Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Nuclear Receptors: Development, Physiology and Disease (X8)

Organizer(s): Carl S. Thummel, David D. Moore and Joyce J. Repa
March 21 - 26, 2010
Keystone Resort · Keystone, Colorado
Abstract Deadline: November 23, 2009
Late Abstract Deadline: December 28, 2009
Scholarship Deadline: November 23, 2009
Early Registration Deadline: January 22, 2010

Supported by The Directors' Fund

Joint meeting: Nuclear Receptors: Signaling, Gene Regulation and Cancer (X7)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Nuclear receptors represent a family of ligand-regulated transcription factors that play central roles in development, physiology, and metabolism. Upon binding small lipophilic hormones and metabolites, such as steroids, fatty acids, and bile acids, nuclear receptors switch their regulatory status, reprogramming gene expression in target tissues. Current research is aimed at defining roles for these receptors in normal development and metabolism as well as better understanding how nuclear receptor dysfunction contributes to diabetes, cancer, cardiovascular disease, obesity, and neuronal disorders. Nuclear receptors are also a major target for drug development, with many compounds on the market and several in ongoing human trials. This meeting will highlight recent breakthroughs in nuclear receptor research, promote interactions between scientists from industry and academia, and provide opportunities for senior scientists to interact with younger researchers and trainees.

Sunday, March 21
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	Grays/Longs Peaks

	Gideon Dreyfuss, HHMI, University of Pennsylvania School of Medicine RNA-Protein Complexes (RNPs): The Instruments of Post-Transcriptional Gene Regulation

Monday, March 22
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Nuclear Receptors in Development and Disease	Longs Peak
	* Carl S. Thummel, University of Utah School of Medicine
	†,
	Peter Tontonoz, University of California, Los Angeles Liver X Receptors in Metabolism, Inflammation and Disease
	Carlie J. M. de Vries, Academic Medical Center NR4A Orphan Nuclear Receptors in Vascular Disease
	Joe Thornton, University of Oregon Evolution of Nuclear Receptors
	Henry M. Krause, University of Toronto Coordination of Developmental Check Points and Metabolism
	Jason M. Tennessen, University of Utah School of Medicine Short Talk: The Drosophila Estrogen-Related Receptor Coordinates Carbohydrate Metabolism with Cell Growth
	Marc R. Van Gilst, Fred Hutchinson Cancer Research Center Short Talk: From the Nematode Nuclear Receptor Milieu, C. elegans NHR-49 Emerges as a Casanova
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Shavano/Torreys
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys
2:30 - 4:30 PM	Workshop 1: Hot Topics: Nuclear Receptors in Development and Disease	Longs Peak
	Lilach Gilboa, Weizmann Institute of Science Hormonal Coordination of Niche Formation and Germ Line Stem Cell Establishment
	Chris R. Gissendanner, University of Louisiana at Monroe The C. elegans NR4A Nuclear Receptor: Conserved Functions in Cell Proliferation and Cell Differentiation during Organ Morphogenesis
	Wen Xie, University of Pittsburgh Unexpected Hepatotoxicity and Inflammatory Gene Activation in FXR Transgenic Mice
	Wendong Huang, Beckman Research Institute of City of Hope FXR, Liver Repair and Aging
	* Li Wang, University of Utah Nuclear Receptor SHP-dependent Mitochondrial Targeting in Apoptosis Signaling and Tumor Growth
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Mechanisms of Nuclear Receptor Signaling (Joint)	Grays/Longs Peaks
	* Donald P. McDonnell, Duke University Medical Center
	Christopher K. Glass, University of California, San Diego Lineage-Determining Transcription Factors Prime Cis-regulatory Elements Required for Ligand-dependent Gene Expression

