Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Cell Biology of Virus Entry, Replication and Pathogenesis (C4)

Organizer(s): Herbert W. Virgin, Robert A. Lamb, Richard W. Compans, Robert W. Doms and Michael B.A. Oldstone
February 24 - March 1, 2006
Eldorado Hotel & Spa · Santa Fe, New Mexico
Abstract Deadline: October 25, 2005
Late Abstract Deadline: November 17, 2005
Scholarship Deadline: October 25, 2005
Early Registration Deadline: December 23, 2005

Supported by The Director's Fund

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

This meeting took place in the 2006 season.

Listed below are current meetings that are similar to this meeting in nature/content:

Cell Biology of Virus Entry, Replication and Pathogenesis (B5)
February 16 - 21, 2010

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The elucidation of the molecular interactions between viral components and cells, and how this determines the outcome of infection is the most exciting area of modern virology. New advances in structural biology, genetics, and molecular virology have speeded the pace of discovery in this area and led to significant insights into virology, immunology and cell biology. The new NIH emphasis on mechanisms of viral infection provides new support and excitement for this already fertile area. The pivotal areas to be covered are (i) the cell biology of virus entry, uncoating, protein traffic, assembly, budding and release, (ii) the defensive mechanisms that cells and organisms use to combat viruses, (iii) strategies of viral immune evasion. These areas impact significantly on fundamental issues in cell biology, cell and species tropism, and pathogenesis of viral diseases. The meeting will once again provide a cross disciplinary forum for discussing novel insights into cell biology of virus infection and the relationship of these findings to pathogenesis and defense. Each session covers a topic rather than a virus family in order to foster discussion across virus family-boundaries. Our topic oriented program has been very successful in the many successful meetings organized since 1988.

Objectives
Upon completion of this conference, participants should be able to:

To explain how viruses utilize cell surface receptors and endocytic pathways to effect viral entry.
To define how viruses interact with cellular machinery to effect rapid and directed intracellular movement.
To explain how viruses usurp normal cellular pathways to mediate assembly and release from the cell.
To identify how viruses subvert and modify the host immune response to aid viral survival.

Friday, February 24
3:00 - 7:30 PM	Registration	Zia Concourse
6:30 - 7:30 PM	Refreshments	Sunset Room
7:30 - 8:30 PM	Keynote Address	Anasazi Ballroom
	Stephen C. Harrison, Harvard Medical School Viral Membrane Fusion: The Converging Paradigms
Saturday, February 25
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Viral Receptor Binding and Entry (a)	Anasazi Ballroom

