Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Toward Understanding Islet Biology (X1)

Organizer(s): Lydia Aguilar-Bryan, Bo Ahrén and Christopher B. Newgard
February 23 - 28, 2006
Sagebrush Inn and Conference Center · Taos, New Mexico
Abstract Deadline: October 24, 2005
Late Abstract Deadline: November 16, 2005
Scholarship Deadline: October 24, 2005
Early Registration Deadline: December 23, 2005

Supported by The Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Pancreatic Islets: From Development to Transplantation (X2)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2006 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Islet Biology (Z5)
April 12 - 17, 2010

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The past decade has seen a burgeoning of interest in the biology of the pancreatic islets of Langerhans. The surge in activity is driven in large measure by the rapid increase in the incidence of diabetes, and the critical role of failure of the insulin secreting cells (beta-cells) within the pancreatic islets in the pathogenesis of both major forms of the disease. This symposium will focus specifically on mechanisms of beta-cell failure in type 2 diabetes, which is fast becoming an epidemic disease world-wide (estimated prevalence in the United States alone, 18 million people). Beta-cell failure is now recognized as the event that triggers the transition from pre-diabetes/metabolic syndrome to full-blown type 2 diabetes. Major advances have occurred in our understanding of fundamental beta-cell biology, mechanisms of loss of function and loss of beta-cell mass in type 2 diabetes, and development of new strategies for enhancing beta-cell survival and function in diabetic animals and humans. These advances deserve careful review and discussion in the form of a Keystone symposium to which we expect to attract the very best scientists in the field. These recent advances in knowledge have occurred based on contributions of academic and industrial contributors alike, and our meeting includes invitations to key contributors from both sectors. The meeting will be divided into three major sections: A) Review of recent progress in understanding basic beta-cell biology, including mechanisms of fuel-stimulated insulin secretion and the role of receptor-mediated processes in potentiation of fuel-driven responses; B) Mechanisms of beta-cell dysfunction and destruction in response to metabolic fuel imbalance, including the roles of hyperlipidemia, hyperglycemia, and stress responses; C) Targets for improvement of beta cell function and new technological approaches. In sum, we believe that this program will be a timely and valuable contributor to advancement of a research field that is just beginning to achieve peak visibility and medical relevance.

Objectives
Upon completion of this conference, participants should be able to:

To explain recent progress in understanding basic beta-cell biology, including mechanisms of fuel-stimulated insulin secretion and the role of receptor-mediated processes in potentiation of fuel-driven responses.
To describe the mechanisms of beta-cell dysfunction and destruction in response to metabolic fuel imbalance, including the roles of hyperlipidemia, hyperglycemia, and stress responses.
To identify targets for improvement of beta cell function and new technological approaches.

Thursday, February 23
3:00 - 7:30 PM	Registration	Chamisa Lobby
6:30 - 7:30 PM	Refreshments	Chamisa Lobby
7:30 - 9:30 PM	Keynote Session (Joint)	Chamisa Ballroom
	* Lydia Aguilar-Bryan, Pacific Northwest Research Institute
	* Alvin C. Powers, Vanderbilt University
	Philip F. Smith, NIDDK, National Institutes of Health The NIDDK Agenda for Research on Islet Development, Biology and Transplantation

	Philippe A. Halban, Geneva University Connecting Beta Cell Biology to Effective Therapies for Type 1 and Type 2 Diabetes
Friday, February 24
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:00 AM	Joint Session with the Transplantation Meeting	Chamisa Ballroom
	* Chris Wright, Vanderbilt University Medical Center
	* Christopher B. Newgard, Duke University Medical Center Metabolic networks of the mature beta-cell
	Frans C. Schuit, Katholieke Universiteit Leuven Molecular Mechanism of Food Intake-Dependent Fluctuations in the Functional Beta Cell Mass

