Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

HIV Pathogenesis (X5)

Organizer(s): Tristram G. Parslow, Julie M. Overbaugh and John M. Coffin
March 27 - April 2, 2006
Keystone Resort · Keystone, Colorado
Abstract Deadline: November 29, 2005
Late Abstract Deadline: December 20, 2005
Scholarship Deadline: November 29, 2005
Early Registration Deadline: January 27, 2006

Part of the Global Health Series, Supported by the Bill & Melinda Gates Foundation

The University of Colorado School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The University of Colorado School of Medicine designates this educational activity for a maximum of 28-35 category 1 credits toward the AMA Physician's Recognition Award. Each physician should claim only those credits that he/she actually spent in the activity.

To receive CME credits, mark the box on the registration form, and pay the additional $50.00.

Joint meeting: HIV Vaccines (X6)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
Our agenda for the Pathogenesis meeting is organized in 10 plenary sessions, each showcasing the latest insights gained from studying a particular aspect or model of HIV and HIV-related illness. Individual sessions will, for example, highlight recent studies of the HIV virion, its growth in infected cells and tissues, its resistance to antiviral drugs, and its transmission in human populations. Others will feature illuminating work on related viruses and viral diseases, including simian AIDS. Two sessions on HIV immune responses will be convened jointly with the Vaccines symposium, as will the keynote address. We also envision at least two afternoon workshops featuring speakers chosen from submitted abstracts, as these offer an opportunity to involve new and lesser-known investigators.

Objectives
Upon completion of this conference, participants should be able to:

To describe the range of experimental approaches and research models that have proven useful in studying HIV and HIV-related illness.
To explain the latest insights and provocative findings that have arisen from these various experimental approaches.
To identify the current status of antiretroviral therapeutics as well as new emerging and potential drug targets.

Monday, March 27
3:00 - 7:30 PM	Registration	Longs Peak Foyer
6:30 - 7:30 PM	Refreshments	Longs Peak Foyer
7:30 - 9:30 PM	Keynote Session (Joint)	Longs/Grays Peak
	* Tristram G. Parslow, Emory University Hospital Introduction of HIV Pathogenesis Meeting
	Joseph G. Sodroski, Dana Farber Cancer Institute Antiretroviral Activity of TRIM5 and Related TRIM Proteins
	* Ruth M. Ruprecht, Dana-Farber Cancer Institute Introduction of HIV Vaccines Meeting
	Ulrich H. Von Andrian, Harvard Medical School Homing And Cellular Traffic In Lymphoid Tissues
Tuesday, March 28
7:00 - 8:00 AM	Breakfast	Shavano/Torreys/Red Cloud
8:00 - 11:15 AM	Lessons from the Virus	Grays Peak
	* Tristram G. Parslow, Emory University Hospital
	Michael F. Summers, University of Maryland Baltimore County and HHMI Structural Basis for Specific Membrane Targeting by the HIV-1 Gag Protein
	Hans-Georg Kräusslich, Universitat Heidelberg HIV Assembly and its Inhibition
	Peter E. Prevelige, University of Alabama, Birmingham HIV Core Assembly and Its Inhibitors
	Wei-Shau Hu, National Cancer Institute, National Institutes of Health Recombination and Complementation: Two Modes of Interactions among HIVs
	Jacob Anglister, Weizmann Institute of Science Short Talk: Cross-Strand Electrostatic Interactions at the Base of the â-Hairpin of the HIV-1 V3 Region Create a Molecular Switch for Phenotype Conversion
	Nathalie Arhel, Institut Pasteur Short Talk: Video Imaging of HIV-1 Intracellular Transport and Role of the Central DNA Flap in Active Nuclear Import

9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM - 1:00 PM	Poster Setup	Shavano/Torreys/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys/Red Cloud
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Lessons from the Target Cell (I) -- Factors that Inhibit	Grays Peak