	* Theodore S. Jardetzky, Stanford University
	Terence S. Dermody, Vanderbilt University School of Medicine Reovirus Cell Entry and Activation of Innate Immune Response Signaling
	Yusuke Yanagi, Kyushu University Measles Virus Receptors: Their Roles in Tropism and Signal Transduction
	John A. T. Young, The Salk Institute Early Steps of Retroviral Replication
	Susan R. Ross, University of Pennsylvania MMTV Interaction with Toll-like Receptors and Other Immunological Signaling Pathways
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM - 1:00 PM	Poster Setup	Sunset Room
1:00 - 10:00 PM	Poster Viewing	Sunset Room
2:30 - 4:30 PM	Workshop 1: Viral Receptors and Entry
	* Frederic S. Cohen, Rush Medical College
	Christopher Aiken, Vanderbilt University School of Medicine Inside-Out Regulation of HIV-1 Particle Fusion
	Carolyn B. Coyne, University of Pittsburgh Virus-Induced Abl and Fyn Kinase Signals Permit Coxsackievirus Entry through Epithelial Tight Junctions
	Kimberly A. Bishop, Uniformed Services University of the Health Sciences Characterization of the EphrinB2-Binding Site on the Henipavirus G Glycoprotein
	Robert A. Davey, University of Texas Medical Branch siRNA Screening for Cellular Factors Required for Infection by Human Respiratory Syncytial Virus Reveals Important Role for Clathrin-Mediated Endocytosis
	Karin Stiasny, Medical University of Vienna Structural and Functional Dissection of the Flavivirus Membrane Fusion Pathway
	Oscar A. Negrete, University of California, Los Angeles EphrinB3 is an Alternate Receptor for Nipah Virus
	Lily Y. Lee, Harvard Medical School Poliovirus Entry and RNA Release: A Multidisciplinary Study
	Roy Duncan, Dalhousie University Simplified Fusion Machines: The Reovirus Fusion-Associated Small Transmembrane (FAST) Proteins.
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	Receptor Binding and Entry (b)	Anasazi Ballroom
	* Robert A. Lamb, Northwestern University
	Theodore S. Jardetzky, Stanford University Structural Insights into Paramyxovirus Fusion Protein Folding and Function
	Robert P. Blumenthal, NCI, National Institutes of Health Conformational Changes and Fusion Activity of HIV Envelope Glycoproteins
	Richard W. Compans, Emory University, Rollins Research Center Specific Inhibition of Paramyxovirus F-Mediated Membrane Fusion
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 1	Sunset Room
Sunday, February 26
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Viral Movement and Trafficking	Anasazi Ballroom
	* Robert W. Doms, University of Pennsylvania School of Medicine
	Ari Helenius, ETH Zurich How Viruses Enter Animal Cells
	Thomas J. Hope, Northwestern University, Feinberg School of Medicine Virus Interactions with Dendritic Cells: Moving to the Synapse
	Geoffrey L. Smith, Imperial College London Ligand-Induced and Non-Fusogenic Dissolution of a Virus Membrane
	Xiaowei Zhuang, Harvard University Entry and Trafficking of Influenza Viruses by Single-Virus Tracking
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM - 1:00 PM	Poster Setup	Sunset Room
1:00 - 10:00 PM	Poster Viewing	Sunset Room
2:30 - 4:30 PM	Workshop 2: Immunity, Antivirals and Vaccines
	* Mary K. Estes, Baylor College of Medicine
	Sheri L. Hanna, University of Pennsylvania Contribution of WNV Envelope N-linked Glycosylation to Assembly, Infectivity and Tropism
	Grant E. Nybakken, Washington University Mechanistic Correlates of Antibody-Mediated Protection against West Nile Virus Infection
	Christian D.S. Nelson, Cornell University Antibody Neutralization Mechanisms: Different Responses to Antibody Binding at the Same Site in a Virus Capsid
	Rebecca K. Holmes, King's College London Unravelling the Importance of Cytidine Deamination for the Anti-Viral Activity of APOBEC3G and APOBEC3F
	Dapeng Zhou, University of Texas, MD Anderson Cancer Center A Natural Glycolipid Ligand of NKT Cells: Implications for Anti-Viral Immunity
	Byeongwoon Song, Emory University TRIM5alpha: Retroviral Restriction and Subcellular Localization
	Xiuyan Wang, Yale University School of Medicine A Novel Antiviral Mechanism Mediated by the Interferon-Inducible Protein Viperin
	Michael S. Kay, University of Utah School of Medicine Steric Accessibility of the HIV-1 gp41 N-Trimer Region
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	Virus Assembly and Release	Anasazi Ballroom
	* Richard W. Compans, Emory University, Rollins Research Center
	Eric Hunter, Emory University Cell Biology of Retroviral Assembly and Release
	Robert A. Lamb, Northwestern University Influenza Virus Assembly at the Viral Budozone
	Wesley I. Sundquist, University of Utah School of Medicine The Biochemistry of HIV Release
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 2	Sunset Room
Monday, February 27
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Cellular Genes and Virus Infection	Anasazi Ballroom
	* Otto Haller, University of Freiburg
	Jeff Bergelson, University of Pennsylvania Kinase Signals Permit Coxsackievirus Entry through Epithelial Type Junction
	Stephen P. Goff, Columbia University Host Factors Involved in Retroviral Replication
	Beth Levine, University of Texas Southwestern Medical Center Autophagy in Innate Antiviral Immunity
	Daved Fremont, Washington University School of Medicine Structural Mechanisms of Viral Immune Evasion
9:20 - 9:40 AM	Coffee Break	Zia Concourse
11:00 AM - 1:00 PM	Poster Setup	Sunset Room
1:00 - 10:00 PM	Poster Viewing	Sunset Room
2:30 - 4:30 PM	Workshop 3: Intracellular Movement, Trafficking and Assembly of Viruses
	* Jeff Bergelson, University of Pennsylvania