	Keith R. Yamamoto, University of California, San Francisco Cell and Gene Selectivity of Glucocorticoid Action: DNA Sequences as Specific GR Ligands
	Gordon L. Hager, National Cancer Institute, National Institutes of Health Global Regulation of Chromatin Structure and Gene Expression by Glucocorticoid Receptors
	Jason S. Carroll, Cancer Research UK Short Talk: FoxA1 is the Critical Determinant of ER Binding and Activity in Breast Cancer Cells
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys
7:30 - 10:00 PM	Poster Session 1	Shavano/Torreys
Tuesday, March 23
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Metabolic Control and Circadian Rhythms	Longs Peak
	* Susanne Mandrup, University of Southern Denmark

	Urs Albrecht, University of Fribourg The Clock Component Per2 Coordinates Circadian Output by Interaction with Nuclear Receptors

	Ueli Schibler, University of Geneva The Regulation of Circadian Gene Expression in Peripheral Cell Types
	David D. Moore, Baylor College of Medicine Gut Feelings
	Johan Auwerx, École Polytechnique Fédérale de Lausanne Integrating Metabolic Control by NAD+ Sensors

	Pavlos Pissios, Beth Israel Deaconess Medical Center Short Talk: Regulation of Glucose and Lipid Metabolism by Nicotinamide N-Methyltransferase
	Thomas P. Burris, The Scripps Research Institute Short Talk: Characterization of Synthetic REV-ERB ligands
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Shavano/Torreys
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys
2:30 - 4:30 PM	Workshop 2: Hot Topics: Co-Regulators and Post-Transcriptional Control	Longs Peak
	Inna I. Astapova, Beth Israel Deaconess Medical Center The Nuclear Corepressor, NCoR, Controls the Set Point of the Thyroid Axis In vivo
	Karine Cecile Gauthier, ENS de Lyon The Thyroid Hormone Receptor TRalpha Protects Against Atherosclerosis Development
	Atul Chopra, Baylor College of Medicine Hepatic SRC-2 Regulates Energy Balance by Coordinating Bile Secretion and Dietary Fat Absorption
	Nan Wu, University of Pennsylvania Arf-bp1 and Pam are Novel Regulators of Circadian Rhythm that Target Rev-erbalpha for Degradation
	William Bourguet, Centre de Biochimie Structurale A Unique Secondary Structure Switch Controls Constitutive Gene Silencing by Retinoic Acid Receptor
	* Patrick R. Griffin, The Scripps Research Institute HDX of Intact VDR/RXR Heterodimer Reveals Agonist and DNA-Induced Conformational Changes Important for Coactivator Interaction
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Physiology and Metabolism (Joint)	Grays/Longs Peaks
	* David J. Mangelsdorf, University of Texas Southwestern Medical Center
	Bruce M. Spiegelman, Harvard Medical School Transcriptional Regulation of Adipogenesis and Energy Homeostasis
	Deborah Clegg, University of Texas Southwestern Medical Center Estrogen, Adipose Tissue, and The Metabolic Syndrome

	Ronald M. Evans, The Salk Institute PPARs in Metabolism and Disease
	Austin J. Cooney, Baylor College of Medicine Short Talk: Regulation of ES Cells and iPS by Nuclear Receptors
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys
7:30 - 10:00 PM	Poster Session 2	Shavano/Torreys
Wednesday, March 24
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Cell Fate and Tissue Homeostasis	Longs Peak
	* Joyce J. Repa, University of Texas Southwestern Medical Center
	Thomas Perlmann, Karolinska Institutet, Ludwig Institute for Cancer Research NR4A Orphan Nuclear Receptors Trigger a Neuroprotective Pathway Induced by Elevated Cyclic AMP

	Gary D. Hammer, University of Michigan SF-1/DAX: Adrenocortical Stem/Progenitor Cell Fate and Multipotency
	Frances M. Sladek, University of California, Riverside HNF4alpha Function and Regulation -- New Insights into an Old Receptor
	Erin G. Schuetz, St. Jude Children's Research Hospital Cis and Trans Genetic Variation Affecting Hepatic Nuclear Hormone Receptor Expression
	Jae W. Lee, Baylor College of Medicine Short Talk: Histone H3-lysine 4 Methyltransferases Specialized for Nuclear Receptor-Mediated Metabolic Homeostasis

