Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Chemokines and Chemokine Receptors (A4)

Organizer(s): Andrew Luster and Philip Murphy
January 15 - 20, 2006
Snowbird Resort · Snowbird, Utah
Abstract Deadline: September 15, 2005
Late Abstract Deadline: October 6, 2005
Scholarship Deadline: September 15, 2005
Early Registration Deadline: November 15, 2005

Supported by The Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Chemokines are chemotactic cytokines that induce the directed migration of cells by activating specific G protein-coupled receptors. This system of ~50 cytokines and ~20 receptors plays a particularly prominent role in development, homeostasis and activation of leukocytes in the mammalian immune system. Chemokines determine the nature of the tissue inflammatory response in a wide range of human diseases and represent attractive new therapeutic targets. Chemokines may also attract and stimulate non-immune cells, such as tumor cells, neurons and blood vessels. This meeting will address major unanswered questions in the chemokine field including how chemokines regulate lymphoid development, how cells sense chemokine gradients, the nature of the chemokine signaling pathway, how chemokines amplify immunologically-mediated disease, and whether disrupting chemokine signaling can treat or prevent disease. A systems biology approach to chemokine function in vivo will be highlighted and will extend to the regulation and interrelationship of the chemokine system with other regulatory systems in vivo.

Objectives
Upon completion of this conference, participants should be able to:

To describe how chemokines regulate lymphoid development.
To explain how cells sense chemokine gradients.
To describe the nature of the chemokine signaling pathway.
To recognize how chemokines amplify immunologically-mediated disease.
To assess whether disrupting chemokine signaling can treat or prevent disease.
To summarize the current knowledge of chemokine and chemokine receptor control of leukocyte trafficking in vivo, molecular mechanisms of chemoattractant signal transduction, and regulation of chemokine action in vivo.
To identify the role of chemokines and chemokine receptors in disease and identify novel therapeutic targets.

Sunday, January 15
3:00 - 7:30 PM	Registration	Ballroom Lobby
6:30 - 7:30 PM	Refreshments	Ballroom Mezzanine & Lobby
7:30 - 8:30 PM	Keynote Address	Ballroom 2-3
	Eugene C. Butcher, Stanford University Leukocyte-Endothelial Cell Recognition: Toward a General Model of Leukocyte Trafficking
Monday, January 16
7:00 - 8:00 AM	Breakfast	Golden Cliff, Wasatch, Superior Lobby
8:00 - 11:30 AM	Chemokine Control of Leukocyte Trafficking in the Adaptive Immune Response	Ballroom 2-3
	* Martin Lipp, Max-Delbrück-Center, MDC
	Ulrich H. Von Andrian, Harvard Medical School T Cell and DC Trafficking in the Lymph Node

