Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Integration of Developmental Signaling Pathways (Z2)

Organizer(s): Jim Woodgett and Joseph Kelleher
March 23 - 28, 2010
Fairmont Empress Victoria · Victoria, British Columbia
Abstract Deadline: November 24, 2009
Late Abstract Deadline: December 29, 2009
Scholarship Deadline: November 24, 2009
Early Registration Deadline: January 25, 2010

Supported by The Directors' Fund

Joint meeting: New Paradigms in Cancer Therapeutics (Z1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
While the importance of developmental signaling pathways such as Wnt, Notch, TGFb, Hedgehog, Hippo, etc., in controlling cell fate determination, tissue organization/homeostasis, and their frequent abrogation in disease has been realized over the past few years, the molecular processes by which these pathways conspire combinatorially and temporally to build sophisticated cellular outcomes is only now becoming apparent. Moreover, simplistic approaches that selectively interfere with one pathway in isolation have resulted in unpredicted outcomes and revealed the presence of interdependencies that require consideration of contextual interactions. Therefore, effective therapeutic manipulation of these systems will require understanding of the mechanisms and interdependencies that determine complex physiology. This is emerging from diverse areas of biology and so requires a meeting of different minds to assimilate the findings. This symposium will bring together experts addressing the interactive mechanisms of developmental signaling with the aim of promoting better models of networks and the design of more effective therapeutic strategies.

Tuesday, March 23
3:00 - 7:30 PM	Registration	Prefunction 2
6:30 - 7:30 PM	Refreshments	Prefunction 2
7:30 - 8:30 PM	Keynote Address (Joint)	Salon B-C
	Hans C. Clevers, Hubrecht Institute Wnt, Lgr5 Stem Cells and Cancer

Wednesday, March 24
7:00 - 8:00 AM	Breakfast	Palm Court
8:00 - 11:15 AM	Integrating Signal Gradients in Development Hh vs. Wnt or TGFbeta, Notch, etc. in developing Neural Tube, Fly Wing Imaginal Disc., A/P or D/V Polarity etc.	Salon C
	* Elaine Fuchs, HHMI/Rockefeller University
	Jean-Denis Benazet, University of Basel Interlinked Signaling Feedback Loops and Self-Regulation during Mouse Limb Development


	Xi He, Harvard Medical School Mechanisms of Wnt Signaling and Regulation

	Chi-chung Hui, Hospital for Sick Children Regulators of Gli Transcription Factors in Development and Cancer


	Brandon J. Wainwright, University of Queensland The Intersection between Hedgehog and Notch Signaling in Development and Cancer
	Elizabeth Ann Grove, University of Chicago Signaling Gradients in Patterning the Mammalian Cerebral Cortex
9:20 - 9:40 AM	Coffee Break	Prefunction 2
11:00 AM -	On Own for Lunch and Recreation
11:00 AM - 1:00 PM	Poster Setup	Salon A
1:00 - 10:00 PM	Poster Viewing	Salon A
4:30 - 5:00 PM	Coffee Available	Prefunction 2
5:00 - 7:00 PM	Mechanisms of Signal Integration I - Hippo Pathway and Cilia	Salon C
	* Ken M. Cadigan, University of Michigan
	Jeremy F. Reiter, University of California, San Francisco Primary Cilia Transduce Hedgehog Signals in Both Development and Cancer
	Elaine Fuchs, HHMI/Rockefeller University Developmental Signaling Pathways in the Skin

	Helen McNeill, Samuel Lunenfeld Research Institute Fat Cadherins in the Regulation of Growth and Planar Cell Polarity
	Rhonda Hui Ping Kan, Institute for Molecular Bioscience Short Talk: N-myc and C-myc are Functionally Redundant in Mediating the Effects of Ptch1 Mutation in Epidermis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Salon A
7:30 - 10:00 PM	Poster Session 1	Salon A
Thursday, March 25
7:00 - 8:00 AM	Breakfast	Palm Court
8:00 - 11:15 AM	Targeting Developmental Pathways in Cancer (Joint)	Salon B-C
	* Marion B. Dorsch, Novartis Institutes for BioMedical Research Hedgehog Inhibitors

	A. Thomas Look, Dana-Farber Cancer Institute Activating Mutations in the ALK Tyrosine Kinase Provide a Therapeutic Target in Neuroblastoma
	Luisa Iruela-Arispe, University of California, Los Angeles Angiogenesis, Developmental Pathways and Cancer
	James F. Amatruda, University of Texas Southwestern Medical Center Short Talk: BMP Signaling in Germ Cell Differentiation and Germ Cell Tumors
	Leni S. Jacob, University of Texas Southwestern Medical Center Short Talk: Assignment of Aberrant Hedgehog and Wnt Pathway Activity to Disease by Genome-Wide RNAi in Cultured Cells
9:20 - 9:40 AM	Coffee Break	Prefunction 2
11:15 AM -	On Own for Lunch and Recreation
11:15 AM - 1:00 PM	Poster Setup	Salon A
1:00 - 10:00 PM	Poster Viewing	Salon A
4:30 - 5:00 PM	Coffee Available	Prefunction 2
5:00 - 7:00 PM	Mechanisms of Signal Integration II - Coordinated Proteolysis	Salon C
	* Xi He, Harvard Medical School
	Randall T. Moon, University of Washington School of Medicine Elucidating Wnt/beta-Catenin Signaling Networks by Integrated siRNA, Proteomic, and Small Molecule Screens
	Jin Jiang, University of Texas Southwestern Medical Center Kinase Regulation of Hedgehog Signaling


