Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Rethinking the Pathogenesis of Asthma (B4)

Organizer(s): Daniel Rotrosen, Jeffrey M. Drazen and Stephen T. Holgate
February 8 - 13, 2002
Hilton Santa Fe/Historic Plaza · Santa Fe, New Mexico
Abstract Deadline: October 8, 2001
Early Registration Deadline: December 7, 2001

Sponsored by Aventis Pharmaceuticals, Inc. and Inflazyme Pharmaceuticals, Ltd.

This meeting took place in the 2002 season.

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Summary of Meeting
Asthma is a major cause of illness and disability worldwide. During the past 2-3 decades, the prevalence of asthma and morbidity due to asthma have increased substantially. Since previous models of asthma pathogenesis cannot explain this trend, this conference will bring together basic and clinical scientists representing a wide range of scientific disciplines to reexamine the pathogenesis of asthma from the perspective of new insights into human immune system development and biology and an expanding awareness of the role of environmental factors. Examples include advances in gene discovery and receptor-mediated signaling, an appreciation of the importance of early life events in molding the allergic diathesis, and an understanding of the role of the innate immune system in the establishment and maintenance of airway inflammation and hyperreactivity. This conference will highlight current research and future directions in areas that hold promise for the development of new therapeutic agents and preventive approaches.

Objectives
Upon completion of this conference, participants should be able to:

Reexamine the pathogenesis of asthma from the perspective of new insights into human immune system development and biology and an expanding awareness of the role of environmental factors.
Understand the role of the innate immune system in the establishment and maintenance of airway inflammation and hyperactivity.
Identify current research and future directions in areas that hold promise for the development of new therapeutic agents and preventative approaches.

Friday, February 8
4:00 - 7:00 PM	Registration	Promenade
6:15 - 7:15 PM	Welcome	Promenade
7:15 - 7:30 PM	Orientation	Mesa A-B
7:30 - 8:30 PM	Keynote Address. Sponsored in part by OSI Pharmaceuticals, Inc.	Mesa A-B
	Andrew Saxon, University of California, Los Angeles Environment, the Immune System and Asthma
Saturday, February 9
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Developmental Immunobiology and Immunologic Origins of Asthma	Mesa A-B
	* Fernando D. Martinez, University of Arizona
	Denis J. Reen, Our Lady's Hospital for Sick Children, Dublin T-Cell Function at Birth in Humans

	Patrick G. Holt, University of Western Australia Fetal and Neonatal Immunity in Asthma and Allergy
	Becky Adkins, University of Miami Medical School Development of Murine Neonatal Th1/Th2 Function
	Erika von Mutius, University Children's Hospital, Munich The Hygiene Hypothesis
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Mesa C
1:00 - 10:00 PM	Poster Viewing	Mesa C
2:30 - 4:30 PM	Workshop 1	Mesa A-B
	* K. Frank Austen, Harvard Medical School
	Talal A. Chatila, University of California, Los Angeles Function of the I4R Motif in IL-4Ra Signaling
	Udo Herz, Philipps-Universität Influence of Maternal Allergic Sensitization on the Development of Atopy in the Offspring
	Edith M. Hessel, Dynavax Technologies A Restricted Subset of Dendritic Cells Captures Airborne Allergens and Retains the Capacity to Activate Antigen-Specific T Cells Long after the Last Exposure
	Ann E. Welch, American Red Cross/Holland Lab Contribution of the IL-4Ra to Inflammatory Responses in the Lung
	David J. Klinke, Entelos, Inc. Contributions of Th2 Cytokines to Airway Hyperresponsiveness in Asthma
	Douglas A. Kuperman, University of California, San Francisco Direct Effects of IL-13 on Epithelial Cells Cause Airway Hyperreactivity and Mucus Production in the Absence of Inflammation
	Claudia Zuany-Amorim, Pfizer Global Research & Development Suppression of Airway Eosinophilia by Allergen Specific, IL-10-Producing Regulatory CD4+ T Cells from Heat-Killed Mycobacterium vaccae-Treated Mice
	Joel E. Tocker, Immunex Corporation Comparative Effects of Blocking either IL-4 or IL-4R in a Mouse Model of Asthma
4:30 - 5:00 PM	Coffee & Snacks Available	Promenade
5:00 - 7:00 PM	Immune Mechanisms in Asthma (Session I). Session Sponsored by AstraZeneca R&D, Lund.	Mesa A-B
	* Robert L. Coffman, Dynavax Technologies
	Stefanie N. Vogel, University of Maryland New Insights into Differential Gene Expression Induced by Toll-Like Receptors (TLRs) TLR2 vs. TLR4
	Bali Pulendran, Emory University Sensing Pathogens and Tuning Immune Responses with Dendritic Cells
	Muriel Moser, Université Libre de Bruxelles Dendritic Cell Regulation of Th1/Th2 Development
7:00 - 8:00 PM	Mixer	Promenade
8:00 - 10:00 PM	Poster Session 1: Immunologic Origins of Asthma/Immune Mechanisms in Asthma	Mesa C
Sunday, February 10
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:30 AM	Immune Mechanisms in Asthma (Session II) Session Sponsored by AstraZeneca R&D, Lund	Mesa A-B
	* A. Barry Kay, National Heart and Lung Institute
	K. Frank Austen, Harvard Medical School Mast Cell Effector Mechanisms
	Soman N. Abraham, Duke University Medical Center Caveolae Mediated Uptake of Particulate Allergens and Bacteria by Mast Cells
	Donald W. MacGlashan, Johns Hopkins University IgE and its Receptor
	Achsah D. Keegan, University of Maryland School of Medicine Signaling by the IL-4Ralpha
	Craig Gerard, Children's Hospital-Boston Complement in Asthma
9:20 - 9:40 AM	Coffee Break	Promenade
4:30 - 5:00 PM	Coffee & Snacks Available	Promenade
5:00 - 7:00 PM	Environmental Factors and Epidemiology of Asthma (Session I)	Mesa A-B
	* Jeffrey M. Drazen, New England Journal of Medicine
	Jonathan M. Samet, Johns Hopkins University The Changing Epidemiology of Asthma: What is the Environment's Role?
	Stephen T. Holgate, Southampton General Hospital Airway Epithelium and Responses to Environmental Factors
	Thomas A.E. Platts-Mills, University of Virginia Health System The Modified Th2 Response (IgG/IgG4) as a Mechanism of Tolerance to Inhaled Allergens
7:00 - 8:00 PM	Mixer	Promenade
Monday, February 11
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 11:00 AM	Environmental Factors and Epidemiology of Asthma (Session II)	Mesa A-B
	* Erika von Mutius, University Children's Hospital, Munich
	Scott T. Weiss, Brigham and Women's Hospital The Natural History of Asthma: Early Childhood Events and Asthma in Later Life: The Obesity/Growth Story
	Fernando D. Martinez, University of Arizona Gene-Environment Interactions
	Diane R. Gold, Brigham and Women's Hospital Environment, The Early Childhood Immune Response, and Asthma
	Charles G. Plopper, University of California, Davis Allergen-Ozone Interactions in Non-Human Primates
9:20 - 9:40 AM	Coffee Break	Promenade
11:00 AM - 1:00 PM	Poster Setup	Mesa C
1:00 - 10:00 PM	Poster Viewing	Mesa C
2:30 - 4:30 PM	Workshop 2	Mesa A-B
	* Thomas A.E. Platts-Mills, University of Virginia Health System
	Susan J. Wilson, University of Southampton Advanced Glycation End-Products in the Pathogenesis of Airway Remodeling in Asthma

