| Sunday, January 24 |
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3:00 - 7:30 PM
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Registration
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Longs Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 8:30 PM
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Keynote Address (Joint)
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Grays/Longs Peak
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Jeffrey M. Friedman,
Rockefeller University
Leptin’s Loop: Dissecting the Physiologic Systems Regulating Food Intake and Metabolism
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| Monday, January 25 |
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7:00 - 8:00 AM
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Breakfast
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Torreys 1-3, Shavano, Red Cloud
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8:00 - 11:15 AM
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Circadian Control of Adiposity and Metabolism (Joint)
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Grays/Longs Peak
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Martin G. Myers, Jr.,
University of Michigan
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Joseph T. Bass,
Northwestern University
Clock and Per: Gene Network Controls on Metabolism/Adiposity
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Julian Mercer,
Rowett Research Institute
Effect of Rhythms, Diet and Feeding Patterns on Hypothalamic Gene Expression
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Georgios Paschos,
University of Pennsylvania
Short Talk: Obesity in Mice with Adipose Tissue-Specific Deletion of Bmal1
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Mitchell A. Lazar,
University of Pennsylvania School of Medicine
Epigenomic Roles of Nuclear Receptors Regulating Adipogenesis and
Metabolism
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Etienne Challet,
CNRS
Synchronization of Multiple Circadian Clocks by Feeding
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Clifford J. Rosen,
Maine Medical Center
Short Talk: Nocturnin, a Circadian Clock Gene, Stimulates Adipogenesis by Promoting Nuclear Transport of PPARgamma
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 - 11:30 AM
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NIDDK Discussion of Funding Issues
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Grays/Longs Peak
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Philip F. Smith,
NIDDK, National Institutes of Health
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11:00 AM -
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On Own for Lunch and Recreation
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11:00 AM - 1:00 PM
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Poster Setup
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Torreys 1-3, Shavano, Red Cloud
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1:00 - 10:00 PM
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Poster Viewing
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Torreys 1-3, Shavano, Red Cloud
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Molecular Programming of Hypothalamic Circuitry
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Grays Peak
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Kevin L. Grove,
Oregon National Primate Research Center
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Joel K. Elmquist,
University of Texas Southwestern Medical Center
Cellular and Molecular Mechanisms Regulating Energy Balance and Glucose Homeostasis
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Richard B. Simerly,
Children's Hospital Los Angeles
Hormonal Specification of Hypothalamic Connectivity
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I. Sadaf Farooqi,
University of Cambridge
Mutations of Hypothalamic Circuits in Humans
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Yi-Chun Loraine Tung,
University of Cambridge Metabolic Research Laboratories
Short Talk: Hypothalamic-Specific Manipulation of Fto, the Ortholog of the Human Obesity Gene FTO, Affects Food Intake in Rats
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Torreys 1-3, Shavano, Red Cloud
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7:30 - 10:00 PM
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Poster Session 1
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Torreys 1-3, Shavano, Red Cloud
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| Tuesday, January 26 |
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7:00 - 8:00 AM
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Breakfast
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Torreys 1-3, Shavano, Red Cloud
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8:00 - 11:15 AM
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Nutrient Sensing in the Brain
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Grays Peak
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Roger D. Cone,
Vanderbilt University
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Martin G. Myers, Jr.,
University of Michigan
Neuromodulators of Leptin Action
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Michael A. Cowley,
Monash University
Melanocortins and Glucose Homeostasis
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Michael Rosenbaum,
Columbia University Medical College
Leptin and Energy Homeostasis in Humans
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Tamas L. Horvath,
Yale University School of Medicine
Fuel Utilization by Neurons: A Determinant of “Nutrient Sensing"
