Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Viral Immunity: From Basic Mechanisms to Vaccines (X7)

Organizer(s): Marcia A. Blackman, Peter C. Doherty and Ralph A. Tripp
March 28 - April 2, 2006
Sheraton Steamboat Resort · Steamboat Springs, Colorado
Abstract Deadline: November 30, 2005
Late Abstract Deadline: December 21, 2005
Scholarship Deadline: November 30, 2005
Early Registration Deadline: January 27, 2006

Supported by The Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: Advances in Influenza Research: From Birds to Bench to Bedside (X8)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Most human viruses lack an effective vaccine, and the problems posed by emerging viruses and the use of exotic viruses in acts of terrorism are extremely complex. Recent advances in basic and applied research have provided an unparalleled opportunity to understand the interplay between the virus and the immune system. This meeting will bring together basic and applied viral immunologists from academia, government, and industry to foster collaborative efforts to take advantage of recent progress in understanding basic mechanisms in the generation and long-term maintenance of anti-viral immunity for the development of effective anti-viral strategies. Experts in the field will present plenary talks on the latest breakthroughs in key areas of viral immunology, including molecules and immune cells involved in the initiation of immunity, cellular and humoral effector mechanisms, and mechanisms involved in establishing and maintaining protective memory responses. Workshops will provide a more interactive format for discussion of cutting-edge results. The overall emphasis of the meeting is to discuss how to exploit advances made in fundamental concepts to make vaccines. The goal of the meeting is to accelerate vaccine development for existing viruses, and to facilitate a rapid response to the threat of emerging viruses and bioterrorism.

Objectives
Upon completion of this conference, participants should be able to:

To define the signals that initiate an anti-viral immune response .
To identify the mechanisms of innate immunity .
To explain the cellular and humoral aspects of adaptive immunity.
To describe the mechanisms associated with the generation and maintenance of immune memory.
To assess the fundamental concepts to make vaccines .
To explain emerging and re-emerging virus infections.

Tuesday, March 28
3:00 - 7:30 PM	Registration	Foyer
6:30 - 7:30 PM	Refreshments	Foyer
7:30 - 8:30 PM	Keynote Address (Joint)	Sunshine / Mt. Werner / Storm Peak

	* Kanta Subbarao, NIAID, National Institutes of Health Introduction of Influenza Meeting
	* Ralph A. Tripp, University of Georgia
	Peter C. Doherty, University of Melbourne Structure-Function Relationships in the Influenza Virus-Specific CD8+ T Cell Response
Wednesday, March 29
7:00 - 8:00 AM	Breakfast	3 Saddles / Bear River
8:00 - 11:15 AM	Emerging and Re-Emerging Respiratory Virus Infections (Joint)	Sunshine / Mt. Werner / Storm Peak
	* Ralph A. Tripp, University of Georgia

	Malik Peiris, University of Hong Kong Human Infections with Avian Influenza Viruses
	Jeffery K. Taubenberger, NIAID, National Institutes of Health Lessons from the 1918 Pandemic
	Paul A. Rota, Centers for Disease Control The Emergence of Two Novel Respiratory Viruses: Nipah Virus and SARS-CoV
	Jason W. Botten, The Scripps Research Institute Short Talk: Identification of Protective HLA-A2 Supertype-Restricted CD8+ T Lymphocyte Epitopes in Lassa Virus
	Coreen M. Beaumier, NIAID, National Institutes of Health Short Talk: Kinetics and Specificity of CD8+ T Cell Responses to Sequential Dengue Virus Infections
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Rainbow / Twilight / Sunset / Skyline
1:00 - 10:00 PM	Poster Viewing	Rainbow / Twilight / Sunset / Skyline
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Alerting the Immune System	Mt. Werner / Storm Peak
	Evelyn Kurt-Jones, University of Massachusetts Medical School PAMPS and Viral Infections - Gathering Evidence
	Amaya Iparraguirre, Wistar Institute Short Talk: Overlapping and Distinct Transcriptional Programs of Murine Plasmacytoid Dendritic Cells in Response to TLR7 and TLR9 Engagement
	* Christine A. Biron, Brown University Innate Signaling of Effective Antiviral Immunity
	Maureen C. Howard, ChemoCentryx Cytokine and Chemokine Signaling of Effective Antiviral Immunity

