Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Diabetes Mellitus and the Control of Cellular Energy Metabolism (J3)

Organizer(s): Silvia Corvera, Bruce M. Spiegelman and Luciano Rossetti
January 21 - 26, 2006
Fairmont Hotel Vancouver · Vancouver, British Columbia
Abstract Deadline: September 21, 2005
Late Abstract Deadline: October 13, 2005
Scholarship Deadline: September 21, 2005
Early Registration Deadline: November 21, 2005

Sponsored by Novo Nordisk A/S

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Adipogenesis, Obesity and Inflammation (J4)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The alarming increase in the number of individuals developing Type 2 Diabetes, together with the disproportionately high expense of its treatment, has raised intensive efforts in understanding the physiopathology of this chronic disease and its complications. The application of technologies of gene expression profiling, gene silencing, proteomics and imaging has led to a wealth of new insights and avenues into this disease. New exciting developments relate to the role of mitochondrial function in the pathogenesis of insulin resistance, in the mechanism of action of insulin sensitizers and in the development of diabetic complications. Other important developments relate to the mechanisms of secretion and action of adipocyte-derived factors such as leptin, adiponectin, and inflammatory cytokines in the periphery and in the central nervous system. A goal of this meeting is to bring together scientists working in the fields of insulin action, diabetes pathogenesis and complications with scientists working in areas of mitochondrial biogenesis, energy metabolism and membrane trafficking in the secretory pathway. The meeting will seek to integrate this information with gene and protein databases from humans and model systems such as rodents, yeast, Drosophila and C.elegans. In addition, half the sessions will be held jointly with the ongoing adipogenesis and obesity meeting to maximize information flow between the highly interrelated problems of obesity, cellular energy homeostasis, and insulin resistance. Collaborative efforts between investigators in these areas and those involved in chemistry and therapeutics are envisioned to result from this meeting.

Objectives
Upon completion of this conference, participants should be able to:

To explain current knowledge of the mechanisms that determine mitochondrial number, composition and function, and the potential role of mitochondria in the pathogenesis of diabetes and its complications.
To explain current knowledge of the mechanisms that determine the volume and folding capacity of the endoplasmic reticulum and the secretory pathway, and the potential role of these mechanisms in regulating the secretion of adipokines and cytokines.
To define whether components of the pathways that regulate mitochondrial and endoplasmic reticulum function are novel therapeutic targets for the treatment of diabetes.

Saturday, January 21
3:00 - 7:30 PM	Registration	BC Foyer
6:30 - 7:30 PM	Refreshments	BC Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	British Columbia Ballroom
	Christopher B. Newgard, Duke University Medical Center Comprehensive Metabolic Profiling for Understanding of Obesity and Diabetes Mechanisms


Sunday, January 22
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Lipid and Carbohydrate Metabolism and Energy Homeostasis (Joint)	British Columbia Ballroom
	* Bei B. Zhang, Merck Research Laboratories Short Talk: Role of DPP-4 Inhibitors in Glycemia Control and Beta-cell Preservation
	Bruce M. Spiegelman, Harvard Medical School The Transcriptional Basis of Energy Homeostasis

	Richard N. Bergman, University of Southern California Pathophysiology of the Metabolic Syndrome
	Christopher K. Glass, University of California, San Diego Anti-inflammatory and Antidiabetic Roles of PPARgamma in Macrophages
	Domenico Accili, Columbia University Forkhead Proteins in Diabetes and Obesity
	Rudolf Zechner, University of Graz Short Talk: ATGL: A Newly Discovered Rate-limiting Enzyme for the Lipolysis of Stored Fat
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM - 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
2:30 - 4:30 PM	Hot Topics I
	* Silvia Corvera, University of Massachusetts Medical School
	Takehide Ogihara, Tohoku University Graduate School of Medicine Role of eNOS in Beta Cell Regeneration after Bone Marrow Transplantation in STZ-Diabetic Mouse Models
	Su-Jin Kim, University of British Columbia Quantitative Post-Transplant Islet Imaging In Vivo Using Micro Positron Emission Tomography (PET) for the Determination of Islet Graft Survival
	Haruhisa Iguchi, National Cancer Center Research Institute SOX6 Attenuates Glucose Stimulated Insulin Secretion and Acts as a Co-Repressor for PDX1
	Dinesh C. Gautam, NIDDK, National Institutes of Health A Critical Role for Beta-Cell M3 Muscarinic Acetylcholine Receptors in Regulating Insulin Release and Blood Glucose Homeostasis
	Mirela Delibegovic, Harvard Medical School Dessecting the Tissue Specific Roles of Protein-Tyrosine Phosphatase 1B (PTP1B)
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Mitochondria and Diseases	British Ballroom
	* E. Dale Abel, University of Utah School of Medicine Short Talk: Regulation of Myocardial Mitochondrial Oxidative Capacity by PI3-Kinase and Akt
	Michael A. Brownlee, Albert Einstein College Of Medicine Mitochondrial Disfunction, Methylhlyoxal Generation and Diabetic Complications: A Novel Mechanism for Regulation of Gene Expression of Hyperglycemra

