Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Eicosanoids in Inflammation and Chronic Diseases (A3)

Organizer(s): K. Frank Austen, Roy J. Soberman and Jilly F. Evans
January 10 - 15, 2006
Yarrow Resort Hotel · Park City, Utah
Abstract Deadline: September 14, 2005
Late Abstract Deadline: October 6, 2005
Scholarship Deadline: September 14, 2005
Early Registration Deadline: November 10, 2005

Supported by The Director's Fund

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This meeting took place in the 2006 season.

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Summary of Meeting
The consideration of eicosanoids in chronic inflammatory disease will provide a molecular and structural background that will integrate basic, translational, clinical and therapeutic findings. To focus on eicosanoids as elements in chronic inflammation, it appears instructive to examine three clinical entities in which inflammation is superimposed on pathobiology modulated by genetic and environmental susceptibilities. These entities -- atherosclerosis, rheumatoid arthritis, and bronchial asthma with remodeling -- involve different organ systems, yet share the cellular events of chronicity and evidence for involvement of eicosanoids. Various eicosanoids have been implicated in chronic inflammatory diseases by identification of eicosanoid producing cells within clinical lesions, positional cloning of disease associated candidate genes within the eicosanoid generating pathway, and targeted mutations within the eicosanoid generating pathway that interrupt surrogate animal models of a clinical entity. The identification of two or more receptors for a particular eicosanoid at the cellular membrane of bone marrow-derived inflammatory cells has expanded the role of eicosanoids to all aspects of the innate and adaptive immune host inflammatory responses. The generation of eicosanoids by leukocytes is regulated during cell differentiation and after maturation by local peripheral tissue-derived growth factors and cytokines. Finally, particular eicosanoids can have opposing cellular functions uncovered through the time course of their appearance or the profile of receptor expression on the target cell.

Objectives
Upon completion of this conference, participants should be able to:

To explain current knowledge of the molecular mechanisms regulating the synthesis and response to eicosanoids.
To identify the roles of eicosanoids in chronic diseases focusing on atherosclerosis, rheumatoid arthritis, and bronchial asthma.
To define novel therapeutic strategies centered on eicosanoids to control chronic inflammatory diseases.

Tuesday, January 10
3:00 - 7:30 PM	Registration	Lobby
6:30 - 7:30 PM	Refreshments	Summit C
7:30 - 8:30 PM	Keynote Address	Summit A-B

	Garret A. FitzGerald, University of Pennsylvania Prostaglandins and Cardiovascular Biology
Wednesday, January 11
7:00 - 8:00 AM	Breakfast	Ivers/Hearst/Kearns & Mountain View
8:00 - 11:00 AM	The Biology and Biochemistry of Phospholipases	Summit A-B
	* Christina C. Leslie, National Jewish Medical and Research Center Regulation of Cytosolic Phospholipase A2 Activation and COX2 Expression in Macrophages by the Beta-Glucan Receptor
	Michael H. Gelb, University of Washington The Role of Phospholipases A2 in Eicosanoid Generation and Airway Inflammation
	Jonathan P. Arm, Brigham and Women's Hospital, Harvard Medical School How Group V Phospholipase A2 Amplifies Inflammation

	Dieter Steinhilber, University of Frankfurt Pathways Involved in Cellular 5-Lipoxygenase Activation
	Peter F. Weller, Beth Israel Deaconess Medical Center Short Talk: 5-Lipoxygenase Localization to Cytosolic Lipid Bodies in Rat Basophil Leukemia Cells
9:20 - 9:40 AM	Coffee Break	Summit Hallway
11:00 AM - 1:00 PM	Poster Setup	Summit C
1:00 - 10:00 PM	Poster Viewing	Summit C
4:30 - 5:00 PM	Coffee Available	Summit Hallway
5:00 - 7:00 PM	Structural Biology of Proteins in the Eicosanoid Pathways	Summit A-B
	* William L. Smith, University of Michigan Omega-3 and Omega-6 Essential Fatty Acids, COX-1 and COX-2, and TP and IP Receptors
	Ingeborg Schmidt-Krey, Georgia Institute of Technology Structure Determination of LTC4 Synthase by Electron Crystallography
	Daniel J. Müller, Center of Biotechnology, University of Dresden Observing Folding Kinetics, Ligand Binding and Activation of a Single Antiporter
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Summit C
7:30 - 10:00 PM	Poster Session 1	Summit C
Thursday, January 12
7:00 - 8:00 AM	Breakfast	Ivers/Hearst/Kearns & Mountain View
8:00 - 11:00 AM	Integrative Biology of Leukotriene Synthesis	Summit A-B
	* Roy J. Soberman, Massachusetts General Hospital, Harvard Medical School The Membrane Organization of Leukotriene and Prostaglandin Formation
	Douglas K. Miller, The Structure/Function of FLAP

