Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

HIV Vaccines (X5)

Organizer(s): Wayne C. Koff, Lynn Morris and Marcus Altfeld
March 21 - 26, 2010
Fairmont Banff Springs · Banff, Alberta
Abstract Deadline: November 19, 2009
Late Abstract Deadline: December 23, 2009
Scholarship Deadline: November 19, 2009
Early Registration Deadline: January 21, 2010

Part of the Keystone Symposia Global Health Series, Supported by the Bill & Melinda Gates Foundation

Joint meeting: Viral Immunity (X6)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Protection from HIV: Targeted Intervention Strategies (X8)
March 20 - 25, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Traditionally, the Keystone Joint HIV Symposia have integrated vaccines and pathogenesis to comprehensively cover the field—from HIV’s fundamental biology to its interaction with the human immune system and how to design a vaccine—and these Joint Symposia have been convened every year. Since an HIV vaccine is proving to be a particularly recalcitrant problem, a novel approach with this year's experimental format, that facilitates a wider cross-fertilization of ideas would be very valuable and would be welcomed by the broader HIV vaccine research community. To that end, the major development proposed for the 2010 Keystone HIV Vaccine Symposium is to foster innovative ideas and new collaborations with immunology and vaccinology as it pertains to other viral diseases. Specifically, we propose that a new Joint Symposium of HIV Vaccines in conjunction with Viral Immunity be convened. This Joint Symposium would retain the valuable format that includes joint and separate sessions covering general and specific principles.

Sunday, March 21
3:00 - 7:30 PM	Registration	Van Horne Foyer
6:15 - 7:15 PM	Refreshments	Van Horne Foyer
7:15 - 7:30 PM	Orientation for New Attendees and New Investigators (Joint) Keystone Symposia's Chief Scientific Officer, Dr. Andy Robertson, to lead discussion in a "What to Expect during your Attendance" for interested delegates.	Van Horne Ballroom A-B
7:30 - 9:30 PM	Keynote Session (Joint)	Van Horne Ballroom A-B
	Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard Durable Control of HIV Infection: Implications for Vaccine Design
	Peter C. Doherty, University of Melbourne Anti-Viral Immunity: Lessons from Influenza Virus
Monday, March 22
6:30 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Adaptive Immunity/T- and B-Cell Responses	Van Horne Ballroom A-B
	* Marcus Altfeld, Massachusetts General Hospital
	Kim J. Hasenkrug, NIAID, National Institutes of Health T Cell and B Cell Memory in Protection against Mouse Retrovirus Infection
	Richard A. Koup, National Institutes of Health Adaptive Immunity to HIV
	Hendrik Streeck, Massachusetts General Hospital, Harvard Medical School Short Talk: Increased Control of Viral Replication by HIV-1-Specific CD8+ T Cells Mediated by HIV-Specific CD4+ T Helper Signals
	Barbara L. Shacklett, University of California, Davis Mucosal Immune Responses to HIV Infection

	Barton F. Haynes, Duke University Medical Center B-Cell Immune Responses to Acute HIV Infection