	Nils-Goran Larsson, Max Planck Institute for the Biology of Ageing The Role of Mitochondrial Dysfunction in Aging and Diabetes
	David E. Kelley, Merck & Co., Inc. Mitochondrial Dysfunction in the Pathogenesis of Insulin Resistance
	Ingrid A. Dahlman, Karolinska Institute Short Talk: Downregulation of Electron Transport Genes in Visceral adipose Tissue in Type 2 Diaberes Independantly of Obesity and Possibly Involving Tumor Necrosis Factor alpha
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 1	Pacific Ballroom
Monday, January 23
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Organelle Biogenesis and Energy Control	British Ballroom
	* Sheila Collins, Sanford-Burnham Medical Research Institute Short Talk: Signaling Networks Fueling Mitochondrial Metabolism in Fat

	Tracey A. Rouault, NICHD, National Institutes of Health The Role of Iron Regulatory Proteins in Mammalian Iron Metabolism and Neurodegeneration
	Daniel P. Kelly, Sanford-Burnham at Lake Nona Mitochondrial Adaptation and Maladaptin in Cardiac and Skeletal Muscle
	Janet M. Shaw, University of Utah Mitochondrial Dynamics and Function in Eukaryotic Cells
	Mary-Elizabeth Patti, Joslin Diabetes Center The Mitochondrial Hypothesis and Diabetes Pathogenesis: A Genomics Perspective
	Carles Lerin, Joslin Diabetes Center Short Talk: Transcriptional Regulation of Glucose Metabolism through PGC-1alpha Acetylation by the GCN5 Acetyl Transferase Complex
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM - 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Cellular Responses to Cytokines (Joint)	British Columbia Ballroom
	* Randal J. Kaufman, University of Michigan Medical Center Stress in the Endoplasmic Reticulum Activates an Acute Inflammatory Response
	Steven E. Shoelson, Harvard Medical School, Joslin Diabetes Center Tissue-specific Effects of Inflammation in Insulin Resistance, Type II Dianetes, and the metabolic Syndrome
	Silvia Corvera, University of Massachusetts Medical School Cellular Energy Control and Secretion
	Philipp E. Scherer, University of Texas Southwestern Medical Center at Dallas Secretory Proteins from Adiose Tissue - Significance for Insulin Resistance
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 2	Pacific Ballroom
Tuesday, January 24
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Signal Transduction and Glucose Homeostasis (Joint)	British Columbia Ballroom
	* Paul F. Pilch, Boston University School of Medicine
	Morris J. Birnbaum, University of Pennsylvania The Regulation of Glucose and Lipid Metabolism by Akt/PKB
	Barbara B. Kahn, Beth Israel Deaconess Medical Center Novel Adipocyte-secreted Molecule, Retinol Binding Protein 4, and the Metabolic Syndrome
	Markus Stoffel, Institut f. Molekulare Systembiologie Insulin Regulated Transcription Factors
	Luciano Rossetti, Merck Research Laboratories Insulin Signal Transduction in the Hypothalamus
	Jacqueline M. Stephens, Louisiana State University The Regulation of CT-1 and STAT 5A in Adipocytes
	Reuben J. Shaw, The Salk Institute The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Theraputic Effects of Metformin
9:20 - 9:40 AM	Coffee Break	BC Foyer
11:15 AM - 1:00 PM	Poster Setup	Pacific Ballroom
1:00 - 10:00 PM	Poster Viewing	Pacific Ballroom
2:30 - 4:30 PM	Hot Topics II
	* Ann Louise Olson†, Oklahoma University Health Sciences Center
	Nigel Turner, Garvan Institute of Medical Research Role of C-Cbl in the Regulating Fatty Acid Oxidation and Energy Metabolism

