Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Developmental Origins and Epigenesis in Human Health and Disease (D1)

Organizer(s): Judith Swain, Peter D. Gluckman, Michael Meaney and Anne Ferguson-Smith
April 26 - 30, 2010
Swissotel The Stamford · Singapore,
Abstract Deadline: December 28, 2009
Late Abstract Deadline: January 29, 2010
Scholarship Deadline: December 28, 2009
Early Registration Deadline: March 12, 2010

In collaboration with Agency for Science, Technology and Research (A*STAR)

This meeting took place in the 2010 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Environmental Epigenomics and Disease Susceptibility (D3)
March 27 - April 1, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Developmental plasticity results from the interplay of fetal environment and genetic factors. There is considerable data to indicate that these interactions play an important role in the susceptibility of the individual to the development of chronic diseases such as diabetes, obesity, and to the cognitive capacity of that individual. Evidence suggests that gene/environment interactions may result in epigenetic changes that not only indicate susceptibility to chronic disease, but may play a causative role in the processes. The specific nature of the signaling pathways that dictate these susceptibilities and capacities are not known. This symposium is designed to explore experimental models of development, to understanding the role of epigenetics in regulating important signaling pathways, and to examine the relationship of the fetal environment to normal development and the susceptibility to chronic disease.

Monday, April 26
3:00 - 7:30 PM	Registration	Stamford Foyer
6:30 - 7:30 PM	Refreshments	Stamford Foyer
7:30 - 7:45 PM	Opening Address and Welcoming Remarks	Stamford Ballroom
	* Judith L. Swain, Singapore Institute for Clinical Sciences
	Chuan Poh Lim, Chairman, Agency for Science Technology and Research (A*STAR)
7:45 - 8:45 PM	Keynote Address	Stamford Ballroom
	* Anne Ferguson-Smith, University of Cambridge
	Adrian P. Bird, University of Edinburgh Investigating the Molecular Basis of Rett Syndrome
Tuesday, April 27
8:00 - 9:00 AM	Breakfast	Stamford Ballroom
8:00 - 9:00 AM	Poster Setup	Stamford Foyer
9:00 AM - 12:00 PM	Mechanisms of Developmental Plasticity	Stamford Ballroom
	* Anne Ferguson-Smith, University of Cambridge Genomic Imprinting as an Adaptive Model of Developmental Plasticity
	Stephen M. Cohen, Temasek Life Sciences Laboratory MicroRNA Functions: Insights from Drosophila Genetics
	Emma Whitelaw, Queensland Institute of Medical Research Epigenetics and Transgenerational Effects
	John S. Mattick, University of Queensland RNA as the Regulator of Epigenetic Memory and the Mediator of Epigenome-Environment Interactions
	Kian Peng Koh, Immune Disease Institute, Harvard Medical School Short Talk: Tet1/Cxxc6 and Related Enzymes, a New Family of 5-Methylcytosine Hydroxylases, Modulate Pluripotency and Cell Lineage Specification in Mouse Embryonic Stem Cells
10:20 - 10:40 AM	Coffee Break	Stamford Foyer
12:00 - 1:00 PM	Lunch	Stamford Ballroom
12:00 - 5:00 PM	Poster Viewing	Stamford Foyer
12:00 - 2:30 PM	Poster Session 1	Stamford Foyer
2:30 - 3:00 PM	Coffee Available	Stamford Foyer
3:00 - 5:00 PM	Phenotypic Plasticity in Evolution	Stamford Ballroom
	* Russell D. Fernald, Stanford University Social Control of the Brain

	Hamish G. Spencer, University of Otago The Evolution of Phenotypic Plasticity: Insights from Theory



	Yijun Ruan, Genome Institute of Singapore Short Talk: Estrogen Induced Chromatin Interaction and Transcription Regulation in Cancer Cells
Wednesday, April 28
8:00 - 9:00 AM	Breakfast	Stamford Ballroom
8:00 - 9:00 AM	Poster Setup	Stamford Foyer
9:00 AM - 12:00 PM	Developmental Influences in Chronic Disease	Stamford Ballroom
	* Peter Gluckman, University of Auckland The Developmental Contribution to the Risk of Chronic Disease
	Caleb E. Finch, University of Southern California Early Exposure to Infections Accelerates Aging

	Joseph Nadeau, Case Western Reserve University Transgenerational Epigenetic Control of Phenotypic Variation and Disease Risk

10:20 - 10:40 AM	Coffee Break	Stamford Foyer
12:00 - 1:00 PM	Lunch	Stamford Ballroom
12:00 - 5:00 PM	Poster Viewing	Stamford Foyer
12:30 - 2:30 PM	Poster Session 2	Stamford Foyer
2:30 - 3:00 PM	Coffee Available	Stamford Foyer
3:00 - 5:00 PM	Neural and Developmental Epigenetics	Stamford Ballroom
	* Michael Meaney, McGill University Developmental Influences on Cognitive Processes

	Yi Eve Sun, University of California, Los Angeles DNA Methylation and Neural Cell Fate

	Zhao Xu, Beth Israel Deaconess Medical Center Short Talk: Pathway Discovery in Adipocyte Biology Using Epigenomics
	Assam El-Osta, Baker Heart Research Institute Short Talk: Persistent Changes in the Epigenetic Code Explaining Hyperglycemic Memory
Thursday, April 29
8:00 - 9:00 AM	Breakfast	Stamford Ballroom
9:00 - 11:40 AM	Environmental Control of Tissue Differentiation	Stamford Ballroom
	Zofia Zukowska, Georgetown University Gender-Specific Stress-Induced Programming for Obesity: Role of Neuropeptide Y and Adipose Stem Cells

	Davor Solter, Institute of Medical Biology
	Judy C. Sng, Singapore Institute of Clinical Sciences Control of the Critical Period in Sensory Development
	* Jonathan R. Seckl, University of Edinburgh School of Clinical Sciences & Community Health Glucocorticoid 'Programming' of the Brain: From Stress to Liquorice
10:20 - 10:40 AM	Coffee Break	Stamford Foyer
2:45 - 3:00 PM	Coffee Available	Stamford Foyer
3:00 - 5:00 PM	Environmental Factors and Developmental Plasticity	Stamford Ballroom

	Michael K. Skinner, Washington State University The Environment and Epigenetics on Transgenerational Inheritance
	Robert A. Waterland, Baylor College of Medicine The Search for Human Metastable Epialleles
	Corrado Spadafora, Istituto Superiore di Sanità (Italian National Institute of Health) Short Talk: Retrotransposons, Reverse Transcriptase and the Genesis of New Genetic Information
5:00 - 7:00 PM	Social Hour w/ Lite Bites	Stamford Foyer
Friday, April 30
	Departure

*Session Chair †Speaker invited, not yet responded.