	Susan P. C. Cole, Queen's University Structure Function Studies of the LTC4 Transporter, MRP1 (ABCC1)
	Robert C. Murphy, University of Colorado Denver Moving LTA4 Through and Between Cells: Transcellular Biosynthesis
	Thomas G. Brock, University of Michigan Short Talk: Protein Kinase A Inhibits 5-Lipoxygenase Activity by Two Mechanisms
9:20 - 9:40 AM	Coffee Break	Summit Hallway
11:00 AM - 1:00 PM	Poster Setup	Summit C
1:00 - 10:00 PM	Poster Viewing	Summit C
2:30 - 4:30 PM	Workshop 1: Eicosinoids in Human Disease, Animal Models, and Mechanisms of Action	Summit A-B
	* Shuh Narumiya, Kyoto University

	Hans-Erik Claesson, Biolipox AB Evidence for a Pathophysiological Role of Cysteinyl Leukotrienes in Hodgkin Lymphoma
	Nora A. Barrett, Brigham and Women's Hospital Short Talk: Cysteinyl Leukotriene-Dependent Th2 Pulmonary Inflammation
	John-David H. Herlihy, University of Florida Alterations in Gene Expression in the Eicosanoid Pathway in a Mouse Model of Allergic Asthma in Normal and CFTR Knockout Mice
	Irving Coy Allen, University of North Carolina at Chapel Hill Thromboxane A2 Induces Airway Constriction Through An M3 Muscarinic Acetylcholine Receptor Dependent Mechanism
	Charles D. Loftin, University of Kentucky Genetic or Pharmacological Inactivation of COX-2 Attenuates Abdominal Aortic Aneurysm Formation in Mice
	Sylvain Dore, Johns Hopkins University Prostaglandin EP1 Receptor Contributes to Excitotocicity and Focal Ischemic Brain Damage
4:30 - 5:00 PM	Coffee Available	Summit Hallway
5:00 - 7:00 PM	Eicosanoids and Adaptive Immunity	Summit A-B
	Gwendalyn J. Randolph, Mount Sinai School of Medicine The Regulation of Langerhans Cell Migration by LTC4

