Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Central Nervous System Inflammation: Mechanisms, Consequences and Therapeutic Strategies (J2)

Organizer(s): Scott R. Barnum, Iain L. Campbell and Pedro R. Lowenstein
January 11 - 15, 2005
Snowbird Resort · Snowbird, Utah
Abstract Deadline: September 17, 2004
Early Registration Deadline: November 11, 2004

Sponsored by Sanofi-Aventis Pharmaceuticals, Inc. and The Director's Fund

Joint meeting: Molecular Mechanisms of Transmissible Spongiform Encephalopathies (Prion Diseases) (J1)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2005 season.

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see our meeting list, or search for a meeting.

Summary of Meeting
Knowledge of the immunologic and inflammatory mechanisms contributing to acute and chronic central nervous system (CNS) diseases has increased dramatically in recent years. Inflammatory mediators and cellular processes once thought to be restricted to peripheral immune responses are now known to be central to the pathogenesis of many important CNS diseases, such as multiple sclerosis, Alzheimer's disease, stroke, HIV-dementia and others. Immune cell recruitment and regulation in the brain are known to be molded by the CNS environment where cells such as the microglia and astrocytes elaborate a variety of potent regulatory mediators. The mediators include an expanding array of cytokines, chemokines, proteases, as well as, complement proteins and reactive oxygen species. Determining the role of these mediators in CNS disease has been advanced considerably by the development of transgenic and knockout animal models. These animal models have, in many cases, provided unexpected results, thus broadening our understanding of inflammatory mechanisms in the CNS. This meeting will address recent advances in basic mechanisms, model approaches and novel therapies in immunologic and inflammatory diseases of the CNS and promote the interaction of basic and clinical researchers from diverse fields representing academia and industry.