7:00 - 8:00 PM	Social Hour w/ Lite Bites	Foyer
7:30 - 10:00 PM	Poster Session 1	Rainbow / Twilight / Sunset / Skyline
Thursday, March 30
7:00 - 8:00 AM	Breakfast	3 Saddles / Bear River
8:00 - 11:15 AM	Induction of Adaptive Immunity	Mt. Werner / Storm Peak
	Anne Barbara Krug, Technical University Munich The Two Faces of Nucleic Acid Recognition in Dendritic Cells – Induction of Antiviral Responses and Autoimmunity
	Francis R. Carbone, University of Melbourne DC Subsets in T Cell Immunity to Peripheral Viral Infection
	* Thomas J. Braciale, University of Virginia Early Events in the T cell Response to Respiratory Virus Infection
	Jack R. Bennink, NIAID, National Institutes of Health Immunodominance Rules

	Misty Jenkins, University of Melbourne Short Talk: Diversity of Granzyme and Perforin Co-Expression in Effector and Memory Influenza-Specific CD8+ T Cells
	Heath M. Guay, Centocor Short Talk: MyD88 is Required to Generate Long-Term Humoral Immunity to Virus Infection
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Rainbow / Twilight / Sunset / Skyline
1:00 - 10:00 PM	Poster Viewing	Rainbow / Twilight / Sunset / Skyline
2:30 - 3:30 PM	Workshop 1A: Immune Modulation	Sunshine
	* Joan Durbin, Ohio State University
	Nancy A. Jewell, Lovelace Respiratory Research Institute Type I Interferon Induction by Respiratory Viruses in vivo
	Kapil Bahl, University of Massachusetts Medical School Interferon-Induced Attrition of CD8 T Cells in the Presence or Absence of Cognate Antigen during the Early Stages of Viral Infections
	Ulf Dittmer, University of Essen Kinetics of the Development of CD8+ Effector T Cells and CD4+ Regulatory T Cells during Friend Retrovirus Infection
	Peter Johannes Holst, Institute of International Health, Immunology and Microbiology Prompt Protection Against Lethal Viral Disease Induced by an Improved Adenoviral Vaccine
3:30 - 4:30 PM	Workshop 1B: Disease and Pathogenesis	Sunshine
	* Stanley Perlman, University of Iowa Pathogenic Role for Virus-Specific CD4 T cells in Mice with Coronavirus-induced Acute Encephalitis
	Richard I. Enelow, Dartmouth Medical School NKG2A Expression by Influenza-Specific Effector CD8+ T Cells Regulates Pulmonary Immunopathology
	Fei Liu, The Salk Institute Peptide Vaccination of a Virus-Immune Recipient May Cause Serious CD8+ T Cell Mediated, TNF-Dependent, Immunopathology
	Kerstin Luhn, Weatherall Institute of Molecular Medicine Increased Frequencies of CD4+CD25high Regulatory T Cells in Acute Dengue Infection
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Memory to Virus Infections	Mt. Werner / Storm Peak
	* David L. Woodland, Trudeau Institute Unique Aspects of T Cell Memory in the Respiratory Tract
	Liisa K. Selin, University of Massachusetts Medical School Heterologous Immunity and CD8 T Cell Cross-Reactivity during Viral Infections
	Hao Shen, University of Pennsylvania Epigenetic Modification of the IL-2 and IFN-gamma Genes in Memory CD8+ T Cells is Influenced by CD4+ T Cell Help
	David Masopust, Emory University Short Talk: Antigen Experience Dictates Central and Effector Memory CD8 T Cell Differentiation: Implications for Heterologous Prime-Boost Vaccination
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Foyer
7:30 - 10:00 PM	Poster Session 2	Rainbow / Twilight / Sunset / Skyline
Friday, March 31
7:00 - 8:00 AM	Breakfast	3 Saddles / Bear River
8:00 - 11:00 AM	Challenges Presented by Persistent Viruses	Mt. Werner / Storm Peak
	* Ralph A. Tripp, University of Georgia Respiratory Syncytial Virus Manipulation of the Anti-Viral Cytokine Response Facilitates Infection and Contributes to Persistence
	Alan B. Rickinson, University of Birmingham Immunity to Epstein-Barr Virus
	Marcia A. Blackman, Trudeau Institute Gamma-Herpesvirus Latency: Lessons from the Mouse
	Alfredo Nicosia, Instituto di Ricerche di Biologia Molecolare Prospects for T-Cell Based HCV Vaccine

