Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Tolerance and Autoimmunity (B7)

Organizer(s): Betty Diamond and Diane J. Mathis
February 21 - 26, 2010
Taos Convention Center (meeting only) · Taos, New Mexico
Abstract Deadline: October 21, 2009
Late Abstract Deadline: November 20, 2009
Scholarship Deadline: October 21, 2009
Early Registration Deadline: December 21, 2009

Sponsored by Novo Nordisk A/S

This meeting took place in the 2010 season.

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Summary of Meeting
Elegant studies of central T and B cell tolerance have been performed, leading to the identification of multiple mechanisms that remove or silence autoreactive cells during their maturation, but also reminding us that some autoreactive cells do mature to immunocompetence in all individuals. Furthermore, studies of the B cell response to antigen have clearly demonstrated that autoreactivity can arise de novo in antigen-activated cells, which also requires silencing. Finally, it has now been established in studies of multiple autoimmune diseases that a critical checkpoint exists between autoreactivity and tissue injury, one of the issues about which we remain most ignorant. Understanding peripheral mechanisms for maintaining self-tolerance offers promise for better therapies for autoimmune disease. The proper implementation of this new knowledge requires an understanding of similarities and differences between animal models and human disease. Specific Issues: • Translating results from studies of animal models to human studies • Peripheral and central tolerance • T cells and B cells • The relationship between autoimmunity and immunodeficiency • The role of dendritic cells in autoimmunity • What dictates generation of autoreactive antibody in one individual and not in another? • How much autoreactivity must occur in order to progress to disease and what governs this? • What exactly is "pathogenic autoreactivity", i.e, are all investigators talking about the same thing? • How much of pathogenesis is due to autoreacting antibodies per se versus the tissue's response to antibody? • What role is innate immunity playing in all of this?

Sunday, February 21
3:00 - 7:30 PM	Registration	Rio Grande A
6:30 - 7:30 PM	Refreshments	Rio Grande A
7:30 - 8:30 PM	Keynote Address	Bataan
	Alexander Y. Rudensky, Memorial Sloan-Kettering Cancer Center T cells in the framework of immunological tolerance
Monday, February 22
7:00 - 8:00 AM	Breakfast	Rio Grande B,C,D
8:00 - 11:00 AM	Signaling Negative Selection of Autoreactive Lymphocytes	Bataan
	Chang-Zheng Chen, Stanford University Immune modulation: lessons and puzzles from the miR81 family of genes
	* Eric M. Verdin, University of California, San Francisco HDAC7 and Autoimmunity
	Philippe Bouillet, Walter and Eliza Hall Institute of Medical Research Bim Kills Cells Mostly by Inhibiting the Bcl-2 Pro-Survival Proteins
	Jane H. Buckner, Benaroya Research Institute at Virginia Mason Blunted BCR Signaling, a Source of Lost Tolerance in Autoimmunity
	Maria (Toni) A. Gutierrez, University of Texas Southwestern Medical Center Short Talk: Separate Checkpoints Regulate Plasma Cell Accumulation and IgG Autoantibody Production in Lyn-/- Mice
9:20 - 9:40 AM	Coffee Break	Rio Grande B,C
11:00 AM -	On Own for Lunch and Recreation
11:00 AM - 1:00 PM	Poster Setup	Rio Grande A,B,C
1:00 - 10:00 PM	Poster Viewing	Rio Grande A,B,C
2:30 - 4:30 PM	Workshop 1	Bataan
	* Kristin Tarbell, National Institutes of Health
	* Zhibin Chen, University of Miami
	Hsin-Jung Wu, Harvard Medical School Gut-Residing Segmented Filamentous Bacteria can Trigger Autoimmune Arthritis via T Helper 17 Cells
	Yong Fan, University of Pittsburgh Autoimmune Diabetes Induced by Thymic Medullary Epithelium-Specific Deletion of Insulin
	Brandy Lynn Houser, Harvard University Two Distinct Subsets of Macrophages at the Human Maternal-Fetal Interface: Neither Proinflammatory nor Immunosuppressive
	Siamak Jabbarzadeh Tabrizi, Kyushu University BCR Signaling Regulates the Expression of IRAK Proteins in Human B Cell Subsets
	Scott M. Lieberman, Children's Hospital of Philadelphia Characterizing Natural CD4+Foxp3+ Regulatory T Cells by Anatomical Location
	Heather Niederer, University of Cambridge Copy Number, Linkage Disequilibrium and Disease Association in the FCGR Locus
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Early Moments in Autoimmunity	Bataan
	Jacques F. Banchereau, Baylor Institute for Immunology Research Tolerogenic and Immunogenic DCs
	* Teresa P. DiLorenzo, Albert Einstein College of Medicine Autoimmunity and Tolerance in Type 1 Diabetes

	Partha S. Biswas, Hospital for Special Surgery Short Talk: ROCK2 and IRF4: A Novel Interaction Regulating IL-17 and IL-21 Production and the Development of Autoimmunity
	Lars Rönnblom, Uppsala Universitet Controls of the Unfolding of Lupus
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rio Grande A,B,C
7:30 - 10:00 PM	Poster Session 1	Rio Grande A,B,C
Tuesday, February 23
7:00 - 8:00 AM	Breakfast	Rio Grande B,C,D
8:00 - 11:00 AM	B Cell Effectors and Regulators	Bataan

	Robert Brink, Garvan Institute of Medical Research Early B cell differentiation and the germinal centre response

