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Proteomics and Bioinformatics (X3)

Organizer(s): Matthias Mann and Catherine E. Costello
April 8 - 13, 2005
Keystone Resort  ·  Keystone, Colorado
Abstract Deadline: December 7, 2004
Early Registration Deadline: February 8, 2005


Supported by The Director's Fund

Joint meeting: Systems and Biology (X4)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).



This meeting took place in the 2005 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.
Summary of Meeting
Proteomics has emerged as a key discipline in the post-genomic 'tool chest' and over the last few years, proteomics technology has become extraordinarily powerful. Mass spectrometry, array based protein methods and single cell imaging methods have combined to give us rich data of all the expressed proteins of the cell, 'its proteome'. While the technology is still developing rapidly, and 'data collection' efforts are just gathering steam, the focus of this meeting will be on applications of proteomics to problem solving in molecular cell biology as well as in molecular medicine. Bioinformatics methods to keep track of the wealth of data and beginning efforts to integrate disparate large-scale data sets will also be highlighted. Another emerging area in bioinformatics and systems biology is the building of models of whole cells.

Friday, April 8
3:00 - 7:30 PM Registration Grays Peak Foyer
6:30 - 7:30 PM Refreshments Longs Peak Foyer
7:30 - 8:30 PM Keynote Address (Joint) Quandary Peak
Marc W. Kirschner, Harvard Medical School
Specificity and Timing in the Cell Cycle: A Kinetic and Proteomic Exploration
Saturday, April 9
7:00 - 8:00 AM Breakfast Grays Peak
8:00 - 11:15 AM Mapping and Analyzing Networks I (Joint) Quandary Peak
* Anne-Claude Gavin, Cellzome AG
Global Interaction Networks Probed by Mass Spectrometry
Marc Vidal, Dana Farber Cancer Institute
Interactome Networks
Matthias Mann, Max-Planck Institute for Biochemistry
Global Elucidation of Phosphorylation Dependent Protein-Protein Interactions
Michael Tyers, University of Edinburgh
Integration of Interaction Networks
Igor Stagljar, University of Toronto
Short Talk: Large-Scale Analysis of Yeast and Human Integral Membrane Protein Interactions
Ariel Jaimovich, Hebrew University of Jerusalem
Short Talk: Towards an Integrated Probabilistic Protein-Protein Interaction Map
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:15 AM - 1:00 PM Poster Setup Grays Peak
1:00 - 10:00 PM Poster Viewing Grays Peak
3:00 - 4:30 PM Workshop 1: Location, Location, Location: Mapping Phosphorylation
* Forest M. White, Massachusetts Institute of Technology
Alejandro M. Wolf Yadlin, Massachusetts Institute of Technology
Comparative Phosphotyrosine Proteomics of the EGFR, HER2 and HER3 Pathways
Steen Gammeltoft, Glostrup Hospital, University of Copenhagen
Neural Network and Mass Spectrometry for Identification of Protein Kinase A Substrates Involved in Apoptosis
Irina H. Kratchmarova, University of Southern Denmark
Quantitative Proteomics of EGF and PDGF Signaling Networks Reveals Controlling Mechanism of Mesenchymal Stem Cell Differentiation
Hanno Steen, Harvard Medical School
Stable Isotope-Free Relative and Absolute Quantitation of Protein Phosphorylation Stoichiometry by Mass Spectrometry
4:30 - 5:00 PM Coffee & Snacks Available Longs Peak Foyer
5:00 - 7:00 PM Proteomics in an Array Format Quandary Peak
* John J.M. Bergeron, McGill University
Michael Snyder, Stanford University School of Medicine
Global Activity Mapping of Yeast Proteins
