| Sunday, March 21 |
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3:00 - 7:30 PM
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Registration
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Longs Peak Foyer
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6:30 - 7:30 PM
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Refreshments
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Longs Peak Foyer
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7:30 - 8:30 PM
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Keynote Address (Joint)
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Grays/Longs Peaks
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Gideon Dreyfuss,
HHMI, University of Pennsylvania School of Medicine
RNA-Protein Complexes (RNPs): The Instruments of Post-Transcriptional Gene Regulation
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| Monday, March 22 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:00 AM
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Signaling and Physiology
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Grays Peak
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Kathryn B. Horwitz,
University of Colorado Health Sciences Center
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Carole R. Mendelson,
University of Texas Southwestern Medical Center
Mechanisms in Progesterone Receptor Regulation of Inflammatory Signaling in Pregnancy and Labor
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Sheue-Yann Cheng,
National Institutes of Health
Novel Signaling of Mutant Thyroid Hormone Receptors in Carcinogenesis
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John A. Cidlowski†,
NIEHS, National Institutes of Health
Talk Title to be Determined
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Iris Z. Jaffe,
Tufts-New England Medical Center
Mineralocorticoid Receptor Regulation of Vascular Gene Expression: Role in Vascular Function and Disease
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Jennifer K. Richer,
University of Colorado
Short Talk: MicroRNAs Differentially Expressed in Luminal versus Triple Negative Breast Cancer Control Estrogen Receptor alpha and Growth Factor Receptor Expression and Aspects of Tumor Metabolism
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Mark G. Obukowicz,
Pfizer Inc.
Short Talk: Dissociated Agonist of the Glucocorticoid Receptor (DAGR): 60 Years in the Making (and of Waiting)
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:00 AM -
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On Own for Lunch and Recreation
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11:00 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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2:30 - 4:30 PM
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Workshop 1: Hot Topics: Physiology
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Grays Peak
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Carolyn L. Smith,
Baylor College of Medicine
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Michihisa Umetani,
University of Texas Southwestern Medical Center
LXRbeta Promotes Vascular Reendothelialization via a Novel Mechanism Involving non-Nuclear Signaling in Endothelium
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Terry D. Hinds,
University of Toledo
Discovery of Glucocorticoid Receptor beta in Mice and its Role in Insulin Signaling and Metabolism
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Ronni Nielsen,
University of Southern Denmark
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Brian Sandri,
University of Minnesota
Evidence for a Global Role of the Estrogen- Regulated ZEB1 Transcription Factor in Modulating Adiposity through Regulation of FGF-21
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Jens Tiefenbach,
University of Toronto
A live Zebrafish-based Screening System for Human Nuclear Receptors Allows for Tissue Selective Drug Discovery
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Mechanisms of Nuclear Receptor Signaling (Joint)
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Grays/Longs Peaks
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Donald P. McDonnell,
Duke University Medical Center
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Christopher K. Glass,
University of California, San Diego
Lineage-Determining Transcription Factors Prime Cis-regulatory Elements Required for Ligand-dependent Gene Expression
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Keith R. Yamamoto,
University of California, San Francisco
Cell and Gene Selectivity of Glucocorticoid Action: DNA Sequences as Specific GR Ligands
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Gordon L. Hager,
National Cancer Institute, National Institutes of Health
Global Regulation of Chromatin Structure and Gene Expression by Glucocorticoid Receptors
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Jason S. Carroll,
Cancer Research UK
Short Talk: FoxA1 is the Critical Determinant of ER Binding and Activity in Breast Cancer Cells
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 1
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Shavano/Torreys
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| Tuesday, March 23 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:15 AM
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Ligands, Cofactors, and Gene Regulation
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Grays Peak
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Kenneth S. Korach,
NIEHS, National Institutes of Health
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Donald P. McDonnell,
Duke University Medical Center
The ERRalpha/PGC-1 Complex Links HER2/IGF1 Initiated Signaling Events to the Expression of Target Genes that Impact Breast Cancer Pathogenesis
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Michael G. Rosenfeld,
University of California, San Diego
Epigenetics: Life, Death, and Tumor Translocations
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Carol A. Lange,