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Dong Kong,
Beth Israel Deaconess Medical Center, Harvard Medical School
Short Talk: Glucose Sensing by MCH Neurons Regulates Glucose Homeostasis and is Inhibited by UCP2
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Hong Wang,
University of Colorado Health Science Center
Short Talk: Neuron-Specific Lipoprotein Lipase Deficiency Perturbs the Regulation of Energy Balance and Leads to Obesity by Modifying the Expression of the Orexigenic Neuropeptides AgRP and NPY
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Torreys 1-3, Shavano, Red Cloud
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1:00 - 10:00 PM
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Poster Viewing
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Torreys 1-3, Shavano, Red Cloud
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2:30 - 4:30 PM
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Workshop 1: New Aspects of Adipogenesis, Lipid Droplets and Triglyceride Metabolism
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Grays/Longs Peaks
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Sheila Collins,
Sanford-Burnham Medical Research Institute
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Cristina M. Rondinone,
Roche
Introductory 'In Memoriam' for Dean Londos
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Chris E. Lowe,
University of Cambridge Metabolic Research Laboratories
The ATF6alpha Pathway of the Unfolded Protein Response is Required for Adipogenesis
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Ana G. Cristancho,
University of Pennsylvania School of Medicine
Transcription Factor 7-like 1 (TCF7L1) is required for PPARgamma2 Expression during Adipogenesis
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Kai Ge,
NIDDK, National Institutes of Health
Epigenetic Regulation of Adipogenesis
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Susanne Mandrup,
University of Southern Denmark
MED14 Tethers the Mediator to the N-Terminal Domain of PPARgamma and is Required for Full Transcriptional Activity and Adipogenesis
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Charles Harris,
Gladstone Institute for Cardiovascular Disease
DGAT Enzymes Are Required for Triglyceride Synthesis and Lipid Droplet Formation But Not for Other Aspects of Adipogenesis
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Cynthia Smas,
University of Toledo
Functional Analysis of FSP27 Protein Regions for Lipid Droplet Localization, Caspase-Dependent Apoptosis and Dimerization with CIDEA
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Lise Madsen†,
University of Copenhagen
Transdifferentiation of White into Brown Adipose Tissue Requires Cyclooxygenases
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Insights from Model Organisms (Joint)
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Grays/Longs Peak
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Karsten Kristiansen,
University of Copenhagen
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Roger D. Cone,
Vanderbilt University
Biological Functions of AgRP and AgRP2 in Zebrafish
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Sri Devi Narasimhan,
University of Massachusetts Medical School
Identifying Phosphatases that Modulate the Insulin/IGF-1 Signaling Pathway
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Sean M. Oldham,
Burnham Institute for Medical Research
Role of Nutrient Sensing TOR Pathway in High Fat Diet-induced Signaling Pathway and aging
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Biao Wang,
The Salk Institute
Short Talk: Drosophila Salt Inducible Kinase (SIK) in Fat Metabolism
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Christine Könner,
Institute for Genetics, University of Cologne
Short Talk: Conserved Role for Insulin Receptor Signaling in Catecholaminergic Cells in Control of Energy Homeostasis
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Torreys 1-3, Shavano, Red Cloud
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7:30 - 10:00 PM
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Poster Session 2
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Torreys 1-3, Shavano, Red Cloud
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| Wednesday, January 27 |
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7:00 - 8:00 AM
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Breakfast
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Torreys 1-3, Shavano, Red Cloud
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8:00 - 11:15 AM
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Immune Signals and Energy Homeostasis/Body Composition (Joint)
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Grays/Longs Peak
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Randy J. Seeley,
University of Cincinnati
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Steven E. Shoelson,
Harvard Medical School, Joslin Diabetes Center
Obesity, Inflammation and Insulin Resistance (Basic and Clinical Issues)
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Ajay Chawla,
Stanford University Medical Center
Immune Regulation of Nutrient Metabolism and Aging
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Carey N. Lumeng,
University of Michigan
Short Talk: MGL1 Promotes Adipose Tissue Inflammation and Insulin Resistance by Regulating 7/4hi Monocytes in Obesity
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Umut Ozcan,
Children's Hospital Boston, Harvard Medical School
The ER Stress and Leptin Resistance
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Daniel Lee Marks,