	Ann J. Hessell, The Scripps Research Institute Short Talk: A Non-Fucosylated Variant of the Anti-HIV-1 MAb b12 Results in Greatly Increased ADCC and ADCVI and Binds FcgammaRIIIa with Higher Affinity than Wild-Type b12
9:30 - 9:50 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
1:00 - 2:30 PM	Hands-on Computer Session on Los Alamos Sequence Database Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.	Ivor Petrak
	* Brian T. Foley, Los Alamos National Laboratory
	* Bette T. Korber, Los Alamos National Laboratory
2:30 - 4:30 PM	Workshop 1: Advances in Vaccine Development: Clinical Trials	Van Horne Ballroom A-B
	* M. Juliana McElrath, Fred Hutchinson Cancer Research Center
	* Nelson L. Michael, Walter Reed Army Institute of Research RV 144 Update: Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thai Adults
	Jill Gilmour, International AIDS Vaccine Initiative Short Talk: Induction of Viral Inhibition in Clinical HIV Vaccine Trials of Diverse Immunogens
	Julia Rood, National Institute of Allergy and Infectious Diseases, National Institutes of Health Short Talk: HIV-Specific CD8+ T-Cells of Vaccinees Exhibit Per-Cell Cytotoxic Capacity Comparable to Those of Progressors
	Erica Andersen-Nissen, Fred Hutchinson Cancer Research Center Short Talk: Systemic Innate Immune Responses to a DNA/MVA Candidate HIV Vaccine
	William C. Adams, Karolinska Institutet Short Talk: Adenovirus Type-35 Vectors Block Human CD4+ T Cell Activation by CD46 Ligation
	Ruth M. Ruprecht, Dana-Farber Cancer Institute Short Talk: Prevention of Systemic Infection by a Multigenic Recombinant Protein Vaccine after Heterologous R5 Clade C SHIV Challenge: Correlates of Protection
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Control of HIV Infection	Van Horne Ballroom A-B
	* Andrew J. McMichael, John Radcliffe Hospital Vaccine Design: Lessons from Acute HIV-1 Infection
	Mark Brockman, Simon Fraser University Short Talk: Reduced Replication Capacity of Recombinant Viruses Encoding Acute/Early HIV-1 Gag-Protease Sequences from Individuals Expressing Protective HLA Class I Alleles
	R. Paul Johnson, Harvard Medical School Lessons Learned from Live Attenuated SIV
	Guido Silvestri, University of Pennsylvania School of Medicine Nonpathogenic Natural SIV Infections
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 1	Mezzanine 2
Tuesday, March 23
6:30 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:45 AM	Neutralizing Antibody	Van Horne Ballroom A-B
	Eric Hunter, Emory University and
	Cynthia A. Derdeyn, Emory University Recently Transmitted HIV and the Early Neutralizing Antibody Response
	Peter D. Kwong, Vaccine Research Center, National Institutes of Health Antibody VRC01: To Be or Not To Be Like CD4

	Sriram Subramaniam, National Institutes of Health Molecular Architecture of Trimeric SIV and HIV-1 Envelope Glycoproteins
	Quentin J. Sattentau, Sir William Dunn School of Pathology Antigen and Adjuvant Design for Antibody-Based HIV-1 Vaccination
	* Lynn Morris, National Institute for Communicable Diseases How Does Neutralization Breadth Develop in HIV Infection
	Joseph Joyce, Merck & Co., Inc. Short Talk: Vaccination with Peptide Mimetics of the gp41 Pre-Hairpin Fusion Intermediate Yields Neutralizing Antisera Against HIV-1 Isolates
9:50 - 10:10 AM	Coffee Break	Van Horne Foyer
11:45 AM -	On Own for Lunch and Recreation
11:45 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
1:00 - 2:30 PM	Hands-on Computer Session on Los Alamos Sequence Database Maximum attendance: 60. Interested participants may sign up at the meeting on a first-come, first-serve basis.	Ivor Petrak
	* Brian T. Foley, Los Alamos National Laboratory
	* Bette T. Korber, Los Alamos National Laboratory
2:30 - 4:30 PM	Workshop 2: Novel Vector and Adjuvant Development	Van Horne Ballroom A-B
	* Gerald H. Voss, GlaxoSmithKline Biologicals
	John K. Rose, Yale University School of Medicine Short Talk: Strong Protection Against SIVsmE660 Mucosal Challenge Conferred by a Novel, Heterologous, Prime-Boost Vaccine Regimen
	Mauricio A. Martins, University of Wisconsin-Madison Short Talk: Recombinant Yellow Fever Vaccine Virus 17D Expressing SIVmac239 Gag Induces SIV-Specific CD8+ T Cell Responses in Rhesus Macaques
	* Nancy L. Haigwood, Oregon Health and Science University Short Talk: Novel VLPs Rapidly Induce High Titer Neutralizing Antibodies when Combined with DNA Vaccines in Rabbits
	Adrian McDermott, International AIDS Vaccine Initiative Short Talk: Control of Pathogenic SIVmac239 Following Electroporated DNA + IL-12 Prime and Adenovirus 5 Boost in a Study Designed to Compare Priming Strategies in the NHP Model
	Magdalini Moutaftsi, Infectious Disease Research Institute Short Talk: Glucopyranosyl Lipid A (GLA), a Synthetic TLR4 Vaccine Adjuvant, Induces Potent Th1-Promoting Immune Responses
	Anna Bershteyn, Massachusetts Institute of Technology Short Talk: Versatile Lipid-Based Vaccine Carriers Elicit CTL and Antibody Responses to Surface-Conjugated or Encapsulated Antigen
	Ben Berkhout, University of Amsterdam, Academic Medical Center Short Talk: Live Attenuated SIV: Characterising the Role of Vaccine Persistence in Protection
	Tomas Hanke, Weatherall Institute of Molecular Medicine Short Talk: Long Peptides Induce Polyfunctional Macaque T Cells Against Conserved Regions of HIV-1 with Superior Breadth to Single-Gene Vaccines
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Innate Immunity	Van Horne Ballroom A-B
	* Bali Pulendran, Emory University

