Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

HIV Pathogenesis (X7)

Organizer(s): Michael M. Lederman, Richard A. Koup and Michael H. Malim
April 9 - 15, 2005
Fairmont Banff Springs · Banff, Alberta
Abstract Deadline: December 9, 2004
Early Registration Deadline: February 10, 2005

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: HIV Vaccines: Current Challenges and Future Prospects (X8)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2005 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
More than 20 years of basic and applied research have help to dissect the intimate relationship between HIV and its host. Since HIV targets, infects and compromises cells of the immune system, the interactions between this virus and host defenses are both especially complex and also offer key insights into mechanisms of cell biology, immune defenses and evolutionary adaptation. This Keystone symposium will focus on the mechanisms utilized by the virus for establishment of infection and propagation, protective innate and adaptive host defense mechanisms and mechanisms utilized by HIV to elude these defenses. This meeting will bring together scientists representing a number of different disciplines who have addressed these key issues. The goal of this meeting is to facilitate interdisciplinary interactions that will promote better insights into HIV disease pathogenesis.

Objectives
Upon completion of this conference, participants should be able to:

Identify mechanisms utilized by the virus for establishment of infection and propagation.
Cite protective innate and adaptive host defense mechanisms.
Describe mechanisms utilized by HIV to elude these defenses.

Saturday, April 9
3:00 - 7:30 PM	Registration	Van Horne Ballroom Foyer
6:30 - 7:30 PM	Refreshments	Van Horne Ballroom Foyer
7:30 - 9:30 PM	Keynote Address (Joint)	Van Horne Ballroom
	Douglas D. Richman, University of California, San Diego HIV Pathogenesis: Twenty Years of Successes and Failures


	José G. Esparza, Bill & Melinda Gates Foundation Harnessing Science and Policy to Accelerate HIV Vaccine Development
Sunday, April 10
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:00 AM	Transmission	Van Horne Ballroom AB
	* John P. Moore, Weill Medical College of Cornell University
	Ashley T. Haase, University of Minnesota The Fast Phase of Slow Lentiviral Infection
	Susan A. Allen, Emory University School of Public Health Couples' HIV Counseling and Testing in basic science research and public health
	Yvette van Kooyk, Vrije University Medical Center Viruses Use Carbohydrates to Escape Immunity Induced by Dendritic Cells
	Andrew Blauvelt, Oregon Health & Science University CCR5-Mediated HIV Infection of Langerhans Cells
	Clare Jolly, University College London Short Talk: Cell to Cell Spread of HIV-1 Across a Virological Synapse
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:00 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
2:30 - 4:30 PM	Workshop 1: Intracellular Interactions	Van Horne Ballroom AB
	* Greg J. Towers, University College London
	Vincent Piguet, University Hospital of Geneva Trafficking of HIV-1 to the Dendritic Cell-T cell Infectious Synapse Uses DC-SIGN and the Pathway of Tetraspanin Sorting to the Immunological Synapse