	Reinhold Förster, Hannover Medical School DC Migraton in Tolerance and Immunity
	Hans-Christian Reinecker, Massachusetts General Hospital Short Talk: Chemokine Receptors Regulate Intestinal DC Subsets in Mucosal Defense
	Federica Sallusto, Institute for Research in Biomedicine Leukocyte Trafficking to the Inflamed Lymph Node
	Joshua M. Farber, NIAID, National Institutes of Health Chemokines in CD4+ T Cell Memory
	Thomas B. Issekutz, Dalhousie University Short Talk: Migration of CCR4+ Memory CD4 T Cells to Dermal Inflammation is Mediated by CXCR3
	Hanna Stenstad, Lund University Short Talk: Gut Associated Lymphoid Tissue Primed CD4+ T Cells Display CCR9 Dependent and Independent Homing to the Murine Small Intestine
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:30 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Maybird
2:00 - 4:30 PM	Workshop 1: Novel Chemokine Biology	Ballroom 2-3
	* Osamu Yoshie, Kinki University
	* Joost J. Oppenheim, National Institutes of Health Alarmins are Non-Cognate Chemokine Receptor Ligands and Activators of Dendritic Cells
	Brigitte Gomperts, University of California, Los Angeles Circulating Progenitor Epithelial Cells Traffic via CXCR4/CXCL12 in Response to Airway Injury
	Yang Hu, Weill Graduate School of Medical Sciences of Cornell University Costimulation of Chemokine Receptor Signaling by MMP-9 Mediates Enhanced Migration of IFNá-DCs
	George Ed Rainger, University of Birmingham A Multi-Cellular in Vitro Model of Chronic Inflammatory Joint Disease Identifies Novel Routes of Chemokine Expression Presentation and Function
	Ewan A. Ross, University of Birmingham Platelet Endothelial Cell Adhesion Molecule (Pecam)-1 Modulates Sdf-1alpha/Cxcr4 Responses of Hematopoietic Stem Cells
	Marcus Svensson, Lund University Role of CCR9 in Thymic T Cell Development
	Raffaella Bonecchi, Istituto Clinico Humanitas The Chemokine Decoy Receptor D6 Protects the Fetus from Inflammation Acting as an Inflammatory CC Chemokine Scavenger at the Fetal-Maternal Interface
	Gabriele S.V. Campanella, Massachusetts General Hospital IP-10 (CXCL10) Oligomerization is Important for its in Vivo Activity
	Jana Barlic, National Institutes of Health Oxidized LDL Metabolites Upregulate Expression and Function of Monocyte CX3CR1 through a PPARgamma-dependent Pathway
4:30 - 5:00 PM	Coffee Available	Ballroom Mezzanine & Lobby
5:00 - 7:15 PM	Chemokines in Immune System Homeostasis	Ballroom 2-3
	* Bernhard Moser, Cardiff University School of Medicine Steady-State T Cell Traffick in Human Skin
	Mehrdad Matloubian, University of California, San Francisco Regulation of Lymphocyte Exit from Lymphoid Organs
	Hugh Rosen, The Scripps Research Institute S1P1 Control of Lymphocyte Trafficking
	Shannon Bromley, Massachusetts General Hospital Short Talk: CCR7 Guides T Cell Exit from Peripheral Tissues and Entry into Afferent Lymphatic

	Ariel Achtman, Max-Delbrück-Centrum für Molekulare Medizin Short Talk: CCR7 Deficiency Leads to Disturbed Lymphocyte Recirculation through Non-Lymphoid Tissues and Causes Hypertrophic Gastropathy
	Shahin Rafii, Weill Cornell Medical College Chemokine-Mediated Interaction of Hematopoietic Progenitors with the Bone Marrow Vascular Niche
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird
7:30 - 10:00 PM	Poster Session 1	Superior/Superior Lobby/Maybird
Tuesday, January 17
7:00 - 8:00 AM	Breakfast	Golden Cliff, Wasatch, Superior Lobby
8:00 - 11:15 AM	Chemoattractant Signal Transduction	Ballroom 2-3
	* Ann Richmond, Vanderbilt University School of Medicine Localiztion of Signaling Events in Chemotaxing
	Ronen Alon, Weizmann Institute of Science Chemokine Regulation of Lymphocyte Adhesion and Migration
	Tatsuo Kinashi, Kansai Medical School Roles of Rap1-RAPL in Chemokine-Mediated Immune Cell Migration
	Dianqing Dan Wu, Yale University School of Medicine Genetic Study of Chemoattractant Signaling
	Antonella Viola, University of Milan Orchestration of Leukocyte Chemotaxis by Mitochondrial Dynamics
	Jens V. Stein, University of Bern Short Talk: A Central Role for DOCK2 During Interstitial T and B Lymphocyte Migration and Lymph Node Egress
	Barbara Walzog, Ludwig-Maximilians-Universität Short Talk: The Vav Binding Site of the Non-Receptor Tyrosine Kinase Syk at Tyr 348 Is Critical for Beta2 Integrin (CD11/CD18)-Mediated Leukocyte Polarization and Migration
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:30 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Mezzanine & Lobby
5:00 - 7:15 PM	Regulation of Chemokine Action	Ballroom 2-3

	* Gerry J. Graham, University of Glasgow The Chemokine Decoy Receptor, D6, Regulates the Inflammatory Response in vivo

