Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Frontiers in Structural Biology (Z2)

Organizer(s): Michael F. Summers, John Kuriyan and William I. Weis
April 13 - 19, 2004
Snowbird Resort · Snowbird, Utah
Abstract Deadline: December 15, 2003
Early Registration Deadline: February 13, 2004

Sponsored by The Director's Sponsor Fund

Joint meeting: Structural Genomics (Z1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2004 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Upon completion of this conference, participants should be able to: - Appreciate and understand the latest methodological breakthroughs that have enabled structural and dynamical studies of ever larger and complex systems at higher resolution and with greater throughput. - Appreciate and understand how the latest methodologies have been applied to current problems in biology, particularly those involving multiple components (i.e., systems that include combinations of proteins, nucleic acids and membranes). - Understand the role of dynamics in biomolecular interactions and function. Rapid technical developments in NMR, X-ray crystallography, atomic force microscopy, cyroelectron microscopy, and computational biology have led to the present explosion of knowledge in structural biology. While structural studies continue to flow into the databases at an ever-accelerating pace, there is an urgent need to couple the flood of structural information with biochemical and biophysical analysis of function. Insights into the structural organization and allosteric mechanisms of complex multidomain macromolecular assemblies, such as transcriptional and signaling complexes, will be important for understanding the malfunction of these systems in human diseases and in the development of therapeutics for cancer and other diseases. The organizers of this symposium find a need to bring together structural biologists working in diverse methodological areas that are interested in these common issues in biology.

Tuesday, April 13
3:00 - 7:00 PM	Registration	Ballroom Lobby
6:15 - 7:15 PM	Refreshments	Ballroom Mezzanine
7:15 - 7:30 PM	Orientation	Ballroom
7:30 - 9:30 PM	Keynote Session (Joint)	Ballroom
	* Michael F. Summers, University of Maryland Baltimore County and HHMI

	Kurt Wüthrich, ETH Zurich/The Scripps Research Institute Structural Biology and Proteomics using Solution NMR
	* Stephen K. Burley, Eli Lilly and Company
	Stephen C. Harrison, Harvard Medical School Assembling Structures
Wednesday, April 14
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby/Eagels Nest
8:00 - 11:00 AM	Membrane Proteins	Ballroom 2-3
	* Patricia A. Jennings, University of California, San Diego
	Donald M. Engelman, Yale University Folding and Evolution of Membrane Proteins

	Charles R. Sanders, Vanderbilt University School of Medicine Membrane Protein Folding, Misfolding, and Disease
	William M. Clemons, Harvard University Medical School X-ray Structure of a Protein-Conducting Channel


	Werner Kühlbrandt, Max-Planck-Institute of Biophysics Electron Microscopy of Membrane Transport Proteins
	Yafei Huang, New York University Medical Center Short Talk: Structure and Mechanism of the Glycerol-3-Phosphate Transporter
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM	Poster Setup	Wasatch/Superior/Superior Lobby
1:00 - 10:00 PM	Poster Viewing	Wasatch/Superior/Superior Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 6:50 PM	Pushing the Limits in Structural Biology I (Joint)	Ballroom
	* David A. Agard, University of California, San Francisco
	Brian T. Chait, Rockefeller University New Approaches for the Study of Protein Complexes

	Barry Honig, Columbia University and Howard Hughes Medical Institute Pushing the Limits of Computational Structural Biology
	Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Weak Alignment NMR: How Detailed a View Can We Get?
6:50 - 7:00 PM	NIH Protein Structure Initiative	Ballroom
	John C. Norvell, NIGMS, National Institutes of Health
7:00 - 8:00 PM	Social Hour	Wasatch/Superior/Superior Lobby
7:30 - 10:00 PM	Poster Session 1	Wasatch/Superior/Superior Lobby
Thursday, April 15
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby/Eagels Nest
8:00 - 11:00 AM	Signaling at the Membrane	Ballroom 2-3
	* Charles R. Sanders, Vanderbilt University School of Medicine

	Patricia A. Jennings, University of California, San Diego Structure and Mechanism of Kinases and Anchoring Proteins
	Wendell A. Lim, University of California, San Francisco The Logic of Signaling Switches and Scaffolds
	Daniel J. Leahy, Johns Hopkins School of Medicine Conformational Change in ErbB Receptor Signaling
	K. Christopher Garcia, Howard Huges Medical Institute Unraveling the Mechanisms of Neurotrophin Receptor Signaling
	Douglas M. Freymann, Northwestern University Short Talk: Structure of the Homo-Heterodimeric GTPase Core of the SRP Targeting Complex

9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM	Poster Setup	Wasatch/Superior/Superior Lobby
1:00 - 10:00 PM	Poster Viewing	Wasatch/Superior/Superior Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:00 PM	Macromolecular Interactions I	Ballroom 2-3
	* William I. Weis, Stanford University
	G. Marius Clore, National Institute of Diabetes and Digestive and Kidney Diseases Insights into Recognition in Transient Protein-Protein Complexes
	Wei Yang, National Institutes of Health Insights into the Mechanism of DNA Polymerase
	Sepideh Khorasanizadeh, University of Virginia Health System Recognition of Lysine-Methylated Histone Tails by the Chromodomain
	Josep Rizo, University of Texas Southwestern Medical Center Short Talk: Mad Conformational Signaling in the Mitotic Spindle Checkpoint
7:00 - 8:00 PM	Social Hour	Wasatch/Superior/Superior Lobby
7:30 - 10:00 PM	Poster Session 2	Wasatch/Superior/Superior Lobby
Friday, April 16
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby/Eagels Nest
8:00 - 11:00 AM	Macromolecular Machines	Ballroom 2-3