	Jun Wada, Okayama University Graduate School of Medicine Gene Delivery of Tim44 Reduces Mitochondrial Superoxide Production and Ameliorates Neointimal Proliferation
	Xiaoyong Yang, Yale University Phosphatidylinositol Signaling Links Protein O-GlcNAc Modification to Insulin Resistance
	Sarah L. Gray, University of Cambridge Metabolic Characterization of Mice Heterozygous for a Dominant-Negative PPARgamma Mutation
	Katja A. Lamia, The Salk Institute for Biological Studies Circadian Clocks and Mammalian Energy Homeostasis
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Molecular Control of Insulin Sensitivity	British Ballroom
	* Morris F. White†, Children's Hospital Boston

	Michael P. Czech, University of Massachusetts Medical School Pathways Controlling Insulin Sensitivity in Adipose Cells

	Evan D. Rosen, Beth Israel Deaconess Medical Center, Harvard University A Genomic Screen for the Cellular Basis of Insulin Resistance
	Timothy E. McGraw, Weill Medical College of Cornell University Molecular Control of Glucose Uptake
	Liza Makowski, Duke University Medical Center Short Talk: A Novel Role for Mitochondrial-derived Fatty Acid Metabolites in Regulating Insulin Signaling
	Sarah L. Dunn, Children's Hospital Boston Short Talk: Serine Phosphorylation of Irs2: Regulation of Irs2(Ser965) Phosphorylation by MAP kinase Pathways
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
7:30 - 10:00 PM	Poster Session 3	Pacific Ballroom
Wednesday, January 25
7:00 - 8:00 AM	Breakfast	Pacific Ballroom
8:00 - 11:15 AM	Secretory Pathway and Energy Homeostasis	British Ballroom
	* Fumihiko Urano, University of Massachusetts Medical School
	Jonathan S. Weissman, University of California, San Francisco Exploration of the Topological Requirements of ERAD Identifies Yos9p as a Lectin Sensor of Misfolded Glycoproteins in the ER Lumen
	Takashi Kadowaki, University of Tokyo Adiponenctin,Adiponenctin Receptors, and Metabolic Regulation
	Mitchell A. Lazar, University of Pennsylvania School of Medicine Part I: Resistin and Atherosclerosis Part II: A Post-Translational Nuclear Receptor Switch That Synchronizes Circadian Rhythms
	Jeffrey E. Pessin, Stony Brook University Regulation of Insulin Responsive Vesicle Trafficking in Adipocytes
	Hans P.M.M. Lauritzen, Short Talk: Imaging of Insulin Signaling in Skeletal Muscle of Living Mice Shows Major Role of T-Tubules
	Sonya G. Fonseca, University of Massachusetts Medical School Short Talk: WFS1 is Important in Mitigating Endplasmic Retuculum Stress in Beta Cells through the Unfolded Protein Response
9:20 - 9:40 AM	Coffee Break	BC Foyer
4:30 - 5:00 PM	Coffee Available	BC Foyer
5:00 - 7:00 PM	Metabolic Crosstalk and Energy Homeostasis (Joint)	British Columbia Ballroom

	* Silvia Corvera, University of Massachusetts Medical School
	* Philipp E. Scherer, University of Texas Southwestern Medical Center at Dallas
	C. Ronald Kahn, Joslin Diabetes Center Tissue Specific PPARgamma Effects, Insulin Responsiveness and Energy Homeostasis
	Stephen O'Rahilly, University of Cambridge Human Obesity and Insulin Resistance: Lessons from Experiments of Nature
	Gerald I. Shulman, HHMI/Yale University School of Medicine Mitochondrial Dysfunction and Type 2 Diabetes
	Silvana Obici, University of Cincinnati Short Talk: Metabolic Consequences of the Activation of the Hexosamine Biosynthesis Pathway in Skeletal Muscle
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Pacific Ballroom
8:00 - 11:00 PM	Entertainment	Pacific Ballroom
Thursday, January 26
	Departure

*Session Chair †Speaker invited, not yet responded.