	Mark E. Sharkey, University of Massachusetts Medical School Stable Sequestration and Dissemination in Trans of Intracellular Virions by HIV-1 Infected Macrophages
	Mojgan H. Naghavi, Centre for Research in Infectious Diseases, University College Dublin Overexpression of Fasciculation and Elongation Protein zeta-1 (FEZ1) Induces a Postentry Block to Retroviruses in Cultured Cells
	Philippe Gallay, The Scripps Research Institute Interplay Between HIV-1 Capsid, Cyclophilin A and Primate Restriction
	Thomas J. Hope, Northwestern University, Feinberg School of Medicine Cell Biology of TRIM5alpha
	Eric M. Poeschla, Mayo Clinic College of Medicine Identification of the LEDGF/p75 HIV-1 Integrase-Interaction Domain and NLS Reveals NLS-Independent Chromatin Tethering
4:30 - 5:00 PM	Coffee & Snacks Available	Van Horne Ballroom Foyer
5:00 - 7:15 PM	Virus and Cells: The Way In	Van Horne Ballroom AB
	* Thomas J. Hope, Northwestern University, Feinberg School of Medicine
	Robert W. Doms, University of Pennsylvania School of Medicine HIV Entry and its Inhibition
	Judy Lieberman, Harvard Medical School Use of Small Interfering RNAs to Block Transmission of HIV and Other Sexually Transmitted Diseases
	Stuart F.J. Le Grice, National Cancer Institute, National Institutes of Health Reverse Transcription – A New Look at an Old Adversary
	Frederic D. Bushman, University of Pennsylvania School of Medicine Targeting of HIV DNA Integration to Transcription Units: Tethering via a Human Transcription Factor
7:15 - 8:15 PM	Social Hour	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 1	New Brunswick, Alberta, Cascade
Monday, April 11
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:00 AM	Protective Immunity I: Neutralizing Antibodies (Joint)	Van Horne Ballroom
	* Lynn Morris, National Institute for Communicable Diseases Neutralizing Antibody Responses to Subtype C HIV-1 Infection in Africa
	John R. Mascola, NIAID, National Institutes of Health Evaluating the Neutralizing Antibody Response Elicited by DNA and Recombinant Adenoviral Vaccines
	Dennis R. Burton, The Scripps Research Institute Envelope on the Surface on HIV is Heterogeneous
	George M. Shaw, University of Alabama at Birmingham Antigenic Conservation and Immunogenicity of the Co-Receptor Binding Site and Membrane-Proximal External Region (MPER) of HIV-1 and HIV-2
	Bing Chen, Children's Hospital Boston Short Talk: Structure of an Unliganded Simian Immunodeficiency Virus gp120 Core
	Ping Zhu, Florida State University Short Talk: Cryo-Electron Microscopy of Envelope Spikes on SIV Surfaces
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:00 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
4:30 - 5:00 PM	Coffee & Snacks Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Virus and Cells: The Way Out	Van Horne Ballroom AB
	* Mario Stevenson, University of Massachusetts Medical School
	Jaisri R. Lingappa, University of Washington HIV-1 Capsid Assembly Intermediates: Biochemical Sites for Regulation of Anti-Viral Factors and Virus Production Kinetics


