Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

HIV-1 Protection and Control by Vaccination (X8)

Organizer(s): M. Juliana McElrath, Gary J. Nabel and Daniel R. Littman
April 5 - 11, 2002
Keystone Resort · Keystone, Colorado
Abstract Deadline: December 13, 2001
Early Registration Deadline: February 5, 2002

Sponsored by Wyeth-Lederle Vaccines

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: HIV Pathogenesis: Recent Advances in the Biology and Pathogenesis of Primate Lentiviruses (X7)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2002 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Recent progress in vaccine development offers hope that immunization may slow the HIV-1 epidemic. Insights into immune mechanisms of protection against HIV-1 infection and disease are emerging in clinical and animal studies, which can be applied to immunization strategies. New vaccines designed to elicit these immune responses are rapidly becoming available for implementation in human trials worldwide. Despite these advances, it remains unclear which approach is more likely to be efficacious, and if so, by what mechanism. The overall goal of this symposium is to accelerate understanding of the components necessary to prevent HIV-1 infection by vaccination, and to stimulate the scientific field to participate in moving this effort forward. The most current relevant studies will be integrated with recent advances in HIV pathogenesis and therapeutic interventions. The program will identify barriers to vaccine development, with the intent to foster new avenues of research collaborations that can overcome these hurdles.

Objectives
Upon completion of this conference, participants should be able to:

Discuss the most exciting research developments and major problems in AIDS research.
Recognize the components necessary to prevent HIV-1 infection by vaccination.
Identify barriers to vaccine development, with the intent to foster new avenues of research collaborations that can overcome these hurdles.
Develop new collaborations among the scientists in attendance and new insights that will lead to novel and effective interventions.

Friday, April 5
4:00 - 7:00 PM	Registration	Shavano Foyer
6:15 - 7:15 PM	Welcome	Shavano Foyer/Lobby
7:15 - 7:30 PM	Orientation	Shavano/Torreys
7:30 - 9:30 PM	Keynote Address (Joint)	Shavano/Torreys
	Rafi Ahmed, Emory University School of Medicine Vaccines and Immune Memory
	Joseph G. Sodroski, Dana Farber Cancer Institute Structure and Function of the HIV-1 Envelope Glycoproteins and Receptors
Saturday, April 6
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Current Strategies in Clinical Vaccine Trials	Shavano/Torreys
	* M. Juliana McElrath, Fred Hutchinson Cancer Research Center Induction of HIV-Specific Immunity in HIV-1 Vaccine Trials (HVTN)
	Emilio A. Emini, Wyeth Pharmaceuticals A Potential HIV Vaccine that Elicits Specific and Effective Cellular Immune Responses
	Andrew J. McMichael, John Radcliffe Hospital DNA and MVA Phase I Trials
	Barney S. Graham, NIAID, National Institutes of Health Phase I Clinical Trials
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	Preclinical Vaccine Trials: Promising Leads	Shavano/Torreys

	* David I. Watkins, University of Wisconsin-Madison T Cell Responses Against SIV
	Norman L. Letvin, Beth Israel Deaconess Medical Center Correlates of Immunity in the Macaque Model
	Jay A. Berzofsky, National Cancer Institute, National Institutes of Health The Importance of Mucosal Immunity in Controlling SHIV Infection and Strategies to Enhance Vaccines
	Jeffrey D. Lifson, SAIC-Frederick, Inc. Early Transient Antiretroviral Treatment of SIV Infection
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 1	Grays Peak
Sunday, April 7
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Virus - Host Interaction (Joint)	Shavano/Torreys
	Dan R. Littman, New York University School of Medicine HIV Entry: Animal Models and Strategies for Vaccine Development
	* John P. Moore, Weill Medical College of Cornell University Studies on Disulfide-Stabilized HIV-1 Envelope Glycoproteins
	Robert W. Doms, University of Pennsylvania School of Medicine HIV Entry and its Inhibition
	James A. Hoxie, University of Pennsylvania New Insights into gp120-Chemokine Receptor Interactions from CD4-Independent Isolates of HIV-1 and HIV-2
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	HIV Structure (Joint)	Shavano/Torreys
	B. Matija Peterlin, University of California, San Francisco From Tat to Nef: Fine Tuning HIV Replication and Infectivity
	* Wesley I. Sundquist, University of Utah School of Medicine HIV-1 Budding

	Richard T. Wyatt, National Institutes of Health HIV-1 Envelope Glycoproteins: Structural Insights and Vaccine Design
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 2	Grays Peak
Monday, April 8
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Viral Pathogenesis (Joint)	Shavano/Torreys
	Robert F. Siliciano, Johns Hopkins School of Medicine Latency and Viral Evolution in HIV-1 Infection
	* Ashley T. Haase, University of Minnesota The Fast Phase of Slow Lentiviral Infection

	James I. Mullins, University of Washington Selective Pressure and Progression of HIV Infection
	Douglas D. Richman, University of California, San Diego HIV Pathogenesis: Twenty Years of Successes and Failures
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	Immune Reconstitution and Therapeutic Vaccination (Joint)	Shavano/Torreys
	* Bruce D. Walker, Ragon Institute of MGH, MIT and Harvard Harnessing the Immune System in the Fight Against AIDS
	Joseph M. McCune, University of California, San Francisco HIV-induced perturbations of CD8+ T cell maturation
	Brigitte Autran, Hôpital Pitié-Salpétrière, UPMC Restoration of HIV-Specific Immunity with Immune-Based Therapeutic Strategies
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 3	Grays Peak

