Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Innate Immunity: Mechanisms Linking with Adaptive Immunity (D3)

Organizer(s): Luke A.J. O'Neill, Kate A. Fitzgerald and Averil I. Ma
June 7 - 12, 2010
Trinity College Dublin · Dublin, Ireland
Abstract Deadline: February 24, 2010
Late Abstract Deadline: February 24, 2010
Scholarship Deadline: February 24, 2010
Early Registration Deadline: April 7, 2010

Organized in Collaboration with Science Foundation Ireland

This meeting took place in the 2010 season.

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see our meeting list, or search for a meeting.

Summary of Meeting
In the past 5 years there have been remarkable advances in our understanding of the molecular basis of innate immunity. We now have considerable detail on the major classes of innate immune receptors that sense pathogens and provoke immune and inflammatory responses. These include the Toll-like receptors (TLRs), NOD-like receptors (NLRs) and RIG-I-like receptors (RLRs). The role these receptors play in host defense against microbes has been studied, their signaling pathways elucidated, and their roles in infectious and inflammatory diseases examined in detail. As well as stimulating innate immunity via induction of various effector mechanisms, these receptors also participate in the establishment of adaptive immunity. This occurs via the induction of key cytokines to promote T and B cell development and activation, and also via the induction of co-stimulatory molecules on the surface of dendritic cells, notably CD80 and CD86. A final aspect concerns adjuvancy – microbial or synthetic agents that activate these receptors act as powerful adjuvants required for the establishment of memory responses. This conference will bring together scientists working on innate immune mechanisms activated by these receptors, and will have as a key focus the ability of these receptors and the responses they elicit to promote adaptive immunity. The conference will therefore be of interest to many investigators interested in immunity and the role the immune system plays in disease.

Monday, June 7
3:00 - 7:30 PM	Registration	Lower Concourse
6:30 - 7:30 PM	Refreshments	Lower Concourse
7:30 - 8:30 PM	Keynote Address	Burke Theatre/Beckett Rooms
	* Luke A.J. O'Neill, Trinity College Dublin
	Ruslan M. Medzhitov, Yale University School of Medicine Innate Control of Adaptive Immunity
Tuesday, June 8
7:30 - 8:30 AM	Breakfast	At Lodging Location
7:30 - 8:30 AM	Poster Setup	Beckett Rooms/Lower Concourse
8:30 AM - 3:00 PM	Poster Viewing	Beckett Rooms/Lower Concourse
8:30 - 11:45 AM	The Modulation of Innate and Adaptive Immune Responses by Innate Receptors	Burke Theatre/Beckett Rooms

	Shizuo Akira, Osaka University Functional Analysis of TLR Inducible Genes by Gene Targeting
	* Alberto Mantovani, Istituto Clinico Humanitas The Interplay between Cellular and Humoral Innate Immunity: The Long Pentraxin PTX3 as a Paradigm
	Julie Magarian Blander, Mount Sinai School of Medicine Phagosomes and Adaptive Immunity
	* Mihai G. Netea, Radboud University Nijmegen Medical Centre Modulation of Antifungal Immune Responses by Innate Receptors