	* Betty Diamond, Feinstein Institute for Medical Research Regulation of GC-matured B cells
	Claudia Mauri, University College London Regulatory B Cells in Health and in Patients with SLE
	Gregg J. Silverman, University of California, San Diego Regulatory Natural Antibodies Control Inflammatory Responses and Protect From Autoimmune Disease
	Tomabu G. Adjobimey, Institute for Medical Immunology Microbiology and Parasitology Short Talk: Regulatory T Cells Induce IgG4 Production by B Cells through GITR/GITR-L Interaction, IL-10 and TGF-beta
9:20 - 9:40 AM	Coffee Break	Rio Grande B,C
11:00 AM -	On Own for Lunch and Recreation
11:00 AM - 1:00 PM	Poster Setup	Rio Grande A,B,C
1:00 - 10:00 PM	Poster Viewing	Rio Grande A,B,C
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Braking Autoimmunity	Bataan
	* Diane J. Mathis, Harvard Medical School Molecular Pathways Controlling Autoimmunity
	Shohei Hori, RIKEN Research Center for Allergy and Immunology Stability and Plasticity in Regulatory T Cell Differentiation
	Juan J. Lafaille, New York University School of Medicine Anergy and Tolerance
	Anneleen Bosma, University College London Short Talk: Lipid Antigen Presentation by B Cells is Important to Trigger iNKT Cell Expansion for Mediation of an Anti-Inflammatory Response
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rio Grande A,B,C
7:30 - 10:00 PM	Poster Session 2	Rio Grande A,B,C
Wednesday, February 24
7:00 - 8:00 AM	Breakfast	Rio Grande B,C,D
8:00 - 11:00 AM	Regulating Thresholds for Activation and Tolerance I	Bataan
	Bruce Compton Richardson, University of Michigan Chromatin Structure and Immune Activation in Autoimmunity


	Ian R. Rifkin, Boston University Toll-like Receptor Signaling Pathways and Lupus Pathogenesis
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center The Adipocyte and the Monocyte
	* Jeffrey V. Ravetch, Rockefeller University The Up- and Down-Side of Immune Complexes
9:20 - 9:40 AM	Coffee Break	Rio Grande B,C
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Rio Grande A,B,C
1:00 - 10:00 PM	Poster Viewing	Rio Grande A,B,C
2:30 - 4:30 PM	Workshop 2	Bataan
	* William M. Ridgway, University of Cincinnati College of Medicine
	* Alessandra B. Pernis, Columbia University
	Donald M. Simons, Wistar Institute Inflammatory Monocytes from Arthritic Mice Induce Th17 Cell Differentiation
	Reiko Takahashi, Keio University School of Medicine SOCS1 Mediates Stabilization of Foxp3 Expression in Treg Cells
	Charis E. Teh, John Curtin School of Medical Research Combinatorial Defects in Central and Peripheral Tolerance Checkpoints Precipitate Autoimmune Pancreatitis and Sialadenitis
	Falk Weih, Leibniz-Institute for Age Research Role of RelA and RelB in Medullary Thymic Epithelial Cells in the Establishment of Immunological Self-Tolerance
	Duane R. Wesemann, Harvard Medical School Peripheral B Cell Receptor Editing

4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Tissue Response: Turning the Other Cheek (Or Not)	Bataan
	Bryce A. Binstadt, University of Minnesota Effector Pathways in Multi-Organ Autoimmunity
	Matthias Kretzler, University of Michigan A Systems View of Regulatory Networks in Lupus Nephritis
	* William M. Ridgway, University of Cincinnati College of Medicine Why Some Tissues are Targeted for Damage
	Javier Ochoa-Repáraz, Dartmouth Medical School Short Talk: Oral Treatment with Purified Polysaccharide A (PSA) of Human Commensal Bacteroides Fragilis Protects Against Experimental CNS Demyelinating Disease
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rio Grande A,B,C
7:30 - 10:00 PM	Poster Session 3	Rio Grande A,B,C
Thursday, February 25
7:00 - 8:00 AM	Breakfast	Rio Grande B,C,D
8:00 - 11:00 AM	Regulating Thresholds for Activation and Tolerance II	Bataan
	Charlotte Cunningham-Rundles, Mount Sinai Medical Center Immunodeficiency and Autoimmunity in Man

	Roberta Pelanda, National Jewish Health Antigen and BAFF Receptors Guide the Selection and Differentiation of Immature B Cells

	* Carola G. Vinuesa, Australian National University T Follicular Helper Cells in the Control of Autoimmune Disease
	Jarish N. Cohen, University of Virginia Health Systems Short Talk: Lymphatic Endothelial Cells Mediate CD8+ T Cell Peripheral Tolerance by Direct Antigen Presentation that is Independent of Aire
	Norihito Kawasaki, The Scripps Research Institute Short Talk: CD22 is a Potent Negative Regulator of TLRs in B Cells
9:20 - 9:40 AM	Coffee Break	Rio Grande B,C
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Novel Insights and Novel Therapeutics	Bataan
	Antonio Uccelli, University of Genoa Mesenchymal Stem Cells: A New Cell Therapy for Autoimmune Diseases
	* Kevin J. Tracey, Feinstein Institute for Medical Research Reflexive Control of Autoinflammation and Immunity
	Marijke Niens, The Jackson Laboratory Short Talk: Prevention of Type 1 Diabetes in “HLA Humanized” NOD Mice by a Multi-Peptide Coupled-Cell Approach
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Rio Grande A,B,C
8:00 - 11:00 PM	Entertainment	Rio Grande
Friday, February 26
	Departure

*Session Chair †Speaker invited, not yet responded.