	Kenji Izuhara, Saga Medical School Analysis of Novel Disease-Related Genes in Bronchial Asthma
	Philip J. Cooper, Hospital Pedro Vicente Maldonado Reduced Risk of Atopy Among School Age Children Infected with Geohelminth Parasites in a Rural Area of the Tropics
	Michael J. Evans, University of California, Davis Perlecan and Fibroblast Growth Factor-2 Immunoreactivity During Postnatal Development and Remodeling of the Basement Membrane Zone of Rhesus Monkeys Exposed to Allergen and Ozone
	Miriam F. Moffatt, University of Oxford Epigenetic Effects on Association of Atopic Disease to the SPINK5 Gene
	Benjamin J. Marsland, Malaghan Institute of Medical Research Influenza A Induced Memory CD8+ T Cells Inhibit Allergen-induced CD4+ T Cell Migration and Effector Function
	Andrea M. Keane-Myers, NIAID, National Institutes of Health Alterations in Allergic Inflammation Following Ascaris Infection
	Peter D. Sly, TVWT Telethon Institute for Child Health Measurement of Airway Tone in vivo to Assess Post-Viral Wheeze Mechanisms
4:30 - 5:00 PM	Coffee & Snacks Available	Promenade
5:00 - 7:00 PM	Genetics of Asthma	Mesa A-B
	* Stephen T. Holgate, Southampton General Hospital
	William O.C. Cookson, Wellcome Trust Centre for Human Genetics Genetics of Asthma: Recent Advances
	Carole Ober, University of Chicago Gene-Gene and Gene-Environment Interactions and the Genetics of Asthma
	Jeffrey M. Drazen, New England Journal of Medicine Pharmacogenetics of Asthma
7:00 - 8:00 PM	Mixer	Promenade
8:00 - 10:00 PM	Poster Session 2: Environmental Factors and Epidemiology of Asthma/Genetics and Therapeutics of Asthma	Mesa C
Tuesday, February 12
7:00 - 8:00 AM	Breakfast	Chamisa
8:00 - 10:45 AM	Novel Therapeutic Approaches (Session I). Session Sponsored by Merck & Co., Inc.	Mesa A-B
	* Achsah D. Keegan, University of Maryland School of Medicine
	Lars Jacobsen, ALK-Abello A/S Immunotherapy to Prevent Asthma in Children

	Arthur M. Krieg, Pfizer Research Technology Center Shifting from Th2 to Th1 with Immune Stimulatory CpG DNA
	A. Barry Kay, National Heart and Lung Institute Tolerance Induction by T Cell Peptide Immunotherapy
9:20 - 9:40 AM	Coffee Break	Promenade
4:30 - 5:00 PM	Coffee & Snacks Available	Promenade
5:00 - 7:00 PM	Novel Therapeutic Approaches (Session II). Session Sponsored by Merck & Co., Inc.	Mesa A-B
	* Arthur M. Krieg, Pfizer Research Technology Center

	Robert W. Egan, Schering-Plough Research Institute Eosinophils in Asthma
	Larry Borish, University of Virginia Medical Center Interleukin-4 Antagonism in the Treatment of Asthma
	Robert L. Coffman, Dynavax Technologies Modulating Th2 Responses in Asthma with Immunostimulatory DNA
7:00 - 8:00 PM	Mixer	Promenade
8:00 - 11:00 PM	Entertainment	Mesa Ballroom
Wednesday, February 13
	Departure

*Session Chair †Speaker invited, not yet responded.