Dolores J. Cahill, Pfizer Inc.
Generation and Recent Applications of Protein and Antibody Arrays
Amy E. Keating, Massachusetts Institute of Technology
Short Talk: Combinatorial Associations of the Human bZIP Transcription Factors: Microarray Measurements and Computational Predictions
Viorica Lopez-Avila, Agilent Technologies, Inc.
Short Talk: Focused-Proteomics Using Protein Microarrays
Erin N. Warren, University of North Carolina at Chapel Hill
Short Talk: A Novel MS-Based Peptide Chip Approach for Quantitating Expression and Modification Levels of Cancer-Related Proteins
7:00 - 8:00 PM Social Hour Grays Peak
7:30 - 10:00 PM Poster Session 1 Grays Peak
Sunday, April 10
7:00 - 8:00 AM Breakfast Grays Peak
8:00 - 11:15 AM Mapping and Analyzing Networks II (Joint) Quandary Peak
Dalia Cohen, Rosetta Genomics
Functional Genomics to New Drug Targets
Catherine E. Costello, Boston University School of Medicine
Glycoproteomics
* Richard A. Young, Whitehead Institute for Biomedical Research
Yeast Transcriptional Networks
Leroy E. Hood, Institute for Systems Biology
Systems Approaches to Biology and Disease
Andrew Emili, University of Toronto
Short Talk: Interaction Network of Conserved and Essential Protein Complexes in Escherichia coli
Alan M. Moses, University of California, Berkeley
Short Talk: Models for Evolution of Simple Transcription Networks
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:15 AM - 1:00 PM Poster Setup Grays Peak
1:00 - 10:00 PM Poster Viewing Grays Peak
4:30 - 5:00 PM Coffee & Snacks Available Longs Peak Foyer
5:00 - 7:00 PM Visualizing the Proteome Quandary Peak
* Catherine E. Costello, Boston University School of Medicine
Philippe Bastiaens, European Molecular Biology Laboratory
Identification of Novel Proteins in Growth Factor Signaling by Functional Imaging on Cell Arrays
Wolfgang P. Baumeister, Max Planck Institute of Biochemistry
Exploring the Cellular Proteome by Cryo Electron Tomography
Carol V. Robinson, University of Oxford
Deciphering Multiprotein Complexes from the Cellular Environment
Leonard J. Foster, University of British Columbia
Short Talk: A Mammalian Organelle Map by Protein Correlation Profiling
7:00 - 8:00 PM Social Hour Grays Peak
7:30 - 10:00 PM Poster Session 2 Grays Peak
Monday, April 11
7:00 - 8:00 AM Breakfast Grays Peak
8:00 - 11:00 AM Proteomic Databases Quandary Peak
* Leonard J. Foster, University of British Columbia
Cathy H. Wu, Georgetown University Medical Center
UniProt and PIR Databases for Proteomic Bioinformatics
Gianni Cesareni, University of Rome Tor Vergata
Protein Interaction Domain Network in the MINT Database
Christopher Hogue, University of Toronto
The Roadmap for the Biomolecular Interaction Network Database and its Related Tools to Enable Proteomics Research
Kara Dolinski, Princeton University
Short Talk: Utilizing Bioinformatics Methods and Open Source Packages to Create Useful Functional Genomics Tools for the Research Community
Michael Hippler, Plant Science Institute
Short Talk: Digging into the Proteome of Chlamydomonas by Optimizing the Search of Mass Spectrometric Data in Genomic Databases
David P. Leader, University of Glasgow
Short Talk: The Protein Motif Database
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
11:00 AM - 1:00 PM Poster Setup Grays Peak
1:00 - 10:00 PM Poster Viewing Grays Peak
3:00 - 4:30 PM Workshop 2: Protein IDS: How Certain do the Results Need to Be?
* Roman Zubarev, Uppsala University
Vanathi Gopalakrishnan, University of Pittsburgh
Proteomic Data Mining identifies Potential Biomarkers of Amyotrophic Lateral Sclerosis
