Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Tuberculosis: Integrating Host and Pathogen Biology (D1)

Organizer(s): Gilla Kaplan, Clifton Barry III and Stewart Cole
April 2 - 7, 2005
Whistler Conference Centre (meeting only) · Whistler, British Columbia
Abstract Deadline: December 2, 2004
Early Registration Deadline: February 2, 2005

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2005 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Tuberculosis: Immunology, Cell Biology and Novel Vaccination Strategies (J3)
January 15 - 20, 2011
Mycobacteria: Physiology, Metabolism and Pathogenesis - Back to the Basics (J4)
January 15 - 20, 2011

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Tuberculosis is the leading infectious cause of mortality in the world today with 4 million deaths predicted for the year 2004. With the completion of the genome sequence of both Mycobacterium tuberculosis and Homo sapiens it is now possible to elucidate the dynamic interaction between the pathogen and its human host. Contemporary tools and novel technologies are currently being used to explore the molecular mechanisms that underlie host resistance and susceptibility, microbial drug resistance, the metabolic adaptations of the organism to latency and reactivation, and mechanisms of microbial pathogenesis. Recent studies have highlighted the importance of microbial regulatory systems and cell wall lipids in determining the ultimate outcome of infection. The development of novel vaccine candidates based on an understanding of the host response to infection has been facilitated by recent scientific advances. The aim of this meeting is to review the latest knowledge in these diverse fields of research and to provide an open forum for discussion and collaboration for scientists from the various disciplines required to control this disease.

Objectives
Upon completion of this conference, participants should be able to:

Explain the dynamic interaction between the pathogen and its human host.
Identify contemporary tools and novel technologies that are currently being used to explore the molecular mechanisms that underlie host resistance and susceptibility, microbial drug resistance, the metabolic adaptations of the organism to latency and reactivation, and mechanisms of microbial pathogenesis.
Cite recent studies that have highlighted the importance of microbial regulatory systems and cell wall lipids in determining the ultimate outcome of infection.
Assess the latest knowledge in these diverse fields of research.

Saturday, April 2
3:00 - 7:30 PM	Registration	Grand Foyer
6:30 - 7:30 PM	Refreshments	Grand Foyer
7:30 - 8:30 PM	Keynote Address	Sea to Sky Ballrm A
	Paul W. Ewald, University of Louisville Vaccines and the Evolution of Virulence
Sunday, April 3
7:00 - 8:00 AM	Breakfast	Sea to Sky Ballrm B/C
8:00 - 11:00 AM	Exploratory Genomics. Plenary Session sponsored by The Ellison Medical Foundation	Sea to Sky Ballrm A
	* Stewart T. Cole, École Polytechnique Fédérale de Lausanne Evolutionary and Comparative Genomics of the M. tuberculosis Complex
	Gary K. Schoolnik, Stanford University The Transcriptome of M. tuberculosis: Lessons Learned from a Study of the DosR Regalon
	Eric J. Rubin, Harvard School of Public Health Genetic and Proteomic Approaches to Virulence in Tuberculosis
	Rajesh S. Gokhale, National Institute of Immunology How Metabolic Diversity may be Generated from Limited Number of Genes: Exploring the Architecture of Mycobacterial Cell Envelope
9:20 - 9:40 AM	Coffee Break	Grand Foyer
11:00 AM - 1:00 PM	Poster Setup	Sea to Sky Ballrm B/C
1:00 - 10:00 PM	Poster Viewing	Sea to Sky Ballrm B/C
4:30 - 5:00 PM	Coffee & Snacks Available	Grand Foyer
5:00 - 7:00 PM	Mycobacterial Metabolism	Sea to Sky Ballrm A
	* Douglas B. Young, Imperial College London and
	Brian D. Robertson, Imperial College London The Role of Trehalose in Mycobacterial Persistence
	David R. Sherman, Seattle Biomedical Research Institute The Hypoxia/NO Stress Regulon
	Christophe Guilhot, Centre National de la Recherche Scientifique Phenolic glycolipid biosynthesis
7:00 - 8:00 PM	Social Hour	Sea to Sky Ballrm B/C
7:30 - 10:00 PM	Poster Session 1	Sea to Sky Ballrm B/C
Monday, April 4
7:00 - 8:00 AM	Breakfast	Sea to Sky Ballrm B/C
8:00 - 10:20 AM	Mechanism of Drug Action	Sea to Sky Ballrm A
	* Clifton E. Barry III, NIAID, National Institutes of Health The Role of Nitroimidazoles in Understanding Non-Replicating Persistence of MTB
	James C. Sacchettini, Texas A & M University Structural Biology on Drug Targets from M. tuberculosis