	Michael C. Abt, University of Pennsylvania Short Talk: Signals Derived from Intestinal Microbial Communities Regulate Anti-Viral Immunity
	Anna M. Hansen, National Institutes of Health Short Talk: An Innate, Non-NK T Cell with Memory-Like Phenotype Produces Large Amounts of IL-17 Independently of IL-6 and IL-21
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:45 AM - 12:45 PM	Lunch	Dining Hall/Atrium/Java Vaults
12:00 - 2:30 PM	Poster Session 1	Beckett Rooms/Lower Concourse
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	Autoimmunity as a Consequence of Innate Immunity Defects	Burke Theatre/Beckett Rooms
	Robert L. Coffman, Dynavax Technologies Targeting TLR7 and TLR9 in Autoimmune Disease
	* Jos van der Meer, dept general internal medicine The auto-inflammatory syndromes
	* Averil I. Ma, University of California, San Francisco Ubiquitination and Innate Immunity
	Dominik Schenten, Yale University Short Talk: The Role of TLR-Induced IL-6 and IL-1 in the Control of Adaptive Immunity
5:00 PM -	On Own for Dinner
Wednesday, June 9
7:30 - 8:30 AM	Breakfast	At Lodging Location
8:30 - 11:45 AM	Evolution of Innate and Adaptive Immunity	Burke Theatre/Beckett Rooms
	* Max D. Cooper, Emory University Evolution of the Adaptive Immune System
	* Gary W. Litman, University of South Florida The Evolution of Immune Receptor Diversity
	Jenny P. Ting, University of North Carolina at Chapel Hill NLR Proteins: From Plants to Animals
	Neal Silverman, University of Massachusetts Medical School What the Fly has Taught us about Innate Immunity: New Lessons for NF-kappaB Signaling?
	A. Neil Barclay, University of Oxford Short Talk: The Evolution and Ligands of Macrophage Paired Receptors
	Gregory Ian Vladimer, University of Massachusetts Medical School Short Talk: NLRP12 and Other Inflammasome Components Participate in the Resistance to Yersinia pestis Producing a Potent LPS
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:45 AM - 12:45 PM	Lunch	Dining Hall/Atrium/Java Vaults
11:45 AM - 12:45 PM	Poster Setup	Beckett Rooms/Lower Concourse
12:45 - 2:45 PM	Workshop	Burke Theatre/Beckett Rooms
	* Averil I. Ma, University of California, San Francisco
	Amy Grace Hise, Case Western Reserve University Innate Immune Host Defense to Fungal Pathogens
	Clare E. Bryant, University of Cambridge Allergen Lipid Binding Proteins (Alps) Sensitise Ligand Induced Activation of TLR4: A Common Mechanism of Allergen Recognition?
	Paul J. Hertzog, Monash Institute of Medical Research Regulation of Mucosal Immunity by a New Interferon (IFNepsilon) with Unusual Properties Evolved to Protect Reproductive Tract from Bacterial and Viral Infection
	Mirjam Kool, Ghent University / VIB An Unexpected Role for Uric Acid as an Inflammatory Mediator of Allergic Asthma
	Susan B. Carpenter, Trinity College Dublin TRIL: A Novel Modulator of TLR4 Signaling is also Required for TLR3 Mediated Immune Responses
	Shruti Sharma, University of Massachusetts Medical School Innate Immune Recognition of a Novel AT-rich DNA Motif in the P. falciparum Genome.
2:45 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	The Role of Innate Receptors in Adjuvancy	Burke Theatre/Beckett Rooms
	* Kingston H. G. Mills, Trinity College Dublin Activation and Manipulation of TLR and NLR Signalling Pathways in Dendritic Cells for Selective Induction of T Cell Responses
	Alan Sher, NIAID, National Institutes of Health Critical Role for IL-1R Signaling and the Inflammasome in the Th1/Th17 cell Adjuvant Activity of Mycobacteria
	* Bart N. Lambrecht, Ghent University Molecular Basis for Alum Adjuvancy
	Sheri Dubey, Merck & Co., Inc. Short Talk: Novel TLR9 Agonists Combined with Alum for Use as Vaccine Adjuvants
5:00 - 6:00 PM	Social Hour w/ Lite Bites	Lower Concourse
5:30 - 8:00 PM	Poster Session 2	Beckett Rooms/Lower Concourse
Thursday, June 10
7:30 - 8:30 AM	Breakfast	At Lodging Location
7:30 - 8:30 AM	Poster Setup	Beckett Rooms/Lower Concourse
8:30 AM - 3:00 PM	Poster Viewing	Beckett Rooms/Lower Concourse
8:30 - 11:45 AM	Control of T Cell Subsets by Innate Immune Signals	Burke Theatre/Beckett Rooms
	* Laurence A. Turka, Beth Israel Deaconess/Harvard Regulation of T Lymphocytes by "Innate Immune Pathways"
	Shimon Sakaguchi, Institute for Frontier Medical Sciences, Kyoto University Regulatory T Cells in Innate and Adaptive Immunity
	Hilde Cheroutre, La Jolla Institute for Allergy and Immunology Omitting Felony by Switching Fate: TGF-beta and Retinoic Acid Mediate Lineage Conversion of CD4 Th Cells to CD8 CTLs