	Ben Berkhout, University of Amsterdam, Academic Medical Center HIV-1 Can Evade RNAi-Mediated Inhibition by Altering the Secondary Structure of its RNA Genome
	Wesley I. Sundquist, University of Utah School of Medicine HIV-1 Budding
	Elena Chertova, National Cancer Institute, National Institutes of Health Short Talk: Proteomic and Biochemical Analysis of HIV-1 Produced from Human Monocyte-Derived Macrophages
7:00 - 8:00 PM	Social Hour	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 2	New Brunswick, Alberta, Cascade
Tuesday, April 12
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:15 AM	Pathogenesis: Determinants of Disease Progression. Session Sponsored in Part by Gilead Sciences, Inc.	Van Horne Ballroom AB
	* Michael M. Lederman, Case Western Reserve University
	Julie M. Overbaugh, Fred Hutchinson Cancer Research Center Studies HIV-1 Acquisition in the Absence and Presence of Existing Infection
	Mary Carrington, National Cancer Institute, National Institutes of Health The Influence of HLA on HIV: Relating Allelic Effects in Disease Progression to Those in Infection
	Steven G. Deeks, University of California, San Francisco Immune Activation, Viral Fitness and Disease Progression
	Mark B. Feinberg, Merck & Co., Inc. Lessons from Sooty Mangabeys
	Bruce D. Walker, Massachusetts General Hospital Immunology and Virology of Controlled HIV Infection
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:00 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
2:30 - 4:30 PM	Workshkop 2: Immune Pathogenesis	Van Horne Ballroom AB
	* Irini Sereti, NIAID, National Institutes of Health
	Arnaud Moris, UPMC - Hôpital Pitié-Salpêtrière HIV-1 Antigen Presentation by DCs: Role of DC-SIGN
	Karin Loré, Karolinska Institutet Productively Infected Myeloid and Plasmacytoid Dendritic Cells Transfer of HIV-1 Preferentially to Antigen-Specific CD4+ T-Cells
	Jean Philippe Herbeuval, National Cancer Institute, National Institutes of Health AIDS Pathogenesis: Effect of HAART on TRAIL/DR5 Mediated CD4+ T Cell Apoptosis
	Scott F. Sieg, Case Western Reserve University Circulating S Phase T Cells from HIV-Infected Persons are Prone to Die, Express Low Levels of bcl-2 and are Rescued from Apoptosis by Interleukin-2
	Michael R. Betts, University of Pennsylvania HIV-Infected Long-Term Nonprogressors Maintain Polyfunctional HIV Specific CD8+ T Cell Responses of Diverse Memory Phenotypes
	Emma L. Turnbull, Jenner Institute, University of Oxford Analysis of the Functional Cross-Reactivity and Clonality of HIV-Specific CD8+ T Cells Restricted by HLA Alleles Associated with Differing Rates of Progression to AIDS
4:30 - 5:00 PM	Coffee & Snacks Available	Van Horne Ballroom Foyer
5:00 - 7:00 PM	Late Breaking Developments	Van Horne Ballroom AB
	* Richard A. Koup, National Institutes of Health
	* Joseph M. McCune, Gladstone Institute of Virology and Immunology
	Cristian Apetrei, University of Pittsburgh Short Talk: SIVsm Derived from Naturally Infected Sooty Mangabeys Is Not Intrinsically Highly Pathogenic for Rhesus Macaques
	Alfredo Garzino-Demo, University of Maryland School of Medicine Short Talk: Insights in the Mechanism of HIV Suppression by beta-Defensins
	Sara R. Klucking, Emory University Short Talk: Functional Differences in Dendritic Cell Populations and Divergent Disease Outcomes in Primate Models of HIV Infection
	Catherine S. Adamson, National Cancer Institute, National Institutes of Health Short Talk: Viral Resistance to PA-457, a Novel Inhibitor of HIV-1 Maturation: Insights in to the Drug Target and Mechanisms of Action
	Joseph J. Mattapallil, Uniformed Services University Short Talk: Massive Infection and Loss of Memory CD4 T-cells in peripheral and mucosal Tissues During Acute SIV Infection
	Alexandra Trkola, Institute of Medical Viroloy Short Talk: Delay of HIV-1 Rebound after Cessation of Antiretroviral Therapy through Passive Administration of Human Neutralizing Antibodies
7:00 - 8:00 PM	Social Hour	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 3	New Brunswick, Alberta, Cascade
Wednesday, April 13
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:00 AM	CD8 Cell Function and Dysfunction (Joint)	Van Horne Ballroom
	* Marcus Altfeld, Massachusetts General Hospital
	Giuseppe Pantaleo, Centre Hospitalier Universitaire Vaudois Functional Signatures of Protective Memory T-Cell Responses
	Richard A. Koup, National Institutes of Health CD8 and CD4 Cel Function in Viral Infection and Vaccintations
	Joseph M. McCune, Gladstone Institute of Virology and Immunology HIV-Induced Perturbations of CD8+ T Cell Maturation
	Annika C. Karlsson, Swedish Institute for Infectious Disease Control (SMI) Short Talk: Diversity of Epitope and Cytokine Profiles at Different Stages of HIV-1 Infection
	Sylvie Le Gall, Massachusetts General Hospital, Harvard Medical School Short Talk: Contribution of Antigen Processing to the Immunodominance of an HLA-A3-Restricted HIV Epitope
	Astrid K.N. Iversen, Weatherall Institute of Molecular Medicine Short Talk: The Effect of Common Amino Acid Mutations in Overlapping HIV-1 p17 Gag CTL Epitopes on HLA Binding and Cytotoxic T-Cell Responses
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
11:00 AM - 1:00 PM	Poster Setup	New Brunswick, Alberta, Cascade
1:00 - 10:00 PM	Poster Viewing	New Brunswick, Alberta, Cascade
4:30 - 5:00 PM	Coffee & Snacks Available	Van Horne Ballroom Foyer
5:00 - 7:30 PM	Innate Host Defenses	Van Horne Ballroom AB