	* Dorothee Kern, Brandeis University
	James A. Spudich, Stanford University Single Molecule Analysis and the Myosin Family of Molecular Motors
	Seth A. Darst, Rockefeller University Structural Studies of Prokaryotic Transcription
	Nikola P. Pavletich, Memorial Sloan-Kettering Cancer Center and Howard Hughes Medical Institute Structural Biology of Ubiquitin Protein Ligases
	Tom E. Ellenberger, Washington University School of Medicine Visualizing the Beginning and End Game of DNA Replication
	Penmetcha K.R. Kumar, National Institute of Advanced Industrial Science & Technology Short Talk: Structural Basis of Activation of HutP by L-Histidine: A RNA-Binding Protein that Regulates the Transcription of Hut Operon in Bacillus subtilis
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM	Poster Setup	Wasatch/Superior/Superior Lobby
1:00 - 10:00 PM	Poster Viewing	Wasatch/Superior/Superior Lobby
4:00 - 5:00 PM	Plenary
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:00 PM	Pushing the Limits in Structural Biology II (Joint)	Ballroom
	* Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health
	Bridget Carragher, The Scripps Research Institute High Throughput Single Particle Electron Microscopy of Macromolecular Assemblies
	David A. Agard, University of California, San Francisco Pushing the Limits of Resolution in Light Microscopy
	Axel T. Brünger, Stanford University Structure of the ATPase p97/VCP
7:00 - 8:00 PM	Social Hour	Wasatch/Superior/Superior Lobby
7:30 - 10:00 PM	Poster Session 3	Wasatch/Superior/Superior Lobby
Saturday, April 17
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby/Eagels Nest
8:00 - 10:45 AM	Protein Stability and Design	Ballroom 2-3
	* Peter E. Wright, The Scripps Research Institute

	Brian W. Matthews, University of Oregon and Howard Hughes Medical Institute T4 Lysozyme as a Test Bed for Protein Design Algorithms



	A. Joshua Wand, University of Pennsylvania Protein Cold Denaturation
	David M. LeMaster, Wadsworth Center, New York State Department of Health The Absence of Kinetic Thermal Stabilization in a Hyperthermophile Rubredoxin Indicated by 40 Microsecond Folding in the Presence of Irreversible Denaturation
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
10:45 - 11:15 AM	Late Breaking Results	Ballroom 2-3
	Kristi Elizabeth Pullen, University of California, Berkeley Short Talk: An Alternate Conformation Stabilized by a Third Metal in the M. tuberculosis PP2c-Family Ser/Thr Protein Phosphatase
	Laura M. Guogas, Harvard University Short Talk: The Crystal Structure of an N-Terminal Basic Peptide Bound to Viral RNA
11:00 AM - 1:00 PM	Poster Setup	Wasatch/Superior/Superior Lobby
1:00 - 10:00 PM	Poster Viewing	Wasatch/Superior/Superior Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:00 PM	Protein and Small Molecule Design	Ballroom 2-3
	* A. Joshua Wand, University of Pennsylvania
	Susan Marqusee, University of California, Berkeley Engineering the Energy Landscape of Proteins

	Homme Hellinga, Duke University Medical Center Computational Design of Biologically Active Proteins
	John R. Desjarlais, Xencor Short Talk: From Structural to Biological Specificity: Improving Antibody Efficacy
	Qiaojuan Jane Su, Abgenix, Inc. Short Talk: Modeling of an EGFRvIII Antibody Combining Site and Simulation of Epitope-Paratope Interaction Energetics
7:00 - 8:00 PM	Social Hour	Wasatch/Superior/Superior Lobby
7:30 - 10:00 PM	Poster Session 4	Wasatch/Superior/Superior Lobby
Sunday, April 18
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby/Eagels Nest
8:00 - 11:15 AM	Macromolecular Interactions II	Ballroom 2-3


	* Michael F. Summers, University of Maryland Baltimore County and HHMI

	Gregory D. Bowman, John Hopkins University Mechanism of DNA Polymerase Clamp-Loaders
	Dorothee Kern, Brandeis University Rigidity and Catalysis in Thermophilic Enzymes
	Peter E. Wright, The Scripps Research Institute RNA Recognition by Zinc Fingers
	Thomas J. Hope, Northwestern University, Feinberg School of Medicine Fluorescent Visualization of HIV Entry and Trafficking in Living Cells
	Peter E. Prevelige, University of Alabama, Birmingham Short Talk: Identification of the Maturation Induced Changes in Intersubunit Interfaces within Intact HIV-1 Virions by Hydrogen/Deuterium Exchange Mass Spectrometry
	J.N. Mark Glover, University of Alberta Short Talk: The Structural Consequences of Mutations on the BRCA1 BRCT Domain
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:15 PM	The RNA World	Ballroom 2-3
	* Michael F. Summers, University of Maryland Baltimore County and HHMI
	Sarah A. Woodson, Johns Hopkins University Insights on RNA Folding Mechanisms from Group I Ribozymes
	Jennifer A. Doudna, University of California, Berkeley A Conformational Switch Controls Hepatitis Delta Virus Ribozyme Catalysis
	Thomas A. Steitz, Yale University and Howard Hughes Medical Institute How the CCA-Adding Enzyme Adds CCA to tRNA without Using an Oligonucleotide Template
	Dinshaw J. Patel, Memorial Sloan-Kettering Cancer Center Short Talk: Crystallographic Structures of Two Protein-siRNA Complexes in the RNA Interference Pathway
	Jeffrey M. Vargason, NIEHS, National Institutes of Health Short Talk: Size Selective Recognition of siRNA by an RNA Silencing Suppressor
7:15 - 8:00 PM	Social Hour	Ballroom Mezzanine
8:00 - 11:00 PM	Entertainment	Ballroom
Monday, April 19
	Departure

*Session Chair †Speaker invited, not yet responded.