	* Warner C. Greene, Gladstone Institute of Virology and Immunology New Perspectives on APOBEC3G Anti-retroviral Action and Regulation
	Kevin C. Klein, University of Washington Short Talk: Apobec3G Adopts Different Conformations in the Presence and Absence of RNA that may Correlate with Enzymatic Activity
	Philippe Gallay, The Scripps Research Institute Short Talk: Selective Destruction of the HIV-1 Capsid Shell by TRIM5alpha
	Klaus Strebel, NIAID, National Institutes of Health Short Talk: Degradation of APOBEC3G and Rescue of Viral Infectivity are Separable Activities of HIV-1 Vif
	Kyeongeun Lee, National Cancer Institute, National Institutes of Health Short Talk: HIV-1 Cell Killing Blocked by Pre-mRNA Factor CPSF6
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys/Red Cloud
7:30 - 10:00 PM	Poster Session 1	Shavano/Torreys/Red Cloud
Wednesday, March 29
7:00 - 8:00 AM	Breakfast	Shavano/Torreys/Red Cloud
8:00 - 11:00 AM	Lessons from the Target Cell (II) -- Factors that Enhance	Grays Peak
	* Carol Carter, Stony Brook University Tsg101 and Other Cofactors of HIV Release
	John A. T. Young, The Salk Institute Cellular Cofactors in Early Steps of Retroviral Entry
	Angela Ciuffi, Institute of Microbiology (IMUL-CHUV) Short Talk: HIV Integration Site Selection is Directed by Cellular LEDGF/p75
	Vicente Planelles, University of Utah Short Talk: Vpr Induces Bax-Dependent Apoptosis Downstream of G2 Checkpoint Activation
	Serge Benichou, Cochin Institute Short Talk: Dynamic Interaction of HIV-1 Nef with Clathrin at the Plasma Membrane Revealed by Evanescent Wave Fluorescence Microscopy
	René Daniel, Thomas Jefferson University Short Talk: Nijmegen Breakage Syndrome Protein 1 Controls the ATM-Dependent DNA Damage Response to HIV-1 Integration
	Erik S. Zimmerman, University of Utah Short Talk: Mechanism of Induction of G2 Arrest by HIV-1 Vpr in vivo
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:00 AM - 1:00 PM	Poster Setup	Shavano/Torreys/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys/Red Cloud
2:30 - 4:30 PM	Workshop 1: Therapeutic Targets in the Virus and Host	Grays Peak
	* Vinay K. Pathak, National Cancer Institute, National Institutes of Health Identification of APOBEC3G Mutants that Exhibit a Defect in Virion Incorporation
	Krishan K. Pandey, St. Louis University Health Sciences Center Human LEDGF/p75 Modulates Assembly and Disassembly of HIV-1 Synaptic Complexes in vitro
	Rik Gijsbers, Katholieke Universiteit Leuven Overexpression of the LEDGF/p75 Integrase Binding Domain abrogates HIV-1 Replication
	Steven P. Edgcomb, The Scripps Research Institute Attenuation of Rev Function by Modulation of the Oligomerization Domain
	Richard E. Sutton, Baylor College of Medicine Human Chromosome 2 Carries a Gene that Allows Infectious HIV Release from Mouse Cells
	Katrina Nolan, University of Pennsylvania HIV-1 Variants Containing Partial Deletions within the V3 Loop: Effects on X4 vs. R5 Tropism and Sensitivity to Entry Inhibitors
	Elena Gustchina, NIDDK, National Institutes of Health Fusion Inhibitors Targeting N- and C-Heptad Repeat Regions of Pre-hairpin Intermediate of gp41 Inhibit Fusion Synergistically
	John J. Dwyer, Trimeris Inc. Design and Mechanism of Action of Fusion Inhibitor Peptides with Enhanced Activity Against ENF-Resistant Virus
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Lessons from the Immune Response I (Joint)	Grays Peak
	* Ruth M. Ruprecht, Dana-Farber Cancer Institute
	* Nelson L. Michael, Walter Reed Army Institute of Research
	Susan Zolla-Pazner, New York University VA Hospital Defining Shared Epitopes that Induce Broadly Neutralizing Antibodies
	Gary J. Nabel, National Institutes of Health New Antigen Designs for Env Responses
	Barton F. Haynes, Duke University Medical Center Immunoregulation of Broadly Reactive Anti-HIV Antibody Responses
	Morgane Bomsel, Institut Cochin Short Talk: Characterization of HIV-1 Neutralizing Anti gp41-IgA by Screening a Phage-Display Fab IgA Library Derived from Mucosal Cells from HIV Highly Exposed but IgG sero Negative Individuals
	George M. Shaw, University of Alabama at Birmingham Short Talk: Characterization of HIV-1 Envelope in Acute HIV-1 Infection