	Sara R. Cherry, University of Pennsylvania School of Medicine COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication
	Susana Guix, Baylor College of Medicine Studies of Norwalk Virus RNA Encapsidation
	Christopher T. Cornell, TSRI-Mail Code SP30-2110 Inhibition of Host Protein Secretion by Coxsackievirus b3 (CVB3): Multiple Gene Products Target a Common Organelle
	Benjamin J. Chen, Northwestern University Influenza Virus Hemagglutinin (H3) Requires Palmitoylation of its Cytoplasmic Tail for Assembly: M1 Proteins of Two Subtypes Differ in their Ability to Support Assembly
	Markus Thali, University of Vermont Tetraspanin-Enriched Microdomains (TEMs) Function as Gateways for HIV-1
	Glenn F. Rall, Fox Chase Cancer Center Neurokinin-1 Interacts with the Measles Virus Fusion Protein to Facilitate Trans-Synaptic Spread in Neurons
	David C. Johnson, Oregon Health & Science University Spread of Herpes Simplex Virus in Epithelial and Neuronal Tissues is Promoted by Membrane Proteins gE/gI and US9 which Sort Virions to Cell Junctions
	Laura Burleigh, Institut Pasteur Long–Term Transfer of HIV from Immature Dendritic Cells to T Cells Occurs Exclusively through DC-SIGN-Mediated Cis Infection and not Intracellular Storage of Incoming Virus
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	Viruses and Immunity	Anasazi Ballroom
	* Herbert (Skip) W. Virgin IV, Washington University School of Medicine

	Elina I. Zuniga, University of California, San Diego Viral Deregulation of Innate Immunity
	Ira Mellman, Genentech, Inc. Dendritic Cells and Virus Infection
	Raymond M. Welsh, University of Massachusetts Medical School Privacy of T Cell-Dependent Heterologous Antiviral Immunity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
7:30 - 10:00 PM	Poster Session 3	Sunset Room
Tuesday, February 28
7:00 - 8:00 AM	Breakfast	Eldorado Court
8:00 - 11:00 AM	Control of Infection and Viral Vaccines	Anasazi Ballroom
	* Ann M. Arvin, Stanford University
	Rafi Ahmed, Emory University School of Medicine Mechanisms of T Cell Memory in Antiviral Immunity
	Robert W. Doms, University of Pennsylvania School of Medicine

	Nancy J. Sullivan, Vaccine Research Center, National Institutes of Health Ebola Virus Immunity
	Curt M. Horvath, Northwestern University Activation and Inhibition of Cellular Interferon Responses and Innate Antiviral Immunity
9:20 - 9:40 AM	Coffee Break	Zia Concourse
4:30 - 5:00 PM	Coffee Available	Zia Concourse
5:00 - 7:00 PM	Viral Disease and Pathogenesis	Anasazi Ballroom
	* Rafi Ahmed, Emory University School of Medicine

	Francis V. Chisari, The Scripps Research Institute Robust Hepatitis C Virus Infection in Vitro: Coevolution of Virus and Host
	Herbert (Skip) W. Virgin IV, Washington University School of Medicine Replication of, and Resistance to, a Novel Norovirus
	Ann M. Arvin, Stanford University New Insights into Varicella-Zoster Virus Pathogenesis
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Eldorado Court/Sunset Room
8:00 - 11:00 PM	Entertainment	Eldorado Court/Sunset Room
Wednesday, March 1
	Departure

*Session Chair †Speaker invited, not yet responded.