	Ying E. Zhang, National Cancer Institute, National Institutes of Health Proteolysis in TGF-beta Signaling and Cancer
	Masahiro Narimatsu, Samuel Lunenfeld Research Institute, Mount Sinai Hospital Short Talk: Smurf Ubiqutin Ligases are Required for Embryo Patterning during Gastrulation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Salon A
7:30 - 10:00 PM	Poster Session 2	Salon A
Friday, March 26
7:00 - 8:00 AM	Breakfast	Palm Court
8:00 - 11:00 AM	Mechanisms of Integration III - Transcriptional Regulation and/or Epigenetics/Reversible Histone Methylation	Salon C
	* Austin G. Smith, University of Cambridge

	Michael D. Taylor, Hospital for Sick Children A Role for Histone Lysine Methylation in the Pathogenesis of Pediatric Brain Tumors?

	Marion B. Dorsch, Novartis Institutes for BioMedical Research Smoothened Antagonists: Anticipating and Treating Resistance

	Ken M. Cadigan, University of Michigan Selection of Wnt Targets and Subsequent Chromatin Modifications

	Feng Cong, Novartis Institutes for BioMedical Research Short Talk: Targeting Wnt Signaling through TNKS Inhibition and Axin Stabilization

	Felix Lohmann, Novartis Institutes for BioMedical Research Short Talk: KMT1E Mediated H3K9 Methylation is Required for the Maintenance of Embryonic Stem Cells by Repressing Trophectoderm Differentiation
	Robert Rottapel, Princess Margaret Hospital, Toronto Medical Discovery Tower Short Talk: Tankyrase Functions as a Cross-Regulator of Signalling Pathways
9:20 - 9:40 AM	Coffee Break	Prefunction 2
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Prefunction 2
5:00 - 7:00 PM	Stem Cell Fate and Signaling	Salon C
	* Morag Park, McGill University
	Jim Woodgett, Mount Sinai Hospital Coordinate Regulation of Multiple Signaling Pathways and Differentiation Processes by Glycogen Synthase Kinase-3
	Austin G. Smith, University of Cambridge Intrinsic and Extrinsic Regulation of the Pluripotent Ground State

	Jeffrey L. Wrana, Mount Sinai Hospital Cell Fate and Polarity Signals
	Rita U. Lukacs, University of California, Los Angeles Short Talk: Bmi-1 is a Dominant Self-Renewal Gene in the Murine Prostate that Controls both Stem Cell Maintenance and Cancer Initiation
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Salon A
Saturday, March 27
7:00 - 8:00 AM	Breakfast	Palm Court
8:00 - 11:00 AM	Integrated Signaling in Tumor/Stromal Interaction Emerging stories around tumors and stroma feeding each other signals and each changing to reinforce cancer.	Salon C
	* Jeffrey L. Wrana, Mount Sinai Hospital
	Morag Park, McGill University Breast Tumor Microenvironment: Impact on Tumor Heterogeneity and Outcome

	John Condeelis, Albert Einstein College of Medicine The Tumor Microenvironment Invasion Signature: Effects on Tumor Cell Plasticity in vivo
	Christine Dierks, University of Freiburg Hedgehog Signaling in Hematologic Malignancies
	Minoti Apte, University of New South Wales Pancreatic Stellate Cells: Partners in Crime with Pancreatic Cancer Cells
	Gabri Van der Pluijm, Leiden University Medical Center Short Talk: TGFbeta-BMP7 Interactions in Bone Metastasis; Potential Therapeutic Implications
9:20 - 9:40 AM	Coffee Break	Prefunction 2
11:00 AM -	On Own for Lunch and Recreation
4:30 - 5:00 PM	Coffee Available	Prefunction 2
5:00 - 7:00 PM	Aberrant Signal Interactions and Disease	Salon C
	* Jim Woodgett, Mount Sinai Hospital
	Geraldine Weinmaster, David Geffen School of Medicine at UCLA Ligand Endocytosis and Force Generation in Activation of Notch Signaling

	Bruce A. Edgar, Zentrum für Molekulare Biologie University of Heidelberg Signaling and Stem Cell Control in the Drosophila Intestine
	Adolfo Ferrando, Columbia University NOTCH1 Transcriptional Networks in Human Leukemia
	Daniela Quail, University of Western Ontario Short Talk: Nodal Promotes Metastasis and Stem Cell Phenotypes in Breast Cancer
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Palm Court
8:00 - 11:00 PM	Entertainment	Palm Court
Sunday, March 28
	Departure

*Session Chair †Speaker invited, not yet responded.