	Frances E. Lund, University of Rochester Medical Center Regulation of Cell Trafficking under Homeostatic and Inflammatory Conditions: Roles for CD38, cADPR and Galphaq
	Christopher M. Overall, University of British Columbia Dynamic Regulation of the Chemokine Web by Matrix Metalloproteinases
	Ifor Williams, Emory University Short Talk: Developmental Regulation of Sulfation of N-Terminal Tyrosine of Mouse CCR9 by Tyrsoylprotein Sulfotransferase-2
	Andrea Meiser, Imperial College, Faculty of Medicine Short Talk: The Chemokine Receptor CXCR3 is Replenished at the Cell Surface by de novo Synthesis of Receptor and not by Receptor Recycling
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird
7:30 - 10:00 PM	Poster Session 2	Superior/Superior Lobby/Maybird
Wednesday, January 18
8:00 - 11:30 AM	Chemokines in Immunologically-Mediated Disease I	Ballroom 2-3
	* Richard M. Ransohoff, Cleveland Clinic EAE in D6-/- Mice
	Klaus Ley, La Jolla Institute for Allergy and Immunology Arrest Chemokines in Atherosclerosis: Specialized Receptors and Signaling Pathways
	Seema S. Ahuja, University of Texas Health Science Center Chemokines and Chemokine Receptors in Rheumatoid Arthritis
	Thomas J. Schall, ChemoCentryx, Inc. Novel Chemokines and Chemokine Receptors in Development and Disease
	Israel F. Charo, Gladstone Institute of Cardiovascular Disease Chemokines and the Metabolic Syndrome
	Robert E. Gerszten, Massachusetts General Hospital Short Talk: The T Cell Chemokine CXCL10 (IP-10) Modulates Atherogenesis via the Local Balance of the Effector and Regulatory Arms of the Immune System
	Nikolaos G. Frangogiannis, Baylor College of Medicine Short Talk: Role of the C-C Chemokines in Myocardial Infarction
	Amnon Peled, Hebrew University, Hadassah Medical School Role of Chemokine Receptors in NK Cell Mobilization and Trafficking
	Toshihiro Nanki, Tokyo Medical and Dental University Short Talk: Pathogenic Role of CXCL16-CXCR6 Pathway in Rheumatoid Arthritis
7:00 - 8:00 AM	Breakfast	Golden Cliff, Wasatch, Superior Lobby
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
11:00 AM - 1:00 PM	Poster Setup	Superior/Superior Lobby/Maybird
1:00 - 10:00 PM	Poster Viewing	Superior/Superior Lobby/Maybird
4:30 - 5:00 PM	Coffee Available	Ballroom Mezzanine & Lobby
5:00 - 7:30 PM	Chemokines in Immunologically-Mediated Disease II	Ballroom 2-3
	* Craig Gerard, Children's Hospital Harvard University
	Nicholas W. Lukacs, University of Michigan Chemokine Receptors and Chronic Airway Disease