7:15 - 8:15 PM	Social Hour w/ Lite Bites	Shavano/Torreys/Red Cloud
7:30 - 10:00 PM	Poster Session 2	Shavano/Torreys/Red Cloud
Thursday, March 30
7:00 - 8:00 AM	Breakfast	Shavano/Torreys/Red Cloud
8:00 - 11:30 AM	Lessons from the Immune Response II (Joint)	Grays Peak
	* Jay A. Levy, University of California, San Francisco
	* Judy Lieberman, Harvard Medical School Mechanisms of CTL Killing
	Rafick-Pierre Sekaly, University of Montreal Memory T Cell Homeostasis in the Natural History of HIV Infection

	Sarah L. Rowland-Jones, MRC Human Immunology Unit Long-Term Non-Progression with HIV Infection: Lessons from HIV-2
	Mark B. Feinberg, Merck & Co., Inc. Host-Virus Relationships in Nonpathogenic SIV Infections
	David A. Price, NIAID, National Institutes of Health Short Talk: Functional Consequences of Peptide-Major Histocompatibility Complex Class I Antigen Presentation in the Context of Enhanced CD8 Coreceptor Binding: Implications for Vaccine Delivery
	Arne Schneidewind, Massachusetts General Hospital Short Talk: Impact of HLA-B27-Associated CTL Escape Mutations on HIV-1 Replicative Fitness
	Photini Kiepiela, University of KwaZulu Natal Short Talk: Epitope-Specific Differences in Control of HIV-1 Infection
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM - 1:00 PM	Poster Setup	Shavano/Torreys/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys/Red Cloud
2:30 - 4:30 PM	Workshop 2: HIV Pathogenesis in Host Cells and Tissues	Grays Peak
	* Anna Aldovini, Children's Hospital Boston and Harvard Medical School TRAIL-Mediated Apoptosis is Induced by HIV and SIV in Human and Macaque CD4+ T Cells but does Not Occur in Virus-Exposed CD4+ T cells from AIDS-Resistant Species
	Elena Martinelli, Population Council HIV-1 gp120 Inhibits TLR9 Mediated Activation and IFN-gamma Secretion in Plasmacytoid Dendritic Cells
	Ivona Pandrea, Tulane National Primate Research Center Dramatic CD4+ T Cell Depletion in the Intestine is a Hallmark of SIVagm.sab Infection in Caribbean AGMs
	David E. Verhoeven, University of Maryland at Baltimore Mechanistic and Phenotypic Analysis of Delayed Restoration of Intestinal CD4+ Lymphocytes during Antiviral Therapy of SIV Infected Rhesus Macaques
	Desiree Kunkel, BCRT Regulatory T Cells in the Gastrointestinal Mucosa in HIV/SIV Infection
	Bin Li, Rapid Reversion of Transmitted Sequence Polymorphisms Dominates Early HIV-1 Evolution
	James P. Gregson, Brigham Young University Distinct HIV Compartmentalization In and Among Secondary Lymphoid Tissues
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:15 PM	Lessons from Other Viruses	Grays Peak
	* Stephen P. Goff, Columbia University Host Restriction of Retrovirus Replication
	Jonathan P. Stoye, National Institute for Medical Research A Collection Of Retrovirus Restriction Factors
	Hung Y. Fan, University of California, Irvine Oncogenic Properties of the Envelope Protein of Jaagsiekte Sheep Retrovirus

	James H. McLinden, University Of Iowa Short Talk: Hepatitis C Virus and GB Viruses B and C NS5A Proteins Inhibit HIV Replication in Jurkat Cells
	Melody G. Duvall, NIAID, National Institutes of Health Short Talk: Maintenance of HIV-Specific CD4+ T Cell Help Distinguishes HIV-2 from HIV-1 Infection
7:15 - 8:15 PM	Social Hour w/ Lite Bites	Shavano/Torreys/Red Cloud
7:30 - 10:00 PM	Poster Session 3	Shavano/Torreys/Red Cloud
Friday, March 31
7:00 - 8:00 AM	Breakfast	Shavano/Torreys/Red Cloud
8:00 - 11:15 AM	Lessons from Therapy	Grays Peak
	* John M. Coffin, Tufts University Host-Virus Interactions
	François Clavel, Université Denis Diderot HIV Drug Resistance : Viral Strategies for Treatment Escape