Joshua E. Elias, Harvard Medical School
Comparative Evaluation of Complementary MS/MS Analysis and Instrumentation Platforms
Michael L. Nielsen, Uppsala University
Doubling the Number of Identified Proteins using Complementary Fragmentation Techniques in Fourier Transform Mass Spectrometry On-line with nanoLC
Maria E. Warren, University of North Carolina at Chapel Hill
In-gel Digestion from Unstained Gels for Increased Confidence in Protein Identification
4:30 - 5:00 PM Coffee & Snacks Available Longs Peak Foyer
5:00 - 7:00 PM Protein Mapping Quandary Peak
* Matthias Mann, Max-Planck Institute for Biochemistry
Roman Zubarev, Uppsala University
ECD FTMS for Complete Protein Primary Structure Determination of Proteins
Forest M. White, Massachusetts Institute of Technology
Phosphoproteomic Analysis of Cellular Signaling
John J.M. Bergeron, McGill University
Proteomics of the Early Secretory Pathway
Sean A. Beausoleil, Harvard Medical School
Short Talk: Large-Scale, Automated Analysis of HeLa Cell Phosphoproteins
7:00 - 8:00 PM Social Hour Grays Peak
7:30 - 10:00 PM Poster Session 3 Grays Peak
Tuesday, April 12
7:00 - 8:00 AM Breakfast Grays Peak
8:00 - 9:20 AM Function and Dynamics of Networks Qauandry Peak
* Jennifer A. Lippincott-Schwartz, National Institutes of Health
The Golgi Apparatus as a Two-Phase System for Protein Sorting and Transport
David M. Sabatini, Whitehead Institute for Biomedical Research
Deciphering Mammalian Signaling Networks
9:40 - 11:00 AM Proteomics for Clinical Diagnostics Quandary Peak
* Ronald C. Hendrickson, Merck Research Laboratories
Catherine Fenselau,
Applications of Proteomics to Homeland Security: Rapid Analysis of Airborne Microorganisms
Carol L. Nilsson, Florida State University
Bacterial Proteomics and Vaccine Development
Mahadevan Sethuraman, Boston University School of Medicine
Short Talk: Isotope-Coded Affinity Tag (ICAT) Approach to the Proteomic Identification and Quantitation of Oxidant-Sensitive Cysteine Thiols in Complex Protein Mixtures
Robert J. Cotter, Johns Hopkins School of Medicine
Short Talk: Special K: The Center for Networks and Pathways of Lysome Modification
9:20 - 9:40 AM Coffee Break Longs Peak Foyer
4:30 - 5:00 PM Coffee & Snacks Available Longs Peak Foyer
5:00 - 7:00 PM Quantitative Methods and Systems Biology Quandary Peak
* Matthias Mann, Max-Planck Institute for Biochemistry
Ruedi H. Aebersold, Institute of Molecular Systems Biology, ETH Zurich
Quantitative Proteomics: An Essential Component of Systems Biology
Dieter Oesterhelt, Max Planck Institute of Biochemistry
A Quantitative Model of Archaeal Signal Transduction
Robert L. Hettich, Oak Ridge National Laboratory
Short Talk: Proteomics Measurements of a Natural Microbial Community Reveal Information about Community Structure and Metabolic Potential
Judith A. Jebanathirajah, Harvard Medical School
Short Talk: Directed Biomarkers: Phosphorylation Analysis of the Anaphase Promoting Complex in Response to Spindle Poisons and Cell Cycle Progression Using Mass Spectrometry
Cameron O. Scarlett, University of North Carolina at Chapel Hill
Short Talk: Modeling the In Vivo Subunit Assembly of a Multi-Component Protein Complex with Discrete Molecular Dynamics using Data from a Binary in Vitro Interaction Study and Crosslinking Combined with Mass Spectrometry
7:00 - 8:00 PM Social Hour Grays Peak
8:00 - 11:00 PM Entertainment Grays Peak
Wednesday, April 13
Departure
*Session Chair   †Speaker invited, not yet responded.



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