	Stephen H. Gillespie, Royal Free and University College London Developing Understanding of Anti-tuberculosis Chemotherapy through Monotherapy Studies
10:20 - 11:00 AM	Host-Pathogen Interaction 1	Sea to Sky Ballrm A
	Alan Aderem, Institute for Systems Biology Systems Biology and Immunity: A Systems Approach to Dissecting Immunity
9:20 - 9:40 AM	Coffee Break	Grand Foyer
11:00 AM - 1:00 PM	Poster Setup	Sea to Sky Ballrm B/C
1:00 - 10:00 PM	Poster Viewing	Sea to Sky Ballrm B/C
4:30 - 5:00 PM	Coffee & Snacks Available	Grand Foyer
5:00 - 7:00 PM	Host-Pathogen Interaction 2	Sea to Sky Ballrm A
	* Gilla Kaplan, Public Health Research Institute, UMDNJ Differential Host Response to Clinical Isolates of M. tuberculosis
	JoAnne L. Flynn, University of Pittsburgh School of Medicine Non-human Primates as a Model for Human Tuberculosis
	Adrian V.S. Hill, Jenner Institute, Oxford University Tuberculosis - Immunogenetics and Vaccine Design
7:00 - 8:00 PM	Social Hour	Sea to Sky Ballrm B/C
7:30 - 10:00 PM	Poster Session 2	Sea to Sky Ballrm B/C
Tuesday, April 5
7:00 - 8:00 AM	Breakfast	Sea to Sky Ballrm B/C
8:00 - 11:00 AM	Macrophage Biology	Sea to Sky Ballrm A
	* David G. Russell, Cornell University Mycobacterium and the Macrophage: Who Says What to Whom?
	David J. Kusner, University Of Iowa Phagosome Maturation in Response to MTB Infection

	Lalita Ramakrishnan, University of Washington Monitoring and modulating Mycobacterium-Macrophage Interactions in Real-Time in Transparent Zebrafish Embryos
	Vojo Deretic, University of New Mexico Autophagy - Novel Innate Immunity Mechanism
9:20 - 9:40 AM	Coffee Break	Grand Foyer
11:00 AM - 1:00 PM	Poster Setup	Sea to Sky Ballrm B/C
1:00 - 10:00 PM	Poster Viewing	Sea to Sky Ballrm B/C
4:30 - 5:00 PM	Coffee & Snacks Available	Grand Foyer
5:00 - 7:00 PM	Genetic Determinants of Host Response	Sea to Sky Ballrm A
	* Stefan H.E. Kaufmann, Max Planck Institute for Infection Biology-Berlin Host Pathogen Interactions in Tuberculosis: From a Global to a Specific View
	Emil Skamene, McGill University Health Centre Genetic Determinants of Resistance and Susceptibility
	Warwick J. Britton, Centenary Institute of Cancer Medicine & Cell Biology Manipulating the Cytokine Environment to Enhance Responses to Vaccines against Tuberculosis.
7:00 - 8:00 PM	Social Hour	Sea to Sky Ballrm B/C
7:30 - 10:00 PM	Poster Session 3	Sea to Sky Ballrm B/C
Wednesday, April 6
7:00 - 8:00 AM	Breakfast	Sea to Sky Ballrm B/C
8:00 - 11:00 AM	Vaccines and Immune Response	Sea to Sky Ballrm A
	* Peter Andersen, Statens Serum Institut TB Subunit Vaccines - Recent Developments in the Post Antigen Discovery Era
	Robert J. North, Trudeau Institute Mouse Tuberculous as a Model of Tuberculosis in Susceptible Humans

	Mark R. Alderson, Corixa Corporation Development of a Subunit Vaccine for Tuberculosis: Rational Selection of Antigens and Adjuvants
	Willem A. Hanekom, University of Cape Town The Host Immune Response to BCG Vaccination
9:20 - 9:40 AM	Coffee Break	Grand Foyer
4:30 - 5:00 PM	Coffee & Snacks Available	Grand Foyer
5:00 - 7:00 PM	Bacterial Signaling and Defense Mechanisms	Sea to Sky Ballrm A
	* Carl F. Nathan, Weill Cornell Medical College New Targets In M. Tuberculosis: Stress Resistance and Repair
	Valerie Mizrahi, University of the Witwatersrand - MMRU The Role of Error-Prone DNA Polymerases in Damage Tolerance and Genetic Adaptation in Mycobacteria
	William Bishai, Johns Hopkins School of Medicine Mycobacterial Stress Response Systems and Animal Models
7:00 - 8:00 PM	Social Hour	Sea to Sky Ballrm B/C
8:00 - 11:00 PM	Entertainment	Sea to Sky Ballrm B/C
Thursday, April 7
	Departure

*Session Chair †Speaker invited, not yet responded.