	Markus Stoffel, Institut f. Molekulare Systembiologie Role of Micro RNAs in Islet Function
	Roger H. Unger, University of Texas Southwestern Medical Center Metabolic “Rejection” of Intraportal Islet Transplants: Evidence for Lipotoxic Destruction of Islets by Hepatic Lipids and its Prevention by Leptinization
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 1
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 1
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:15 PM	Regulation of Insulin Secretion I	Chamisa Ballroom 1
	* Christopher J. Rhodes, Pacific Northwest Research Institute
	Kenneth S. Polonsky, Washington University School of Medicine Pancreatic beta cell survival: critical roles of pdx-1 and insulin
	Jean Claude Henquin, University of Louvain Triggering and amplifying pathways of glucose-stimulated insulin secretion: how and when?
	Joseph Bryan, Pacific Northwest Research Institute Alpha-/Beta-cell Crosstalk
	Thomas C. Becker, Duke University Medical Center Short Talk: Micro RNA ad B Cell Function
	Savita Dhanvantari, Lawson Research Health Institute Short Talk: Cellular and Molecular Imaging of Pancreatic Islet Cells
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Chamisa Lobby
7:30 - 10:00 PM	Poster Session 1	Chamisa Ballroom 1
Saturday, February 25
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Regulation of Insulin Secretion II	Chamisa Ballroom 1
	* Joseph Bryan, Pacific Northwest Research Institute
	Christopher J. Rhodes, Pacific Northwest Research Institute Trafficking ß-Granule Trafficking
	Franz M. Matschinsky, University of Pennsylvania Glutamine metabolism and Insulin Release
	Marc A. Prentki, CRCHUM/ University of Montreal Glucose and Fuel-Stimulated Lipolysis, TG/FFA Cycling and Lipid Signaling for Insulin Secretion in Pancreatic B Cells


	Celia P. Briscoe, GlaxoSmithKline Fatty Acids as Extra-cellular Regulators of Insulin Secretion
	Hassan Mziaut, Medical School TU Dresden Short Talk: Synergy of Glucose and GH Signaling in Islet B Cells via ICA5/2
	Alan D. Attie, University of Wisconsin-Madison Short Talk: Positional Cloning of a Type 2 Diabetes Quantitative Trait Gene
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 1
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 1
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:15 PM	Role of Mitochondrial Metabolism in Health and Disease	Chamisa Ballroom 1
	* Jack Leahy, University of Vermont

	John A. Corbett, St. Louis University School of Medicine A Transgenic Approach to Study the Role of mtDNA Mutations in Pancreatic b-cell Failure
	Claes B. Wollheim, University of Geneva Medical Centre Defective Beta-Cell Mitochondrial Signalling is Restored by the Nuclear Factor TFAM or by Matrix Calcium Elevation.

	Donalyn Scheuner, University of Michigan Signaling the Unfolded Protein Response Protects the Endoplasmic Reticulum Compartment and Prevents Beta Cell Failure
	Cedric Le May, Baylor College of Medicine Short Talk: Estrogens Protect Pancreatic Beta-Cells From Apoptosis via Activation of the Estrogen Receptor-alpha and Prevent Insulin-Deficient Diabetes
	Christine Bruun, Steno Diabetes Center Short Talk: Proliferative and Anti-Apoptotic Signalling Pathways in Human Beta-Cells
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Chamisa Lobby
7:30 - 10:00 PM	Poster Session 2	Chamisa Ballroom 1
Sunday, February 26
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Pathways for Development of Beta Cell Dysfunction	Chamisa Ballroom 1
	* Frans C. Schuit, Katholieke Universiteit Leuven
	Jack Leahy, University of Vermont Mitochondrial Metabolism and Beta Cell Dysfunction

	Vincent Poitout, University of Montreal Fatty-Acid Inhibition of Insulin Gene Expression.
	Michele Solimena, Dresden University of Technology Insulin Secretory Granule Biogenesis and Signaling
	Michael J. MacDonald, University of Wisconsin-Madison Roles Of Mitochondrially Synthesized Products In Insulin Secretion
	Jonathan C. Schisler, Duke University Medical Center Short Talk: The Transcription Factor Nkx6.1 Regulates Mature Beta-Cell Proliferation Through Control of Multiple Cell Cycle Genes
	Helle Frobøse, Steno Diabetes Center Short Talk: IL-1 Signalling is Inhibited by Suppressor of Cytokine Signalling (SOCS)-3 Targeting The TRAF-6/TAK1 Complex
9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
11:15 AM - 1:00 PM	Poster Setup	Chamisa Ballroom 1
1:00 - 10:00 PM	Poster Viewing	Chamisa Ballroom 1
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:15 PM	Autonomic Regulation of Insulin Release	Chamisa Ballroom 1