	Marcus Altfeld, Massachusetts General Hospital Natural Killer Cells in HIV-1 Infection
	Silke Paust, Harvard Medical School Short Talk: Critical Role for CXCR6 in NK Cell Mediated Adaptive Immunity to Viruses
	Mariapia A. Degli-Esposti, LEI, University of Western Australia NK/DC Crosstalk and Regulation of Adaptive Immunity
	Veronica Anna Sofia Tjomsland, University of Linköping Short Talk: Receptors and Pathways Utilized by Dendritic Cells for Antigen Presentation of Free and Complement Opsonized HIV
	Jay A. Berzofsky, National Cancer Institute, National Institutes of Health Short Talk: Innate and Adaptive Immune Correlates of Vaccine-Induced Control of Mucosal Transmission of SIV in Macaques
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 2	Mezzanine 2
Wednesday, March 24
6:30 - 8:00 AM	Breakfast	Mezzanine 2
8:00 - 11:15 AM	Vaccines: Immunologic Mechanisms of Action (Joint)	Van Horne Ballroom A-B
	* Kim J. Hasenkrug, NIAID, National Institutes of Health
	Bali Pulendran, Emory University Lessons from Yellow Fever Vaccine
	Ian H. Frazer, University of Queensland Lessons from the Human Papillomavirus Vaccines
	Shane Crotty, La Jolla Institute for Allergy and Immunology Lessons from the Smallpox Vaccine: Follicular Helper CD4+ T Cell (Tfh) Differentiation and Neutralizing Antibodies
	Mark Stephen de Souza, AFRIMS Short Talk: Immunogenicity of the Thai Phase III (RV144) HIV Vaccine Regimen
	Monica Vaccari, National Cancer Institute, National Institutes of Health Short Talk: HIV/SIV Vaccine Efficacy Dependent on the Dose of SIVmac251 Challenge Exposure in Macaques

	M. Juliana McElrath, Fred Hutchinson Cancer Research Center Lessons from the STEP Trial and the Current Clinical Pipeline
9:50 - 10:10 AM	Coffee Break	Van Horne Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Mezzanine 2
1:00 - 10:00 PM	Poster Viewing	Mezzanine 2
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Imaging of the Antiviral Immune Response (Joint)	Van Horne Ballroom A-B
	* Jonathan W. Yewdell, National Institutes of Health
	Heather D. Hickman, NIAID, National Institutes of Health Intravital Imaging of the CD8+ T Cell Response to Virus
	Matteo Iannacone, Harvard Medical School Short Talk: Lymph Node Subcapsular Sinus Macrophages Confer Resistance to CNS Invasion Upon Peripheral Infection With a Neurotropic Virus

	Ashley T. Haase, University of Minnesota In Vivo Imaging of the Cellular Immune Response to Viral Infections
	Ronald N. Germain, NIAID, National Institutes of Health Intravital Imaging of Adaptive Immune Effector Activity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
7:30 - 10:00 PM	Poster Session 3	Mezzanine 2
Thursday, March 25
6:30 - 8:00 AM	Breakfast	Mezzanine 2
7:00 AM - 12:00 PM	Poster Setup	Mezzanine 2
7:00 AM - 12:00 PM	Poster Viewing	Mezzanine 2
8:00 - 11:15 AM	Novel Vaccine Approaches	Van Horne Ballroom A-B
	Gerald H. Voss, GlaxoSmithKline Biologicals AS01, an Adjuvant System Potentiating Vaccines against Complex Pathogens
	Bette T. Korber, Los Alamos National Laboratory Vaccine Antigen Designs to Address HIV Variability


