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Cell Migration and Adhesion (D3)

Organizer(s): Frank B. Gertler and Denise Montell
April 9 - 14, 2005
Snowbird Resort  ·  Snowbird, Utah
Abstract Deadline: December 8, 2004
Early Registration Deadline: February 9, 2005


Supported by The Director's Fund



This meeting took place in the 2005 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Cell motility and adhesion play key roles in organismal development, physiology and disease. Movement requires coordinated regulation of cellular protrusions, adhesion, contractile forces and rear detachment. Migrating cells must respond to a plethora of diffusible and surface bound environmental cues and integrate these signals to coordinate the dynamic cytoskeletal remodeling underlying movement. In the past few years, advances in imaging, biochemical purification and genetics have resulted in an explosion in the study of movement at the molecular, cellular and organismal levels. The goal of this meeting is to bring together leading experts in different aspects of cell migration to discuss recent developments in the field and emerging technologies.

Saturday, April 9
3:00 - 7:30 PM Registration Ballroom Lobby
6:30 - 7:30 PM Refreshments Ballroom Mezzanine & Lobby
7:30 - 8:30 PM Keynote Address Ballroom 2-3
John Condeelis, Albert Einstein College of Medicine
Actin Polymerization Pathways Contributing to Cell Migration in vivo during Tumor Invasion and Metastasis
Sunday, April 10
7:00 - 8:00 AM Breakfast Golden Cliff/Eagles Nest
8:00 - 11:00 AM Cellular Protrusions Ballroom 2-3
* Gary G. Borisy, Northwestern University Medical School
Cytoskeletal Assembly during Lamellipodial and Filopodial Extension
Naoki Watanabe, Kyoto University, Faculty of Medicine
Short Talk: Molecular Kinetics of the Arp 2/3 Complex and Capping Proteins at the Leading Edge
Giorgio Scita, IFOM Foundation at Campus IFOM-IEO
Short Talk: Eps8Ls Define a Novel Family of Barbed End Capping Proteins Involved in Signaling to Actin-Based Motility
Julie A. Theriot, Stanford University
Biophysical Forces Underlying Protrusion
John H. Hartwig, Brigham and Women's Hospital
Cytoskeletal Remodeling during Platelet Activation
9:20 - 9:40 AM Coffee Break Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM Poster Setup Superior/Superior Lobby/Maybird
1:00 - 10:00 PM Poster Viewing Superior/Superior Lobby/Maybird
4:30 - 5:00 PM Coffee & Snacks Available Ballroom Mezzanine & Lobby
5:00 - 7:00 PM Cell Adhesion Ballroom 2-3
* Alan Rick Horwitz, University of Virginia
The Regulation of Adhesion Turnover and Protrusion
Gareth E. Jones, King's College London
WASP Signalling to Podosome Turnover in Migrating Dendritic Cells
Patricia J. Keely, University of Wisconsin-Madison
Ras Protein Regulation of Adhesion and Membrane Protrusion
Ellen J. Ezratty, Columbia University
Short Talk: Microtubule Induced Focal Adhesion Disassembly is Regulated by Dynamin and Focal Adhesion Kinase
7:00 - 8:00 PM Social Hour Superior/Superior Lobby/Maybird
7:30 - 10:00 PM Poster Session 1 Superior/Superior Lobby/Maybird
Monday, April 11
7:00 - 8:00 AM Breakfast Golden Cliff/Eagles Nest
8:00 - 11:00 AM Cell Polarity Ballroom 2-3
* Peter N. Devreotes, Johns Hopkins University
Lipid Signaling, Directional Sensing, and Cell Shape Control
William Wood, Instituto de Medicina Molecular
Short Talk: Drosophila Macrophages Require Phosphoinositide 3-Kinase to Chemotax Towards a Wound but not for Developmental Migrations
Jean-François Côté, Clinical Research Institute of Montreal
Short Talk: A Novel and Evolutionarily Conserved PtdIns(3,4,5)P3-Binding Domain is Necessary for DOCK180-Induced Cell Migration
Clare M. Waterman-Storer, National Heart, Lung and Blood Institute National Institutes of Health
Microtubule Dynamics and Cell Polarity
Kozo Kaibuchi, Nagoya University Graduate School of Medicine