University of Minnesota
Mechanisms of PR Coupling to MAP Kinases
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Geoffrey L. Greene,
University of Chicago
Structural Basis of ER Ligand Selectivity
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Kendall W. Nettles,
The Scripps Research Institute
Short Talk: Coupling of Estrogen Receptor Conformation and Ligand Orientation Determine Graded Signaling Activity
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Wei Xu,
University of Wisconsin-Madison
Short Talk: “Yin-Yang” Principle for Estrogen Receptor Heterodimers in Breast Cancer: A Targeted Molecular Approach for Therapeutic Development
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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2:30 - 4:30 PM
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Workshop 2: Hot Topics: Gene Regulation
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Grays Peak
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Steven K. Nordeen,
University of Colorado Health Sciences Center
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Katherine Anne Burns,
NIEHS, National Institutes of Health
Selective Mutations in the D-domain of Mouse ERalpha Alters Nuclear Translocation and ERalpha’s Non-ERE Gene Regulatory Mechanism
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Nasun Hah,
Cornell University
Exploring the Direct Estrogen-Regulated Transcriptome in Breast Cancer Cells Using GRO-Seq
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Moray J. Campbell,
Roswell Park Cancer Institute
VDR Regulation of Histone Modifications and miRNA Combine to Fine-Tune Transcriptional Cycling of Target Genes
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Robert H. Oakley,
NIEHS, National Institutes of Health
Crosstalk between Glucocorticoid and G Protein-Coupled Receptor Signaling Pathways Mediated by Arrestins
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Joshua D. Stender,
University of California, San Diego
Control of Pro-Inflammatory Gene Programs by Active Histone Methylation and Demethylation
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Daniel G. Gioeli,
University of Virginia
CDK9 Regulates AR Activity and Cell Growth through Serine 81 Phosphorylation
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Physiology and Metabolism (Joint)
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Grays/Longs Peaks
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David J. Mangelsdorf,
University of Texas Southwestern Medical Center
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Bruce M. Spiegelman,
Harvard Medical School
Transcriptional Regulation of Adipogenesis and Energy Homeostasis
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Deborah Clegg,
University of Texas Southwestern Medical Center
Estrogen, Adipose Tissue, and The Metabolic Syndrome
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Ronald M. Evans,
The Salk Institute
PPARs in Metabolism and Disease
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Austin J. Cooney,
Baylor College of Medicine
Short Talk: Regulation of ES Cells and iPS by Nuclear Receptors
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 2
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Shavano/Torreys
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| Wednesday, March 24 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:15 AM
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Chromatin and Transcription
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Grays Peak
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Dean P. Edwards,
Baylor College of Medicine
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Roland Schüle,
Klinikum der Universität Freiburg
Androgen Receptor Function is Regulated by Histone Demethylases: Implication for Prostate Cancer
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W. Lee Kraus,
University of Texas Southwestern Medical Center
Genomic Analyses of Estrogen-Regulated Transcription Reveal New Facets of the Estrogen Signaling Pathway
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Raphael Metivier,
Université de Rennes I
Estrogen Receptor Transcriptional Activity: A Dynamic Integration of Multi-Leveled Information
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Shigeaki Kato,
University of Tokyo
Epigenetic Regulators Supporting Nuclear Receptor Function
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Inez Rogatsky,
Weill Medical College of Cornell University
Short Talk: The Role of GRIP1 in Type I Interferon Signaling and Glucocorticoid-Induced Immunosuppression
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Catharine L. Smith,
University of Arizona
Short Talk: Histone Deacetylases Function as Glucocorticoid Receptor Coactivators
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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11:15 AM - 1:00 PM
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Poster Setup
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Shavano/Torreys
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1:00 - 10:00 PM
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Poster Viewing
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Shavano/Torreys
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2:30 - 4:30 PM
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Workshop 3: Hot Topics: Signaling and Cancer
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Grays Peak
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Jonna Frasor†,
University of Illinois, Chicago
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Shannon T. Bailey,
Dana-Farber Cancer Institute
Loss of ER-Regulated microRNAs is Fundamental to Hormone-Independent Breast Cancer Cells
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Ruby Dhar,
University of Chicago
Genome Wide RNAi Screen to Identify Novel Targets for Estrogen Signaling in Breast Cancer
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Zeynep Madak-Erdogan,
University of Illinois at Urbana-Champaign