	Martin R. Hodge, Biogen Idec Regulation of Allergic Inflammation by CRTH2
	* Bart N. Lambrecht, Ghent University Control of Dendritic Cell Function by Prostaglandin D2
	Richard M. Breyer, Vanderbilt University Short Talk: The Role of PGD2 In Experimental Autoimmune Encephalomyelitis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Summit C
7:30 - 10:00 PM	Poster Session 2	Summit C
Friday, January 13
7:00 - 8:00 AM	Breakfast	Ivers/Hearst/Kearns & Mountain View
8:00 - 11:00 AM	Eicosanoids and Cardiovascular Disease	Summit A-B
	* Linda K. Curtiss, The Scripps Research Institute Atherosclerosis is a Chronic Inflammatory Disease
	Colin D. Funk, Queen's University 5-Lipoxygenase in Vascular Disease and a New Knock-in Model (COX-1>COX-2) to Study Prostaglandin Function
	Andreas J. R. Habenicht, University of Jena LTD4-Induced Endothelial Cell Genes Indicate Roles of 5-Lipoxygenase in Vascular Inflammation
	Margarete Mehrabian, University of California, Los Angeles 5-Lipoxygenase: Pleiotropic Effects on Atherosclerosis, Obesity and Insulin Resistance
	Kári Stefánsson, deCode Genetics The Role of the Leukotriene Pathway in the Risk of Myocardial Infarction
9:20 - 9:40 AM	Coffee Break	Summit Hallway
4:30 - 5:00 PM	Coffee Available	Summit Hallway
5:00 - 7:00 PM	Eicosanoids in Arthritis: Human Disease and Animal Models	Summit A-B
	* K. Frank Austen, Brigham and Women's Hospital, Harvard Medical School
	Leslie J. Crofford, University of Kentucky Prostaglandins in Rheumatoid Arthritis: Can Safe Drugs be Developed?
	David M. Lee, Novartis Pharma AG Dissecting the 5-LO Pathway in Models of Arthritis
	Ichiro Kudo, Showa University Characterization of Mice Lacking Mircrosomal and Cytosolic Prostaglandin E Synthases
	Eri Segi-Nishida, Kyoto University Faculty of Medicine Short Talk: Prostacyclin Signaling Mediates Arthritic Inflammation by Promoting Synovial Cell Activation in Mouse Collagen-Induced Arthritis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Summit C
8:00 - 10:15 PM	Workshop 2: Eicosanoids in Human Disease and Relevant Animal Models	Summit A-B
	* Jilly F. Evans, Amira Pharmaceuticals Technologies for Identifying and Designing Future Inhibitors of Enzymes and Receptors
	* Takao Shimizu, University of Tokyo
	Masataka Majima, Kitasato University School of Medicine Stromal Prostaglandin Receptor Signaling Relevant to Tumor-Associated Angiogenesis: Role of Recruitment of Prostaglandin Receptor-Expressing Bone Marrow Cells
	Yan Cheng, University of Pennsylvania Beyond Inhibition of COX-2: Differential Effects of PG/H and mPGE Synthase Disruption on Prostacyclin Biosynthesis and Cardiovascular Function in vivo
	Christianne Bandeira-Melo, Universidade Federal do Rio de Janeiro PGD2 Controls LTC4 Synthesis by Eosinophils during Allergic Inflammation: Synergistic Role of Endogenous Eotaxin
	Pallavi R. Devchand, Harvard Medical School Chemical Probing in Rats to Understand Impact of Eicosonoids in Human Colitis-Induced Cancers
	Annalisa Del Prete, University of Bari Leukotriene B4 Receptors: Multiple Roles for LTB4 in Dendritic Cell Functions
	Naonori Uozumi, Cincinnati Children's Hospital Medical Center Disease Model Studies on cPLA2alpha-deficient Mice
Saturday, January 14
7:00 - 8:00 AM	Breakfast	Ivers/Hearst/Kearns & Mountain View
8:00 - 11:00 AM	Eicosanoids, Asthma, and Airway Inflammation	Summit A-B
	* Peter F. Weller, Beth Israel Deaconess Medical Center



	Larry Borish, University of Virginia Medical Center Cysteinyl Leukotriene Over-Production and Over-Responsiveness in Aspirin-Exacerbated Respiratory Disease

	Marc Peters-Golden, University of Michigan Eicosanoids in Fibrotic Lung Disease: A Tale of Two Lipids
	Alysia K. Lovgren, University of North Carolina at Chapel Hill Short Talk: COX-2 Mediated Protection against Pulmonary Fibrosis is Not Dependent on Prostaglandin E2 Production
	Yoshihide Kanaoka, Brigham and Women's Hospital, Harvard Medical Center The Function of Cysteinyl Leukotriene Receptors in Lung Inflammation
	Joshua A. Boyce, Brigham and Women's Hospital, Harvard Medical Center Cysteinyl Leukotrienes and their Receptors as Autocrine Regulators of Mast Cell Function
9:20 - 9:40 AM	Coffee Break	Summit Hallway
4:30 - 5:00 PM	Coffee Available	Summit Hallway
5:00 - 7:00 PM	Receptors for Leukotrienes and Prostaglandins	Summit A-B
	* Takao Shimizu, University of Tokyo Biochemistry and Biology of Leukotriene B4 receptors
	Shuh Narumiya, Kyoto University Pro- and Anti-Inflammatory Actions of Prostanoids as Revealed by Receptor KO Mice Studies
	* Lawrence J. Marnett, Vanderbilt University School of Medicine Glyceryl Prostaglandins: Novel Bioactive Lipids Produced from Endocannabinoids
	Hajime Yoshisue, Southampton General Hospital Short Talk: Cysteinyl-Leukotrienes Synergise with Receptor Tyrosine Kinase Growth Factors on Mitogenesis of Human Lung Fibroblasts
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Summit C
8:00 - 11:00 PM	Entertainment	Summit C
Sunday, January 15
	Departure

*Session Chair †Speaker invited, not yet responded.