Oregon Health & Science University
The Role of Central Melanocortin’s in Cachexia
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Jose Manuel Garcia,
Michael E. DeBakey Veterans Affairs Medical Center
Short Talk: The Effects of Peripheral Ghrelin Administration on the Lipid Metabolism are Primarily Mediated through Changes in Food Intake in a Model of Cachexia
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Torreys 1-3, Shavano, Red Cloud
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1:00 - 10:00 PM
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Poster Viewing
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Torreys 1-3, Shavano, Red Cloud
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:30 PM
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Bariatric Surgery and the Treatment of Metabolic Disease
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Grays Peak
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Lee M. Kaplan,
Massachusetts General Hospital
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Francesco Rubino,
Weill Cornell Medical College
Resolution of Diabetes and Bariatric Surgery
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Paul O'Brien,
Monash University
Appetite Control and Bariatric Surgery
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Randy J. Seeley,
University of Cincinnati
Bariatric Surgery: Beyond Restriction and Malabsorption
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Thomas Alexander Lutz,
Institute of Veterinary Physiology
Short Talk: Roux-en-Y Gastric Bypass Increases Energy Expenditure Affects Taste Preference and Impairs Bone Structure Rats
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Jocelyne Magré,
INSERM
Genetics of Congenital Generalized Lipodystrophy
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7:30 - 8:30 PM
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Social Hour w/ Lite Bites
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Torreys 1-3, Shavano, Red Cloud
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7:30 - 10:00 PM
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Poster Session 3
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Torreys 1-3, Shavano, Red Cloud
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| Thursday, January 28 |
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7:00 - 8:00 AM
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Breakfast
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Torreys 1-3, Shavano, Red Cloud
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8:00 - 11:15 AM
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Thinking Outside of the Hypothalamus
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Grays Peak
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Daniel Lee Marks,
Oregon Health & Science University
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Marta Korbonits,
Barts and The London, Queen Mary's School of Medicine and Dentistry
Cross-Talk of Endocannabinoids and Ghrelin
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Darren Opland,
University of Michigan
Short Talk: VTA Leptin Receptor Neurons Specifically Project to and Regulate CART Neurons of the Extended Central Amygdala
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Alastair V. Ferguson,
Queen's University
Sensory Circumventricular Organs: Integrative Control Centers Regulating Energy Balance?
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Hans-Rudolf Berthoud,
Pennington Biomedical Research Center
Hedonic, Emotional, Cognitive, and Metabolic Controls of Appetite and Energy Balance: Who is The Boss?
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Lora K. Heisler,
University of Cambridge
Serotonin Influences Melanocortin Pathways to Affect Energy Balance
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Matthew R. Hayes,
University of Pennsylvania
Short Talk: Endogenous Leptin Signaling in the NTS is Required for Energy Balance Regulation
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Drug Development: Treating the Brain and Beyond (Joint)
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Grays/Longs Peak
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Michael A. Cowley,
Monash University
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Eduardo Dunayevich,
Orexigen Therapeutics, Inc.
The Combination of Bupropion and Naltrexone in the Treatment of Obesity: From Bench to Pivotal Trials
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Donald J. Marsh,
Merck Research Laboratories
New Neuropeptide Target Systems: Neuromedin U
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Michael Culler,
Ipsen/Biomeasure
Novel Peptide Ligands of the Melanocortin Type 4 Receptor for the Treatment of Obesity and Metabolic Disease
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Lee M. Kaplan,
Massachusetts General Hospital
Short Talk: Roux-en-Y Bypass Stimulates BAT Activity and Central Control Thermogenesis in Mice
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Alan Koncarevic,
Acceleron Pharma
Short Talk: Induction of a Thermogenic Program in White Adipose Tissue of HFD-Fed Mice Treated with a Soluble ActRIIB
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Torreys 1-3, Shavano, Red Cloud
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8:00 - 11:00 PM
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Entertainment
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Torreys 1-3, Shavano, Red Cloud
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| Friday, January 29 |
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Departure
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