Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

HIV Pathogenesis: Recent Advances in the Biology and Pathogenesis of Primate Lentiviruses (X7)

Organizer(s): Mario Stevenson, Bryan R. Cullen, Beatrice H. Hahn and Ronald C. Desrosiers
April 5 - 11, 2002
Keystone Resort · Keystone, Colorado
Abstract Deadline: December 13, 2001
Early Registration Deadline: February 5, 2002

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: HIV-1 Protection and Control by Vaccination (X8)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2002 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Steady advances are being made in understanding the functions of viral regulatory genes in virus replication and pathogenecity. However, there has been relatively little advance in attempting to exploit such regulatory proteins as antiviral targets. One goal of the meting would be to stimulate discussion on what regulatory protein functions could be exploited for antiviral strategies. Several emerging studies suggest that HIV-1 replication may persist in the host despite suppression of virus replication to below detectable limits by current plasma-based viral RNA assays. Thus, highly active antiretroviral therapy in its current form appears to be incapable of eradicating these reservoirs. The task ahead is to identify the nature of the persistent reservoir and to develop alternate strategies to more effectively control virus replication. In an attempt to establish the underlying basis for lymphocyte depletion in HIV-1 infection, investigators are taking various approaches to evaluate various aspects of the hematopoietic function, lymphocyte maturation, lymphocyte turnover and compartmentalization. These approaches are providing a more complete understanding of how primate lentiviruses affect lymphocyte depletion. In addition, these studies are providing important information on the processes that regulate hematopoiesis and lymphocyte function in humans. This information is critical to immune-based strategies to restore immune function in immunocompromised HIV-1 infected individuals. We believe that the meeting format will provide a unique opportunity for scientists with interests in AIDS immunology, virology and pathogenesis to be appraised of and to discuss the most exciting research developments and major problems in AIDS research. Such a forum does not exist outside of the National AIDS and Human Retrovirus meeting, however, the small size of the Keystone Symposium allows the intimacy in which scientific ideas can be exchanged and such an intimacy is not provided by the National AIDS meeting.

Objectives
Upon completion of this conference, participants should be able to:

Discuss what regulatory protein functions could be exploited for antiviral strategies.
Identify the nature of the persistent reservoir and to develop alternate strategies to more effectively control viral replication.
Evaluate various aspects of the hematopoietic function, lyphocyte maturation, lymphocyte turnover and compartmentalization.

Friday, April 5
4:00 - 7:00 PM	Registration	Shavano Foyer
6:15 - 7:15 PM	Welcome	Shavano Foyer
7:15 - 7:30 PM	Orientation	Shavano/Torreys
7:30 - 9:30 PM	Keynote Address (Joint)	Shavano/Torreys
	Rafi Ahmed, Emory University School of Medicine Vaccines and Immune Memory
	Joseph G. Sodroski, Dana Farber Cancer Institute Structure and Function of the HIV-1 Envelope Glycoproteins and Receptors
Saturday, April 6
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	HIV Life Cycle	Red Cloud
	* Bryan R. Cullen, Duke University Medical Center Role and Mechanism of Action of Tat and Rev
	* David Kabat, Oregon Health & Science University Innate Resistance of Human Lymphocytes to HIV-1 is Overcome by Vif
	Didier Trono, Ecole Polytechnique Fédérale de Lausanne HIV and Chromatin Remodeling Factors
	Mark A. Goldsmith, Genencor International, Inc. Determinants of Cellular Infection and Depletion by HIV-1
	Roger J. Pomerantz, Tibotec, Inc. Short Talk: Residual HIV-1 Disease Eradication (RHIDE) Using Stimulatory and Novel Intensification Therapy: Dissecting Residual Disease Pathogenesis
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	Enzymes	Red Cloud
	* Daria J. Hazuda, Merck Research Laboratories Inhibitors of HIV-1 Integrase
	Stuart F.J. Le Grice, National Cancer Institute, National Institutes of Health Programmed Initiation of DNA Synthesis in Lentiviruses
	Frederic D. Bushman, University of Pennsylvania School of Medicine Host Factors Affecting the Early Steps of HIV Replication
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 1	Grays Peak

Sunday, April 7
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Virus - Host Interactions (Joint)	Shavano/Torreys
	Dan R. Littman, New York University School of Medicine HIV Entry: Animal Models and Strategies for Vaccine Development
	* John P. Moore, Weill Medical College of Cornell University Studies on Disulfide-Stabilized HIV-1 Envelope Glycoproteins
	Robert W. Doms, University of Pennsylvania School of Medicine Virus Attachment, Receptor Engagement and Membrane Fusion
	James A. Hoxie, University of Pennsylvania New Insights into gp120-Chemokine Receptor Interactions from CD4-Independent Isolates of HIV-1 and HIV-2
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	HIV Structure (Joint)	Shavano/Torreys
	B. Matija Peterlin, University of California, San Francisco From Tat to Nef: Fine Tuning HIV Replication and Infectivity
	* Wesley I. Sundquist, University of Utah School of Medicine Biochemical and Structural Studies of HIV Budding