	Ed C. Lavelle, Trinity College Dublin
	Aisling Dunne, Trinity College Dublin Short Talk: Inflammasome Activation by Adenylate Cyclase Toxin Directs TH17 Responses and Protection Against Bordetella Pertussis
	Mattias Enoksson, Karolinska Institute Short Talk: Mast Cells as Novel Sensors of Cell Injury through Interleukin-33 Recognition
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:45 AM - 12:45 PM	Lunch	Dining Hall/Atrium/Java Vaults
12:00 - 2:30 PM	Poster Session 3	Beckett Rooms/Lower Concourse
2:30 - 3:00 PM	Coffee Available	Lower Concourse
3:00 - 5:00 PM	Innate Immune Mechanisms: Molecular and Structural Aspects	Burke Theatre/Beckett Rooms
	* Luke A.J. O'Neill, Trinity College Dublin Novel Components in Innate Immune Signaling
	* Kate A. Fitzgerald, University of Massachusetts Medical School Inflammasomes and Anti-Viral Responses
	Eicke Latz, University of Massachusetts Medical School Regulation of NLRP3 and AIM2 Inflammasome Signaling
	Tilmann Bürckstümmer, Center for Molecular Medicine Short Talk: Functional Dissection of the TBK1 Molecular Machine
5:00 PM -	On Own for Dinner
Friday, June 11
7:30 - 8:30 AM	Breakfast	At Lodging Location
7:30 AM - 8:30 PM	Poster Setup	Beckett Rooms/Lower Concourse
8:30 AM - 3:00 PM	Poster Viewing	Beckett Rooms/Lower Concourse
8:30 - 11:30 AM	Therapeutic Manipulation of Innate Immunity in Inflammatory Diseases	Burke Theatre/Beckett Rooms


	* Anthony J. Coyle, Pfizer Role of Type I Interferons in Autoimmune Disease
	Carla Vanina Rothlin, Yale University TAMing Inflammation in vivo

	Nicola La Monica, Idera Pharmaceuticals Synthetic Agonists and Antagonists of Toll-like Receptor 7, 8, and 9
	* Andrew E. Parker, Opsona Therapeutics Targeting TLR2 in Ischemic Organ Damage
	Alison A. Humbles, MedImmune, LLC Short Talk: RAGE Deficiency Protects Mice from RSV Infection
	Greg CA Elson, NovImmune Short Talk: Mechanistic Studies Reveal the Mode of Action of Highly Potent TLR4 Neutralizing MAbs
9:40 - 10:00 AM	Coffee Break	Lower Concourse
11:30 AM - 12:30 PM	Lunch	Lower Concourse
12:00 - 2:30 PM	Poster Session 4	Beckett Rooms/Lower Concourse
4:30 - 5:00 PM	Coffee Available	Lower Concourse
5:00 - 7:15 PM	Pathogen-Specific Responses	Burke Theatre/Beckett Rooms
	* Tracy Hussell, Imperial College London The Role of Innate Immunity in Host Defence against Respiratory Pathogens

	Lynda M. Stuart, Massachusetts General Hospital, Harvard Medical School Sensing Bacterial Virulence
	Stefanie N. Vogel, University of Maryland Distinct Roles of Alternatively Activated Macrophages in the Host Response to Bacterial and Viral Infection
	* Andrew G. Bowie, Trinity College Dublin Novel Components of Anti-Viral Pattern Recognition Receptor Pathways
7:15 - 7:30 PM	Closing Remarks	Burke Theatre/Beckett Rooms
	Kate A. Fitzgerald, University of Massachusetts Medical School Closing Remarks
7:30 - 8:00 PM	Social Hour	Grand Dining Hall
8:00 - 9:00 PM	Dinner	Grand Dining Hall
7:30 - 9:00 PM	Entertainment	Grand Dining Hall
Saturday, June 12
	Departure

*Session Chair †Speaker invited, not yet responded.