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Larrisa A. Shimoda,
Johns Hopkins School of Medicine
HIF-1 and Pulmonary Responses to Hypoxia
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Marlene Rabinovitch,
Stanford University
Dysregulated Wnt-PPARgamma Interactions in Pulmonary Vascular Pathology
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Gregory B. Waypa,
Northwestern University
Short Talk: Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells
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Friederike C. Weisel,
University of Giessen Lung Center (UGLC)
Short Talk: Reverse Remodeling in Pulmonary Arterial Hypertension
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Quandary Peak
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7:30 - 10:00 PM
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Poster Session 1
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Quandary Peak
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| Thursday, January 21 |
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7:00 - 8:00 AM
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Breakfast
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Quandary Peak
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8:00 - 11:15 AM
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Cancer
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Grays/Longs Peaks
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William G. Kaelin Jr.,
Dana Farber Cancer Institute
Dioxygenases as Therapeutic Targets in Cancer
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Patrick H. Maxwell,
Rayne Institute
The HIF/PHD/VHLAxis in Kidney Cancer
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Tricia M. Wright,
University of North Carolina, Chapel Hill
Short Talk: Ror2 is a Non-Hypoxia HIF Target of VHL Inactivation in Renal Cell Carcinoma
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Giovanni Melillo,
SAIC Frederick, Inc, National Cancer Institute at Frederick
Targeting Hypoxic Cell Signaling for Cancer Therapy
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Leisa K. Johnson,
Genentech, Inc.
Interrogating alpha-VEGF responses in genetically engineered mouse models of oncology
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Luciana P. Schwab,
University of Tennessee Health Science Center
Short Talk: HIF-1alpha Promotes Primary Tumor Growth, Lung Macrometastasis and Stem Cell Activity in the MMTV-PyMT Model of Luminal Breast Cancer
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Quandary Peak
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1:00 - 10:00 PM
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Poster Viewing
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Quandary Peak
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Acute Responses to Hypoxia
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Grays/Longs Peaks
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Nanduri R. Prabhakar,
University Of Chicago
Acute Hypoxic Sensing and Reactive Oxygen Species
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Joseph A. Garcia,
University of Texas Southwestern Medical Center
Intersections of Stress-Responsive Signal Transduction Pathways
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Gabriel G. Haddad,
University of California, San Diego
Adaptive responses to hypoxia: Insights from a genetic model
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Vikram Sudarsan,
Stanford University
Short Talk: Acute Oxygen and Carbon Dioxide Sensing in a Drosophila Respiratory Neural Circuit
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Mark R. Band,
University of Illinois
Short Talk: Evolution of the p53 Pathway in the Hypoxia Tolerant Mole-Rat Mimics a Cancer Survival Mechanism
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Quandary Peak
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7:30 - 10:00 PM
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Poster Session 2
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Quandary Peak
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| Friday, January 22 |
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7:00 - 8:00 AM
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Breakfast
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Quandary Peak
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8:00 - 11:15 AM
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Stem Cells and Hypoxia
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Grays/Longs Peaks
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M. Celeste Simon,
University of Pennsylvania
Hypoxia and Stem Cells
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Toshio Suda,
Keio University
Hematopoietic Stem Cell in Hypoxic Niche
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Emin Maltepe,
University of California, San Francisco
Oxygen, Mitochondria and Stem Cell Fate in the Placenta
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Lorenz Poellinger,
Karolinska Institutet
Hypoxia Signaling of Notch
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Till Acker,
Institute of Neuropathology, University of Giessen
Short Talk: A Hypoxic Niche Regulates Glioma Stem Cells
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Ernestina Schipani,
Massachusetts General Hospital
Short Talk: Dual Action of Von Hippel Lindau Protein (pVHL) in Limb Bud Mesenchyme
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Quandary Peak
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1:00 - 10:00 PM
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Poster Viewing
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Quandary Peak
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2:30 - 4:30 PM
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Workshop 2: Therapeutics
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Grays/Longs Peaks