Signaling for Neuronal Polarity
9:20 - 9:40 AM Coffee Break Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM Poster Setup Superior/Superior Lobby/Maybird
1:00 - 10:00 PM Poster Viewing Superior/Superior Lobby/Maybird
4:30 - 5:00 PM Coffee & Snacks Available Ballroom Mezzanine & Lobby
5:00 - 7:00 PM Signaling Pathways Ballroom 2-3
* Keith W.T. Burridge, University of North Carolina at Chapel Hill
Regulation of Rho Protein Guanine Nucleotide Exchange Factors
Andres M. Lebensohn, Harvard Medical School
Short Talk: Pure Native WAVE2 Complex is Tightly Inhibited in its Basal State, and Cannot be Activated in vitro by Rac or Nck
Mark H. Ginsberg, University of California, San Diego
Integrin Signaling in Cell Migration
Ronald D. Vale, University of California, San Francisco
Genomic Screen for Proteins that Affect Cell Morphology
7:00 - 8:00 PM Social Hour Superior/Superior Lobby/Maybird
7:30 - 10:00 PM Poster Session 2 Superior/Superior Lobby/Maybird
Tuesday, April 12
7:00 - 8:00 AM Breakfast Golden Cliff/Eagles Nest
8:00 - 11:00 AM Cytoskeletal Dynamics Ballroom 2-3
* John A. Cooper, Washington University
The Role of Cortactin in Actin Assembly and Cell Motility
Margaret A. Titus, University of Minnesota
Unconventional Myosins
Rex L. Chisholm, Northwestern University Feinberg School of Medicine
In Vivo Analysis Of MLCK Activity During Cell Migration, Spreading and Mitosis.
Gregg G. Gundersen, Columbia University
Regulation of Microtubules by Rho GTPases in Migrating Cells
9:20 - 9:40 AM Coffee Break Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM Poster Setup Superior/Superior Lobby/Maybird
1:00 - 10:00 PM Poster Viewing Superior/Superior Lobby/Maybird
2:30 - 4:30 PM Cell Migration Consortium Workshop
Alan Rick Horwitz, University of Virginia
J. Thomas Parsons, University of Virginia Health Science Center
4:30 - 5:00 PM Coffee & Snacks Available Ballroom Mezzanine & Lobby
5:00 - 7:00 PM Epithelial Cell Migration and Adhesion Ballroom 2-3
* Mark Peifer, University of North Carolina at Chapel Hill
Epithelial Morphogenesis in Drosophila
Joan S. Brugge, Harvard Medical School
Migration in Epithelial Cell Culture Systems
Walter Birchmeier, Max Delbruck Center for Molecular Medicine
Essential Role of BCL9-2 in the Switch between ß-Catenin’s Adhesive and Transcriptional Functions
Melinda Larsen, University at Albany, State University New York
Short Talk: Visualizing Epithelial Cell Dynamics During Branching Morphogenesis
7:00 - 8:00 PM Social Hour Superior/Superior Lobby/Maybird
7:30 - 10:00 PM Poster Session 3 Superior/Superior Lobby/Maybird
Wednesday, April 13
7:00 - 8:00 AM Breakfast Golden Cliff/Eagles Nest
8:00 - 11:00 AM Axon Guidance Ballroom 2-3
* Frank B. Gertler, Massachusetts Institute of Technology
Actin Dynamics in Axon Formation and Guidance
David L. Van Vactor, Harvard Medical School
Signaling Mechanisms that Control Axon Guidance in Drosophila
Yi Rao, Peking University
Signal Transduction in Netrin-Mediated Attraction
James P. Fawcett, Mount Sinai Hospital
Short Talk: Functions of the Adaptor Protein NCK in Neuronal Development
9:20 - 9:40 AM Coffee Break Ballroom Mezzanine & Lobby
4:30 - 5:00 PM Coffee & Snacks Available Ballroom Mezzanine & Lobby
5:00 - 7:00 PM Migration in vivo Ballroom 2-3
* Denise J. Montell, Johns Hopkins School of Medicine
Developmental Control of Border Cell Migration
Ruth Lehmann, New York University School of Medicine
Germ Cell Migration
Paul Martin, University of Bristol
Live Studies of Wound Healing and Inflammation
Francis G. Szele, Northwestern University
Short Talk: Multiple Dynamic Behaviors in the Rostral Migratory Stream Visualized with Multiphoton Time-lapse Microscopy
8:00 - 9:00 PM Social Hour Ballroom 2-3
8:00 - 11:00 PM Entertainment Ballroom 2-3
Thursday, April 14
Departure
*Session Chair   †Speaker invited, not yet responded.



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