	Dan H. Barouch, Beth Israel Deaconess Medical Center Short Talk: Heterologous Rare Serotype Adenovirus Vectors for HIV-1 +
	* Louis J. Picker, Oregon Health & Science University Cytomegalovirus Vectors
	Brad Jones, University of Toronto Short Talk: Comprehensive Elimination of Globally Diverse HIV Primary Isolate Infections by HERV-K-Specific CD8+ T Cells
	Wayne C. Koff, International AIDS Vaccine Initiative Future Directions in AIDS Vaccine Development
9:30 - 9:50 AM	Coffee Break	Van Horne Foyer
11:15 AM - 1:00 PM	Lunch	Mezzanine 2
12:00 - 2:30 PM	Poster Session 4	Mezzanine 2
2:30 - 4:30 PM	Workshop 3: HIV Pathogenesis to Inform Vaccine Design	Van Horne Ballroom A-B
	* David I. Watkins, University of Wisconsin-Madison
	* Barbara L. Shacklett, University of California, Davis
	Srinika R.F. Ranasinghe, Weatherall Institute of Molecular Medicine Short Talk: The Antiviral Efficacy of HIV-Specific CD8+ T-Cells to a Conserved Epitope is Heavily Dependent on the Infecting HIV-1 Isolate
	Anne-Sophie M. Dugast, Ragon Institute, Massachusetts General Hospital Short Talk: Significant Impairment in Innate Immune Cells Recruitment by Chronic Untreated Antibodies to Mediate ADCC
	Matthew R. Reynolds, University of Wisconsin-Madison Short Talk: Macaques Vaccinated with SIVmac239deltanef Delay Acquisition and Control Replication after Repeated Low Dose Heterologous SIV Challenge
	Todd M. Allen, Massachusetts General Hospital Short Talk: Ultra-Deep Sequencing During Acute HIV Infection Reveals the Earliest Adaptive Changes to Host Selection Pressures
	Qingsheng Li, University of Minnesota Short Talk: Maturation of Virus-specific Antibodies in Cervicovaginal Tissues in SIVmac239deltanef-vaccinated Macaques
	Suzanne English, University of Oxford Short Talk: Sexual Transmission of Highly-Distinct HIV-1 Variants from a Single Donor to Two Recipients on the Same Night: Divergent Immune-Recognition and Clinical Outcomes
	Suresh Pallikkuth, University of Miami Short Talk: Recombinant IL-21 Induces Cytotoxic Molecule Granzyme B in Lymph Nodes of Chronic SIV Infected Rhesus Macaques
	Adam D. Burgener, National Microbiology Lab Short Talk: HIV-1-Resistant Sex Workers Overexpress Novel Antiproteases and Antiviral Factors in their Cervical Mucosa. Protective Milieu Against HIV-1 Infection?
4:30 - 5:00 PM	Coffee Available	Van Horne Foyer
5:00 - 7:00 PM	Antigenic Variation (Joint)	Van Horne Ballroom A-B
	* Wayne C. Koff, International AIDS Vaccine Initiative

	David I. Watkins, University of Wisconsin-Madison The Effect of Vaccine-Induced SIV-Specific Immune Response on Viral Acquisition and Replication
	Arnaud Moris, UPMC - Hôpital Pitié-Salpêtrière Short Talk: The Antiviral Factor APOBEC3G Improves CTL Recognition of HIV-Infected T Cells: Linking Intrinsic and Adaptive Immune Responses
	Dennis R. Burton, The Scripps Research Institute HIV Env and Approaches to Neutralizing Abs
	Jonathan W. Yewdell, National Institutes of Health Still Drifting: Mechanisms of Influenza A Virus Hemagglutinin Immune Escape
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Mezzanine 2
8:00 - 11:00 PM	Entertainment	Mezzanine 2
Friday, March 26
	Departure

*Session Chair †Speaker invited, not yet responded.