	* Donald E. Mosier, The Scripps Research Institute

	Robert H. Silverman, Cleveland Clinic Foundation Interferon Antiviral Defenses Mediated by the 2-5A/RNase L Pathway
	Aaron Weinberg, Case Western Reserve University Mucosal Antiviral beta Defensins
	Greg J. Towers, University College London Restriction of Retroviral Infection by TRIM5
	Michael H. Malim, King's College London School of Medicine APOBEC Proteins, Cytidine Deamination and Innate Resistance to HIV Infection
	Olivier Schwartz, Institut Pasteur Short Talk: APOBEC3G: An Ancestral Wide Cellular Defence Against Endogenous and Exogenous Retroviruses
7:15 - 8:15 PM	Social Hour	New Brunswick, Alberta, Cascade
7:30 - 10:00 PM	Poster Session 4	New Brunswick, Alberta, Cascade
Thursday, April 14
7:00 - 8:00 AM	Breakfast	New Brunswick, Alberta, Cascade
8:00 - 11:15 AM	Latency and Activation	Van Horne Ballroom AB
	* Frederic D. Bushman, University of Pennsylvania School of Medicine
	Jerome A. Zack, David Geffen School of Medicine at UCLA Modeling HIV Latency
	Gary J. Nabel, National Institutes of Health The Gene Product Murr1 Restricts HIV-1 Replication in Resting CD4+ Lymphocytes
	Jonathan Karn, Case Western Reserve University NF-kappaB and CBF-1: Specific Activators and Repressors of HIV Transcription
	Mario Stevenson, University of Massachusetts Medical School Cellular Factors that Influence Virus-Host Cell Interplay
	Roger J. Pomerantz, Tibotec, Inc. Short Talk: IL-7 Potently and Strain-Specifically Induces the Latent HIV-1 Reservoirs
	Nancie M. Archin, University of North Carolina at Chapel Hill Short Talk: Chromatin Deacetylation does not Precede Waning of HIV Expression
9:20 - 9:40 AM	Coffee Break	Van Horne Ballroom Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Van Horne Ballroom Foyer
5:00 - 6:45 PM	Immune Defense and Pathogenesis	Van Horne Ballroom AB
	* Gene M. Shearer, National Cancer Institute, National Institutes of Health

	Rafick-Pierre Sekaly, University of Montreal Genomic Profiling of Memory T Cell Population in Healthy and HIV Patients
	Daniel C. Douek, NIAID, National Institutes of Health T-Cell Receptor Recognition Motifs and Immune Escape in Acute SIV Infection
	Fatema A. Legrand, University of California, San Francisco Short Talk: Divergent Immune Responses in HIV-1 Vertically Infected Monozygotic Twins
	Guillaume B.E. Stewart-Jones, University of Oxford Short Talk: Crystal Structures of HIV-1 HLA-B5703-Peptide Complexes and Identification of Related HLA Motifs*

6:45 - 7:00 PM	Closing Remarks	Van Horne Ballroom AB
	Michael M. Lederman, Case Western Reserve University
7:00 - 8:00 PM	Social Hour	New Brunswick, Alberta, Riverview
8:00 - 11:00 PM	Entertainment	New Brunswick, Alberta, Riverview
Friday, April 15
	Departure

*Session Chair †Speaker invited, not yet responded.