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Cilia, Signaling and Human Disease (G1)

Organizer(s): Peter Jackson and Tim Stearns
February 21 - 26, 2010
Portola Hotel & Spa  ·  Monterey, California
Abstract Deadline: October 21, 2009
Late Abstract Deadline: November 20, 2009
Scholarship Deadline: October 21, 2009
Early Registration Deadline: December 21, 2009


Supported by The Directors' Fund



This meeting took place in the 2010 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Proteins mediating a host of signaling pathways are organized within primary cilia. Human genetic studies have identified many developmental and degenerative diseases linked to ciliary function. These “ciliopathies” include retinal degeneration, sensory and neurological deficiencies, polycystic kidney disease, and obesity. Molecular genetic studies have connected ciliary transport and assembly mechanisms to developmental pathways, including the Hedgehog pathway, and signaling pathways, including GPCR regulators, but much remains unclear. This meeting will focus on how signaling is organized within cilia. Presentations will span signaling, the cell biology of cilia, human and molecular genetics of ciliopathies, and the biology of ciliated tissues, including morphogen pathways, tissue repair, and links to cell cycle or tumor suppressor control. Drawing on broad expertise and multiple systems, we hope to discuss both well-validated and candidate ciliary genes. The goal is to better define pathways coordinating morphogenesis of ciliated tissue with ciliary assembly and signaling.