	Gary J. Schwartz, Albert Einstein College of Medicine Integrated Neural Control of Glucose Homeostasis
	* Gerald J. Taborsky, Jr., Seattle VA Puget Sound Health Center Neural Control of Islet Function
	* Bo Ahrén, Lund University Neuropeptides and Islet Function
	Maria L. Golson, University of Pennsylvania Short Talk: Jagged1 is Required for Normal Cell Lineage Allocation in the Endocrine Pancreas
	Nada Nekrep, University of California, San Francisco Short Talk: Target Genes of Nkx2.2 During Pancreatic Development and in Mature Beta Cells
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Chamisa Lobby
7:30 - 10:00 PM	Poster Session 3	Chamisa Ballroom 1
Monday, February 27
7:00 - 8:00 AM	Breakfast	Los Vaqueros
8:00 - 11:15 AM	Emerging Technologies for Beta Cell Research	Chamisa Ballroom 1
	* Christopher B. Newgard, Duke University Medical Center
	Mark A. Magnuson, Vanderbilt School of Medicine Multi-Allelic Gene Targeting Strategies and Their Application to Studies of Pancreas Development and Beta Cell Function
	Klaus H. Kaestner, University of Pennsylvania School of Medicine Orthogonal Analysis of Transcriptional Programs in the Endocrine Pancreas: A Novel Role for the MODY1 Gene HNF4alpha
	Dean Sherry, University of Texas at Dallas 13C NMR Isotopomer Analysis Reveals Metabolic Details of Beta Cell Function
	Anna Moore, Massachusetts General Hospital Strategies for Molecular Imaging of Diabetic Pancreas
	Kazuaki Ohtsubo, University of California, San Diego, Howard Hughes Medical Institute Short Talk: A Dietary and Genetic Mechanism of Pancreatic Beta Cell Failure in the Pathogenesis of Type 2 Diabetes
	James Herrington, Merck & Co., Inc. Short Talk: Inhibitors of the Pancreatic Beta-Cell Delayed Rectifier Potassium Current Enhance Insulin Secretion

9:20 - 9:40 AM	Coffee Break	Chamisa Lobby
4:30 - 5:00 PM	Coffee Available	Chamisa Lobby
5:00 - 7:15 PM	Targets for Improving Beta Cell Function	Chamisa Ballroom 1
	* Joseph Bryan, Pacific Northwest Research Institute

	Nancy A. Thornberry, Merck Research Laboratories New Agents for the Treatment of Type 2 Diabetes



	Rebecca A. Taub, VIA Pharmaceuticals, Inc Potential Novel Therapy for Type 2 Diabetes

	Shinsaku Aramata, Nara Institute of Science and Technology Short Talk: Synergistic Activation of the Insulin Promoter by the Beta-Cell Enriched Transcription Factors Mafa, Beta2, And Pdx1
	Gary W. Cline, Yale University Short Talk: 13C Isotopomer Analysis of Impaired Insulin Secretion following siRNA Knockdown of Cytosolic and Mitochondrial Malic Enzyme Isoforms in INS-1 Cells
	Claudia E. Robert, University of Pennsylvania Short Talk: Transgenic Mice Overexpressing the Novel Islet Specific Cytokine, PANDER, Exhibit Glucose Intolerance and Decreased beta Cell Mass
7:15 - 8:15 PM	Social Hour	Sagebrush Lounge
8:15 - 9:15 PM	Dinner	Chamisa Ballroom
8:00 - 11:00 PM	Entertainment	Chamisa Ballroom
Tuesday, February 28
	Departure

*Session Chair †Speaker invited, not yet responded.