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Amato Giaccia,
Stanford University
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Matthew R. Pawlus,
University of Colorado, Denver
USF2 is a HIF2 Specific Co-transcriptional Activator
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Sven Påhlman,
Lund University
HIF-2alpha is a Negative Prognostic Marker in Human Neuroblastoma and Maintains Stemness in Neural Crest-like Neuroblastoma Tumor-Initiating Cells
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William Y. Kim,
University of North Carolina
HIF2alpha Cooperates with RAS Activation to Promote Lung Cancer Progression
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Hilda Mujcic,
Ontario Cancer Institute
Hypoxic Activation of the Unfolded Protein Response (UPR) Induces Expression of the Metastasis-Associated Gene LAMP3
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Stilla Frede,
University of Duisburg-Essen
Acute Hypoxia Induces HIF-1 Independent Monocyte Adhesion to Endothelial Cells through Increased ICAM-1 Expression
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Isabelle Ader,
Institut de Pharmacologie et de Biologie Structurale
Neutralization of Exogenous Sphingosine 1-Phosphate by Therapeutic Antibody Strategy Inhibits Hypoxia in vitro and Animal Models
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Peppi Koivunen,
University of Oulu
Hearts of Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection Against Ischemia-Reperfusion Injury
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Dana L. Miller,
Fred Hutchinson Cancer Research Center
Hydrogen Sulfide Protects against Hypoxia in C. elegans
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Inflammation
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Grays/Longs Peaks
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Agnes Görlach,
German Heart Center Munich
ROS and HIF Crosstalk
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Sean P. Colgan,
University of Colorado, Denver
The Interplay of Hypoxia and Mucosal Inflammation
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Cormac T. Taylor,
University College Dublin
Short Talk: Loss of Prolyl Hydroxylase-1 (PHD-1) is Protective in a Murine Model of Inflammatory Bowel Disease
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Gabriele A.I. Bergers,
UCSF, Helen Diller Family Cancer Research Building
HIF Induces Influx of Intratumoral Bone Marrow Derived Cells to Drive Neovascularization
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Thorsten Cramer,
Charite, Campus Virchow-Klinikum
Short Talk: Dual Role of HIF-1alpha in the Pathogenesis of Inflammation-Associated Cancer
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Quandary Peak
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7:30 - 10:00 PM
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Poster Session 3
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Quandary Peak
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| Saturday, January 23 |
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7:00 - 8:00 AM
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Breakfast
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Quandary Peak
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8:00 - 11:15 AM
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Metabolism
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Grays/Longs Peaks
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Christopher J. Schofield,
University of Oxford
Iron- and 2-Oxoglutarate-Dependent Dioxygenases
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Tak W. Mak,
Campbell Family Institute for Breast Cancer Research at PMH, UHN
Fatty Acid Oxidation and Survival of Cancer Cells
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Navdeep S. Chandel,
Northwestern University
Mitochondrial Complex III Regulates Signaling
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Siegfried Hekimi,
McGill University
Short Talk: Mitochondrial ROS Increases HIF-1alpha Expression and Enhance the Immune Response in Long-Lived Mclk1+/- Mutant Mice
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Lewis C. Cantley,
Harvard Medical School
PI-3Kinase and cancer metabolism
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Luis del Peso,
Universidad Autonoma
Short Talk: Hypoxia Promotes Glycogen Accumulation through Hypoxia Inducible Factor (HIF)-Mediated Induction of Glycogen Synthase 1
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Stress Responses to Hypoxia
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Grays/Longs Peaks
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Thomas Kietzmann,
University of Kaiserslautern
Signalling Cross-Talk between Hypoxia and Insulin
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L. Eric Huang,
University of Utah School of Medicine
HIF-1alpha, Genetic Alteration, and Tumor Progression
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Amato Giaccia,
Stanford University
Stress Responses Induced by Hypoxia that Modulate Tumor Progression
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Tobias Eckle,
University of Colorado, Denver
Short Talk: Adenosine-Dependant Stabilization of Period 2 Promotes Metabolic Adaptation of the Myocardium to Limited Oxygen Availability
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Lisa Heiserich,
Beatson Institute for Cancer Research
Short Talk: PHD3 Activity Regulates Hypoxia-Induced Actin Cytoskeleton Rearrangement and Cell Migration
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Quandary Peak
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8:00 - 11:00 PM
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Entertainment
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Quandary Peak
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| Sunday, January 24 |
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Departure
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