Tuesday, January 11
3:00 - 7:30 PM	Registration	Ballroom Lobby
6:30 - 7:30 PM	Refreshments	Ballroom Mezzanine & Lobby
7:30 - 8:30 PM	Keynote Address	Ballroom 2
	* Scott R. Barnum, University of Alabama at Birmingham
	Jonathon D. Sedgwick, Lilly-Singapore Insights at the Molecular Level of Cell-Cell Interactions Modulating Microglial Cell Activation and Brain Inflammation
Wednesday, January 12
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby
8:00 - 11:15 AM	Molecular Effectors of CNS Inflammation	Ballroom 2
	* Trevor Owens, University of Southern Denmark Immune-glial interactions in induction and regulation of CNS inflammation
	Iain L. Campbell, University of Sydney Cytokine Signaling in CNS Inflammation and Disease
	Scott R. Barnum, University of Alabama at Birmingham Complement and Demyelinating Disease: Not as Simple as We Thought
	V. Wee Yong, University of Calgary Matrix Metalloproteinases
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM	Poster Setup	Wasatch/Superior/Superior Lobby
1:00 - 10:00 PM	Poster Viewing	Wasatch/Superior/Superior Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:15 PM	Brain Entry of Cellular Effectors of CNS Inflammation	Ballroom 2
	* Richard M. Ransohoff, Cleveland Clinic Chemokines
	Britta Engelhardt, Theodor Kocher Institute/Universitat Bern Molecular Steps involved in T lymphocyte migration across the blood-brain barrier
	Francesca Aloisi, Instituto Superior de Sanita Lymphod neogenesis in the inflamed CNS
	Candice C. Clay, University of California, Davis Short Talk: CNS Inflammation and Acute Neuroinvasion of Fluorescein+ Monocytes in the Nonhuman Primate Model for AIDS
	Dorian B. McGavern, National Institutes of Health Short Talk: Dendritic Cell Recruitment into the CNS during the Clearance of a Persistent Viral Infection
	Dyana K. Dalton, Trudeau Institute Short Talk: Mechanisms of Protection from CNS Inflammation during Th1-Mediated Autoimmunity: Protective Roles for iNOS in EAE
7:00 - 8:00 PM	Social Hour	Wasatch/Superior/Superior Lobby
7:30 - 10:00 PM	Poster Session 1	Wasatch/Superior/Superior Lobby
Thursday, January 13
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby
8:00 - 11:00 AM	New Perspectives in Neurodegeneration: From Prions to Inflammation (Joint)	Ballroom 2-3
	* Pedro R. Lowenstein, Cedars Sinai Medical Center
	Adriano M. Aguzzi, University Hospital of Zurich Immunology and Immunopathology of Prion Infections
	Jenny P. Ting, University of North Carolina at Chapel Hill CNS Inflammation: Friend or Foe?
	Neil Mabbott, Institute for Animal Health, Edinburgh Prions and the Immune System: Identifying Targets for Intervention
	Monica J. Carson, University of California, Riverside Microglia and the Regulation of Autoreactive Immune Responses
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM	Poster Setup	Wasatch/Superior/Superior Lobby
1:00 - 10:00 PM	Poster Viewing	Wasatch/Superior/Superior Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:15 PM	Inflammation: Good or Bad in Neurodegeneration?	Ballroom 2
	* V. Wee Yong, University of Calgary
	Tony Wyss-Coray, Stanford University School of Medicine Genetic Dissection of Inflammation in Neurodegenerative Diseases
	Vitaly Vasilevko, University of California, Irvine Short Talk: Affects of Peripheral Inflammation and Age on the Clearance of A-beta in a Transgenic Model of Alzheimer's Disease
	John M. Hallenbeck, National Institutes of Health Cytokines in the Initiation and Immunomodulation of Stroke
	Stanley H. Appel, Methodist Neurological Institute Inflammation: The Good, the Bad, and the Ugly: Lessons from ALS and Parkinson's Disease
	Ikuo Tsunoda, Louisiana State University Short Talk: Is the Lack of Axonal Injury in C57BL/Wlds Mice Beneficial or Detrimental in Animal Models for Multiple Sclerosis?
	Palwinder K. Mander, Short Talk: Key Role of NADPH Oxidase and iNOS in Microglial Proliferation and Inflammatory Neurodegeneration
7:00 - 8:00 PM	Social Hour	Wasatch/Superior/Superior Lobby
7:30 - 10:00 PM	Poster Session 2	Wasatch/Superior/Superior Lobby
Friday, January 14
7:00 - 8:00 AM	Breakfast	Golden Cliff/Superior Lobby
8:00 - 11:15 AM	Pathogen-Induced Brain Inflammation: Cause or Consequence?	Ballroom 2
	* Iain L. Campbell, University of Sydney
	Kenneth C. Williams, Beth Israel Deaconess Medical Center Activated Monocytes Drive CNS Neuronal Injury in NeuroAIDS: The Role of Virus and CD8 T Lymphocytes Controlling Disease Progression
	John K. Fazakerley, University of Edinburgh Innate and Adaptive Immune Responses in Viral Encephalitis

	Jay A. Nelson, University of Nebraska Medical Center Short Talk: Proton Magnetic Resonance Spectroscopic Imaging and Neuronal Impairments in a Murine Model of HIV-1 Encephalitis
	Martina Deckert, University of Cologne Immune Reactions in Bacterial and Parasitic Infections of the CNS
	Robyn S. Klein, Washington University School of Medicine Short Talk: Neurons are Responsible for CXCL10-Mediated CD8+ T Cell Infiltration in WNV Encephalitis
	Pedro R. Lowenstein, Cedars Sinai Medical Center Inflammatory and Immune Responses to Viral Vectors for CNS Gene Therapy: Peculiarities, Mechanisms and Consequences
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
4:30 - 5:00 PM	Coffee & Snacks Available	Ballroom Mezzanine & Lobby
5:00 - 7:00 PM	Inflammation, Stem Cells and Neurogenesis	Ballroom 2
	* Francesca Aloisi, Instituto Superior de Sanita
	Theo D. Palmer, Stanford University Medical Center Inflammatory Modulation of Adult Hippocampal Neurogenesis

	Larisa Poluektova, University of Nebraska Medical Center Short Talk: HIV-1 Encephalitis Affects Hippocampal Neurogenesis

	Evan Snyder, Burnham Institute Inflammation, Stem Cells and Neurogenesis
	Gianvito Martino, San Raffaele Scientific Institute Neural Stem Cells as a Neuroprotective Therapy in Inflammatory Demyelinating Disorders
8:00 - 9:00 PM	Social Hour	Ballroom 1-3
8:00 - 11:00 PM	Entertainment	Ballroom 1-3
Saturday, January 15
	Departure

*Session Chair †Speaker invited, not yet responded.