	Kai Ge, NIDDK, National Institutes of Health Short Talk: Epigenetic Regulation of PPARgamma and Adipogenesis
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Shavano/Torreys
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys
2:30 - 4:30 PM	Workshop 3: Hot Topics: Nuclear Receptors in Metabolism	Longs Peak
	* Carolyn L. Cummins, University of Toronto
	Kari T. Chambers, Washington University School of Medicine PGC-1beta Regulates Hepatic Energy Metabolism Under ad Libitum Fed Conditions
	Philipp M. Kulozik, German Cancer Research Center Lack of Hepatic TBL1/TBLR1 Transcriptional Co-Activator Function Promotes Obesity-Related Dyslipidemia
	Hong Soon Kang, NIEHS, National Institutes of Health Retinoid-Related Orphan Receptor alpha (RORalpha) Positively Regulates Obesity, Hepatic Steatosis, and Inflammation
	Yanqiao Zhang, Northeastern Ohio Universities College of Medicine Identification of Novel Pathways that Control FXR-mediated Hypocholesterolemia
	Katja A. Lamia, The Salk Institute for Biological Studies AMPK Regulates the Circadian Clock by Cryptochrome Phosphorylation and Degradation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Coregulators and Gene Expression (Joint)	Grays/Longs Peaks
	* Carole R. Mendelson, University of Texas Southwestern Medical Center
	Bert W. O'Malley, Baylor College of Medicine NR Coactivators: Physiology and Disease
	Catherine C. Thompson, Pfizer LXR is a Therapeutic Target for Skin Aging and Dermal Inflammatory Indications

	Mitchell A. Lazar, University of Pennsylvania School of Medicine Epigenetic Regulation of Nuclear Receptor Expression, Cistromes, and Function
	Ralf Kittler, University of Texas Southwestern Medical Center Short Talk: A cis-Regulatory Map for Nuclear Receptors in Breast Cancer
	Ronald N. Margolis, NIDDK, National Institutes of Health Short Talk: dkCOIN: A BIG Solution to Data Integration
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Shavano/Torreys
7:30 - 10:00 PM	Poster Session 3	Shavano/Torreys
Thursday, March 25
7:00 - 8:00 AM	Breakfast	Shavano/Torreys
8:00 - 11:15 AM	Nuclear Receptors in Metabolism	Longs Peak
	Joyce J. Repa, University of Texas Southwestern Medical Center Nuclear Receptors in Pancreatic Beta Cells
	Steven A. Kliewer, University of Texas Southwestern Medical Center Regulation of Metabolism by Nuclear Receptor-FGF Pathways
	Anastasia Kralli, The Scripps Research Institute ERR Function in Energy Metabolism and Cancer
	* Vincent Giguère, McGill University Metabolic Gene Networks in Normal and Cancer Cells: One Nuclear Receptor Subfamily to Rule them All
	Carolyn L. Cummins, University of Toronto Short Talk: LXRbeta is Required for Glucocorticoid-Induced Hyperglycemia and Hepatosteatosis
	Yihong Wan, University of Texas Southwestern Medical Center Short Talk: PGC1beta Mediates PPARgamma Activation of Osteoclastogenesis and Rosiglitazone-Induced Bone Loss
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Nuclear Receptors, Signaling, and Gene Regulation (Joint)	Grays/Longs Peaks
	* Ronald M. Evans, The Salk Institute
	David J. Mangelsdorf, University of Texas Southwestern Medical Center Nutrient-Sensing and Metabolic Control by Nuclear Receptors
	Benita S. Katzenellenbogen, University of Illinois at Urbana-Champaign Genomics of Estrogen Receptor Signaling in Breast Cancer and Endocrine Resistance
	Myles Brown, Dana Farber Cancer Institute Nuclear Receptor Cistromes and Epigenomes
	Edwin Cheung, Genome Institute of Singapore Short Talk: Global and Funcational Analyses of ER-Mediated Long-Range Chromatin Interactions
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys
8:00 - 11:00 PM	Entertainment	Shavano/Torreys
Friday, March 26
	Departure

*Session Chair †Speaker invited, not yet responded.