	Richard T. Wyatt, National Institutes of Health Analysis of HIV-1 Envelope Glycoproteins for Immunogen Design to Elicit Broadly Neutralizing Antibodies
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 2	Grays Peak
Monday, April 8
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Viral Pathogenesis (Joint)	Shavano/Torreys
	Robert F. Siliciano, Johns Hopkins School of Medicine Latency and Viral Evolution in HIV-1 Infection
	* Ashley T. Haase, University of Minnesota Mechanisms, Sites and Sources of Persistent Infection
	James I. Mullins, University of Washington Genetic Evolution in Forward and Reverse

	Douglas D. Richman, University of California, San Diego Rapid Evolution of Neutralizing Antibody Response following Primary HIV Infection
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	Immune Reconstitution and Therapeutic Vaccination (Joint)	Shavano/Torreys
	* Bruce D. Walker, Massachusetts General Hospital Harnessing the Immune System in the Fight Against AIDS
	Joseph M. McCune, Gladstone Institute of Virology and Immunology Regulation of T Lymphopoiesis in HIV Disease
	Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC Restoration of HIV-Specific Immunity with Immune-Based Therapeutic Strategies
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 3	Grays Peak

Tuesday, April 9
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Accessory Functions	Red Cloud
	* Warner C. Greene, Gladstone Institute of Virology and Immunology HIV Infection Results in G2 Cell Cycle Arrest in vivo
	Mario Stevenson, University of Massachusetts Medical School Mimicry of CD40 by HIV-1 Nef
	Nathaniel R. Landau, New York University School of Medicine Blocks to HIV Replication in Non-Human Cells

	Jon W. Marsh, National Institutes of Health Nef Actvity in T Cells
	Andreas S. Baur, University of Miami, School of Medicine Short Talk: The HIV NEF N-Terminus Activates LCK Involving A PcG-Complex Protein
	Jacek Skowronski, Cold Spring Harbor Laboratory Short Talk: Host Factors that Mediate Nef Function.
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	HIV Life Cycle	Red Cloud
	Michael H. Malim, King's College London School of Medicine Modulation of HIV-1 Infection Through VIF-Host Cell Interactions
	C. Martin Stoltzfus, University of Iowa Repression of HIV-1 RNA Splicing by Exonic Splicing Silencers
	Heinrich Göttlinger, Dana Farber Cancer Institute Host Factors in HIV-1 Particle Release
	Paul D. Bieniasz, Aaron Diamond AIDS Research Center Short Talk: Recruitment of Tsg101 to Sites of Particle Assembly, Mediated by Short Peptide Motifs, is Required for Efficient HIV-1 and Ebola Virus Particle Budding
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 4	Grays Peak
Wednesday, April 10
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Special Topics/Late Breaker	Red Cloud
	David Camerini, University of California, Irvine HIV-1 Mediated Signal Transduction via CCR5 Allows Infection of Resting Memory T Cells
	Jean-Marc Jacque, University of Massachusetts Medical School Modulating the HIV-1 Replication Cycle through RNAi
	Melissa J. Robbiani (Pope), Population Council Nef-Expressing Immature Dendritic Cells Secrete Inflammatory Cytokines and Chemokines, Activate Autologous CD4+ T Cells, and Rescue SIV Delta Nef Replication
	Michael P. Sherman, J. David Gladstone Institutes HIV-1 Vpr Nuclear Export is Required for Efficient Macrophage Infection in Lymphoid Tissue
	Christopher Aiken, Vanderbilt University School of Medicine Role of Virion Capsid Stability in HIV-1 Infection
	Olivier Schwartz, Institut Pasteur HIV-1 Nef-Induced Up-Regulation of DC-SIGN in Dendritic Cells Promotes Lymphocyte Clustering and Viral Spread
	Laura A. Napolitano, Gladstone Institute of Virology and Immunology Increased Thymic Mass and Circulating Naive CD4+ T Cell Counts in HIV-1-Infected Adults Treated with Growth Hormone
	Juan Lama, RetroVirox Inc. Cell-Surface CD4 Modulates HIV Infectivity in T-Cells
	Ann-Marie M. Roy, University of California, San Francisco Impact of Co-Receptor Use on HIV-1 "Burst Size" in Dispersed Human Lymphoid Tissue
	David McDonald, Case Western Reserve University HIV Trafficking in Dendritic Cells
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	Viral Evolution (Joint)	Shavano/Torreys
	Martine Peeters, IRD/University of Montpellier Ongoing Exposure of Humans to an Extraordinary Variety of Simian Immunodeficiency Viruses in West Central Africa: Identification of New SIV Lineages
	* Beatrice H. Hahn, University of Alabama at Birmingham SIVcpz Infection in Wild Chimpanzees
	Bette T. Korber, Los Alamos National Laboratory Factors that Drive the Diversity of the HIV-1 Epidemic.
7:00 - 8:00 PM	Mixer	Longs/Quandary
8:00 - 11:00 PM	Entertainment	Longs/Quandary
Thursday, April 11
	Departure

*Session Chair †Speaker invited, not yet responded.