	Dan R. Littman, New York University School of Medicine Chemokines in Myeloid and T Cell Function
	Richard M. Ransohoff, Cleveland Clinic
	Joseph El Khoury, Massachusetts General Hospital Short Talk: Chemokine Regulation of Microglial Recruitment in Alzheimer's Disease
	Jesús Rivera-Nieves, University of Colorado Health Sciences Center Short Talk: Role of CCR9/CCL25 in Chronic Murine Ileitis
	Julie A. DeMartino, Merck Research Laboratories Updates and Future Directions of Anti-Chemokine Therapeutics
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Superior/Superior Lobby/Maybird
7:30 - 10:00 PM	Poster Session 3	Superior/Superior Lobby/Maybird
Thursday, January 19
7:00 - 8:00 AM	Breakfast	Golden Cliff, Wasatch, Superior Lobby
8:00 - 11:30 AM	Chemokines and Infectious Disease	Ballroom 2-3
	* Steven L. Kunkel, University of Michigan Medical School
	Antonio Alcami, Centro Nacional de Biotecnologia Viral Chemokine Binding Proteins
	Eric G. Pamer, Memorial Sloan-Kettering Cancer Center Regulation of Leukocyte Trafficking during Infection
	Kouji Matsushima, University of Tokyo School of Medicine Chemokine-Regulated Subsets of DCs in Anti-Viral Immunity
	Michael J. Holtzman, Washington University Chemokine Protection from Virus-Induced Cell Death
	Jean K. Lim, National Institutes of Health Short Talk: Chemokine Receptor CCR5 Mediates Resistance to West Nile Virus Infection in Mouse and Man
	Fang Liao, Academia Sinica Short Talk: Both CXCR3 and CXCL10/IP-10 are Required for Resistance to Primary Infection by Dengue Virus
	Kathleen A. Kelly, University of California, Los Angeles Short Talk: CXCL13 is Induced within Human Fallopian Tubes Following Infection with Chlamydia and Alters Oviduct Pathology
9:20 - 9:40 AM	Coffee Break	Ballroom Mezzanine & Lobby
2:00 - 4:30 PM	Workshop 2: Preclinical and Clinical Development of Anti-Chemokine Therapy for Disease	Ballroom 2-3
	* Amanda E.I. Proudfoot Fichard, Merck Serono Geneva Research Centre
	* Albert Zlotnik, Senomyx Inc Diagnostic and Therapeutic Uses of Chemokines
	Andreas J. Kungl, ProtAffin Biotechnologie AG Developing Receptor-Deficient Chemokine Mutants Towards Glycosaminoglycan Antagonists: The CellJammer Anti-Inflammatory Approach
	Andrea Paula Martin, Mount Sinai School of Medicine The Chemokine Binding Protein M3 Prevents Inflammatory and Autoimmune Diabetes
	Christina Anne Bursill, Heart Reserach Institute Membrane-Bound CC-Chemokine Inhibitor ‘M35K’ Provides Localised Inhibition of CC-Chemokine Activity in Vitro and in Vivo
	Jennifer Alexander-Brett, Washington University School of Medicine Promiscuous Chemokine Sequestration By a Herpesvirus Decoy Receptor
	R. William Hipkin, Schering-Plough Research Institute The Affinity and Intrinsic Activity of Chemokines at hCXCR1 and hCSCR2: CXCL8 is Functionally CXCR1-Selective
	Kathleen A. Sullivan, Merck & Co., Inc. In Vivo Consequences of CXCR3 Blockade with Small Molecule Antagonists
	Kenneth R. Cooke, University of Michigan CCR1:CCL5 (RANTES) Receptor:Ligand Interactions Modulate Allogeneic T Cell Responses Following Allogeneic Bone Marrow Transplantation
	Oliver Dewald, University Clinical Center Bonn CCL2/MCP-1 Deficiency Prevents Development of Ischemic Cardiomyopathy Decreasing Interstitial Fibrosis
4:30 - 5:00 PM	Coffee Available	Ballroom Mezzanine & Lobby
5:00 - 7:15 PM	Chemokines in Cancer and Development	Ballroom 2-3

	* Robert M. Strieter, University of Virginia School of Medicine Chemokines and Cancer
	Fabienne Mackay, Nursing and Health Sciences Central Clinical School CXCR7 Deficient Mice Reveal a Key Role for this Receptor in Cardiac Development and Splenic Marginal Zone B Cell Formation


	Tyler J. Curiel, University of Texas Health Science Center Chemokines in Cancer Pathogenesis
	Sergio A. Lira, Mount Sinai School of Medicine Tumorigenesis Induced by the HHV8-Encoded Chemokine Receptor
	Gwendal Lazennec, INSERM Short Talk: IL-8 is a Novel Marker for Breast Cancer
	Hiroshi Miyazaki, Philips Institute-Virginia Commonwealth University Short Talk: Regulation of Squamous Cell Carcinoma Proliferation and Invasion by CXCL5
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Golden Cliff, Eagles Nest, Superior Lobby
8:00 - 11:00 PM	Entertainment	Golden Cliff, Eagles Nest, Superior Lobby
Friday, January 20
	Departure

*Session Chair †Speaker invited, not yet responded.