Keystone Symposia | Scientific Conferences on Biomedical and Life Science Topics

Structural Genomics (J5)

Organizer(s): Cheryl H. Arrowsmith, Christine A. Orengo, and Andrzej Joachimiak
January 29 - February 3, 2006
Keystone Resort · Keystone, Colorado
Abstract Deadline: September 29, 2005
Late Abstract Deadline: October 21, 2005
Scholarship Deadline: September 29, 2005
Early Registration Deadline: November 29, 2005

Joint meeting: Frontiers in Structural Biology (J6)
NOTE: Registration for meeting allows attendance at joint meeting (pending space availability).

This meeting took place in the 2006 season.

For a complete list of the meetings for the upcoming/current season,
see our meeting list, or search for a meeting.

Summary of Meeting
The 2006 Keystone Structural Genomics Meeting will provide a venue for discussion of progress and technical advances in the field of rapid, parallel, and economically efficient methods for structural biology. Keynote and Invited Speakers are all thought leaders in the areas of Bioinformatics, Protein Expression/Purification, Sample Preparation, X-ray Crystallography, Solution NMR Spectroscopy, Biophysical characterization of proteins, Functional Annotation, and Structure-Based Drug Discovery. Keynote and Regular Sessions cover the following topics: - Selection of targets that both increase our knowledge of protein structure and enhance biomedical research. - Efficient parallel methods for sample preparation for solution NMR spectroscopy and X-ray crystallography. - Automated data reduction, structure determination, refinement, and data deposition. - Computational and experimental approaches to functional annotation of new protein structures. - Insights into structure, function and evolution of protein gene families. - Applications of high-throughput structural studies to important biomedical problems and drug discovery. Poster Sessions provide opportunity for presentations by conferees, particularly Younger Scientists, as well as detailed presentations by Structural Genomics Centers and Consortia throughout the world.

Sunday, January 29
3:00 - 7:30 PM	Registration	Longs Foyer
6:30 - 7:30 PM	Refreshments	Longs Foyer
7:30 - 8:30 PM	Keynote Session (Joint)	Quandary/Longs

	Roger D. Kornberg, Stanford University RNA Polymerase II Structure and Mechanism
Monday, January 30
7:00 - 8:00 AM	Breakfast	Grays
8:00 - 11:00 AM	Protein Expression/Purification	Quandary
	* Aled M. Edwards, University of Toronto Making Proteins for Structural Biology
	Pär L. Nordlund, Karolinska Institute Library Screening Methods for the Production of Human Proteins and Domains

	Binesh Shrestha, University of Oxford Short Talk: High Throughput Expression of Human Proteins in Insect Cells
	Ian E. Hunt, Novartis Institutes for Biomedical Research Short Talk: From Gene to Protein: A Review of New and Enabling Technologies for Multi-Parallel Baculovirus Mediated Protein Expression
	Shigeyuki Yokoyama, RIKEN Genomic Sciences Center Cell Free Protein Expression
9:20 - 9:40 AM	Coffee Break	Longs Foyer
11:00 AM - 1:00 PM	Poster Setup	Grays
1:00 - 10:00 PM	Poster Viewing	Grays
4:30 - 5:00 PM	Coffee Available	Longs Foyer
5:00 - 7:00 PM	Bioinformatics	Quandary
	* Christine A. Orengo, University College London Target Selection that Samples Structure and Function Space