	Roland Marquet, IBMC du Centre National de la Recherche Scientifique Short Talk: Targeting the Dimerization Initiation Site of HIV-1 Genomic RNA with Aminoglycosides: From Crystal to Cell
	Andreas Schweizer, University Hospital Zurich Short Talk: CD4-Specific Designed Ankyrin Repeat Proteins Potently Inhibit HIV Entry
	Monica Macal, University of California, Davis Short Talk: Restoration of the Gut Mucosal Immune System in HIV Infected Patients during HAART
	Ruy M. Ribeiro, Los Alamos National Laboratory Short Talk: Naïve and Memory Cell Turnover as Drivers of CCR5 to CXCR4-Tropism Switch in HIV-1: Implications for Therapy
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
11:15 AM - 1:00 PM	Poster Setup	Shavano/Torreys/Red Cloud
1:00 - 10:00 PM	Poster Viewing	Shavano/Torreys/Red Cloud
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Lessons from the Tissues	Grays Peak
	* James E.K. Hildreth, Meharry Medical College
	Robert F. Siliciano, Johns Hopkins School of Medicine HIV Resevoirs, Latency, and Evolution
	Thijs van Montfort, Academic Medical Center Short Talk: Transfer of Antibody Neutralized HIV-1 from Dendritic Cells and DC-SIGN Expressing Cells to CD4 Lymphocytes
	Jason M. Brenchley, NIAID, National Institutes of Health Short Talk: Continued Infection of Mucosal CD4+ T Cells is Associated with Mucosal Depletion Despite Years of Antiretroviral Therapy
	Paul J. Peters, University of Massachusetts Short Talk: Macrophage-Tropic R5 Envelopes are Infrequent in Blood, Lymph Nodes and Semen: Implications for Transmission and Pathogenesis
	Jacob D. Estes, SAIC-Frederick, Inc., NCI-Frederick Short Talk: Rapid Secondary Lymphatic Tissue Fibrosis in Pathogenic SIV-Infected Rhesus Macaques Mediated by TGFbeta1+ Tregs
	Jean-Charles J. B. Grivel, National Institute of Child Health and Human Development, NIH Short Talk: HIV-1 Replication in Rectal Mucosa and Tonsillar Explant
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys/Red Cloud
7:30 - 10:00 PM	Poster Session 4	Shavano/Torreys/Red Cloud
Saturday, April 1
7:00 - 8:00 AM	Breakfast	Shavano/Torreys/Red Cloud
8:00 - 11:15 AM	Lessons from Animal Models	Grays/Longs Peak
	Ronald C. Desrosiers, New England Primate Research Center Replication-Competent and Replication-Incompetent SIV as Vaccines
	Jeffrey D. Lifson, SAIC-Frederick, Inc. Inactivated Vaccines
	Louis J. Picker, Oregon Health & Science University New Insights in SIV Immunopathogenesis -- Connecting Viral Replication to Disease
	* Janice C. Clements, Johns Hopkins University Innate Immune Responses Regulate SIV Replication in Macrophages In Vivo
	Miles P. Davenport, University of New South Wales Short Talk: Viral Load Predicts CD4+ T Cell Depletion in Acute SHIV Infection of Macaques
	Julie TerWee, Colorado State University Short Talk: Cellular Signaling following Receptor Engagement: Correlates with Pathogenicity
9:20 - 9:40 AM	Coffee Break	Longs Peak Foyer
4:30 - 5:00 PM	Coffee Available	Longs Peak Foyer
5:00 - 7:00 PM	Lessons from the Real World	Grays Peak
	* Julie M. Overbaugh, Fred Hutchinson Cancer Research Center
	Grace John-Stewart, University of Washington Maternal-Infant HIV-1 Transmission
	Eric Hunter, Emory University Early Events in HIV Infection: Lessons from Transmission Pairs
	Bruce D. Walker, Massachusetts General Hospital Elite Control of HIV Replication: Towards an Understanding of the Correlates of Immune Control
	Anu Rebbapragada, University of Toronto Short Talk: HSV2 and HIV Interaction: Negative Synergy in the Female Genital Tract
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Shavano/Torreys/Red Cloud
8:00 - 11:00 PM	Entertainment	Shavano/Torreys/Red Cloud
Sunday, April 2
	Departure

*Session Chair †Speaker invited, not yet responded.