	Neil Blake, University of Liverpool Short Talk: The Role of the Large Acidic Repeat Domain of Herpesvirus saimiri ORF73 in Immune Evasion
	Erin M. Buckingham, University of Colorado Health Sciences Center Short Talk: Tracking Immune Control of Virus Reactivation in vivo
9:20 - 9:40 AM	Coffee Break	Foyer
11:15 AM - 1:00 PM	Poster Setup	Rainbow / Twilight / Sunset / Skyline
1:00 - 10:00 PM	Poster Viewing	Rainbow / Twilight / Sunset / Skyline
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Humoral Immunity and Viruses	Mt. Werner / Storm Peak
	* Dennis R. Burton, The Scripps Research Institute Anti-HIV Activities of Antibodies in vitro and in vivo
	Jenny M. Woof, University of Dundee Mucosal Immunoglobulins in Viral Immunity

	Robert G. Whalen, Altravax, Inc. Creating Improved Viral Immunogens by Directed Molecular Evolution
	Hyemee Joo, University of Tennessee Short Talk: Distribution of Virus-Specific Memory B Cells Following Influenza Infection of the Respiratory Tract
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Foyer
7:30 - 10:00 PM	Poster Session 3	Rainbow / Twilight / Sunset / Skyline
Saturday, April 1
7:00 - 8:00 AM	Breakfast	3 Saddles / Bear River
8:00 - 11:15 AM	Novel Developments in Antiviral Immunity	Mt. Werner / Storm Peak
	* Barry T. Rouse, University of Tennessee Regulatory T Cells and Control of Viral Immunity and Immunopathology
	Janko Nikolich-Zugich, Oregon Health and Science University Aging and anti-viral Immunity to Acute and Chronic Infections
	Ann M. Arvin, Stanford University Infant and Maternal Immunization and Passive Antibodies: New Insights from Investigations of Measles Vaccination
	Dennis M. Klinman, U.S. Food and Drug Administration Use of CpG Oligonucleotides to Improve Host Protection from Infectious Pathogens
	Maya F. Kotturi, La Jolla Institute for Allergy and Immunology Short Talk: Defining the Spectrum of CD8+ T Cell Responses to LCMV
	Michael A. Brehm, University of Massachusetts Medical School Short Talk: Naïve Virus-Specific CD8 T Cells Rapidly Produce TNF-alpha in vivo following TCR-Engagement
9:20 - 9:40 AM	Coffee Break	Foyer
2:30 - 3:30 PM	Workshop 2A: Antigen Presentation	Sunshine
	* Kevin L. Legge, University of Iowa Carver College of Medicine Elimination of Respiratory APCs Inhibits Pulmonary Influenza-Specific CD8 T Cell Responses
	Gabrielle T. Belz, Walter and Eliza Hall Institute of Medical Research Preactivation of Dendritic Cells and TLR Ligands or Malaria Infection Impairs Cross-Priming
	Brian P. Dolan, NIAID, National Institutes of Health Dendritic Cells Cross-Dressed with Peptide-MHC Class I Complexes from Necrotic Cells Activate CD8+ T Cells
	W.L. William Chang, University of California, Davis Tissue Macrophages are a Main Population of Antigen-Presenting Cells during Early Influenza Virus Infection
3:30 - 4:30 PM	Workshop 2B: Immune Recall	Sunshine
	* David J. Topham, University of Rochester Medical Center
	Timothy J. Chapman, University of Rochester Central Memory CD4 T Cells can Mediate Protection Against Secondary Influenza Infection
	Scott N. Mueller, University of Melbourne Qualitatively Different Memory Cells are Generated Following LCMV or Influenza Virus Infection
	Emilio Flano, Ohio State University Generation of CD8+ T Cell Memory to Latent Viral Infections
	Luis J. Sigal, Fox Chase Cancer Center Long-Lived Memory CD8+ T Cells Protect from a Lethal Viral Disease by Limiting Virus Spread from the Lymph Node Draining the Site of Primary Infection
4:30 - 5:00 PM	Coffee Available	Foyer
5:00 - 7:00 PM	Exploring Fundamental Concepts to Make Vaccines (Joint)	Sunshine / Mt. Werner / Storm Peak
	Stanley A. Plotkin, University of Pennsylvania and Sanofi Pasteur Old and New Vaccine Strategies
	* Yoshihiro Kawaoka, University of Wisconsin-Madison Application of Reverse Genetics to Vaccine Development

	Mark K. Slifka, Oregon Health & Science University Smallpox, Smallpox Vaccination, and the Question of Long-Term Immunity

	Stephen Mark Tompkins, University of Georgia Short Talk: M2-DNA Immunization Induces Broad Protection against Influenza Virus Challenge, Including Potentially Pandemic H5N1 Isolates
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Foyer
8:00 - 11:00 PM	Entertainment	Sunshine
Sunday, April 2
	Departure

*Session Chair †Speaker invited, not yet responded.