	John Moult, University of Maryland Biotechnology Institute Structural Bioinformatics for Target Selection, SNPs, and Alternative Splicing
	Burkhard Rost, Columbia University Structural Genomics Changes our Map of Protein Space
	Olivier Lichtarge, Baylor College of Medicine Short Talk: Evolutionary Importance Guides Functional Annotation of Proteins Based on Local Structural Similarity
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grays
7:30 - 10:00 PM	Poster Session 1: Bioinformatics and Structural Genomics: Project Overviews/Summaries	Grays
Tuesday, January 31
7:00 - 8:00 AM	Breakfast	Grays
8:00 - 11:15 AM	Pushing Limits of Structural Biology (Joint)	Quandary/Longs
	* Gerhard Wagner, Harvard Medical School
	Xiaoliang Sunney Xie, Harvard University Single Molecule Approach to Biochemistry: From in vitro to in vivo Studies
	Lewis E. Kay, University of Toronto NMR Spectroscopy of Supra- Molecular Machines making the new invisible...visible. NMR Studies of Excited Protein States Seeing the Invisible
	Ann E. McDermott, Columbia University Protein Structure and Dynamics by Solid State NMR
	Venki Ramakrishnan, MRC Laboratory of Molecular Biology Crystal structures of functional states of the ribosome
	Joachim Frank, Columbia University Application of Cryo-EM to Image Ribosome Dynamics
9:20 - 9:40 AM	Coffee Break	Longs Foyer
11:00 AM - 1:00 PM	Poster Setup	Grays
1:00 - 10:00 PM	Poster Viewing	Grays
4:30 - 5:00 PM	Coffee Available	Longs Foyer
5:00 - 7:00 PM	Crystallization and NMR Sample Production	Quandary
	* Andrzej Joachimiak, Argonne National Laboratory
	Naomi Chayen, Imperial College London Protein Crystallization: The Current Challenge
	Gaetano T. Montelione, Rutgers University Protein Sample Production Technologies for Large-Scale Structural Proteomics
	Zygmunt S. Derewenda, University of Virginia Protein crystallization: from art to science
	Alexander Shekhtman, University at Albany, State University of New York Short Talk: Mapping STructural INTeractions in Vivo Using in-cell NMR (STINT-NMR)
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grays
7:30 - 10:00 PM	Poster Session 2: NMR, Crystallography and Protein Production Methods	Grays
Wednesday, February 1
7:00 - 8:00 AM	Breakfast	Grays
8:00 - 11:00 AM	Data Collection and Analysis. Session sponsored by Bruker AXS and Bruker Biospin Corporation	Quandary
	* Gaetano T. Montelione, Rutgers University
	Andrzej Joachimiak, Argonne National Laboratory Application of Structural Genomics Pipeline to Expand Protein Fold Space and Discover Protein Function
	Thomas A. Szyperski, University at Buffalo, State University of New York GFT NMR-Based Structural Genomics
	Ad Bax, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health Weak alignment offers shortcuts in NMR structure determination
	Thomas C. Terwilliger, Los Alamos National Laboratory PHENIX: New methods for automated structure solution, model-building, ligand-fitting and refinement
	Wladek Minor, University of Virginia Short Talk: The Integration of Data Reduction and Structure Solution - From Diffraction Images to an Initial Model in Minutes
9:20 - 9:40 AM	Coffee Break	Longs Foyer
11:00 AM - 1:00 PM	Poster Setup	Grays
1:00 - 10:00 PM	Poster Viewing	Grays
4:30 - 5:00 PM	Coffee Available	Longs Foyer
5:00 - 7:00 PM	Late Breaking Developments in Structural Genomics	Quandary
	* Cheryl H. Arrowsmith, Ontario Cancer Institute
	William C. Nierman, Institute for Genomic Research Genomic Sequencing: What Can We Expect in the Next Five Years
	John C. Norvell, NIGMS, National Institutes of Health Protein Structure Imitative: Progress and Plans


	James E. Bradner, Dana-Farber Cancer Institute Chemical Biology Tools to Complement Structural Genomics
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grays
7:30 - 10:00 PM	Poster Session 3: Structures, Structural and Functional Analysis and Applications of Structural Genomics	Grays
Thursday, February 2
7:00 - 8:00 AM	Breakfast	Grays
8:00 - 11:00 AM	Biological/Biochemical Insights from Structural Genomics	Quandary
	Cheryl H. Arrowsmith, Ontario Cancer Institute Structural Proteomics as a Tool for Genome Annotation

	Udo Oppermann, University of Oxford An Integrated Structural and Functional Genomics Approach towards the Human SDR Family
	Susan S. Taylor, University of California, San Diego Evolution and Diversity of the Protein Kinase Superfamily
	* Ian A. Wilson, Joint Center for Structural Genomics Structural proteomics of Thermotoga maritima
	Andrew Robinson, Macquarie University Short Talk: Structural Genomics of the Mobile Metagenome
9:20 - 9:40 AM	Coffee Break	Longs Foyer
4:30 - 5:00 PM	Coffee Available	Longs Foyer
5:00 - 7:00 PM	Applications of Structural Genomics to Drug Discovery	Quandary
	Stephen K. Burley, Eli Lilly and Company Fragment Based Drug Discovery for Oncology Targets
	Tom L. Blundell, University of Cambridge High-Throughput Crystallography, Structural Bioinformatics and Fragment-Based Drug Discovery
	* Michael Sundstrom, University of Oxford Structural Chemistry of Human Protein Families
7:00 - 8:00 PM	Social Hour w/ Lite Bites	Grays
8:00 - 11:00 PM	Entertainment	Grays
Friday, February 3
	Departure

*Session Chair †Speaker invited, not yet responded.