Critical Role of ERK2 in Estrogen Receptor alpha (ERalpha)-mediated Regulation of Gene Expression and Proliferation of Breast Cancer Cells
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Lillian J. Eichner,
McGill University
miR-378 Induces Metabolic Shift in Breast Cancer Cells via the ERRgamma Transcriptional Pathway
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Jun Qin,
Baylor College of Medicine
COUP-TFII Regulates Angiogenesis to Promote Tumor Growth and Metastasis
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Matthew J. Schiewer,
Thomas Jefferson University
Impact of PARP1 on AR Signaling and Therapeutic Response in Prostate Cancer
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:15 PM
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Coregulators and Gene Expression (Joint)
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Grays/Longs Peaks
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Carole R. Mendelson,
University of Texas Southwestern Medical Center
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Bert W. O'Malley,
Baylor College of Medicine
NR Coactivators: Physiology and Disease
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Catherine C. Thompson,
Pfizer
LXR is a Therapeutic Target for Skin Aging and Dermal Inflammatory Indications
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Mitchell A. Lazar,
University of Pennsylvania School of Medicine
Epigenetic Regulation of Nuclear Receptor Expression, Cistromes, and Function
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Ralf Kittler,
University of Texas Southwestern Medical Center
Short Talk: A cis-Regulatory Map for Nuclear Receptors in Breast Cancer
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Ronald N. Margolis,
NIDDK, National Institutes of Health
Short Talk: dkCOIN: A BIG Solution to Data Integration
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7:15 - 8:15 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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7:30 - 10:00 PM
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Poster Session 3
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Shavano/Torreys
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| Thursday, March 25 |
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7:00 - 8:00 AM
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Breakfast
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Shavano/Torreys
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8:00 - 11:15 AM
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Steroid Receptors, Signaling and Cancer
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Grays Peak
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John A. Cidlowski,
NIEHS, National Institutes of Health
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Kathryn B. Horwitz,
University of Colorado Health Sciences Center
Women’s Hormones, Breast Cancer Metastasis and Cancer Stem Cells
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Jan-Åke Gustafsson,
Karolinska Institute
Novel Biological Roles of LXRs
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Karen Elizabeth Knudsen,
Thomas Jefferson University, Kimmel Cancer Center
New Paradigms in Tumor Suppression: The RB-E2F Axis and Nuclear Receptor Regulation in Cancer
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Charles L. Sawyers,
Memorial Sloan-Kettering Cancer Center
Overcoming Resistance to Anti-Androgen Therapy in Prostate Cancer
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Yun Qiu,
University of Maryland School of Medicine
Short Talk: Androgen Receptor Splicing Variants and Castration Resistance in Prostate Cancer
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Suzanne D. Conzen,
University of Chicago
Short Talk: Identification of a Glucocorticoid Receptor Signature in Primary Human Breast Cancers
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9:20 - 9:40 AM
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Coffee Break
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Longs Peak Foyer
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11:15 AM -
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On Own for Lunch and Recreation
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4:30 - 5:00 PM
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Coffee Available
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Longs Peak Foyer
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5:00 - 7:00 PM
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Nuclear Receptors, Signaling, and Gene Regulation (Joint)
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Grays/Longs Peaks
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Ronald M. Evans,
The Salk Institute
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David J. Mangelsdorf,
University of Texas Southwestern Medical Center
Nutrient-Sensing and Metabolic Control by Nuclear Receptors
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Benita S. Katzenellenbogen,
University of Illinois at Urbana-Champaign
Genomics of Estrogen Receptor Signaling in Breast Cancer and Endocrine Resistance
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Myles Brown,
Dana Farber Cancer Institute
Nuclear Receptor Cistromes and Epigenomes
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Edwin Cheung,
Genome Institute of Singapore
Short Talk: Global and Funcational Analyses of ER-Mediated Long-Range Chromatin Interactions
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7:00 - 8:00 PM
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Social Hour w/ Lite Bites
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Shavano/Torreys
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8:00 - 11:00 PM
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Entertainment
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Shavano/Torreys
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| Friday, March 26 |
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Departure
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