Tuesday, April 9
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Optimizing Antigenic Presentation and Effector Responses	Shavano/Torreys
	* Nina Bhardwaj, New York University School of Medicine Dendritic Cells: Antigen Presenting Functions and Applications to Vaccines
	James P. Allison, Memorial Sloan-Kettering Cancer Center More is Less: New Insights into the Mechanisms of Negative Costimulation by CTLA-4 and its Manipulation in the Enhancement of T Cell Responses
	Thomas Spies, Fred Hutchinson Cancer Research Center T Cell Costimulation by NKG2D

9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
11:00 AM - 1:00 PM	Poster Setup	Grays Peak
1:00 - 10:00 PM	Poster Viewing	Grays Peak
2:30 - 4:30 PM	Workshop 1: Vaccine Innovation and New Investigators	Shavano/Torreys
	* Mark B. Feinberg, Merck & Co., Inc.

	* Deborah L. Birx, Centers for Disease Control and Prevention
	Jason E. Hammonds, Emory University Enhanced Stability of Primary Isolate gp120 on Pseudovirions
	Erica Ollmann Saphire, The Scripps Research Institute Crystal Structures of a Broadly Neutralizing Antibody: Two Templates for HIV-1 Vaccine Design
	John R. Mascola, NIAID, National Institutes of Health Evaluating the Neutralizing Antibody Response Elicited by DNA and Recombinant Adenoviral Vaccines
	Francisco Veas, Institut de Recherche pour le Development Serial Analysis Genome Expression Method to Study Transcriptomes from Primary Human T Cells Activated by HIV Envelope or Chemokines
	Michael E. Horn, ProdiGene Expression of an SIV Protein in Transgenic Maize for Use as an Edible Vaccine and Reagent Supply


	Luzheng Liu, Brigham and Women's Hospital Antigen Presentation by Dendritic Cells Following MVA Vaccination
	Phillip W. Berman, University of California Santa Cruz Update on Phase III Vaccine Trials in the US and Thailand
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	New Vaccine Strategies	Shavano/Torreys
	* Gary J. Nabel, National Institutes of Health Progress in the Development of Improved AIDS Vaccines
	David D. Ho, Aaron Diamond AIDS Research Center Clade C Vaccine Approaches
	Philip R. Johnson, Children's Hospital, Columbus AAV Vectors as HIV Vaccines
	Marta L. Marthas, California National Primate Research Center Vaccination of Infant Macaques Against Oral Challenge with Pathogenic SIVmac251
7:00 - 8:00 PM	Mixer	Grays Peak
8:00 - 10:00 PM	Poster Session 4	Grays Peak
Wednesday, April 10
7:00 - 8:00 AM	Breakfast	Longs/Quandary
8:00 - 11:00 AM	Late Breaking Topics	Shavano/Torreys
	* Richard A. Koup, National Institutes of Health HIV and T Cell Help
	Teunis B.H. Geijtenbeek, University of Amsterdam Short Talk: Indetification of Different Binding Sites in DC-SIGN for ICAM-3 AND HIV-1
	Marcus Altfeld, Massachusetts General Hospital Short Talk: Enhancement of HIV-1-Specific CD8+ T Cell Responses During STI is Largely Due to the Expansion of CD8+ T Cell Responses Pre-Existing in Lymphoid Tissue
	Daniel C. Douek, NIAID, National Institutes of Health Short Talk: A Novel Approach to the Analysis of Specificity, Clonality and Frequency of HIV-Specific T Cell Responses Reveals a Mechanism for Control of Viral Escape
	Jianhong Cao, Fred Hutchinson Cancer Research Center Short Talk: Escape of HIV-1 Tat Specific CTL Response During Acute Infection
	Michael A. Egan, Wyeth Pharmaceuticals Short Talk: Immunogenicity and Protective Capacity of VSV-Based Vaccine Vectors Expressing Hiv-1 env and Siv gag in Rhesus Macaques
	Rama Rao Amara, Emory University Short Talk: MVA Compared to a DNA/MVA-Vaccine; Slower but Similar Long-Term Control of a SHIV 89.6P Challenge
	Todd M. Allen, Massachusetts General Hospital Short Talk: Acute Phase CTL Escape in SIV and HIV
	Bartek T. Zuber, Karolinska Institute Short Talk: CCR5 Gene Immunization Lowers Viral Setpoint and May Select for SIV that Uses CCR5 More Efficiently
	Douglas F. Nixon, University of California San Francisco Short Talk: Competitive Selection Pressures From Drug and Immune Responses on HIV RT and Protease Genes
9:20 - 9:40 AM	Coffee Break	Shavano Foyer/Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Shavano Foyer/Lobby
5:00 - 7:00 PM	Viral Evolution (Joint)	Shavano/Torreys
	Martine Peeters, IRD/University of Montpellier Ongoing Exposure of Humans to an Extraordinary Variety of Simian Immunodeficiency Viruses in West Central Africa: Identification of New SIV Lineages
	* Beatrice H. Hahn, University of Alabama at Birmingham SIVcpz Infection in Wild Chimpanzees
	Bette T. Korber, Los Alamos National Laboratory Implications of HIV Evolutionary Patterns for Vaccine Strain Selection
7:00 - 8:00 PM	Mixer	Longs/Quandary
8:00 - 11:00 PM	Entertainment	Longs/Quandary
Thursday, April 11
	Departure

*Session Chair †Speaker invited, not yet responded.