Sunday, February 21
3:00 - 7:30 PM Registration De Anza Foyer
6:30 - 7:30 PM Refreshments De Anza I-II
Monday, February 22
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:00 AM Cell Biology of Cilia and Intraflagellar Transport De Anza III
* Tim Stearns, Stanford University
Joel Rosenbaum, Yale University
Role of IFT in trafficking of polypeptides to and from the ciliary membrane and axoneme
Jonathan Scholey, University of California, Davis
Intraflagellar Transport Motors in C. elegans Neurons
George B. Witman, University of Massachusetts Medical School
Chlamydomonas as a Model for Human Ciliopathies
Gregory Pazour, University of Massachusetts Medical School
Trafficking Proteins to the Ciliary Membrane
Christopher J. Westlake, Genentech, Inc.
Short Talk: Building the Primary Cilium Membrane: Regulation of GEF Trafficking and Activity and a Rab11-Rab8 Cascade
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:00 AM - On Own for Lunch and Recreation
11:00 AM - 1:00 PM Poster Setup De Anza I-II
1:00 - 10:00 PM Poster Viewing De Anza I-II
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:00 PM Bardet-Biedl Syndrome, Alstrom Syndrome, Obesity Syndromes De Anza III
* Jonathan Scholey, University of California, Davis
Val C. Sheffield, University of Iowa
Human Genetics, Function, and Physiology in Bardet-Biedl Syndrome
Maxence V. Nachury, Stanford University School of Medicine
The BBSome is a coat complex for trafficking to the cilium / Discovery and characterization of tubulin acetyl-transferase
Juergen K. Naggert, The Jackson Laboratory
Alstrom Syndrome, a Ciliopathy
Wallace Marshall, University of California, San Francisco
Short Talk: The Flagellar Length Control System
7:00 - 8:00 PM Social Hour w/ Lite Bites De Anza Foyer
7:30 - 10:00 PM Poster Session 1 De Anza I-II
Tuesday, February 23
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:15 AM Morphogen Pathways and Cilia De Anza III
* John Wallingford, University of Texas at Austin
Matthew P. Scott, Stanford University
Hedgehog Signaling: Tracking Down Smo
Andrew P. McMahon, Harvard University
Defective Hedgehog Signaling
H. Joseph Yost, University of Utah
FGF Signaling Pathways and Heparan Sulfate Proteoglycan Fine Structures Converge at Cilia in the Development of Diverse Epithelia
Martin Blum, University of Hohenheim
Short Talk: The Nodal Inhibitor Coco Represents the Critical Target of Leftward Flow in Xenopus
Ivan P.G. Moskowitz, University of Chicago
Short Talk: An Allelic Series of Intraflagellar Transport Protein 172 Implicates a Quantitative Loss of Hedgehog Signaling in VACTERL with Hydrocephalus
Jeremy F. Reiter, University of California, San Francisco
Ofd1, a Ciliopathy Gene, Regulates the Length and Distal Structure of Centrioles
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:15 AM - On Own for Lunch and Recreation
11:15 AM - 1:00 PM Poster Setup De Anza I-II
1:00 - 10:00 PM Poster Viewing De Anza I-II
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:00 PM Neural Development De Anza III
* Matthew P. Scott, Stanford University
Kathryn V. Anderson, Memorial Sloan-Kettering Cancer Center
Trafficking in Primary Cilia and Hedgehog Signaling
Joseph G. Gleeson, University of California, San Diego
Uncovering New Signaling Mechanisms in the Ciliopathy Disorders
Jonathan T. Eggenschwiler, Princeton University
Short Talk: Broad-Minded Links Ciliary Assembly, Cell Cycle-Related Kinase Function, and Mammalian Hedgehog Signaling
Chris R. Kintner, The Salk Institute
Developmental Mechanisms Specifying Different Cilia Subtypes
7:00 - 8:00 PM Social Hour w/ Lite Bites De Anza Foyer
7:30 - 10:00 PM Poster Session 2 De Anza I-II
Wednesday, February 24
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:15 AM Sensory Events and Cilia De Anza III
* Jeremy F. Reiter, University of California, San Francisco
Piali Sengupta, Brandeis University
Generation and Maintenance of Specialized Sensory Cilia in C. elegans
Abigail Tadenev, Johns Hopkins School of Medicine
Short Talk: Olfactory Phenotypes of BBS8-Null Mice
Jagesh V. Shah, Harvard Medical School
Short Talk: Identification of Signaling Pathways Regulating Primary Cilium Length and Flow-Mediated Adaptation
Tomer Avidor-Reiss, Harvard Medical School
Centriole and Cilia - Formation and Inheritance
Brian Dynlacht, New York University School of Medicine
CP110 and Control of the Centriole and Cilia Biogenesis
John Wallingford, University of Texas at Austin
Planar Cell Polarity and Ciliogenesis
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:15 AM - On Own for Lunch and Recreation
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:15 PM Kidneys, Cysts, and Cystic Diseases De Anza III
* Brian Dynlacht, New York University School of Medicine
Peter C. Harris, Mayo Clinic
Role of Cilia in ADPKD and ARPKD
Friedhelm Hildebrandt, University of Michigan
Genes and Mechanisms of Nephronophthisis-Like Ciliopathies
Peter K. Jackson, Genentech, Inc.
The NPHP-Joubert-Meckel-Gruber Network
Michel R. Leroux, Simon Fraser University
Short Talk: Ciliary Transition Zone Proteins are Required for Proper Basal Body Positioning, Structural Integrity of the Ciliary Gate, and Proper Formation of the Axoneme
Rebecca D. Burdine, Princeton University
Short Talk: Seahorse and Kurly are Members of a Cytoplasmic Complex that Functions in Cilia Motility and Downstream Phenotypes
7:15 - 8:15 PM Social Hour w/ Lite Bites De Anza Foyer
Thursday, February 25
7:00 - 8:00 AM Breakfast De Anza I-II
8:00 - 11:00 AM Cell Cycle, Tumor Suppressors, and Cancer De Anza III
* Peter K. Jackson, Genentech, Inc.
Elizabeth Petri Henske, Brigham and Women's Hospital
Tuberous Sclerosis, LAM, and the Primary Cilium: Where are the Links?
James G. Umen, The Salk Institute
Short Talk: A Cyclin Dependent Kinase Mutant from Chlamydomonas Reveals a Conserved Role for the Retinoblastoma Tumor Suppressor Pathway in Cilia Biogenesis
Wilhelm Krek, ETH Zurich
VHL Tumor Suppression Mechanisms: From Maintenance of the Primary Cilium to Promotion of Error-free Mitosis
Benedicte Delaval,
The Cilia Protein IFT88 Forms Novel Mitotic Complexes and Functions in Spindle Pole Organization and the Orientation of the Mitotic Spindle and the Plane of Cell Division
Tim Stearns, Stanford University
From Microarrays to Cell Biology
9:20 - 9:40 AM Coffee Break De Anza Foyer
11:00 AM - On Own for Lunch and Recreation
2:30 - 4:30 PM Workshop: Short Talk Symposium De Anza III
* Peter K. Jackson, Genentech, Inc.
* Tim Stearns, Stanford University
Cosima T. Baldari, University of Siena
Intraflagellar Transport is Required for Polarized Recycling of the TCR/CD3 Complex to the Immune Synapse
Saikat Mukhopadhyay, Genentech, Inc.
"A Short Story of a Known Complex and an Unkown Cargo"
Heather H. Ward, University of New Mexico
A Multimeric GTPase Complex is Required for Trafficking Membrane Cystoproteins to Primary Cilia
Marina Bershteyn, Stanford University School of Medicine
MIM and Cortactin Antagonism Regulates Ciliogenesis and Hedgehog Signaling
Sander Basten, University Medical Center Utrecht
Ciliary Gene LRRC50 and Tumorigenesis
Peter G. Czarnecki, Mayo Clinic
Meckel-Gruber Syndrome Proteins MKS1 and MKS3 in Ciliary Homeostasis and Wnt Signaling
4:30 - 5:00 PM Coffee Available De Anza Foyer
5:00 - 7:00 PM Cilia, Evolution, and Human Disease De Anza III
* Anthony Oro, Stanford University
Arturo Alvarez-Buylla, University of California, San Francisco
Primary Cilia in Neural Stem Cells and Cancer
Mónica Bettencourt Dias, Instituto Gulbenkian de Ciência
Centriole Biogenesis and Evolution
Bill Wickstead, University of Oxford
Short Talk: Reconstructing the Evolutionary History of the Centriole from Protein Components
Nicholas Katsanis, Johns Hopkins School of Medicine
Total Mutational Load and Ciliary Disease
7:00 - 8:00 PM Social Hour w/ Lite Bites De Anza Foyer
8:00 - 11:00 PM Entertainment De Anza I-II
Friday, February 26
Departure
*Session Chair   †Speaker invited, not yet responded.



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